The University of Southampton
Medicine
Phone:
(023) 8059 1785
Email:
G.O'Reilly@soton.ac.uk

Dr Gillian O'Reilly PhD

Trial Manager

Dr Gillian O'Reilly's photo
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Dr Gillian O'Reilly is Trial Manager within Medicine at the University of Southampton.

Gillian O’Reilly has been a trial manager in Primary Care and Population Sciences at the University of Southampton since 2006. Having graduated in genetics from the University of Nottingham in 1987, she gained a PhD in the genetics of psychiatric disorders at the Institute of Psychiatry, University of London in 1991, and undertook postdoctoral research in molecular genetics at the Universites of Cambridge and Oxford. She started managing clinical trials in 2001 at the Institute of Nutrition, University of Southampton before moving to Primary care and Population Sciences.

Gillian O’Reilly is currently managing a HTA funded multi-site randomised controlled trial to investigate CBT for Irritable Bowel Syndrome (ACTIB). Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that affects 10–22% of the UK population and costs the NHS over £200 million a year. Abdominal pain, bloating and altered bowel habit affect quality of life, ability to enjoy social activities and time off work. Guidelines recommend Cognitive Behavioural Therapy (CBT) for patients with IBS who continue to have symptoms after 12 months. However, access to this therapy is limited due to the cost and availability of therapists and there is uncertainty regarding how effective it is in reducing symptoms in the long term and its cost-effectiveness. One way to make CBT accessible to larger numbers of patients is to provide a less intense form of the therapy on the internet. We have developed a CBT-based website, which could be accessed by patients countrywide.

Participants will be recruited from London and Wessex from primary and secondary care. Potential participants will be invited for eligibility screening and will have a simple blood test to exclude other conditions and will be randomly assigned to one of the 3 groups, therapist CBT, LIBT (the website), and treatment as usual (TAU). The main outcomes are IBS symptom severity and the participant’s subjective assessment of relief of symptoms at 12 months. We will also assess cost-effectiveness and wider benefits (e.g. quality of life and mood) as these provide important additional ways of assessing the impact of IBS on people’s lives.

Gillian is also managing the HTA funded ARTIC PC study.

ARTIC PC

This will be an RCT of antibiotic and placebo nested within an observational study. We are looking to investigate the usefulness of antibiotics in this age group, it follows a European wide trial that was very similar for adults. Children will be provided antibiotic or placebo and keep a symptom diary for up to 28 days. They can opt to provide a throat swab, a blood sample and have a chest x-ray.

Design: RCT nested in an observational study.

Intervention: 7 days of tds amoxicillin or placebo for those in the RCT

The aim: To provide evidence to inform the management of chest infections in children.

The objectives are:

• To estimate the effectiveness of amoxicillin overall and in key clinical subgroups of children presenting with uncomplicated (non-pneumonic) lower respiratory tract infection in primary care.

• To estimate the cost-effectiveness of antibiotics overall and in key clinical subgroups of children presenting with uncomplicated lower respiratory tract infection in primary care.

• To explore the estimates of effectiveness according to key pathophysiological subgroups (the presence of bacterial pathogens; raised C reactive protein measurement or white cell count; the presence of clinically undetected consolidation on X ray; pulse oximetry; lung function).

 

Qualifications

BSc, Genetics, Nottingham University (1987)

PhD, University of London (1991)

Research

Responsibilities

Publications

Contact

Research interests

2013-17 Trial Manager (ACTIB), University of Southampton

2013 Trial Manager (CANDID), University of Southampton

Multicentre RCT to investigate symptoms and examinations for predicting lung and bowel cancer in 20,000 patients.

2012-13 Trial Manager (ASPEN), University of Southampton

Pilot RCT in Hampshire to investigate chronic or recurrent back pain, to understand the mechanisms of recovery, and whether Alexander Technique (AT) lessons and physiotherapy courses help in 80 patients.

2011-12 Trial Manager (GRACE WP10b), University of Southampton

Multi-national RCT of web-based training in communication skills and use of a CRP point of care test in acute RTI in 8 EU countries in 14,000 patients.

2007-11 Trial Manager (GRACE WP10a), University of Southampton

Multi-national RCT to investigate the benefit of antibiotic in patients with LRTI in 13 EU networks. 6,000 patients recruited to observational study, 3000 to CTIMP.

2006-07 Trial Manager (GNOME), University of Southampton

RCT to investigate the benefit of steroids in children with glue ear.

Research group

Primary Care & Population Sciences Academic Units

Affiliate research group

Primary care Research group

Research project(s)

ARTIC PC

We are looking to investigate the usefulness of antibiotics in this age group, it follows a European wide trial that was very similar for adults. Children will be provided antibiotic or placebo and keep a symptom diary for up to 28 days. They can opt to provide a throat swab, a blood sample and have a chest x-ray.

ACTIB - Assessing Cognitive behavioural Therapy in Irrital Bowel Syndrome

Assessing Cognitive behavioural Therapy in Irritable Bowel Syndrome (ACTIB)

EU network management & coordination

Trial set-up across centres

Coordination of Trial Steering Group and Data Monitoring and Ethics Committees

Monitoring adverse events

Ensuring trial quality

Overseeing manufacture & distribution of trial supplies to Europe

Ethics and CA approval across Europe

Monitoring, supervision of trial secretary & centre coordinators

EU budget management

Reporting

Articles

Dr Gillian O'Reilly
Primary Care and Population Sciences Faculty of Medicine University of Southampton Aldermoor Health Centre Aldermoor Close Southampton SO16 5ST

Room Number:9590 AHC/143/S2

Telephone:(023) 8059 1785
Email:G.O'Reilly@soton.ac.uk

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