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The University of Southampton
Interdisciplinary Research Excellence

Optimal design in nonlinear mixed effects models with application in pharmacokinetics Event

France Mentre
19 December 2012
Building 54, Room 1031

For more information regarding this event, please email Dr Dave Woods at .

Event details

France Mentre is a Professor of Biostatistics and, since 2003, Director of the research unit UMR 738 of University Paris Diderot and INSERM called "Models and Methods for the therapeutic assessment of chronic diseases" and since 2009 head of the team “ Biostatistical Modelling and Pharmacometrics” created in January 2009.

Her main methodological research areas include:

  • Exact estimation methods in nonlinear mixed-effect models
  • Design optimisation in nonlinear mixed-effect models (
  • Model evaluation in nonlinear mixed-effect models (
  • Model selection, covariate tests and pharmacogenetics
  • Modelling data from interaction or bioequivalence studies

Her main application areas include:


  • Pharmacology and pharmacogenetics of antiretroviral drugs in HIV patients
  • Variability of the response to oral anticoagulant drugs
  • Pharmacokinetic/pharmacodynamic parameters, efficacy and antibiotic resistance
  • Chemosensitivity to antimalarial agents
  • Evolution of biomarkers of the Gaucher disease, with or without treatment
  • Infectious endocarditis
  • Bioequivalence of monoclonal antibodies

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