Professor Richard Oreffo DPhil DSc (Oxon) CBiol FRSB

Professor of Musculoskeletal Science, Director; Centre for Human Development, Stem Cells and Regeneration

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Richard Oreffo holds the chair of Musculoskeletal Science and is co-founder and Director of the Centre for Human Development, Stem Cells and Regeneration. He has held positions in USA, AstraZeneca, and University of Oxford before being appointed to a lectureship in 1999 at the University of Southampton. Richard is internationally recognised for his work on skeletal biology and the mechanisms involved in skeletal stem cell differentiation and bone regeneration. Richard has successfully trained over 30 PhD and MD students since 2002 and currently directly supervises/co-supervise 16 MD/PhD Graduate Fellows.

I am particularly interested in the application of bone stem cells and regenerative medicine strategies for the repair and regeneration of damaged skeletal tissue. We have the potential to make a difference through collaborative teams here at the University of Southampton to treat devastating bone conditions.

Richard has published over 275 peer-reviewed full papers (H-index 60; >13,000 citations ISI WoS), including breakthrough publications on skeletal stem cells and nanotopography, bone regeneration as well as epigenetics in Osteoarthritis, in Nature Materials, ACS Nano, Stem Cells, Small, Arthritis and Rheumatism; holds 6 patents and is co-editor of “Epigenetic aspects of Chronic Diseases” Highly Commended in 2012 BMA Medical Book Awards.

Richard serves / has served on a number of Research Council Committees, Industrial committees and international advisory boards and holds a number of visiting professorships. He is a Fellow of the Royal Society of Biology and in 2015 was awarded a DSc by the University of Oxford. In 2017, he founded and is CSO of Renovos Biologics Limited, a spin-out from the University of Southampton – details on Renovos Biologics Limited.

Qualifications

B.Sc. Honours, Biology, University of Liverpool, 1983

D.Phil. Vitamin A and Bone, University of Oxford, 1986

D.Sc Skeletal Tissue Engineering, University of Oxford, 2015

Appointments held

Demonstrator, Oxford Brookes University, Oxford. 1985-1986

Research Fellow, Department of Medicine, Division of Endocrinology,

University of Texas, San Antonio, Texas, USA. 1987-1989

Postdoctoral Research Fellow, Zeneca Pharmaceuticals, Cheshire, UK.1990-1991

Principal Research Scientist, Zeneca Pharmaceuticals, Cheshire, UK.1991-1993

MRC Research Fellow, University of Oxford, Oxford, UK. 1993-1999

Non-Clinical lecturer, University of Southampton, Southampton, UK.1999-2002

Senior lecturer, University of Southampton, Southampton, UK.2002-2004

Reader, University of Southampton, Southampton, UK. 2004

Personal Chair in Musculoskeletal Science. 2004-present

Director of Enterprise – Faculty of Medicine, Health and Life Sciences. 2005- 2013

Associate Dean (Innovation and Enterprise), Faculty of Medicine, Health and Life Sciences. 2008-2010

Associate Dean Enterprise, Faculty of Medicine. 2010-2011

Associate Dean, International and Enterprise, 2011 - 2013

Adjunct Professor, King Saud University, Saudi Arabia. 2010-present

Links to external websites

The University cannot accept responsibility for external websites.

Other University of Southampton sites

Implants make light work of fixing broken bones

Research

Responsibilities

Publications

Teaching

Contact

Research interests

The aim of the group is to understand the mechanisms of bone development, growth and regeneration, how these differ in skeletal abnormalities and diseases such as osteoporosis and osteoarthritis, and to what extent bone growth is programmed during fetal life.

Thus research in Professor Oreffo’s group is primarily centered on harnessing the potential of skeletal stem cells (whether derived from embryonic or fetal and adult sources) for the development of unique tissue engineering approaches for new cartilage and bone formation for orthopedic application. In parallel we are interested in the role of fetal programming as a consequence of maternal nutritional challenges on bone cell differentiation, activity, potential and bone function with age.

Skeletal Research - the potential of skeletal stem cells

The requirement for new bone to replace or restore the function of traumatised or degenerated bone, or for the replacement of lost mineralised tissue as a consequence of increasing age is a major clinical and socio-economic need. To date, bone formation stimulation regimes, although attractive, have yet to demonstrate clinical efficacy.

Research of the group has primarily centred on:

Understanding human skeletal stem cell biology and the development of unique tissue engineering approaches for cartilage and bone formation for orthopaedic application using human skeletal populations and, elucidating the role of fetal programming as a consequence of maternal nutritional challenge on mesenchymal progenitor cell differentiation, activity, potential and bone function with age.

This involves drawing together the elements of i) progenitor cell differentiation (specifically the control of mesenchymal stem/progenitor cell differentiation and plasticity), ii) generation of osteoconductive and inductive smart scaffold/materials (including the use of natural biomimetic environments and self -assembling scaffolds with appropriate extracellular matrix cues) and, iii) cell signal/growth factor biology to examine tissue regeneration.

Other areas of active research interest within the group include differentiation of pluripotent stem cells along the mesenchymal lineage as well as angiogenesis / revascularisation in tissue development.

The group is currently developing translational strategies for clinical application to couple cell technologies with biomimetic scaffolds in close collaboration with groups in the UK as well as international collaborations in Germany, Canada and the USA.

Thus current concepts, approaches and challenges from work in the group include:

i) The use of isolated and selected human osteoprogenitor cell populations with selected osteotropic agents in an attempt to modulate the phenotype of the skeletal stem cell to generate mineralised bone tissue,
ii) The role of epigenetics, maternal nutrition and intrauterine programming in skeletal development of related offspring
iii) Manipulation of the developmental potential of bone stem cells on modified biomimetic structures with select growth factors,
iv) Epidemiological Studies in Bone & Joint Research
v) Modelling of skeletal tissue formation – including gene network analysis as well as tissue growth modelling.
vi) Translation from bench to clinic

Although clinical efficacy has yet to be achieved, development of protocols, new tools and above all multidisciplinary approaches for de novo bone formation that utilise skeletal stem cells offer significant rewards for an increasing aged population both in terms of healthcare costs and, more importantly, improved quality of life.

Intrauterine Programming, Epigenetics, Skeletal Development and Bone Diseases

In collaboration with Prof. Cyrus Cooper (MRC Environmental Epidemiology Unit) members of HDH and a number of international collaborators we are investigating, using a variety of animal models, how maternal protein deficiency affects bone growth. Our current ex vivo analysis of bone populations shows an important role of maternal nutrition in subsequent fetal bone development with significant implications in understanding the subsequent development of bone chronic diseases in later life such as osteoarthritis.

Growth, analysis and characterization (a-g) — Skeletal stem cells

Growth of skeletal stem cells (a) and their expression of a marker enzyme — Making Bone

Growing on allograft bone for clinical application — Skeletal Stem Cells

Slice of trabecular bone captured using Computer Tomography — Bone Development

Department(s)

Human Development and Health

Affiliate Department(s)

Human development and physiology Research group

Research project(s)

Application of ultrasound standing wave fields for augmentation of cartilage bioengineering strategies

Targeting stem cells with nanoparticles

Promoting tissue regeneration by carrying drugs and molecules directly to stem cells.

The effects of substrate mechanics on keratinocytes and epidermal stem cell behaviour at wound sites

How does the stiffness of a wound affect how it heals?

The healing of a skin wound is a highly co-ordinated series of events involving both biochemical and biomechanical signalling. We are trying to understanding how the mechanical properties of a healing wound affects how it heals.

Postgraduate Supervision (higher research degrees)

2002 Rahul Tare PhD
2002 Xuebin Yang PhD
2003 Daniel Howard PhD
2006 Michael O’Connell PhD
2006 Sayed-Hadi Mirmalek-Sani PhD
2006 Jodie Pound PhD
2007 Jon Dawson PhD
2008 Simon Tiley MD
2008 Ben Bolland MD
2009 Ahmed El Serafi PhD
2010 Catherine Forristal PhD
2010 Ayshe Ismail PhD
2011 Peter Mitchell PhD
2011 Alex Aarvold MD
2012 Andrew Jones MD
2012 James Smith MD
2014 Edward Tayton MD
2014 Stephanie Meakins PhD
2014 Siwei Li PhD

Current

17 PhD and MD Students

PhD

Kelvin Cheung (Yr 3)
Marco Peca (Yr 3)
Yu Hin Man (Yr 3) co-supervisor
Emma McMorrow (Yr3)
Patrick Stumpf (Yr 3) co-supervisor
Joanna Greenhough (Yr3) co-supervisor
Tsiloon Li (Yr3) co-supervisor
Ines Moreno (Yr 1)
Eduardo Scarpa (Yr 1) co-supervisor
Daniel Page (Yr 1) co-supervisor
Umesh Jonnalagadda (yr 1) co-supervisor
Emma Budd (Yr 2)
Cameron Black (Yr 2)
Agnieszka Janeczek (Yr 2) co-supervisor

Emma William
Nicholas Evans

University of Southampton

Southampton Asset Management (to 2013)
Various University Enterprise/Research Groups

National and International responsibilities

Editorial Board Biomaterials
Editorial Board Tissue Engineering
Editorial Board European Cells and Materials
Editorial Board Regenerative Medicine
Editorial Board J. Tissue Engineering
Editorial Board J, Tissue Engineering and Regenerative Medicine
Fellow Institute of Biology
Research Council for Health of the Academy of Finland (to 2013)
Member of BBSRC Healthy Organism Panel (Deputy Chair) (2007 - 2012)
ARC Research Committee (2006 - 2010)
UK National Stem Cell Network Committee (2009 - 2012)
Adjunct Professor King Saud University (2009 - present)

Consultancy

Serve and have served as a consultant to various SME and Pharma Companies in the area of musculoskeletal science and Bone Regeneration

