The study is currently open for recruitment.
Arm 1: Allergy in early life
Recruitment target: 30 neonatal, 30 paediatric patients.
Inclusion criteria
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Male and females.
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Aged 0-18 years.
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Atopic allergic volunteers. Individuals who have experienced an allergic response to one or more allergens.
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Non-allergic individuals. Individuals who have no history of atopy/allergic reactions.
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Patients with atopic dermatitis as diagnosed by a consultant allergologist/dermatologist accordingly to the UK Working Party Diagnostic Criteria for Atopic Dermatitis.
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Undergoing an unrelated surgical procedure
Exclusion criteria
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Subjects on systemic immunosuppressants.
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People with significant long-term illness in which the illness or treatment would be likely to adversely affect the results of the immune assays.
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Individuals whose parents unable to give fully informed consent for reasons of language or general comprehension.
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Individuals with inflammatory skin conditions other than atopic dermatitis.
Arm 2: Tolerance in atopic dermatitis
Recruitment target: 30 adult patients with atopic dermatitis
Inclusion criteria
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Male and females.
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Aged over 18 years.
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Patients with atopic dermatitis as diagnosed by a consultant allergologist/dermatologist accordingly to the UK Working Party Diagnostic Criteria for Atopic Dermatitis.
Exclusion criteria
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Subjects on systemic immunosuppressants.
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People with significant long-term illness in which the illness or treatment would be likely to adversely affect the results of the immune assays.
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Pregnant or lactating women
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Individuals unable to give fully informed consent for reasons of language or general comprehension.
For more details, please contact:
Dr. Marta E Polak
e-mail:
m.e.polak@soton.ac.uk
Arm 3:Inducing immunosuppression
Recruitment target: 50 patients
Inclusion criteria
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Male and females.
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Aged over 18 years.
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Atopic allergic volunteers. Individuals who have experienced an allergic response to one or more allergens.
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Non-allergic individuals. Individuals who have no history of atopy/allergic reactions.
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Undergoing an unrelated surgical procedure
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Individuals with inflammatory skin conditions exposed to natural or artificial ultraviolet light (e.g. as part of treatment).
Exclusion criteria
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Subjects on systemic immunosuppressants.
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People with significant long-term illness in which the illness or treatment would be likely to adversely affect the results of the immune assays.
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Pregnant or lactating women
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Individuals unable to give fully informed consent for reasons of language or general comprehension.