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The University of Southampton
Mathematical Sciences

Applied Seminar - Mechanical models for cell and tissue culture exploring mechanotransduction, Dr Carina Dunlop (University of Surrey) Seminar

Applied Seminar
12:00 - 14:00
9 January 2018
Ketley Room, Room 4001, Building 54, Mathematical Sciences, University of Southampton, Highfield Campus, SO17 1BJ

For more information regarding this seminar, please email Dr Philip Greulich at .

Event details

The ability of cells to sense and respond to the mechanical properties of their environments is fundamental to a range of cellular behaviours, with stiffness increasingly being found to be a key control parameter. The physical mechanisms underpinning mechanosensing are, however, not well understood. I here consider the key physical cellular behaviours of active contractility of the internal cytoskeleton and cell growth, coupling these into mechanical models for tissue culture. These models suggest new distinct mechanisms of mechanotransduction in cell and tissue culture.

Speaker information

Dr Carina Dunlop, University of Surrey. I am interested in using mathematical and computational approaches to solve a broad range of problems in developmental biology, tissue morphogenesis and cancer modelling. A particular research focus is on the cell as a physical object, incorporating an understanding of the role of mechanical forces into models of biological processes. I draw on a diverse range of concepts in pursuing this research ranging from population modelling to the theories of fluid dynamics and elasticity theory. Currently ongoing projects include work on tissue self-organization, mechanical regulation of growth and cellular contractility.

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