Articles

Jonnalagadda, U., Hill, M., Messaoudi, W., Cook, R. B., Oreffo, R. O. C., Glynne-Jones, P., & Tare, R. S. (2018). Acoustically modulated biomechanical stimulation for human cartilage tissue engineering. Lab on a Chip, 18(3), 473. DOI: 10.1039/c7lc01195d
Goriainov, V., McEwan, J. K., Oreffo, R. O., & Dunlop, D. G. (2018). Application of 3D-printed patient-specific skeletal implants augmented with autologous skeletal stem cells. Regenerative Medicine, 13(3), 283-294. DOI: 10.2217/rme-2017-0127
Czekanska, E., Glinka, M., White, K., Kanczler, J., Evans, N., Oreffo, R., & Bradley, M. (2018). Combinatorial delivery of bioactive molecules by a nanoparticle-decorated and functionalized biodegradable scaffold. Journal of Materials Chemistry B, (27), 4437-4445. DOI: 10.1039/C8TB00474A
Inglis, S., Schneider, K., Kanczler, J., Redl, H., & Oreffo, R. (2018). Harnessing human decellularised blood vessel matrices and cellular construct implants to promote bone healing in an ex vivo organotypic bone defect model. Advanced Healthcare Materials, 1-32. DOI: 10.1002/adhm.201800088
Goriainov, V., Hulsart-Billstrom, G., Sjostrom, T., Dunlop, D. G., Su, B., & Oreffo, R. O. C. (2018). Harnessing nanotopography to enhance osseointegration of clinical orthopedic titanium implants-an in vitro and in vivo analysis. Frontiers in Bioengineering and Biotechnology, 6(APR), 1-16. [44]. DOI: 10.3389/fbioe.2018.00044
Jadasz, J. J., Tepe, L., Beyer, F., Samper Agrelo, I., Akkermann, R., Spitzhorn, L-S., ... Kury, P. (2018). Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis. Glia, 66(1), 145-160. DOI: 10.1002/glia.23233
Oreffo, R., Gorianov, V., Cook, R., Walker, J., Dunlop, D. G., & Clare, A. (2018). Human skeletal stem cell response to multiscale topography induced by large area electron beam melting surface treatment. Frontiers in Bioengineering and Biotechnology, 1-12. DOI: 10.3389/fbioe.2018.00091
Scarpa, E., Janeczek, A. A., Hailes, A., de Andrés, M. C., De Grazia, A., Oreffo, R. O. C., ... Evans, N. D. (2018). Polymersome nanoparticles for delivery of Wnt-activating small molecules. Nanomedicine: Nanotechnology, Biology, and Medicine, 14(4), 1267-1277. DOI: 10.1016/j.nano.2018.02.014
Oreffo, R., Tribe, H. C., Jacobs, N., Hancock, N., Qureshi, A., & Dunlop, D. G. (2018). Regenerative medicine in lower limb reconstruction. Regenerative Medicine, 13(4). DOI: 10.2217/rme-2018-0011
Oreffo, R., Moreno-Jimenez, I., Lanham, S., Kanczler, J., Hulsart Billstrom, S. G., & Evans, N. (2018). Remodelling of human bone on the chorioallantoic membrane (CAM) of the chicken egg: De novo bone formation and resorption. Journal of Tissue Engineering and Regenerative Medicine. DOI: 10.1002/term.2711
De Blasio, M. J., Lanham, S. A., Blache, D., Oreffo, R. O. C., Fowden, A. L., & Forhead, A. J. (2018). Sex-and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 314(6), R781-R790. DOI: 10.1152/ajpregu.00351.2017
Orriss, I. R., Lanham, S., Savery, D., Greene, N. D. E., Stanier, P., Oreffo, R., ... Galea, G. L. (2018). Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice. Scientific Reports, 8(1), [3325]. DOI: 10.1038/s41598-018-21718-x
Lanham, S., Cagampang, F., & Oreffo, R. (2018). The influence of a high fat diet on bone and soft tissue formation in Matrix Gla Protein knockout mice. Scientific Reports, 8(1), 1-14. [3635]. DOI: 10.1038/s41598-018-21650-0
Oreffo, R., Yang, S., Cidonio, G., Dawson, J., Ahlfeld, T., Kilian, D., ... Gelinsky, M. (2017). Development of a clay based bioink for 3D cell printing for skeletal application. Biofabrication, 1-24. DOI: 10.1088/1758-5090/aa7e96
De Andres Gonzalez, M., Takahashi, A., Hashimoto, K., Itoi, E., Goldring, M., & Oreffo, R. (2017). DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes. Scientific Reports.
Coutts, L., Jenkins, T., Oreffo, R. O., Dunlop, D. G., Cooper, C., Harvey, N. C., & Thurner, P. J. (2017). Local variation in femoral neck cortical bone: in vitro measured bone mineral density, geometry and mechanical properties. Journal of Clinical Densitometry, 20(2), 205-215. DOI: 10.1016/j.jocd.2015.10.003
Tribe, H. C., McEwan, J., Taylor, H., Oreffo, R. O. C., & Tare, R. S. (2017). Mesenchymal stem cells: potential role in the treatment of osteochondral lesions of the ankle. Biotechnology Journal, 12(12), 1-10. [1700070]. DOI: 10.1002/biot.201700070
Budd, E., De Andres Gonzalez, M., Sanchez-Elsner, T., & Oreffo, R. O. C. (2017). MiR-146b is down-regulated during the chondrogenic differentiation of human bone marrow derived skeletal stem cells and up-regulated in osteoarthritis. Scientific Reports, 7, [46704]. DOI: 10.1038/srep46704
Lee, L. C. Y., Gadegaard, N., de Andrés, M. C., Turner, L-A., Burgess, K. V., Yarwood, S. J., ... Dalby, M. J. (2017). Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency. Biomaterials, 116, 10-20. DOI: 10.1016/j.biomaterials.2016.11.032
Rhodes, A., Gray, J., Harvey, N., Davies, J. H., Oreffo, R. O. C., Reading, I., ... Aarvold, A. (2017). Osteonecrosis following treatment for childhood acute lymphoblastic leukaemia: The Southampton Children's Hospital experience. Journal of Children's Orthopaedics, 11(6), 440-447. DOI: 10.1302/1863-2548.11.170142, 10.1302/1863-2548.11.170142
Janeczek, A. A., Scarpa, E., Horrocks, M. H., Tare, R. S., Rowland, C. A., Jenner, D., ... Evans, N. D. (2017). PEGylated liposomes associate with Wnt3A protein and expand putative stem cells in human bone marrow populations. Nanomedicine, 12(8), 845-863. DOI: 10.2217/nnm-2016-0386
Stacey, G. N., Connon, C. J., Coopman, K., Dickson, A. J., Fuller, B., Hunt, C. J., ... Zimmermann, H. (2017). Preservation and stability of cell therapy products: recommendations from an expert workshop. Regenerative Medicine, 12(5), 553-564. DOI: 10.2217/rme-2017-0073
Tang, D., Yang, L-Y., Ou, K-L., & Oreffo, R. O. (2017). Repositioning titanium: an in vitro evaluation of laser-generated microporous, microrough titanium templates as a potential bridging interface for enhanced osseointegration and durability of implants. Frontiers in Bioengineering and Biotechnology, 5(77). DOI: 10.3389/fbioe.2017.00077
Xavier, M., de Andrés, M. C., Spencer, D., Oreffo, R., & Morgan, H. (2017). Size and dielectric properties of skeletal stem cells change critically after enrichment and expansion from human bone marrow: consequences for microfluidic cell sorting. Journal of the Royal Society Interface, 14(133), 1-13. DOI: 10.1098/rsif.2017.0233
Oreffo, R., Moreno, I., Kanczler, J., Hulsart Billstrom, S. G., & Inglis, S. (2017). The chorioallantoic membrane (CAM) assay for biomaterial testing in tissue engineering: a short term in vivo preclinical model. Tissue Engineering Part C Methods, 23(12), 938-952. DOI: 10.1089/ten.tec.2017.0186
Jenkins, T., Katsamenis, O. L., Andriotis, O. G., Coutts, L. V., Carter, B., Dunlop, D. G., ... Arden, N. (2017). The inferomedial femoral neck is compromised by age but not disease: Fracture toughness and the multifactorial mechanisms comprising reference point microindentation. Journal of the Mechanical Behavior of Biomedical Materials, 75, 399-412. DOI: 10.1016/j.jmbbm.2017.06.036
Budd, E., Waddell, S., De Andres, M. C., & Oreffo, R. O. C. (2017). The potential of microRNAs for stem cell-based therapy for degenerative skeletal diseases. Current molecular biology reports, 3(4), 263-275. DOI: 10.1007/s40610-017-0076-4
Hulsart-Billstrom, G., Dawson, J. I., Hofmann, S., Müller, R., Stoddart, M. J., Alini, M., ... Oreffo, R. O. C. (2016). A surprisingly poor correlation between in vitro and in vivo testing of biomaterials for bone regeneration: results of a multicentre analysis. European Cells & Materials, 31, 312-322.
Tang, D., Tare, R. S., Yang, L-Y., Williams, D. F., Ou, K-L., & Oreffo, R. (2016). Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration. Biomaterials, 83, 363-382. DOI: 10.1016/j.biomaterials.2016.01.024
Gibbs, D. M. R., Black, C. R. M., Hulsart-Billstrom, G., Shi, P., Scarpa, E., Oreffo, R. O. C., & Dawson, J. I. (2016). Bone induction at physiological doses of BMP through localization by clay nanoparticle gels. Biomaterials, 99, 16-23. DOI: 10.1016/j.biomaterials.2016.05.010
Vaezi, M., Black, C., Gibbs, D. M. R., Oreffo, R. O. C., Brady, M., Moshrefi-Torbati, M., & Yang, S. (2016). Characterization of new PEEK/HA composites with 3D HA network fabricated by extrusion freeforming. Molecules, 21(6), 1-21. DOI: 10.3390/molecules21060687
De Andres Gonzalez, M. C., Takahashi, A., & Oreffo, R. O. C. (2016). Demethylation of an NF-KB enhancer element orchestrates iNOS induction in osteoarthritis and is associated with altered chondrocyte cell cycle. Osteoarthritis and Cartilage, 1-10. DOI: 10.1016/j.joca.2016.06.002
Oreffo, R. (2016). Dynamic surfaces for the study of mesenchymal stem cell growth through adhesion regulation. ACS Nano, 1-13. DOI: 10.1021/acsnano.6b01765
Lewis, M. C., MacArthur, B. D., Tare, R., Oreffo, R. O. C., & Please, C. P. (2016). Extracellular matrix deposition in engineered micromass cartilage pellet cultures: measurements and modelling. PLoS ONE, 11(2), 1-12. DOI: 10.1371/journal.pone.0147302
Goggin, P., Zygalakis, K., Oreffo, R., & Schneider, P. (2016). High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: Insights on bone development, ageing, health and disease. European Cells & Materials, 31, 264-295. DOI: 10.22203/eCM.v031a18
Inglis, S., Christensen, D., Wilson, D. I., Kanczler, J. M., & Oreffo, R. O. C. (2016). Human endothelial and foetal femur-derived stem cell co-cultures modulate osteogenesis and angiogenesis. Stem Cell Research & Therapy, 7(13), 1-16. DOI: 10.1186/s13287-015-0270-3
Xavier, M., Rosendahl, P., Herbig, M., Kräter, M., Spencer, D., Bornhäuser, M., ... Otto, O. (2016). Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry. Integrative Biology, 8, 616-623. DOI: 10.1039/c5ib00304k
Scarpa, E., Bailey, J. L., Janeczek, A. A., Stumpf, P. S., Johnston, A. H., Oreffo, R. O. C., ... Newman, T. A. (2016). Quantification of intracellular payload release from polymersome nanoparticles. Scientific Reports, 6(29460), 29460. DOI: 10.1038/srep29460, 10.1038/srep29460
Costa Moura, C., Tare, R., Oreffo, R. O. C., & Mahajan, S. (2016). Raman spectroscopy and coherent anti-Stokes Raman scattering imaging: prospective tools for monitoring skeletal cells and skeletal regeneration. Journal of the Royal Society Interface, 13(118), 1-12. DOI: 10.1098/rsif.2016.0182
Greenhough, J., Papadakis, M., Cutress, R., Townsend, P., Oreffo, R., & Tare, R. (2016). Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1). Scientific Reports, 1-39. DOI: 10.1038/srep33504
Jenkins, T., Coutts, L. V., D'Angelo, S., Dunlop, D. G., Oreffo, R. O., Cooper, C., ... Chan, K. (2016). Site dependent reference point microindentation complements clinical measures for improved fracture risk assessment at the human femoral neck. Journal of Bone and Mineral Research, 31(1), 196-203. DOI: 10.1002/jbmr.2605
Xavier, M., Oreffo, R. O. C., & Morgan, H. (2016). Skeletal stem cell isolation: a review on the state-of-the-art microfluidic label-free sorting techniques. Biotechnology Advances, 1-30. DOI: 10.1016/j.biotechadv.2016.05.008
Moreno-Jiménez, I., Hulsart Billstrom, G., Lanham, S. A., Janeczek, A. A., Kontouli, N., Kanczler, J. M., ... Oreffo, R. O. C. (2016). The chorioallantoic membrane (CAM) assay for the study of human bone regeneration: a refinement animal model for tissue engineering. Scientific Reports, 6(32168), 1-12. DOI: 10.1038/srep32168
Black, C. R. M., Goriainov, V., Gibbs, D., Kanczler, J., Tare, R. S., & Oreffo, R. O. C. (2015). Bone tissue engineering. Current molecular biology reports, 1(3), 132-140. DOI: 10.1007/s40610-015-0022-2
Li, S., Sengers, B. G., Oreffo, R. O. C., & Tare, R. S. (2015). Chondrogenic potential of human articular chondrocytes and skeletal stem cells: a comparative study. Journal of Biomaterials Applications, 29(6), 824-836. DOI: 10.1177/0885328214548604
