Dr Jane Gibson BSc, MSc, PGCAP, PhD

Lecturer in Cancer Bioinformatics and Genomics

Dr Jane Gibson is a Lecturer in Cancer Bioinformatics and Genomics within Medicine at the University of Southampton.

Career History

2019-present: Lecturer in Cancer Bioinformatics and Genomics. Cancer Sciences, Faculty of Medicine, University of Southampton, UK.
2013-2019: Lecturer in Bioinformatics. Biological Sciences, University of Southampton, UK.
2012-2013: Career track award Fellow. Faculty of Medicine, University of Southampton, UK.
2008-2012: Postdoctoral research assistant. School of Medicine, University of Southampton, UK.
2002-2008: Research assistant. School of Medicine, University of Southampton, UK.

Academic Qualifications

2015: PGCAP (Merit) Postgraduate certificate in Academic Practice. University of Southampton, UK.
2008: PhD Genetic Epidemiology and Bioinformatics. University of Southampton, UK.
2002: MSc Biosystems and Informatics. University of Liverpool, UK.
2001: BSc (Hons) Genetics. University of Leeds, UK.

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Dr Gibson has experience in bioinformatics, and expertise the computational analysis of high throughput next generation sequencing data. Including exome, whole genome, epigenome, and transcriptome analyses, as well as Genome-Wide Association studies.

Her research involves bioinformatics approaches to understanding cancer, the human genome and the changes which can lead to disease. Leveraging the molecular data generated from a range of technologies to understand the development, progression, and response to treatment in cancer.

Research areas include:

Characterisation of the genomic landscape in splenic marginal zone lymphoma (with Prof Jon Strefford, Prof Sarah Ennis)
Investigating the Chromatin Landscape of CLL upon stimulation of the B-Cell Receptor (with Prof Jon Strefford)
Genomic analysis of germline and somatic lesions at the FCGR locus using long read sequencing technologies (with Prof Jon Strefford, Prof Mark Cragg)
Investigating the functional role of Hydroxymethylation in the pathogenesis of B-cell malignancies (with Prof Jon Strefford)
The role of epigenetics in Oesophageal Adenocarcinoma (with Prof. Tim Underwood, Dr Zoe Walters, Dr Mat Rose-Zerilli)
Investigating the benefits of directRNA and single cell sequencing using Oxford Nanopore Technologies (with Dr Jade Forster, and Dr Mat Rose-Zerilli)
Next generation sequencing and geResearch areas include:netic association studies which aim to determine genes underlying ophthalmic traits such as Age-related Macular Degeneration, Primary Open Angle Glaucoma and Nystagmus. (with Prof Andrew Lotery, Mr Jay Self & Prof Sarah Ennis).

Research group

Cancer Sciences

Affiliate research groups

Genomics, Epigenomics and Bioinformatics Research Theme, Computational and Systems Biology

Current PhD supervision:

Carolina Jaramillo Oquendo – Characterisation of the genomic landscape in splenic marginal zone lymphoma
Lara Buermann – Investigating the Chromatin Landscape of CLL Upon Stimulation of the B-Cell Receptor
Sarah Frampton – Genomic Analysis of Germline and Somatic Lesions at the FCGR Locus; From Reference Genomes to Clinico-biological Implications
Anna Takeuchi – Investigating the Functional Role of Hydroxymethylation in the Pathogenesis of B-cell Malignancies
Oliver Pickering – The role of epigenetics in Oesophageal Adenocarcinoma

Previous PhD students:

Luke O’Gorman (2018) The Development of Bioinformatic Pipelines for Ophthalmic Disease.
Roshan Sood (2018) Interpreting large-scale next generation sequence data using bioinformatic approaches.
Gaia Andreoletti (2016) Genomic analyses of paediatric inflammatory bowel disease.
Reuben Pengelly (2015) Genomic data analysis: populations, patients and pipelines.

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Articles

Conference

Norman, C. S., O'Gorman, L., Gibson, J., Pengelly, R. J., Baralle, D., Ratnayaka, J. A., Ennis, S., & Self, J. E. (2018). The contribution of common population variants to hypomorphic oculocutaneous albinism phenotypes: a novel tri-allelic TYR genotype. Investigative Ophthamology & Visual Science, 59(9), 5784. https://iovs.arvojournals.org/article.aspx?articleid=2693880&resultClick=1

Reviews

Jaramillo Oquendo, C., Parker, H., Oscier, D., Ennis, S., Gibson, J., & Strefford, J. (2021). The (epi)genomic landscape of splenic marginal zone lymphoma: biological implications, clinical utility, and future questions. Journal of Translational Genetics and Genomics. https://doi.org/10.20517/jtgg.2021.04
Chua, S. Y. L., Thomas, D., Allen, N., Lotery, A., Desai, P., Patel, P., Muthy, Z., Sudlow, C., Peto, T., Khaw, P. T., Foster, P. J., Zheng, Y., Aslam, T., Barman, S. A., Barrett, J. H., Bishop, P., Blows, P., Bunce, C., Carare, R. O., ... UK Biobank Eye and Vision Consortium (2019). Cohort profile: Design and methods in the eye and vision consortium of UK Biobank. BMJ Open, 9(2), [e025077]. https://doi.org/10.1136/bmjopen-2018-025077

Dr Gibson is co-module lead for the MEDI6235 Advanced Genomic Informatics module and lecturer on the MEDI6237 Genomic Technologies and Basic Informatics module of the MSc in Genomic Medicine. She also supervises and marks MSc dissertation projects.

She contributes to the undergraduate BM5 programme, taking on the role of Personal Tutor and supervising 3rd year research projects and associated project marking.

Dr Gibson also contributes to teaching in BSc Biomedical Science, Biochemistry and Pharmacology, delivering lectures and workshops on Bioinformatics (BIOL3063/6074/6055).

Dr Jane Gibson
Faculty of Medicine, Room AB215, Mailpoint 801, South Academic Block, University Hospital Southampton, Tremona Road, Southampton, SO16 6YD

Room Number: SGH/CS/C15/MP824

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