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The University of Southampton
Medicine
Email:
mra1m13@soton.ac.uk

Dr Mohammad Reza Abdollahi MD, PhD

NIHR clinical lecturer in molecular pathology and specialty registrar in cellular pathology

Dr Mohammad Reza Abdollahi's photo
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Dr Mohammad Reza Abdollahi is NIHR clinical lecturer in molecular pathology and specialty registrar in cellular pathology within Medicine at the University of Southampton.

Mohammad Reza Abdollahi was appointed as NIHR clinical lecturer in pathology in 2014. He obtained his MD from Rafsanjan University of Medical Sciences and Health Services in Iran, and completed his PhD in genetics at the University of Southampton in 2004. He continued his research career with a postdoctoral position at the University of Bristol and a Fellowship in molecular genetics at the University of Leeds. He was appointed as a trainee in histopathology within the Wessex deanery in 2011.

Qualifications

MD, Rafsanjan University of Medical Sciences and Health Services, Iran, 1993
PhD, University of Southampton, 2004

Appointments held

PhD student at the Human Genetics Division, University of Southampton, 2001-2004

Postdoctoral Fellow, department of Social Medicine, University of Bristol, 2005-2007

Research Fellow, Institute of Molecular Medicine, University of Leeds, 2007-2010

Registrar in Cellular Pathology, Southampton General Hospital, since 2011

NIHR clinical lecturer in cellular pathology, 2014

Research interests

Research Background: MRA research interests lie in identification and analysis of mutations e.g. SNPs in relation to phenotypes at individual level and population scale. During his PhD, he worked on SNPs and haplotypes of the renin angiotensin pathway with emphasis on AGTR1 (angiotensin II, type 1 receptor) in relation to cardiovascular and metabolic traits. This led to identifying allele specific effect of an AGTR1 3’ UTR SNP on mRNA abundance.

Subsequently, as a postdoc at the University of Bristol, he developed an integrated fluorescence multiplex assay for genotyping Apolipoproten E (APOE). This important development enabled scientists to rapidly genotype this gene in large scale epidemiological studies, without the risks of gel handling as in conventional genotyping techniques.

During his fellowship at the Leeds Institute of Molecular Medicine, he used SNP chips to study patients with polymicrogyria from a consanguineous pedigree. He identified a splicing mutation in TUBA8, which deletes exon2 from the transcript. He continued this work with functional analyses to study the expression of the gene in developing brain.

Department(s)

Cancer Sciences

Pathology teaching to undergraduate medical students

Development of “Teaching Without Boundaries: TWB”. –teaching the etiology and pathogenesis of disease through interactive cross-disciplinary discussion.

Dr Mohammad Reza Abdollahi
Somers Cancer Research Building, MP824, Southampton General Hospital, Southampton SO16 6YD and Cellular Pathology, MP2 Southampton General Hospital Southampton SO16 6YD Tel: +44 (0)23 8120 3483 Fax: +44 (0)23 8120 5152

Email:mra1m13@soton.ac.uk

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