Birkin, P. R., Offin, D. G., Vian, C. J. B., Howlin, R. P., Dawson, J. L., Secker, T. L., ... Leighton, T. G. (2015). Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream. Physical Chemistry Chemical Physics, 17(32), 20574-20579. DOI: 10.1039/C5CP02406D
Takahashi, A., de Andrés, M. C., Hashimoto, K., Itoi, E., & Oreffo, R. O. C. (2015). Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis. Osteoarthritis and Cartilage, 23(11), 1946-1954. DOI: 10.1016/j.joca.2015.02.168
Oreffo, R., Megges, M., & Adjaye, J. (2015). Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells. Stem Cell Research, 16(1), 128-132. DOI: 10.1016/j.scr.2015.12.013
Gothard, D., Smith, E. L., Kanczler, J. M., Black, C. R., Wells, J. A., Roberts, C. A., ... Oreffo, R. O. C. (2015). In vivo assessment of bone regeneration in alginate/bone ECM hydrogels with incorporated skeletal stem cells and single growth factors. PLoS ONE, 10(12), 1-23. DOI: 10.1371/journal.pone.0145080
Lanham, S., Cagampang, F. R., & Oreffo, R. O. C. (2015). Maternal high fat diet affects offspring's vitamin K-dependent proteins expression levels. PLoS ONE, 10(9), 1-19. DOI: 10.1371/journal.pone.0138730
Gothard, D., Cheung, K., Kanczler, J. M., Wilson, D. I., & Oreffo, R. O. C. (2015). Regionally-derived cell populations and skeletal stem cells from human foetal femora exhibit specific osteochondral and multi-lineage differentiation capacity in vitro and ex vivo. Stem Cell Research & Therapy, 6(251), 1-17. DOI: 10.1186/s13287-015-0247-2
Sisti, K. E., de Andrés, M. C., Johnston, D., Almeida-Filho, E., Guastaldi, A. C., & Oreffo, R. O. C. (2015). Skeletal stem cell and bone implant interactions are enhanced by LASER titanium modification. Biochemical and Biophysical Research Communications, 1-7. DOI: 10.1016/j.bbrc.2015.10.013
Smus, J. P., Moura, C. C., McMorrow, E., Tare, R. S., Oreffo, R. O. C., & Mahajan, S. (2015). Tracking adipogenic differentiation of skeletal stem cells by label-free chemically selective imaging. Chemical Science, 1-8. DOI: 10.1039/C5SC02168E
Janeczek, A. A., Tare, R. S., Scarpa, E., Moreno-Jimenez, I., Rowland, C. A., Jenner, D., ... Evans, N. D. (2015). Transient canonical Wnt stimulation enriches human bone marrow mononuclear cell isolates for osteoprogenitors. Stem Cells, 1-13. DOI: 10.1002/stem.2241
Coutts, L. V., Jenkins, T., Li, T., Oreffo, R. O., Dunlop, D. G., Cooper, C., ... the OStEO group (2015). Variability in reference point microindentation and recommendations for testing cortical bone: location, thickness and orientation heterogeneity. Journal of the Mechanical Behavior of Biomedical Materials, 46, 292-304. DOI: 10.1016/j.jmbbm.2015.02.004
Jenkins, T., Coutts, L. V., Dunlop, D. G., Oreffo, R. O. C., Cooper, C., Harvey, N. C., & Thurner, P. J. (2015). Variability in reference point microindentation and recommendations for testing cortical bone: Maximum load, sample orientation, mode of use, sample preparation and measurement spacing. Journal of the Mechanical Behavior of Biomedical Materials, 42, 311-324. DOI: 10.1016/j.jmbbm.2014.09.030
Tayton, E., Purcell, M., Aarvold, A., Smith, J. O., Briscoe, A., Kanczler, J. M., ... Oreffo, R. O. C. (2014). A comparison of polymer and polymer-hydroxyapatite composite tissue engineered scaffolds for use in bone regeneration. An in vitro and in vivo study. Journal of Biomedical Materials Research Part A, 102(8), 2613-2624. DOI: 10.1002/jbm.a.34926
Li, S., Glynne-Jones, P., Andriotis, O. G., Ching, K. Y., Jonnalagadda, U. S., Oreffo, R. O. C., ... Tare, R. S. (2014). Application of an acoustofluidic perfusion bioreactor for cartilage tissue engineering. Lab on a Chip, 14(23), 4475-4485. DOI: 10.1039/c4lc00956h
Imagawa, K., de Andrés, M. C., Hashimoto, K., Itoi, E., Otero, M., Roach, H. I., ... Oreffo, R. O. C. (2014). Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation. Arthritis & Rheumatology, 66(11), 3040-3051. DOI: 10.1002/art.38774
Goriainov, V., Cook, R., Latham, J., Dunlop, D., & Oreffo, R. O. C. (2014). Bone and metal - an orthopaedic perspective on osseointegration of metals. Acta Biomaterialia, 1-15. DOI: 10.1016/j.actbio.2014.06.004
Oreffo, R. O. C. (2014). Centre for human development, stem cells & regeneration. Regenerative Medicine, 9(5), 563-567. DOI: 10.2217/RME.14.48
Dawson, J. I., Kanczler, J., Tare, R., Kassem, M., & Oreffo, R. O. C. (2014). Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies - Where are we now? Stem Cells, 32(1), 35-44. DOI: 10.1002/stem.1559
Alvarez, K., de Andrés, M. C., Takahashi, A., & Oreffo, R. O. C. (2014). Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes. BMC Musculoskeletal Disorders, 15(1), 431-[8pp]. DOI: 10.1186/1471-2474-15-431
Smith, E. L., Kanczler, J. M., Gothard, D., Roberts, C. A., Wells, J. A., White, L. J., ... Oreffo, R. O. C. (2014). Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4186-4196. DOI: 10.1016/j.actbio.2014.06.011
Smith, E. L., Kanczler, J. M., Gothard, D., Roberts, C. A., Wells, J. A., White, L. J., ... Oreffo, R. O. C. (2014). Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4197-4205. DOI: 10.1016/j.actbio.2014.05.025
Dalby, M. J., Gadegaard, N., & Oreffo, R. O. C. (2014). Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. Nature Materials, 13(6), 558-569. DOI: 10.1038/nmat3980
Gibbs, D., Vaezi, M., Yang, S., & Oreffo, R. O. C. (2014). Hope versus hype: what can additive manufacturing realistically offer trauma and orthopedic surgery? Regenerative Medicine, 9(4), 535-549. DOI: 10.2217/rme.14.20
Lanham, S. A., Cagampang, F. R., & Oreffo, R. O. C. (2014). Maternal high-fat diet and offspring expression levels of vitamin K-dependent proteins. Endocrinology, 155(12), 4749-4761. DOI: 10.1210/en.2014-1188
Cheung, K. S. C., Sposito, N., Stumpf, P. S., Wilson, D. I., Sanchez-Elsner, T., & Oreffo, R. O. C. (2014). MicroRNA-146a regulates human foetal femur derived skeletal stem cell differentiation by down-regulating SMAD2 and SMAD3. PLoS ONE, 9(6), e98063. DOI: 10.1371/journal.pone.0098063
Tsimbouri, P., Gadegaard, N., Burgess, K., White, K., Reynolds, P., Herzyk, P., ... Dalby, M. J. (2014). Nanotopographical effects on mesenchymal stem cell morphology and phenotype. Journal of Cellular Biochemistry, 115(2), 380-390. DOI: 10.1002/jcb.24673
Cassidy, J. W., Roberts, J. N., Smith, C-A., Robertson, M., White, K., Biggs, M. J., ... Dalby, M. J. (2014). Osteogenic lineage restriction by osteoprogenitors cultured on nanometric grooved surfaces: the role of focal adhesion maturation. Acta Biomaterialia, 10(2), 651-660. DOI: 10.1016/j.actbio.2013.11.008
Gothard, D., Greenhough, J., Ralph, E., & Oreffo, R. (2014). Prospective isolation of human bone marrow stromal cell subsets: a comparative study between Stro-1-, CD146- and CD105-enriched populations. Journal of Tissue Engineering, 5, 1-17. DOI: 10.1177/2041731414551763
Li, S., Oreffo, R. O. C., Sengers, B. G., & Tare, R. S. (2014). The effect of oxygen tension on human articular chondrocyte matrix synthesis: integration of experimental and computational approaches. Biotechnology and Bioengineering, 111(9), 1876-1885. DOI: 10.1002/bit.25241
Tayton, E. R., Purcell, M., Smith, J. O., Lanham, S., Howdle, S. M., Shakesheff, K. M., ... Oreffo, R. O. C. (2014). The scale-up of a tissue engineered porous hydroxyapatite polymer composite scaffold for use in bone repair: an ovine femoral condyle defect study. Journal of Biomedical Materials Research Part A, 103(4), 1346-1356. DOI: 10.1002/jbm.a.35279
Gothard, D., Smith, E. L., Kanczler, J. M., Rashidi, H., Qutachi, O., Henstock, J., ... Oreffo, R. O. C. (2014). Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man. European Cells & Materials, 28, 166-208.
Tsimbouri, P. M., Murawski, K., Hamilton, G., Herzyk, P., Oreffo, R. O. C., Gadegaard, N., & Dalby, M. J. (2013). A genomics approach in determining nanotopographical effects on MSC phenotype. Biomaterials, 34(9), 2177-2184. DOI: 10.1016/j.biomaterials.2012.12.019
Smith, E. L., Kanczler, J. M., & Oreffo, R. O. C. (2013). A new take on an old story: chick limb organ culture for skeletal niche development and regenerative medicine evaluation. European Cells & Materials, 26, 91-106.
Aarvold, A., Smith, J., Tayton, E. R., Jones, A. M. H., Dawson, J. I., Lanham, S. A., ... Oreffo, R. O. C. (2013). A tissue engineering strategy for the treatment of avascular necrosis of the femoral head. The Surgeon, 11(6), 319-325. DOI: 10.1016/j.surge.2013.02.008
Gothard, D., Dawson, J. I., & Oreffo, R. O. C. (2013). Assessing the potential of colony morphology for dissecting the CFU-F population from human bone marrow stromal cells. Cell and Tissue Research. DOI: 10.1007/s00441-013-1564-3
Khan, F., Smith, J. O., Kanczler, J. M., Tare, R. S., & Oreffo, R. O. C. (2013). Discovery and evaluation of a functional ternary polymer blend for bone repair: translation from a microarry to a clinical model. Advanced Functional Materials, 1-13. DOI: 10.1002/adfm.201202710
Lanham, S. A., Roberts, C., Habgood, A. K., Alexander, S., Burne, T. H. J., Eyles, D. W., ... Oreffo, R. O. C. (2013). Effect of Vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life. Journal of Developmental Origins of Health and Disease, 4(1), 49-55. DOI: 10.1017/S2040174412000542
Tayton, E. R., Smith, J. O., Evans, N. R., Dickinson, A., Aarvold, A., Kalra, S., ... Oreffo, R. O. C. (2013). Effects of setting bone cement on tissue-engineered bone graft: a potential barrier to clinical translation? The Journal of Bone and Joint Surgery, 95(8), 192-197. DOI: 10.2106/JBJS.L.00164
Nadeem, D., Sjostrom, T., Wilkinson, A., Smith, C-A., Oreffo, R. O. C., Dalby, M. J., & Su, B. (2013). Embossing of micropatterned ceramics and their cellular response. Journal of Biomedical Materials Research Part A, 101(11), 3247-3255. DOI: 10.1002/jbm.a.34622
Kingham, E. J., & Oreffo, R. O. C. (2013). Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine. ACS Nano. DOI: 10.1021/nn3037094
Dawson, J. I., Smith, J. O., Aarvold, A., Ridgway, J. N., Curran, S. J., Dunlop, D. G., & Oreffo, R. O. C. (2013). Enhancing the osteogenic efficacy of human bone marrow aspirate: concentrating osteoprogenitors using wave-assisted filtration. Cytotherapy, 15(2), 242-252. DOI: 10.1016/j.jcyt.2012.09.004
Neves, N. M., de Andrés, M. C., Kingham, E., Imagawa, K., Gonzalez, A., Roach, H. I., ... Oreffo, R. O. C. (2013). Epigenetic regulation during fetal femur development: DNA methylation matters. PLoS ONE, 8(1), e54957. DOI: 10.1371/journal.pone.0054957
Evans, N. D., Oreffo, R. O. C., Healy, E., Thurner, P. J., & Man, Y. H. (2013). Epithelial mechanobiology, skin wound healing, and the stem cell niche. Journal of the Mechanical Behavior of Biomedical Materials, 28, 397-409. DOI: 10.1016/j.jmbbm.2013.04.023
Williams, E. L., White, K., & Oreffo, R. O. C. (2013). Isolation and enrichment of Stro-1 immunoselected mesenchymal stem cells from adult human bone marrow. Methods in Molecular Biology, 1035, 67-73. DOI: 10.1007/978-1-62703-508-8_7
de Andrés, M. C., Imagawa, K., Hashimoto, K., Gonzalez, A., Roach, H. I., Goldring, M. B., & Oreffo, R. O. C. (2013). Loss of methylation in CpG sites in the NF-?B enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis and Rheumatism, 65(3), 732-742. DOI: 10.1002/art.37806
Kingham, E. J., White, K., Gadegaard, N., Dalby, M. J., & Oreffo, R. O. C. (2013). Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells. Small, 9(12), 2140-2151. DOI: 10.1002/smll.201202340
Rizzoli, R., Reginster, J-Y., Arnal, J-F., Bautmans, I., Beaudart, C., Bischoff-Ferrari, H., ... Bruyère, O. (2013). Quality of life in sarcopenia and frailty. Calcified Tissue International, 93(2). DOI: 10.1007/s00223-013-9758-y
Hashimoto, K., Otero, M., Imagawa, K., de Andres, M. C., Coico, J. M., Roach, H. I., ... Goldring, M. B. (2013). Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin -1B (IL 1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. The Journal of Biological Chemistry, 288(14), 10061-10072. DOI: 10.1074/jbc.M112.421156
