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The University of Southampton
Institute for Life Sciences

Infectious Diseases

Research within the Infectious Diseases group is focused on investigation of pathogenesis, prevention and diagnosis of infectious diseases.

We cover several complementary areas:

  1. Virology: Our virology research focuses on RNA viruses, which includes short term infections (such as a common cold), and long term infections (HIV, for example). The work builds on strengths in respiratory medicine, gut/epithelial biology, hepatology and global health.
  2. Bacterial pathogenesis: This focuses on the major causative organisms of bacterial meningitis and sepsis, tuberculosis, STDs, keratitis and inflammatory skin conditions. Our overall aim is to apply our research to tackle the unmet needs of infectious diseases.
  3. Molecular epidemiology: This links with many other disciplines such as public health and biofilms. Post-genomic technologies are exploited to investigate the relationships between different microbial species at genomic level. 
  4. Novel Diagnostics: Research into novel diagnostic tools is focused on the development of improved diagnostic methods for the detection of both bacterial and viral infections. Point-of-care tests are currently being developed for respiratory (TB) and sexually transmitted infections. This includes multi-centre studies within the UK as well as international collaborations (the University of Melbourne, the University of Cape Town and the Kwazulu-Natal Research Institute for Tuberculosis and HIV).
  5. Global Health: This research is focused on infectious diseases epidemiology, in particular HIV transmission dynamics, and the impact of antiretroviral drugs on HIV transmission, pregnancy and infant outcomes, sexual behaviour and partnership change.
  6. Experimental Human Challenge: We use controlled infection to investigate pathogenesis and prevention of infectious disease. Carried out in the NIHR Wellcome Trust Clinical Research Facility, we collaborate with colleagues in Oxford to use malaria challenge to investigate new vaccines.
  7. Clinical Trials (vaccines): Focused on the prevention and management of severe bacterial disease and respiratory virus infection, we collaborate with Public Health England and national reference laboratories to evaluate the safety and efficacy of candidate vaccines against meningococcal disease and pandemic influenza strains including H7N9.

View our research impact here

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