Applied Seminar - Modelling and controlling collective behaviours in cell population, Lucia Marucci (University of Bristol) Seminar
- Time:
- 12:00 - 13:00
- Date:
- 7 November 2017
- Venue:
- Room 4001, Ketley Room, Building 54, Mathematical Sciences, University of Southampton, Highfield Campus, SO17 1BJ
For more information regarding this seminar, please email Philip Greulich at P.Greulich@southampton.ac.uk .
Event details
Cell decision-making is orchestrated by the dynamic interplay between complex gene regulatory networks (GRNs), and the extracellular environment. How do these components produce emergent behaviours and, ultimately, affect cell decision-making? What is the role of non-linear dynamics commonly arising in GRNs in cellular fate control? Can we reprogram biological networks and, ultimately, cell fate in a predictable and controllable way?
To answer these questions, in this talk, I will discuss our recent results in Stem Cell Systems Biology and Synthetic Biology, focusing on the analysis of the cellular link between signalling pathways’ dynamics, the cell-cycle and emergent pluripotency phenotypes in mouse embryonic stem cells, using combined experimental and computational techniques. I will indicate current research directions to regulate cell decision-making through the direct engineering of signalling pathway dynamics by means of microfluidics devices and live-cell imaging.
Speaker information
Lucia Marucci, University of Bristol. I am a computational biology scientist, with 10 years research experience in Synthetic Biology (control and modelling of synthetic gene regulatory networks) and Systems Biology (modelling and studying the functional role of signalling and cell-cycle dynamics in mammalian cells). I received a Bachelor degree in Mathematics in the University of L'Aquila (Italy) in 2003, followed in 2007 by a Master degree in Mathematics and Informatics in the same University. In 2010 I received a Ph.D. degree in Automatic Engineering in the University of Naples "Federico II", Italy. My Ph.D. was focused on the mathematical modelling and analysis of synthetic gene regulatory networks. From 2011 to 2013 I was a PostDoc EMBO fellow in the Centre for Genomic Regulation (CRG), Barcelona, Spain, studying the links between signalling pathways dynamics and somatic cell reprogramming. In September 2013 I joined Bristol University as Lecturer in Engineering Mathematics.