Aarvold, A., Smith, J. O., Tayton, E. R., Lanham, S. A., Chaudhuri, J. B., Turner, I. G., & Oreffo, R. O. C. (2013). The effect of porosity of a biphasic ceramic scaffold on human skeletal stem cell growth and differentiation in vivo. Journal of Biomedical Materials Research Part A, 101(12), 3431-3437. DOI: 10.1002/jbm.a.34646
Evans, N. R., Davies, E. M., Dare, C. J., & Oreffo, R. O. C. (2013). Tissue engineering strategies in spinal arthrodesis: the clinical imperative and challenges to clinical translation. Regenerative Medicine, 8(1), 49-64. DOI: 10.2217/rme.12.106
Kanczler, J. M., Smith, E. L., Roberts, C., & Oreffo, R. O. C. (2012). A novel approach for studying the temporal modulation of embryonic skeletal development using organotypic bone cultures and mocrocomputed tomography. Tissue Engineering Part C Methods, 18(10). DOI: 10.1089/ten.tec.2012.0033
Tayton, E., Fahmy, S., Purcell, M., Aarvold, A., Smith, J. O., Kalra, S., ... Oreffo, R. O. C. (2012). An analysis of polymer type and chain length for use as a biological composite graft extender in impaction bone grafting: a mechanical and biocompatibility study. Journal of Biomedical Materials Research Part A, 100(12), 3211-3219. DOI: 10.1002/jbm.a.34264
Ismail, A., Hughes, M. P., Mulhall, H. J., Oreffo, R. O. C., & Labeed, F. H. (2012). Characterization of human skeletal stem and bone cell populations using dielectrophoresis. Journal of Tissue Engineering and Regenerative Medicine. DOI: 10.1002/term.1629
Smith, E. L., Kanczler, J. M., Roberts, C. A., & Oreffo, R. O. C. (2012). Developmental cues for bone formation from parathyroid hormone and parathyroid hormone-related protein in an ex vivo organotypic culture system of embryonic chick femora. Tissue Engineering Part C Methods, 18(12), 984-994. DOI: 10.1089/ten.tec.2012.0132
Aarvold, A., Smith, J. O., Tayton, E. R., Jones, A. M. H., Dawson, J. I., Lanham, S., ... Oreffo, R. O. C. (2012). From bench to clinic and back: skeletal stem cells and impaction bone grafting for regeneration of bone defects. Journal of Tissue Engineering and Regenerative Medicine. DOI: 10.1002/term.1577
Williams, E. L., Edwards, C. J., Cooper, C., & Oreffo, R. O. C. (2012). Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine. Regenerative Medicine, 7(4), 551-570. DOI: 10.2217/rme.12.34
Tare, R. S., Mitchell, P. D., Kanczler, J., & Oreffo, R. O. C. (2012). Isolation, differentiation, and characterisation of skeletal stem cells from human bone marrow in vitro and in vivo. Methods in Molecular Biology, 816, 83-99.
McNamara, L. E., Sjöström, T., Meek, R. M. D., Oreffo, R. O. C., Su, B., Dalby, M. J., & Burgess, K. E. V. (2012). Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine. Journal of the Royal Society Interface, 9(73), 1713-1724. DOI: 10.1098/rsif.2012.0169
Forsey, R. W., Tare, R. S., Oreffo, R. O. C., & Chaudhuri, J. B. (2012). Perfusion bioreactor studies of chondrocyte growth in alginate-chitosan capsules. Biotechnology and Applied Biochemistry, 59(2), 142-152. DOI: 10.1002/bab.1009
Dawson, J. I., Kingham, E., Evans, N. R., Tayton, E., & Oreffo, R. O. C. (2012). Skeletal Regeneration: application of nanotopography and biomaterials for skeletal stem cell based bone repair. Inflammation and Regeneration, 32(3), 72-89. DOI: 10.2492/inflammregen.32.072
Tayton, E., Purcell, M., Aarvold, A., Smith, J. O., Kalra, S., Briscoe, A., ... Oreffo, R. O. C. (2012). Supercritical CO2 fluid-foaming of polymers to increase porosity: a method to improve the mechanical and biocompatibility characteristics for use as a potential alternative to allografts in impaction bone grafting? Acta Biomaterialia, 8(5), 1918-1927. DOI: 10.1016/j.actbio.2012.01.024
González-García, C., Moratal, D., Oreffo, R. O. C., Dalby, M. J., & Salmerón-Sánchez, M. (2012). Surface mobility regulates skeletal stem cell differentiation. Integrative Biology, 4(5), 531-539. DOI: 10.1039/C2IB00139J
Smith, J. O., Sengers, B. G., Aarvold, A., Tayton, E. R., Dunlop, D. G., Oreffo, R. O. C., & sm, N. (2012). Tantalum trabecular metal - addition of human skeletal cells to enhance bone implant interface strength and clinical application. Journal of Tissue Engineering and Regenerative Medicine. DOI: 10.1002/term.1525
Williams, E. L., Edwards, C. J., Cooper, C., & Oreffo, R. O. C. (2012). The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine. Journal of Tissue Engineering and Regenerative Medicine. DOI: 10.1002/term.1455
Aarvold, A., Smith, J. O., Tayton, E. R., Edwards, C. J., Fowler, D. J., Gent, E. D., & Oreffo, R. O. C. (2012). The role of osteoblast cells in the pathogenesis of unicameral bone cysts. Journal of Children's Orthopaedics, 6(4), 339-346. DOI: 10.1007/s11832-012-0419-x
Tayton, E. R., Smith, J. O., Aarvold, A., Kalra, S., Dunlop, D. G., & Oreffo, R. O. C. (2012). Translational hurdles for tissue engineering: an in vitro analysis of commonly used local anaesthetics on skeletal stem cell survival. The Journal of Bone and Joint Surgery, 94(6), 848-855. DOI: 10.1302/0301-620X.94B6.28479
Tsimbouri, P. M., McMurray, R. J., Burgess, K. V., Alakpa, E. V., Reynolds, P. M., Murawski, K., ... Dalby, M. J. (2012). Using nanotopography and metabolomics to identify biochemical effectors of multipotency. ACS Nano, 6(11), 10239-10249. DOI: 10.1021/nn304046m
Motterlini, N., Dimitrov, B. D., Bradley, M., Bennett, K., & Fahey, T. (2012). Variations in General Practitioners' prescribing patterns in Ireland: preliminary results. Irish Journal of Medical Science, 181(4), 119-119. DOI: 10.1007/s11845-012-0838-1
Gennero, I., Laurencin-Dalicieux, S., Conte-Auriol, F., Briand-Mésange, F., Laurencin, D., Rue, J., ... Salles, J. P. (2011). Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass. Bone, 49(3), 395-403. DOI: 10.1016/j.bone.2011.04.018
Lanham, S. A., Bertram, C., Cooper, C., & Oreffo, R. O. (2011). Animal models of maternal nutrition and altered offspring bone structure. European Cells & Materials, 22, 321-332.
Dawson, J. I., Kanczler, J. M., Yang, X. B., Attard, G. S., & Oreffo, R. O. C. (2011). Clay gels for the delivery of regenerative microenvironments. Advanced Materials, 23(29), 3304-3308. DOI: 10.1002/adma.201100968
El-Serafi, A. T., Wilson, D. I., Roach, H. I., & Oreffo, R. O. C. (2011). Developmental plasticity of human foetal femur-derived cells in pellet culture: self assembly of an osteoid shell around a cartilaginous core. European Cells & Materials, 21, 558-567.
Lanham, S., Fowden, A. L., Roberts, C., Cooper, C., Oreffo, R. O. C., & Forhead, A. J. (2011). Effects of hypothyroidism on the structure and mechanical properties of bone in the ovine fetus. Journal of Endocrinology. DOI: 10.1530/JOE-11-0138
El-Serafi, A. T., Oreffo, R. O., & Roach, H. I. (2011). Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A. Differentiation, 81(1), 35-41. DOI: 10.1111/(ISSN)1432-0436
Gothard, D., Tare, R. S., Mitchell, P. D., Dawson, J. I., & Oreffo, R. O. C. (2011). In search of the skeletal stem cell: isolation and separation strategies at the macro/micro scale for skeletal regeneration. Lab on a Chip, 11(7), 1206-1220. DOI: 10.1039/C0LC00575D
McMurray, R. J., Gadegaard, N., Tsimbouri, P. M., Burgess, K. V., McNamara, L. E., Tare, R., ... Dalby, M. J. (2011). Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. Nature Materials, 10(8), 637-644. DOI: 10.1038/nmat3058
Kantawong, F., Robertson, M. E., Gadegaard, N., Oreffo, R. O. C., Burchmore, R. J., & Dalby, M. J. (2011). Protein expression of STRO-1 cells in response to different topographic features. Journal of Tissue Engineering, 2(1), 534603. DOI: 10.4061/2011/534603
McNamara, L. E., Sjöström, T., Burgess, K. E. V., Kim, J. J. W., Liu, E., Gordonov, S., ... Dalby, M. J. (2011). Skeletal stem cell physiology on functionally distinct titania nanotopographies. Biomaterials, 32(30), 7403-7410. DOI: 10.1016/j.biomaterials.2011.06.063
Smith, J. O., Aarvold, A., Tayton, E. R., Dunlop, D. G., & Oreffo, R. O. C. (2011). Skeletal tissue regeneration: current approaches, challenges, and novel reconstructive strategies for an aging population. Tissue Engineering Part B Reviews, 17(5), 307-320. DOI: 10.1089/ten.teb.2011.0143
de Andres, M. C., Imagawa, K., Hashimoto, K., Gonzalez, A., Goldring, M. B., Roach, H. I., & Oreffo, R. O. C. (2011). Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis. Biochemical and Biophysical Research Communications, 1(407), 54-59.
Aarvold, A., Smith, J. O., Tayton, E. R., Tilley, S., Dawson, J. I., Lanham, S. A., ... Oreffo, R. O. C. (2011). Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case. Regenerative Medicine, 6(4), 461-467. DOI: 10.2217/rme.11.33
Tare, R. S., & Oreffo, R. O. C. (2010). Application of human follicular dendritic cells (HK) as an experimental model to study osteoblast function. Bone, 47, S132-S133.
Sengers, B. G., Dawson, J. I., & Oreffo, R. O. C. (2010). Characterisation of human bone marrow stromal cell heterogeneity for skeletal regeneration strategies using a two-stage colony assay and computational modelling. Bone, 46(2), 496-503. DOI: 10.1016/j.bone.2009.10.002
Kanczler, J. M., Sura, H. S., Magnay, J., Green, D., Oreffo, R. O. C., Dobson, J. P., & El Haj, A. J. (2010). Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology. Tissue Engineering Part A, 16(10), 3241-3250. DOI: 10.1089/ten.tea.2009.0638
Kantawong, F., Burgess, K. E. V., Jayawardena, K., Hart, A., Riehle, M. O., Oreffo, R. O., ... Burchmore, R. (2010). Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells. Acta Biomaterialia, 6(9), 3694-3703. DOI: 10.1016/j.actbio.2010.02.038
Forristal, C. E., Wright, K. L., Hanley, N. A., Oreffo, R. O. C., & Houghton, F. D. (2010). Hypoxia inducible factors regulate pluripotency and proliferation in human proliferation in human embryonic stem cells cultured at reduced oxygen tensions. Reproduction, 139(1), 85-97. DOI: 10.1530/REP-09-0300
Hails, L. A., Babister, J. C., Inglis, S., Davis, S. A., Oreffo, R. O., & Mann, S. (2010). Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins. Small, 6(18), 1986-1991. DOI: 10.1002/smll.201000939
Lanham, S. A., Roberts, C., Hollingsworth, T., Sreekumar, R., Elahi, M., Cagampang, F. R., ... Oreffo, R. O. C. (2010). Maternal high-fat diet: effects on offspring bone structure. Osteoporosis International, 21(10), 1703-1714. DOI: 10.1007/s00198-009-1118-4
McNamara, L. E., McMurray, R. J., Biggs, M. J., Kantawong, F., Oreffo, R. O., & Dalby, M. J. (2010). Nanotopographical control of stem cell differentiation. Journal of Tissue Engineering, 2010(120623), 120623-[13pp]. DOI: 10.4061/2010/120623
Lanham, S. A., Roach, H. I., Cooper, C., & Oreffo, R. O. C. (2010). Prenatal and nutritional influences on skeletal development: lessons from animal studies. Clinical Reviews in Bone and Mineral Metabolism, 8(1), 40-48. DOI: 10.1007/s12018-009-9065-3
Tare, R. S., Kanczler, J., Aarvold, A., Jones, A. M. H., Dunlop, D. G., & Oreffo, R. O. C. (2010). Skeletal stem cells and bone regeneration: translational strategies from bench to clinic. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224(12), 1455-1470. DOI: 10.1243/09544119JEIM750
Khan, F., Tare, R. S., Kanczler, J. M., & Oreffo, R. O. C. (2010). Strategies for cell manipulation and skeletal tissue engineering using high-throughput polymer blend formulation and microarray techniques. Biomaterials, 31(8), 2216-2228. DOI: 10.1016/j.biomaterials.2009.11.101
Kanczler, J., Ginty, P., White, L., Clarke, N., Howdle, S., Shakesheff, K., & Oreffo, R. (2010). The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials, 31(6), 1241-1250. DOI: 10.1016/j.biomaterials.2009.10.059
Andres de, M. C., Imagawa, K., Hashimoto, K., gonzalez, A., Oreffo, R. O. C., & Roach, H. I. (2010). The role of epigenetics in iNos induction in osteoarthritic chondrocytes. Osteoarthritis and Cartilage, 18, S167.
Tare, R. S., Khan, F., Tourniaire, G., Morgan, S. M., Bradley, M., & Oreffo, R. O. C. (2009). A microarray approach to the identification of polyurethanes for the isolation of human skeletal progenitor cells and augmentation of skeletal cell growth. Biomaterials, 30(6), 1045-1055. DOI: 10.1016/j.biomaterials.2008.10.038
