A mechanism for regulation of phospholipase C gamma Event
- Time:
- 17:00
- Date:
- 12 November 2012
- Venue:
- Building 85 Room 2207
For more information regarding this event, please email Beatrice Murphy at B.J.Murphy@southampton.ac.uk .
Event details
Phosphatidylinositol-phospholipase Cs (PI-PLCs) constitute a critical component of second messenger-generating system that operates downstream of a great number of cell surface receptors, important for development, cell proliferation and motility (and possibly cell death). Dysregulation of these enzymes is associated with various pathological conditions.
Recently we have been working on PLCγ1 which acts predominantly downstream of growth factor receptor tyrosine kinases and contains a pseudocyclic regulatory element known as the specific array. We have used a combination of NMR, X-ray crystallography, small angle X-ray scattering and biochemical measurements to investigate the role of the specific array, leading us to propose a mechanism for the role it plays in the activation of lipase activity.