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The University of Southampton
Interdisciplinary Research Excellence

Roles of balanced positive and negative feedbacks in inflammatory and infectious diseases Event

18 June 2014
Building 85, Room 2207 Highfield Campus University of Southampton

For more information regarding this event, please telephone Nick Evans on 023 8077 7222 Ext: 3293 .

Event details

Bioengineering Seminar

Homeostasis in biological systems is often attained as a result of a subtle balance between positive and negative feedbacks, and their unbalance may lead to disease conditions. Our group aims to understand essential pathological mechanisms of inflammatory and infectious disease, such as atopic eczema (acute/chronic skin inflammation with defective skin barrier) and bacterial/fungal infection in the respiratory systems, from a viewpoint of control engineering. We develop ODE-based mathematical models to understand the role of epithelial barrier in determining the disease state, identify essential control mechanisms responsible for different pathological symptoms, and evaluate the effects of possible drug treatments. Our model analysis suggests the critical roles of the dual controls for barrier homeostasis, which is a key for the onset/remission of disease.


Speaker information

Dr Reiko Tanaka,Imperial College London. ,Lecturer in Bioengineering, Department of Bioengineering

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