Jonnalagadda, U., Hill, M., Messaoudi, W., Cook, R. B., Oreffo, R. O. C., Glynne-Jones, P., & Tare, R. S. (2018).
Acoustically modulated biomechanical stimulation for human cartilage tissue engineering.
Lab on a Chip,
18(3), 473. DOI:
10.1039/c7lc01195d Inglis, S., Schneider, K.
, Kanczler, J., Redl, H.
, & Oreffo, R. (2018).
Harnessing human decellularised blood vessel matrices and cellular construct implants to promote bone healing in an ex vivo organotypic bone defect model.
Advanced Healthcare Materials, 1-32. DOI:
10.1002/ 01 Oreffo, R., Goriainov, V., Hulsart Billstrom, S. G., Sjostrom, T., Dunlop, D., & Su, B. (2018).
Harnessing nanotopography to enhance osseointegration of clinical orthopaedic titanium implants - an in vitro and in vivo analysis.
Frontiers in Bioengineering and Biotechnology, 1-16.
Jadasz, J. J., Tepe, L., Beyer, F., Samper Agrelo, I., Akkermann, R., Spitzhorn, L-S., ... Kury, P. (2018).
Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.
Glia,
66(1), 145-160. DOI:
10.1002/glia.23233Orriss, I. R.
, Lanham, S., Savery, D., Greene, N. D. E., Stanier, P.
, Oreffo, R., ... Galea, G. L. (2018).
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.
Scientific Reports,
8(1), [3325]. DOI:
10.1038/s41598-018-21718-xOreffo, R., Yang, S., Cidonio, G., Dawson, J., Ahlfeld, T., Kilian, D., ... Gelinsky, M. (2017).
Development of a clay based bioink for 3D cell printing for skeletal application.
Biofabrication, 1-24. DOI:
10.1088/1758-5090/aa7e96 De Andres Gonzalez, M., Takahashi, A., Hashimoto, K., Itoi, E., Goldring, M.
, & Oreffo, R. (2017).
DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes.
Scientific Reports.
Coutts, L., Jenkins, T.
, Oreffo, R. O., Dunlop, D. G.
, Cooper, C., Harvey, N. C., & Thurner, P. J. (2017).
Local variation in femoral neck cortical bone: in vitro measured bone mineral density, geometry and mechanical properties.
Journal of Clinical Densitometry,
20(2), 205-215. DOI:
10.1016/j.jocd.2015.10.003 Tribe, H. C., McEwan, J., Taylor, H.
, Oreffo, R. O. C., & Tare, R. S. (2017).
Mesenchymal stem cells: potential role in the treatment of osteochondral lesions of the ankle.
Biotechnology Journal,
12(12), 1-10. [1700070]. DOI:
10.1002/biot.201700070 Lee, L. C. Y., Gadegaard, N., de Andrés, M. C., Turner, L-A., Burgess, K. V., Yarwood, S. J., ... Dalby, M. J. (2017).
Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency.
Biomaterials,
116, 10-20. DOI:
10.1016/j.biomaterials.2016.11.032Rhodes, A.
, Gray, J., Harvey, N., Davies, J. H.
, Oreffo, R. O. C., Reading, I., ... Aarvold, A. (2017).
Osteonecrosis following treatment for childhood acute lymphoblastic leukaemia: The Southampton Children's Hospital experience.
Journal of Children's Orthopaedics,
11(6), 440-447. DOI:
10.1302/1863-2548.11.170142,
10.1302/1863-2548.11.170142Janeczek, A. A., Scarpa, E., Horrocks, M. H.
, Tare, R. S., Rowland, C. A., Jenner, D.
, ... Evans, N. D. (2017).
PEGylated liposomes associate with Wnt3A protein and expand putative stem cells in human bone marrow populations.
Nanomedicine,
12(8), 845-863. DOI:
10.2217/nnm-2016-0386 Stacey, G. N., Connon, C. J., Coopman, K., Dickson, A. J., Fuller, B., Hunt, C. J., ... Zimmermann, H. (2017).
Preservation and stability of cell therapy products: recommendations from an expert workshop.
Regenerative Medicine,
12(5), 553-564. DOI:
10.2217/rme-2017-0073Xavier, M., de Andrés, M. C.
, Spencer, D., Oreffo, R., & Morgan, H. (2017).
Size and dielectric properties of skeletal stem cells change critically after enrichment and expansion from human bone marrow: consequences for microfluidic cell sorting.
Journal of the Royal Society Interface,
14(133), 1-13. DOI:
10.1098/rsif.2017.0233 Jenkins, T., Katsamenis, O. L., Andriotis, O. G., Coutts, L. V., Carter, B., Dunlop, D. G.
, ... Arden, N. (2017).
The inferomedial femoral neck is compromised by age but not disease: Fracture toughness and the multifactorial mechanisms comprising reference point microindentation.
Journal of the Mechanical Behavior of Biomedical Materials,
75, 399-412. DOI:
10.1016/j.jmbbm.2017.06.036 Hulsart-Billstrom, G.
, Dawson, J. I., Hofmann, S., Müller, R., Stoddart, M. J., Alini, M.
, ... Oreffo, R. O. C. (2016).
A surprisingly poor correlation between in vitro and in vivo testing of biomaterials for bone regeneration: results of a multicentre analysis. European Cells & Materials,
31, 312-322.
Tang, D., Tare, R. S., Yang, L-Y., Williams, D. F., Ou, K-L.
, & Oreffo, R. (2016).
Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration.
Biomaterials,
83, 363-382. DOI:
10.1016/j.biomaterials.2016.01.024 Gibbs, D. M. R., Black, C. R. M., Hulsart-Billstrom, G., Shi, P., Scarpa, E.
, Oreffo, R. O. C., & Dawson, J. I. (2016).
Bone induction at physiological doses of BMP through localization by clay nanoparticle gels.
Biomaterials,
99, 16-23. DOI:
10.1016/j.biomaterials.2016.05.010 Vaezi, M., Black, C., Gibbs, D. M. R., Oreffo, R. O. C., Brady, M.
, Moshrefi-Torbati, M., & Yang, S. (2016).
Characterization of new PEEK/HA composites with 3D HA network fabricated by extrusion freeforming.
Molecules,
21(6), 1-21. DOI:
10.3390/molecules21060687 Lewis, M. C.
, MacArthur, B. D., Tare, R., Oreffo, R. O. C., & Please, C. P. (2016).
Extracellular matrix deposition in engineered micromass cartilage pellet cultures: measurements and modelling.
PLoS ONE,
11(2), 1-12. DOI:
10.1371/journal.pone.0147302Goggin, P., Zygalakis, K., Oreffo, R., & Schneider, P. (2016).
High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: Insights on bone development, ageing, health and disease.
European Cells & Materials,
31, 264-295. DOI:
10.22203/eCM.v031a18 Inglis, S., Christensen, D.
, Wilson, D. I., Kanczler, J. M., & