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The University of Southampton
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Dr Constantinos Savva MD, MSc, PGDip, MRCP (UK), SCE (Medical Oncology)

Clinical Research Fellow and Specialist Registrar in Medical Oncology

Dr Constantinos Savva's photo

Dr Constantinos Savva is a Clinical Research Fellow in Cancer Sciences.

Graduated from the School of Medicine, University of Ioannina, Greece in 2010 with second upper honours.  Completed successfully his MSc in Epidemiology offered by the London School of Hygiene & Tropical Medicine in 2011. From 2011 to 2015, he underwent Foundation and Core Medical training in Mersey and East of England deaneries, respectively. In 2015, he became a member of the Royal College of Physicians.

Subsequently, he was awarded an NIHR Academic Clinical Fellowship and a National Training Number in Medical Oncology at the University of Nottingham and Nottingham University Hospitals NHS Trust. In parallel, he completed the PGDip in Oncology offered by Newcastle University.

In 2018, he obtained a CRUK Clinical Research Fellowship in Cancer Immunology and Biology offered by the University of Southampton.


PGDip in Oncology, Newcastle University (2018)
SCE in Medical Oncology, Royal College of Physicians (2018)
MRCP (UK), Royal College of Physicians (2015)
MSc in Epidemiology, London School of Hygiene & Tropical Medicine, University of London (2011)
MD, University of Ioannina (2010)

Appointments held

CRUK Clinical Research Training Fellow, University of Southampton, 2018 to present.
NIHR Academic Clinical Fellow and Specialty Registrar in Medical Oncology, Nottingham University Hospitals NHS Trust, 2015-2018.
Specialty Doctor in Medical Oncology, Norfolk & Norwich University Hospitals NHS Foundation Trust, 2014-2015.
Core Medical Trainee, Norfolk & Norwich University Hospitals NHS Foundation Trust and James Paget University Hospitals NHS Foundation Trust 2012-2014
Foundation Programme Trainee, Mid-Cheshire Hospitals NHS Foundation Trust, 2011-2012. 

Research interests

I found the link between basic science and medical oncology fascinating and realised that an appreciation of the molecular basis of disease enhanced my understanding of clinical practice. Recent advances in cancer immunotherapy with checkpoint blockade antibodies have made inroads for patients with tumour types that were previously difficult to treat. These new treatments either augment the initiation of immune responses, or prevent the premature termination of immunity. The mechanisms of action of many conventional cancer treatments also involve immune responses in part because of the release of tumour antigens by dying tumour cells and the generation of antitumor T-cell responses. Tumours evolve multiple mechanisms of immune escape and new strategies to prevent this are of particular importance. My aim is to understand and restore immune function in patients with cancer who do not respond to immunotherapy or conventional anticancer therapies such as chemotherapy and radiotherapy. Knowledge gained from this research could ultimately result in new immunotherapies and treatment strategies for patients with cancer.

Honorary NHS Trust Contract, University Hospital Southampton

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Dr Constantinos Savva
Faculty of Medicine, University of Southampton, Cancer Sciences Unit, Centre for Cancer Immunology, Tremona Road, Southampton SO16 6YD.

Room Number : SGH/CCI/2015/MP127

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