Green, D. W., Bolland, B. J. R., Kanczler, J. M., Lanham, S. A., Walsh, D., Mann, S., & Oreffo, R. O. C. (2009). Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites. Biomaterials, 30(10), 1918-1927. DOI: 10.1016/j.biomaterials.2008.12.052
Kanczler, J. M., Mirmalek-Sani, S-H., Hanley, N. A., Ivanov, A. L., Barry, J. J. A., Upton, C., ... Oreffo, R. O. C. (2009). Biocompatibility and osteogenic potential of human fetal femur-derived cells on surface selective laser sintered scaffolds. Acta Biomaterialia, 5(6), 2063-2071. DOI: 10.1016/j.actbio.2009.03.010
Collins, A. M., Skaer, N. J. V., Gheysens, T., Knight, D., Bertram, C., Roach, H. I., ... Mann, S. (2009). Bone like resorbable silk based scaffolds for load bearing osteoregenerative applications. Advanced Materials, 20(1), 75-78. DOI: 10.1002/adma.200802239
Oreffo, R. O. C. (2009). Bridging the gap – skeletal regeneration using skeletal populations at the interdisciplinary interface. Tissue Engineering Part A, 15(3), 680-681. DOI: 10.1089/ten.tea.2009.1500
Mirmalek-Sani, S. H., Stokes, P. J., Tare, R. S., Ralph, E. J., Inglis, S., Hanley, N. A., ... Oreffo, R. O. (2009). Derivation of a novel undifferentiated human fetal phenotype in serum-free cultures with BMP-2. Journal of Cellular and Molecular Medicine, 13(9B), 3541-3555. DOI: 10.1111/j.1582-4934.2009.00742.x
Hashimoto, K., Oreffo, R. O. C., Gibson, M. B., Goldring, M. B., & Roach, H. I. (2009). DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes. Arthritis and Rheumatism, 60(11), 3303-3313. DOI: 10.1002/art.24882
Berry, C. C., Harianawalw, H., Loebus, J., Oreffo, R. O. C., & de la Fuente, J. (2009). Enhancement of human bone marrow cell uptake of quantum dots using tat peptide. Current Nanoscience, 5(4), 390-395. DOI: 10.2174/157341309789378122
Sengers, B. G., Please, C. P., Taylor, M., & Oreffo, R. O. C. (2009). Experimental–computational evaluation of human bone marrow stromal cell spreading on trabecular bone structures. Annals of Biomedical Engineering, 37(6), 1165-1176. DOI: 10.1007/s10439-009-9676-3
Sjostrom, T., Dalby, M. J., Hart, A., Tare, R. S., Oreffo, R. O. C., & Su, B. (2009). Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells. Acta Biomaterialia, 5(5), 1433-1441. DOI: 10.1016/j.actbio.2009.01.007
Morgan, S. M., Ainsworth, B. J., Kanczler, J. M., Babister, J. C., Chaudhuri, J. B., & Oreffo, R. O. C. (2009). Formation of a human-derived fat tissue layer in P(DL)LGA hollow fibre scaffolds for adipocyte tissue engineering. Biomaterials, 30(10), 1910-1917. DOI: 10.1016/j.biomaterials.2008.12.033
Khan, F., Tare, R. S., & Oreffo, R. O. C. (2009). Polymer microarrays – a high-throughout approach to the identification and selection of tissue engineering scaffolds. European Cells & Materials, 18, 69.
Babister, J. C., Hails, L. A., Oreffo, R. O. C., Davis, S., & Mann, S. (2009). The effect of pre-coating human bone marrow stromal cells with hydroxyapatite/amino acid nanoconjugates on osteogenesis. Biomaterials, 30(18), 3174-3182. DOI: 10.1016/j.biomaterials.2009.02.024
Williams, E. L., Roach, H. I., Cooper, C., Oreffo, R. O. C., & Edwards, C. J. (2009). The effects of inflammatory cytokines from arthritic synovium on skeletal stem cell function – implications for reparative strategies. Rheumatology, 48, i40-i41. DOI: 10.1093/rheumatology/kep718
Biggs, M. J., Richards, R. G., Gadegaard, N., Wilkinson, C. D. W., Oreffo, R. O., & Dalby, M. J. (2009). The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+enriched skeletal stem cells. Biomaterials, 30(28), 5094-5103. DOI: 10.1016/j.biomaterials.2009.05.049
Khan, F., Tare, R. S., Oreffo, R. O. C., & Bradley, M. (2009). Versatile biocompatible polymer hydrogels: scaffolds for cell growth. Angewandte Chemie International Edition, 48(5), 978-982. DOI: 10.1002/anie.200804096
Kantawong, F., Burgess, K. E. V., Jayawardena, K., Hart, A., Burchmore, R. J., Gadegaard, N., ... Dalby, M. J. (2009). Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling. Biomaterials, 30(27), 4723-4732. DOI: 10.1016/j.biomaterials.2009.05.040
Biggs, M. J. P., Richards, R. G., McFarlane, S., Wilkinson, C. D. W., Oreffo, R. O. C., & Dalby, M. J. (2008). Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330nm deep microgrooves. Journal of the Royal Society Interface, 5(27), 1231-1242. DOI: 10.1098/rsif.2008.0035
Tare, R. S., Townsend, P. A., Packham, G., Inglis, S., & Oreffo, R. O. C. (2008). BCL-2 associated athanogene-1 (BAG-1): A transcriptional regulator mediating chondrocyte survival and differentiation during endochondral ossification. Bone, 42(1), 113-128. DOI: 10.1016/j.bone.2007.08.032
Dawson, J. I., & Oreffo, R. O. C. (2008). Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering. Archives of Biochemistry and Biophysics, 473(2), 124-31. DOI: 10.1016/j.abb.2008.03.024
Bolland, B. J., Kanczler, J. M., Dunlop, D. G., & Oreffo, R. O. (2008). Development of in vivo muCT evaluation of neovascularisation in tissue engineered bone constructs. Bone, 43(1), 195-202. DOI: 10.1016/j.bone.2008.02.013
Dawson, J. I., Wahl, D. A., Lanham, S. A., Kanczler, J. M., Czernuszka, J. T., & Oreffo, R. O. C. (2008). Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells. Biomaterials, 29(21), 3105-3116. DOI: 10.1016/j.biomaterials.2008.03.040
Kantawong, F., Burchmore, R., Wilkinson, C. D. W., Oreffo, R. O. C., & Dalby, M. J. (2008). Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance. Acta Biomaterialia, 5(4), 1137-1146. DOI: 10.1016/j.actbio.2008.11.001
Pollintine, P., Barrett, G. W., Millais, I. E., Green, L. R., Cooper, C., Lanham, S. A., ... Dolan, P. (2008). Early nutritional compromise affects the mechanical properties of sheep spines. Journal of Bone and Joint Surgery, 90B(Supplement 2), 373-374.
Babister, J. C., Tare, R. S., Green, D. W., Inglis, S., Mann, S., & Oreffo, R. R. O. C. (2008). Genetic manipulation of human mesenchymal progenitors to promote chondrogenesis using “bead-in-bead” polysaccharide capsules. Biomaterials, 29(1), 58-65. DOI: 10.1016/j.biomaterials.2007.09.006
Dalby, M. J., Andar, A., Nag, A., Affrossman, S., Tare, R., McFarlane, S., & Oreffo, R. O. C. (2008). Genomic expression of mesenchymal stem cells to altered nanoscale topographies. Journal of the Royal Society Interface, 5(26), 1055-1065. DOI: 10.1098/rsif.2008.0016
MacArthur, B. D., Tare, R. S., Murawski, K., & Oreffo, R. O. C. (2008). Identification of candidate regulators of multipotency in human skeletal progenitor cells. Biochemical and Biophysical Research Communications, 377(1), 68-72. DOI: 10.1016/j.bbrc.2008.09.084
Biggs, M. J., Richards, R. G., Gadegaard, N., McMurray, R. J., Affrossman, S., Wilkinson, C. D. W., ... Dalby, M. J. (2008). Interaction with nanoscale topography: Adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage. Journal of Biomedical Materials Research Part A, 91A(1), 195-208. DOI: 10.1002/jbm.a.32196
Lanham, S. A., Roberts, C., Cooper, C., & Oreffo, R. O. (2008). Intrauterine programming of bone. Part 1: alteration of the osteogenic environment. Osteoporosis International, 19(2), 147-156. DOI: 10.1007/s00198-007-0443-8
Lanham, S. A., Roberts, C., Perry, M. J., Cooper, C., & Oreffo, R. O. (2008). Intrauterine programming of bone. Part 2: alteration of skeletal structure. Osteoporosis International, 19(2), 157-167. DOI: 10.1007/s00198-007-0448-3
Gribbon, C., Channon, K. J., Zhang, W., Banwell, E. F., Bromley, E. H. C., Chaudhuri, J. B., ... Woolfson, D. N. (2008). Magic-wand: a single, designed peptide that assembles to stable, ordered helical fibres. Biochemistry, 47(39), 10365-10371. DOI: 10.1021/bi801072s
Kanczler, J. M., & Oreffo, R. O. C. (2008). Osteogenesis and angiogenesis: the potential for engineering bone. European Cells & Materials, 15, 100-114.
Kantawong, F., Burchmore, R., Gadegaard, N., Oreffo, R. O. C., & Dalby, M. J. (2008). Proteomic analysis of human osteoprogenitor response to disordered nanotopography. Journal of the Royal Society Interface, 6(40), 1075-1086. DOI: 10.1098/?rsif.2008.0447
Tare, R. S., Babister, J. C., Kanczler, J., & Oreffo, R. O. C. (2008). Skeletal stem cells: phenotype, biology and environmental niches informing tissue regeneration. Molecular and Cellular Endocrinology, 288(1-2), 11-21. DOI: 10.1016/j.mce.2008.02.017
MacArthur, B. D., Please, C. P., & Oreffo, R. O. C. (2008). Stochasticity and the molecular mechanisms of induced pluripotency. PLoS ONE, 3(8), e3086. DOI: 10.1371/journal.pone.0003086
Bolland, B. J., Kanczler, J. M., Ginty, P. J., Howdle, S. M., Shakesheff, K. M., Dunlop, D. G., & Oreffo, R. O. (2008). The application of human bone marrow stromal cells and poly(dl-lactic acid) as a biological bone graft extender in impaction bone grafting. Biomaterials, 29(22), 3221-3227. DOI: 10.1016/j.biomaterials.2008.04.017
Kanczler, J. M., Ginty, P. J., Barry, J. J., Clarke, N. M., Howdle, S. M., Shakesheff, K. M., & Oreffo, R. O. (2008). The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation. Biomaterials, 29(12), 1892-1900. DOI: 10.1016/j.biomaterials.2007.12.031
Pollintine, P., Cooper, I., Anderson, H. L., Green, L. R., Cooper, C., Lanham, S. A., ... Dolan, P. (2008). The influence of early nutritional compromise on bone structure and strength. Journal of Bone and Joint Surgery, 90-B(Supp II), p.392.
Bolland, B. J. R. F., New, A. M. R., Madabhushi, G., Oreffo, R. O. C., & Dunlop, D. G. (2008). The role of vibration and drainage in femoral impaction bone grafting. Journal of Arthroplasty, 23(8), 1-8. DOI: 10.1016/j.arth.2007.10.011
Xu, Y., Mirmalek-Sani, S-H., Lin, F., Zhang, J., & Oreffo, R. O. C. (2007). Adipocyte differentiation induced using nonspecific siRNA controls in cultured human mesenchymal stem cells. RNA, 13(8), 1179-1183. DOI: 10.1261/rna.527207
Bolland, B. J. R. F., Tilley, S., New, A. M. R., Dunlop, D. G., & Oreffo, R. O. C. (2007). Adult mesenchymal stem cells and impaction grafting – a new clinical paradigm shift. Expert Review of Medical Devices, 4(3), 393-404. DOI: 10.1586/17434440.4.3.393
Bolland, B. J., Tilley, S., New, A. M., Dunlop, D. G., & Oreffo, R. O. (2007). Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift. Expert Review of Medical Devices, 4(3), 393-404.
Pound, J. C., Green, D. W., Roach, H. I., Mann, S., & Oreffo, R. O. C. (2007). An ex vivo model for chondrogenesis and osteogenesis. Biomaterials, 28(18), 2839-2849. DOI: 10.1016/j.biomaterials.2007.02.029
Tare, R. S., Townsend, P. A., Packham, G. K., Inglis, S., & Oreffo, R. O. C. (2007). BCL-2-associated athanogene-1: A transcriptional regulator mediating chondrocyte survival and differentiation during endochondral ossification. Journal of Bone and Mineral Research, 22(7), p.1129.
Dawson, J. I., Wahl, D. A., Caernuszka, J. T., & Oreffo, R. O. C. (2007). Biomimetic collagen-Hydroxyapatite composite scaffolds for osteo and chondrogenic conduction of STRO-1 immunoselected Human Bone Marrow Stromal Cells. Tissue Engineering, 13(7).
Gonzalez-McQuire, R., Green, D. W., Partridge, K. A., Oreffo, R. O. C., Mann, S., & Davis, S. A. (2007). Coating of human mesenchymal cells in 3D culture with bioinorganic nanoparticles promotes osteoblastic differentiation and gene transfection. Advanced Materials, 19(17), 2236-2240. DOI: 10.1002/adma.200602770
Sengers, B. G., Taylor, M., Please, C. P., & Oreffo, R. O. C. (2007). Computational modelling of cell spreading and tissue regeneration in porous scaffolds. Biomaterials, 28(10), 1926-1940. DOI: 10.1016/j.biomaterials.2006.12.008
Heyde, M., Partridge, K. A., Howdle, S. M., Oreffo, R. O. C., Garnett, M. C., & Shakesheff, K. M. (2007). Development of a slow non-viral DNA release system from PDLLA scaffolds fabricated using a supercritical CO2 technique. Biotechnology and Bioengineering, 98(3), 679-693. DOI: 10.1002/bit.21446
Hollingworth, T., Lanham, S. A., Roberts, C., Hanson, M., Elahi, M., Cagampang, F., ... Oreffo, R. O. C. (2007). Effects of maternal-dietary cholesterol on offspring bone development. Early Human Development, 83(Supplement 1), S155-S156. DOI: 10.1016/S0378-3782(07)70428-0
