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The University of Southampton
Interdisciplinary Research Excellence

Molecular simulations of proteins undergoing fibrillation in neurodegenerative diseases Event

Time:
14:00 - 15:00
Date:
16 September 2011
Venue:
Building 27, Room 2001

Event details

Many neurodegenerative diseases are associated with the accumulation of fibrillar proteins. The unifying features of a fibril formation is the structural transition from an initial globular or intrinsically disordered state to a β-structural form. Here we will describe our recent effort, based on atomistic simulations, at understanding how the presence of ligands affect the structural stability of proteins undergoing fibrillation in Parkinson’s and Prion diseases. Our calculations may help identify compounds which might affect fibrillation as well as uncover the role of specific cellular partners for protein fibrillation.

http://cmg.soton.ac.uk/events/event-277/

Many neurodegenerative diseases are associated with the accumulation of fibrillar proteins. The unifying features of a fibril formation is the structural transition from an initial globular or intrinsically disordered state to a β-structural form. Here we will describe our recent effort, based on atomistic simulations, at understanding how the presence of ligands affect the structural stability of proteins undergoing fibrillation in Parkinson's and Prion diseases. Our calculations may help identify compounds which might affect fibrillation as well as uncover the role of specific cellular partners for protein fibrillation.

Contact

Dr Chris-Kriton Skylaris

https://www.southampton.ac.uk/chemistry/about/staff/cks.page

http://cmg.soton.ac.uk/people/cks/

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