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Dr Matthew Blunt BSc, PhD

Senior Research Fellow, John Goldman Fellow

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Dr Matthew Blunt is a Senior Research Fellow within the Faculty of Medicine and is currently a John Goldman Fellow funded by Leukaemia UK.

Dr Blunt completed a PhD in immunology and pharmacology at the University of Bath in 2013, funded by the BBSRC and Novartis. He then studied novel treatment strategies for haematological malignancies in the CRUK Centre in Southampton. This work was published in prestigious journals including in Blood and Leukemia and also led to the award of the Catovsky prize (2014) from the UK CLL forum and the John Marsden Prize (2015 and 2016) from the University of Southampton. He then worked with Professor Salim Khakoo on natural killer cells and the development of novel cancer immunotherapies.

In 2018 Dr Blunt received the Postdoctoral Career Track Award from the University of Southampton and in 2019 he was awarded a John Goldman fellowship from Leukaemia UK.


Appointments held

Research interests

My research focuses on NK cells, novel cancer immunotherapies and haematological malignancies.

Examples of published research include:

  • Targeting the PI3K/mTOR pathway in CLL (Blunt MD et al, Blood, 2015).
  • Identification of IL-4 as a resistance mechanism to idelalisib and ibrutinib (Aguilar-Hernandez M, Blunt MD et al, Blood, 2016 *Co-first author).
  • Preclinical evaluation of the dual SYK/JAK inhibitor cerdulatinib alone and in combination with venetoclax (Blunt MD et al, Clinical Cancer Research, 2016).
  • Development of a novel method to assess KIR2DS2 positive NK cells (Blunt et al, HLA, 2019).

Research group

Clinical and Experimental Sciences

Faculty of Medicine
Member of the Faculty of Medicine Patent Panel

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Assessment Lead for MSc Genomics.

Supervision of PhD students.




Dr Matthew Blunt
Cancer Sciences Unit
Somers Cancer Research Building
Southampton General Hospital (MP824)
Tremona Road
Southampton SO16 6YD

Room Number : SGH/LE68/MP811

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