Tare, R. S., Forsey, R. W., Chaudhuri, J. B., & Oreffo, R. O. C. (2007). Engineering carilaginous explants using human stro -1+ pregenitors, alginate scaffolds and perfusion bioreactors. Tissue Engineering, 13(7).
Morgan, S. M., Tilley, S., Perera, S., Ellis, M. J., Kanczler, J., Chaudhuri, J. B., & Oreffo, R. O. (2007). Expansion of human bone marrow stromal cells on poly-(DL-lactide-co-glycolide) (PDL LGA) hollow fibres designed for use in skeletal tissue engineering. Biomaterials, 28(35), 5332-5343. DOI: 10.1016/j.biomaterials.2007.08.029
Sengers, B. G., Please, C. P., & Oreffo, R. O. C. (2007). Experimental characterization and computational modelling of two-dimensional cell spreading for skeletal regeneration. Journal of the Royal Society Interface, 4(17), 1107-1117. DOI: 10.1098/rsif.2007.0233
Heyde, M., Partridge, K. A., Oreffo, R. O. C., Howdle, S. M., Shakesheff, K. M., & Garnett, M. C. (2007). Gene therapy used for tissue engineering applications. Journal of Pharmacy and Pharmacology, 59(3), 329-350.
Berry, C. C., Curtis, A. S. G., Oreffo, R. O. C., Agheli, H. D. S., & Sutherland, D. S. (2007). Human fibroblast and human bone marrow cell response to lithographically nanopatterned adhesive domains on protein rejecting substrates. IEEE Transactions on Nanobioscience, 6(3), 201-209. DOI: 10.1109/TNB.2007.903457
Lanham, S. A., Roberts, C., Perry, M. J., Oreffo, R. O. C., & Cooper, C. (2007). Intrauterine programming of bone-deleterious effects of a low protein diet in late adulthood on the osteogenic environment. Journal of Bone and Mineral Research, 22(7).
Dalby, M. J., Gadegaard, N., Curtis, A. S., & Oreffo, R. O. (2007). Nanotopographical control of human osteoprogenitor differentiation. Current Stem Cell Research & Therapy, 2(2), 129-138. DOI: 10.2174/157488807780599220
Hart, A., Gadegaard, N., Wilkinson, C. D., Oreffo, R. O., & Dalby, M. J. (2007). Osteoprogenitor response to low-adhesion nanotopographies originally fabricated by electron beam lithography. Journal of Materials Science: Materials in Medicine, 18(6), 1211-1218. DOI: 10.1007/s10856-007-0157-7
Bolland, B. J., Kanczler, J., Ginty, P., Shakesheff, K. M., Dunlop, D. G., & Oreffo, R. O. C. (2007). Poly lactic acid scaffold augmented with human bone marrow stromal cells as a bone graft extender in impaction brone grafting. Tissue Engineering, 13(7), p.1742.
Tare, R., Khan, F., Tourniaire, G., Morgan, S. M., Bradley, M., & Oreffo, R. O. C. (2007). Selection of human mesenchymal osteoprogenitors from bone marrow stromal cell populations using polymer microarrays. Tissue Engineering, 13(7), p.1754.
Oreffo, R. O. C. (2007). Skeletal tissue engineering: harnessing interdisciplinary interactions from the laboratory to clinical translation. Wound Repair and Regeneration, 15(6), p.A111. DOI: 10.1111/j.1524-475x.2007.00319.x
Kanczler, J. M., Barry, J., Ginty, P., Howdle, S. M., Shakesheff, K. M., & Oreffo, R. O. (2007). Supercritical carbon dioxide generated vascular endothelial growth factor encapsulated poly(DL-lactic acid) scaffolds induce angiogenesis in vitro. Biochemical and Biophysical Research Communications, 352(1), 135-141.
Dalby, M. J., Gadegaard, N., Tare, R., Andar, A., Riehle, M. O., Herzyk, P., ... Oreffo, R. O. C. (2007). The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nature Materials, 6, 7pp. DOI: 10.1038/nmat2013
Bolland, B. J. R. F., New, A. M. R., Madabhushi, S. P. G., Oreffo, R. O. C., & Dunlop, D. G. (2007). Vibration-assisted bone-graft compaction in impaction bone grafting of the femur. Journal of Bone and Joint Surgery, 89-B(5), 686-692. DOI: 10.1302/0301-620X.89B5.18695
MacArthur, B. D., Tare, R. S., Please, C. P., Prescott, P., & Oreffo, R. C. (2006). A non-invasive method for in situ quantification of subpopulation behaviour in mixed cell culture. Journal of the Royal Society Interface, 3(6), 63-69. DOI: 10.1098/rsif.2005.0080
Bolland, B. J. R. F., Partridge, K., Tilley, S., New, A. M. R., Dunlop, D. G., & Oreffo, R. O. C. (2006). Biological and mechanical enhancement of impacted allograft seeded with human bone marrow stromal cells: potential clinical role in impaction bone grafting. Regenerative Medicine, 1(4), 457-467. DOI: 10.2217/17460751.1.4.457
Oreffo, R. O. (2006). Bone tissue engineering - from cells, mice to man - bridging the gap. Bio materialien, 7(Supplement 1).
Roach, H. I., Inglis, S., Partridge, K., Oreffo, R., & Clarke, N. M. P. (2006). Can epigenetic changes in DNA metylations explain the altered gene expression in osteoarthritis? Journal of Bone and Joint Surgery, 88-B(Supplement III), 385-386.
Partridge, K., Heyde, M., Garnett, M., Howdle, S. M., Shakesheff, K., & Oreffo, R. (2006). Cloning and expression of human BMP-2 potential for use in skeletal tissue engineering. Journal of Bone and Mineral Research, 21(7).
Yamada, N., Cheung, K. S. C., Tilley, S., Clarke, N. M. P., Oreffo, R. O. C., Kokobun, S., ... Roach, H. I. (2006). Does epigenetics play a role in the pathology of osteoarthritis? Journal of Bone and Joint Surgery, 88-B(Supplement III), p.403.
Yang, X. B., Webb, D., Blaker, J., Boccaccini, A. R., Maquet, V., Cooper, C., & Oreffo, R. O. C. (2006). Evaluation of human bone marrow stromal cell growth on biodegradable polymer/Bioglass composites. Biochemical and Biophysical Research Communications, 342(4), 1098-1107. DOI: 10.1016/j.bbrc.2006.02.021
Tare, R. S., Townsend, P. A., Packham, G., & Oreffo, R. O. C. (2006). Insight into the function of Bcl-2-associated athanogene-1 anti-apoptotic protein during chondrocyte development and differentiation. Journal of Bone and Mineral Research, 21(7), p.1150.
Ginty, P. J., Howard, D., Rose, F. R. A. J., Whitaker, M. J., Barry, J. J. A., Tighe, P., ... Shakesheff, K. M. (2006). Mammalian cell survival and processing in supercritical CO2. Proceedings of the National Academy of Sciences of the United States of America, 103(19), 7426-7431. DOI: 10.1073/pnas.0508895103
Green, D. W., Mann, S., & Oreffo, R. O. C. (2006). Mineralized polysaccharide capsules as biomimetic microenvironments for cell, gene and growth factor delivery in tissue engineering. Soft Matter, 2(9), 732-737. DOI: 10.1039/b604786f
Kanczler, J., Barry, J., Ginty, P., Sebald, W., Howdle, S., Shakesheff, K., & Oreffo, R. O. (2006). New scaffolds for skeletal regeneration stimulating angiogenesis and osteogenesis. Journal of Bone and Mineral Research, 21(7), p.1153.
Dalby, M. J., McCloy, D., Robertson, M., Agheli, H. D., Affrossman, S., & Oreffo, R. O. (2006). Osteoprogenitor response to semi-ordered and random nanotopographies. Biomaterials, 27(15), 2980-2987. DOI: 10.1016/j.biomaterials.2006.01.010
Pound, J. C., Green, D. W., Chaudhuri, J. B., Mann, S., Roach, H. I., & Oreffo, R. O. C. (2006). Strategies to promote chondrogenesis and osteogenesis from human bone marrow cells and articular chondrocytes encapsulated in polysaccharide templates. Tissue Engineering, 12(10), 2789-2799. DOI: 10.1089/ten.2006.12.2789
Tilley, S., Bolland, B. J. R. F., Partridge, K., New, A. M. R., Latham, J. M., Dunlop, D. G., & Oreffo, R. O. C. (2006). Taking tissue engineering principles into theatre: augmentation of impacted allograft with human bone marrow stromal cells. Regenerative Medicine, 1(5), 685-692. DOI: 10.2217/17460751.1.5.685
Tilley, S., Bolland, B. J. R. F., Partridge, K., New, A. M. R., Latham, J. M., & Dunlop, D. G. (2006). Taking tissue-engineering principles into theater: augmentation of impacted allograft with human bone marrow stromal cells. Regenerative Medicine, 1(5), 685-692. DOI: 10.2217/17460751.1.5.685
Yang, X. B., Green, D. W., Roach, H. I., Anderson, H. C., Howdle, S. M., Shakesheff, K. M., & Oreffo, R. O. C. (2006). The effect of an admix of bone morphogenetic proteins on human osteoprogenitor activity in vitro and in vivo. Tissue Engineering, 12(4), 1002-1003. DOI: 10.1089/ten.2006.12.983
Silva, M. M., Cyster, L. A., Barry, J. J., Yang, X. B., Oreffo, R. O., Grant, D. M., ... Rose, F. R. (2006). The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds. Biomaterials, 27(35), 5909-5917. DOI: 10.1016/j.biomaterials.2006.08.010
Berry, C. C., Dalby, M. J., Oreffo, R. O., McCloy, D., & Affrosman, S. (2006). The interaction of human bone marrow cells with nanotopographical features in three dimensional constructs. Journal of Biomedical Materials Research Part A, 79(2), 431-439.
Xu, Y., Mirmalek-Sani, S-H., Yang, X., Zhang, J., & Oreffo, R. O. C. (2006). The use of small interfering RNAs to inhibit adipocyte differentiation in human preadipocytes and fetal-femur-derived mesenchymal cells. Experimental Cell Research, 312(10), 1856-1864. DOI: 10.1016/j.yexcr.2006.02.016
Roach, H. I., Yamada, N., Cheung, K. S. C., Tilley, S., Clarke, N. M. P., Oreffo, R. O. C., ... Bronner, F. (2005). Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis and Rheumatism, 52(10), 3110-3124. DOI: 10.1002/art.21300
Green, D. W., Leveque, I., Walsh, D., Howard, D., Yang, X., Partridge, K., ... Oreffo, R. O. C. (2005). Biomineralized polysaccharide capsules for encapsulation, organization, and delivery of human cell types and growth factors. Advanced Functional Materials, 15(6), 917-923. DOI: 10.1002/adfm.200400322
MacArthur, B. D., & Oreffo, R. O. C. (2005). Bridging the gap. Nature, 433(7021), 19-19. DOI: 10.1038/433019a
Mirmalek-Sani, S-H., Tare, R. S., Morgan, S. M., Roach, H. I., Wilson, D. I., Hanley, N. A., & Oreffo, R. O. C. (2005). Characterization and multipotentiality of human fetal femur-derived cells: implications for skeletal tissue regeneration. Stem Cells, 24(4), 1042-1053. DOI: 10.1634/stemcells.2005-0368
Mirmalek-Sani, S. H., Roach, H. I., Hanley, N. A., Wilson, D. I., & Oreffo, R. O. C. (2005). Characterization and plasticity of human fetal-derived cartilage cells: implications for skeletal tissue regeneration. International Journal of Experimental Pathology, 86(3), A18-A19. DOI: 10.1111/j.0959-9673.2005.00426.x
Gonzalez-McQuire, R., Green, D., Walsh, D., Hall, S., Chane-Ching, J-Y., Oreffo, R. O. C., & Mann, S. (2005). Fabrication of hydroxyapatite sponges by dextran sulphate/amino acid templating. Biomaterials, 26(33), 6652-6656. DOI: 10.1016/j.biomaterials.2005.04.037
Oreffo, R. O. C., Cooper, C., Mason, C., & Clements, M. (2005). Mesenchymal stem cells: lineage, plasticity and skeletal therapeutic potential. Stem Cell Reviews and Reports, 1(2), 169-178. DOI: 10.1385/SCR:1:2:169
Dalby, M. J., McCloy, D., Robertson, M., Wilkinson, C. D. W., & Oreffo, R. O. C. (2005). Osteoprogenitor response to defined topographies with nanoscale depths. Biomaterials, 27(8), 1306-1315. DOI: 10.1016/j.biomaterials.2005.08.028
Tare, R. S., Howard, D., Pound, J. C., Roach, H. I., & Oreffo, R. O. C. (2005). Tissue engineering strategies for cartilage generation - micromass and three dimensional cultures using human chondrocytes and a continuous cell line. Biochemical and Biophysical Research Communications, 333(2), 609-621. DOI: 10.1016/j.bbrc.2005.05.117
Yang, X. B., Bhatnagar, R. S., Li, S., & Oreffo, R. O. C. (2004). Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Engineering, 10(7), 1148-1159. DOI: 10.1089/ten.2004.10.1148
Rose, F. R. A. J., Hou, Q., & Oreffo, R. O. C. (2004). Delivery systems for bone growth factors - the new players in skeletal regeneration. Journal of Pharmacy and Pharmacology, 56(4), 415-427. DOI: 10.1211/0022357
Partridge, K. A., & Oreffo, R. O. C. (2004). Gene delivery in bone tissue engineering: progress and prospects using viral and nonviral strategies. Tissue Engineering, 10(1-2), 295-307.
Oreffo, R. O. C. (2004). Growth factors for skeletal reconstruction and fracture repair. Current Opinion in Investigational Drugs, 5(4), 419-423.
Yang, X. B., Whitaker, M. J., Sebald, W., Clarke, N., Howdle, S. M., Shakesheff, K. M., & Oreffo, R. O. C. (2004). Human osteoprogenitor bone formation using encapsulated bone morphogenetic protein 2 in porous polymer scaffolds. Tissue Engineering, 10(7), 1037-1045. DOI: 10.1089/ten.2004.10.1037
MacArthur, B. D., Please, C. P., Taylor, M., & Oreffo, R. O. C. (2004). Mathematical modelling of skeletal repair. Biochemical and Biophysical Research Communications, 313(4), 825-833. DOI: 10.1016/j.bbrc.2003.11.171
Green, D., Walsh, D., Yang, X. B., Mann, S., & Oreffo, R. O. C. (2004). Stimulation of human bone marrow stromal cells using growth factor encapsulated calcium carbonate porous microspheres. Journal of Materials Chemistry, 14(14), 2206-2212. DOI: 10.1039/b400486h
Hall, S. R., Walsh, D., Green, D., Oreffo, R. O. C., & Mann, S. (2003). A novel route to highly porous bioactive silica gels. Journal of Materials Chemistry, 13(2), 186-190. DOI: 10.1039/b209300f
Smith, J. O., Oreffo, R. O. C., Clarke, N. M. P., & Roach, H. I. (2003). Changes in the antiangiogenic properties of articular cartilage in osteoarthritis. Journal of Orthopaedic Science, 8(6), 849-857. DOI: 10.1007/s00776-003-0717-8
Yang, X., Tare, R. S., Partridge, K. A., Roach, H., Clarke, N. M. P., Howdle, S. M., ... Oreffo, R. O. C. (2003). Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering. Journal of Bone and Mineral Research, 18(1), 47-57. DOI: 10.1359/jbmr.2003.18.1.47
Oreffo, R. O. C., Lashbrooke, B., Roach, H. I., Clarke, N. M., & Cooper, C. (2003). Maternal protein deficiency affects mesenchymal stem cell activity in the developing offspring. Bone, 33(1), 100-107. DOI: 10.1016/S8756-3282(03)00166-2
Green, D. W., Howard, D., Yang, X., Kelly, M., & Oreffo, R. O. C. (2003). Natural marine sponge fiber skeleton: a biomimetic scaffold for human osteoprogenitor cell attachment, growth, and differentiation. Tissue Engineering, 9(6), 1159-1166.
Yang, X. B., Green, D. W., Roach, H. I., Clarke, N. M. P., Anderson, H. C., Howdle, S. M., ... Oreffo, R. O. C. (2003). Novel osteoinductive biomimetic scaffolds stimulate human osteoprogenitor activity: implications for skeletal repair. Connective Tissue Research, 44(Supplement 1), 312-317. DOI: 10.1080/713713599
Salem, A. K., Rose, F. R. A. J., Oreffo, R. O. C., Yang, X. B., Davies, M. C., Mitchell, J. R., ... Shakesheff, K. M. (2003). Porous polymer and cell composites that self-assemble in situ. Advanced Materials, 15(3), 210-213. DOI: 10.1002/adma.200390047
Roach, H. I., Mehta, G., Oreffo, R. O. C., Clarke, N. M. P., & Cooper, C. (2003). Temporal analysis of rat growth plates: cessation of growth with age despite presence of a physis. Journal of Histochemistry and Cytochemistry, 51(3), 373-383.
Partridge, K., Yang, X., Clarke, N. M. P., Okubo, Y., Bessho, K., Sebald, W., ... Oreffo, R. O. C. (2002). Adenoviral BMP-2 gene transfer in mesenchymal stem cells: in vitro and in vivo bone formation on biodegradable polymer scaffolds. Biochemical and Biophysical Research Communications, 292(1), 144-152. DOI: 10.1006/bbrc.2002.6623
Rose, F. R. A. J., & Oreffo, R. O. C. (2002). Bone tissue engineering: hope vs hype. Biochemical and Biophysical Research Communications, 292(1), 1-7. DOI: 10.1006/bbrc.2002.6519
Tare, R. S., Oreffo, R. O. C., Sato, K., Rauvala, H., Clarke, N. M. P., & Roach, H. I. (2002). Effects of targeted overexpression of pleiotrophin on postnatal bone development. Biochemical and Biophysical Research Communications, 298(3), 324-332. DOI: 10.1016/S0006-291X(02)02456-7
Howard, D., Partridge, K., Yang, X., Clarke, N. M. P., Okubo, Y., Bessho, K., ... Oreffo, R. O. C. (2002). Immunoselection and adenoviral genetic modulation of human osteoprogenitors: in vivo bone formation on PLA scaffold. Biochemical and Biophysical Research Communications, 299(2), 208-215. DOI: 10.1016/S0006-291X(02)02561-5
Mehta, G., Roach, H. I., Langley-Evans, S., Taylor, P., Reading, I., Oreffo, R. O. C., ... Cooper, C. (2002). Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats. Calcified Tissue International, 71(6), 493-498. DOI: 10.1007/s00223-001-2104-9
Tare, R. S., Oreffo, R. O. C., Clarke, N. M. P., & Roach, H. I. (2002). Pleiotrophin/Osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation. Journal of Bone and Mineral Research, 17(11), 2009-2020. DOI: 10.1359/jbmr.2002.17.11.2009
Green, D. W., Walsh, D., Mann, S., & Oreffo, R. O. C. (2002). The potential of biomimesis in bone tissue engineering: lessons from the design and synthesis of invertebrate skeletons. Bone, 30(6), 810-815. DOI: 10.1016/S8756-3282(02)00727-5
Yang, X. B., Roach, H. I., Clarke, N. M. P., Howdle, S. M., Quirk, R., Shakesheff, K. M., & Oreffo, R. O. C. (2001). Human osteoprogenitor growth and differentiation on synthetic biodegradable structures after surface modification. Bone, 29(6), 523-531. DOI: 10.1016/S8756-3282(01)00617-2
Triffitt, J. T., Oreffo, R. O. C., Virdi, A. S., & Xia, Z. (2001). Osteogenic stem-cell characterization and development: potentials for cytotherapy. Cytotherapy, 3(5), 413-416. DOI: 10.1080/146532401753277760
Oreffo, R. O. C., Virdi, A. S., & Triffitt, J. T. (2001). Retroviral marking of human bone marrow fibroblasts: in vitro expansion and localization in calvarial sites after subcutaneous transplantation in vivo. Journal of Cellular Physiology, 186(2), 201-209. DOI: 10.1002/1097-4652(200102)186:2<201::AID-JCP1021>3.0.CO;2-B
Oreffo, R. O., Romberg, S., Virdi, A. S., Joyner, C. J., Berven, S., & Triffitt, J. T. (1999). Effects of interferon alpha on human osteoprogenitor cell growth and differentiation in vitro. Journal of Cellular Biochemistry, 74(3), 372-385. DOI: 10.1002/(SICI)1097-4644(19990901)74:3<372::AID-JCB6>3.0.CO;2-H
Locklin, R. M., Oreffo, R. O., & Triffitt, J. T. (1999). Effects of TGF? and bFGF on the differentiation of human bone marrow stromal fibroblasts. Cell Biology International, 23(3), 185-194.
Oreffo, R. O., Kusec, V., Virdi, A. S., Flanagan, A. M., Grano, M., Zambonin-Zallone, A., & Triffitt, J. T. (1999). Expression of estrogen receptor-alpha in cells of the osteoclastic lineage. Histochemistry and Cell Biology, 111(2), 125-133. DOI: 10.1007/s004180050342
Oreffo, R. O., & Triffitt, J. T. (1999). Future potentials for using osteogenic stem cells and biomaterials in orthopedics. Bone, 25, 5S-9S.
Oreffo, R. O., Kusec, V., Romberg, S., & Triffitt, J. T. (1999). Human bone marrow osteoprogenitors express estrogen receptor-alpha and bone morphogenetic proteins 2 and 4 mRNA during osteoblastic differentiation. Journal of Cellular Biochemistry, 75(3), 382-392. DOI: 10.1002/(SICI)1097-4644(19991201)75:3<382::AID-JCB4>3.0.CO;2-N
Zambonin, G., Grano, M., Greco, G., Oreffo, R. O. C., & Triffitt, J. T. (1999). Hydroxyapatite coated with insulin-like growth factor-1 (IGF-1) stimulates human osteoblast activity in vitro. Acta Orthopaedica Scandinavica, 70(2), 217-220.
Oreffo, R. O. C., & Triffitt, J. T. (1999). In vitro and in vivo methods to determine the interactions of osteogenic cells with biomaterials. Journal of Materials Science: Materials in Medicine, 10(10/11), 607-611.
Park, S. R., Oreffo, R. O., & Triffitt, J. T. (1999). Interconversion potential of cloned human marrow adipocytes in vitro. Bone, 24(6), 549-554. DOI: 10.1016/S8756-3282(99)00084-8
Virdi, A. S., Shore, E. M., Oreffo, R. O., Li, M., Connor, J. M., Smith, R., ... Triffitt, J. T. (1999). Phenotypic and molecular heterogeneity in fibrodysplasia ossificans progressiva. Calcified Tissue International, 65(3), 250-255.
Oreffo, R. O., Driessens, F. C., Planell, J. A., & Triffitt, J. T. (1998). Effects of novel calcium phosphate cements on human bone marrow fibroblastic cells. Tissue Engineering, 4(3), 293-303. DOI: 10.1089/ten.1998.4.293
Oreffo, R. O., Driessens, F. C., Planell, J. A., & Triffitt, J. T. (1998). Growth and differentiation of human bone marrow osteoprogenitors on novel calcium phosphate cements. Biomaterials, 19(20), 1845-1854. DOI: 10.1016/S0142-9612(98)00084-2
Virdi, A., Cook, L., Oreffo, R., & Triffitt, J. (1998). Modulation of bone morphogenetic protein-2 and bone morphogenetic protein-4 gene expression in osteoblastic cell lines. Cellular and Molecular Biology, 44(8), 1237-1246.
Locklin, R. M., Oreffo, R. O., & Triffitt, J. T. (1998). Modulation of osteogenic differentiation in human skeletal cells in Vitro by 5-azacytidine. Cell Biology International, 22(3), 207-15. DOI: 10.1006/cbir.1998.0240
Triffitt, J. T., Joyner, C. J., Oreffo, R. O., & Virdi, A. S. (1998). Osteogenesis: bone development from primitive progenitors. Biochemical Society Transactions, 26(1), 21-7. DOI: 10.1042/bst0260021
Oreffo, R. O. C., Bord, S., & Triffitt, J. T. (1998). Skeletal progenitor cells and ageing human populations. Clinical Science, 94(5), 549-555.
Inui, K., Oreffo, R. O., & Triffitt, J. T. (1997). Effects of beta mercaptoethanol on the proliferation and differentiation of human osteoprogenitor cells. Cell Biology International, 21(7), 419-425.
Bonewald, L. F., Oreffo, R. O., Lee, C. H., Park-Snyder, S., Twardzik, D., & Mundy, G. R. (1997). Effects of retinol on activation of latent transforming growth factor-? by isolated osteoclasts. Endocrinology, 138(2), 657-666.
Oreffo, R. O., Virdi, A. S., & Triffitt, J. T. (1997). Modulation of osteogenesis and adipogenesis by human serum in human bone marrow cultures. European Journal of Cell Biology, 74(3), 251-261.
Price, J. S., Oyajobi, B. O., Oreffo, R. O., & Russell, R. G. (1994). Cells cultured from the growing tip of red deer antler express alkaline phosphatase and proliferate in response to insulin-like growth factor-I. Journal of Endocrinology, 143(2), R9-R16.
Oreffo, R. O., Marshall, G. J., Kirchen, M., Garcia, C., Gallwitz, W. E., Chavez, J., ... Bonewald, L. F. (1993). Characterization of a cell line derived from a human giant cell tumor that stimulates osteoclastic bone resorption. Clinical Orthopaedics and Related Research, 296, 229-241.
Mundy, G. R., Roodman, G. D., Bonewald, L. F., Oreffo, R. O., & Boyce, B. F. (1991). Assays for bone resorption and bone formation. Methods in Enzymology, 198, 502-510. DOI: 10.1016/0076-6879(91)98049-C
Yates, A. J., Oreffo, R. O., Mayor, K., & Mundy, G. R. (1991). Inhibition of bone resorption by inorganic phosphate is mediated by both reduced osteoclast formation and decreased activity of mature osteoclasts. Journal of Bone and Mineral Research, 6(5), 473-478. DOI: 10.1002/jbmr.5650060508
Bonewald, L. F., Wakefield, L., Oreffo, R. O., Escobedo, A., Twardzik, D. R., & Mundy, G. R. (1991). Latent forms of transforming growth factor-? (TGF?) derived from bone cultures: identification of a naturally occurring 100-kDa complex with similarity to recombinant latent TGF? Molecular endocrinology, 5(6), 741-751.
Oreffo, R. O., Bonewald, L., Kukita, A., Garrett, I. R., Seyedin, S. M., Rosen, D., & Mundy, G. R. (1990). Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-? on isolated osteoclasts. Endocrinology, 126(6), 3069-3075.
Garrett, I. R., Boyce, B. F., Oreffo, R. O., Bonewald, L., Poser, J., & Mundy, G. R. (1990). Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. Journal of Clinical Investigation, 85(3), 632-639. DOI: 10.1172/JCI114485
Oreffo, R. O., Mundy, G. R., Seyedin, S. M., & Bonewald, L. F. (1989). Activation of the bone-derived latent TGF beta complex by isolated osteoclasts. Biochemical and Biophysical Research Communications, 158(3), 817-823. DOI: 10.1016/0006-291X(89)92795-2
Oreffo, R. O., Teti, A., Triffitt, J. T., Francis, M. J., Carano, A., & Zallone, A. Z. (1988). Effect of vitamin A on bone resorption: evidence for direct stimulation of isolated chicken osteoclasts by retinol and retinoic acid. Journal of Bone and Mineral Research, 3(2), 203-210. DOI: 10.1002/jbmr.5650030213
Teti, A., Oreffo, R. O., zambonin-Zallone, A., Triffitt, J. T., & Francis, M. J. (1986). Acid phosphatase activity is stimulated in isolated osteoclasts by vitamin A. Bollettino della Società Italiana di Biologia Sperimentale, 62(10), 1311-1314.
Teti, A., Oreffo, R. O., Zambonin Zallone, A., Triffitt, J. T., & Francis, M. J. (1986). The effect of retinol on osteoclasts is mediated by a specific cytosolic binding protein. Bollettino della Società Italiana di Biologia Sperimentale, 62(10), 1315-1319.
Oreffo, R. O. C., francis, J. A., & Triffitt, J. T. (1985). Vitamin A effects on UMR 106 osteosarcoma cells are not mediated by specific cytosolic receptors. Biochemical Journal, 232(2), 599-603.

Review

Mousa, M., Evans, N. D., Oreffo, R. O. C., & Dawson, J. I. (2018). Clay nanoparticles for regenerative medicine and biomaterial design: a review of clay bioactivity. Biomaterials, 1-28. DOI: 10.1016/j.biomaterials.2017.12.024

Book Chapters

Lindahl, A., Brittberg, M., Gibbs, D., Dawson, J., Kanczler, J., Black, C., ... Oreffo, R. (2015). Cartilage and bone regeneration. In C. Van Blitterswijk, & J. De Boer (Eds.), Tissue Engineering. Second Edition (pp. 529-582). Elsevier. DOI: 10.1016/B978-0-12-420145-3.01001-4
Tare, R., Gothard, D., Kanczler, J., West, J., & Oreffo, R. (2015). Microscale approaches for molecular regulation of skeletal development. In A. Singh, & A. K. Gaharwar (Eds.), Microscale Technologies for Cell Engineering (pp. 167-193). New York, US: Springer. DOI: 10.1007/978-3-319-20726-1_8
Danoux, C., Tare, R. S., Smith, J., Bradley, M., Hunt, J. A., Oreffo, R. O. C., & Habibovic, P. (2013). Development of materials for regenerative medicine: from clinical need to clinical application. In J. de Boer, & C. van Blitterswijk (Eds.), Materiomics: High Throughput Screening of Biomaterial Properties (pp. 155-175). Cambridge, GB: Cambridge University Press.
Macarthur, B., & Oreffo, R. (2013). From mathematical models to clinical reality. In Principles of Tissue Engineering Elsevier. DOI: http://dx.doi.org/10.1016/B978-0-12-398358-9.00003-3
Tare, R. S., Mitchell, P. D., Kanczler, J. M., & Oreffo, R. O. C. (2012). Isolation, differentiation and characterisation of skeletal stem cells from human bone marrow in vitro and in vivo. In M. H. H. Helfrich, & S. H. H. Ralston (Eds.), Bone Research Protocols (pp. 83-99). (Methods in Molecular Biology; No. 816). New York, US: Springer. DOI: 10.1007/978-1-61779-415-5_7

Conferences

Mills, B., Heath, D., Grant-Jacob, J., Oreffo, R., & Eason, R. (2018). Variable pattern projection via a spatial light modulator for laser machining on curved surfaces. In Conference for Lasers and Electro-Optics (CLEO) 2018 OSA Publishing.
Heath, D., Mills, B., Grant-Jacob, J., Eason, R., Feinäugle, M., Oreffo, R., & Goriainov, V. (2017). Digital micromirror device-based adaptive optics approach for enhanced micro-machining fidelity. Paper presented at Emerging Digital Micromirror Device Based Systems and Applications IX, United States.
Vaezi, M., Yang, S., Black, C., Gibbs, D., & Oreffo, R. O. C. (2014). Extrusion freeformed integrated synthetic bone graft and fracture fixation system. International Conference on Progress in Additive Manufacturing (Pro-AM 2014), Singapore.
Sengers, B. G., Please, C. P., Taylor, M., & Oreffo, R. O. C. (2009). Experimental-computational evaluation of human bone marrow stromal cell migration on trabecular bone structures. In P. J. Bartolo, P. R. Fernandes, R. B. Ruben, J. Folgado, H. Almeida, N. Alves, & A. Mendes (Eds.), Proceedings of ICTE2009 International Conference on Tissue Engineering (pp. 119-122). (ECCOMAS thematic conference). Lisbon, Portugal: IST Press.
Bagratashvili, V., Antonov, E. N., Howdle, S. M., Kanczler, J. M., Mirmalek-Sani, S., Popov, V. K., ... Spigulis, J. (Ed.) (2008). Osteogenesis on surface selective laser sintered bioresorbable scaffolds. In 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (Vol. 20, pp. 12-15). (IFMBE Proceedings; Vol. 20). Springer. DOI: 10.1007/978-3-540-69367-3_4
Roach, H. I., Yamanda, N., Hashimoto, K., Cheung, K. S., Oreffo, R. O., Kokubun, S., & Bronner, F. (2006). Epigenetics of osteoarthritis: is DNA Dmethylation involved in the pathogenesis of the disease?. Poster session presented at Bone Research Society and British Orthopaedic Research Society 1st Joint Meeting, .
Lanham, S., Roberts, C., Perry, M. J., Cooper, C., & Oreffo, R. O. C. (2006). Intrauterine programming of skeletal development: a longitudinal study. Poster session presented at Bone Research Society Annual Meeting 2006, .
Bolland, B. J. R. F., Partridge, K., New, A. M. R., Dunlop, D. G., & Oreffo, R. O. C. (1970). Augmentation of allograft with human bone marrow stromal cells: validation of cell survival, proliferation, osteogenic phenotype and mechanical strength. Paper presented at 1st Joint Meeting of the Bone Research Society and the British Orthopaedic Research Society, .
Bolland, B. J. R. F., New, A. M. R., Oreffo, R. O. C., & Dunlop, D. G. (1970). Augmentation of biological and mechanical properties of allograft in impaction bone grafting. Paper presented at Engineers and Surgeons: Joined at the Hip, .
Bolland, B. J. R. F., New, A. M. R., Oreffo, R. O. C., & Dunlop, D. G. (1970). Improving both the biological and mechanical properties of allograft in impaction bone grafting: a role for human bone marrow stromal cells. Paper presented at 8th European Fedaration of National Associations of Orthopaedics and Traumatology Congress, .
Bolland, B. J. R. F., New, A. M. R., Oreffo, R. O. C., & Dunlop, D. G. (1970). The role of vibration in impaction bone grafting. Paper presented at Engineers and Surgeons: Joined at the Hip, .
Bolland, B. J. R. F., New, A. M. R., Oreffo, R. O. C., & Dunlop, D. G. (1970). The role of vibration in impaction bone grafting: reducing the risk of fracture and improving bone graft strength. Paper presented at Meeting of the Orthopaedics Section of the Royal Society of Medicine, .
Bolland, B. J. R. F., New, A. M. R., Oreffo, R. O. C., & Dunlop, D. G. (1970). The use of vibration-assisted graft compaction in impaction bone grafting. Reducing the risk of fracture whilst improving bone graft strength. Poster session presented at 8th European Federation of National Associations of Orthopaedics and Traumatology Congress, .
Bolland, B. J. R. F., New, A. M. R., Oreffo, R. O. C., & Dunlop, D. G. (1970). The use of vibration-assisted graft compaction in impaction bone grafting: improvement in bone graft strength without increased risk of fracture. Poster session presented at 1st Joint Meeting of the Bone Research Society and the British Orthopaedic Research Society, .
Bolland, B. J. R. F., New, A. M. R., Oreffo, R. O. C., & Dunlop, D. G. (1970). Vibration assisted femoral impaction bone grafting: reducing the risk of fracture whilst improving bone graft strength. Paper presented at British Hip Society: Annual Meeting, .

BM5 Year 4. Delivery of on-going lectures to groups of undergraduate students studying Orthopaedics and Rheumatology. Specific lectures given on metabolic bone disease and basic bone biology.

BM5 Year 1. Provides tutorial and lectures on calcium metabolism and physiology of bone

BM4 Year 1. Provides tutorial to year 1 BM4 students on Bone Physiology.

Integrated Stem Cell PhD Programme – Stem Cell PhD Course Director and Lead - Also teach and run projects within the programme

Professor Richard Oreffo
Faculty of Medicine University of Southampton Institute of Developmental Sciences Building Mailpoint 887 Southampton General Hospital Tremona Road Southampton SO16 6YD Tel: +44 (0)23 8120 8502

Room Number:SGH/IDS/MP887

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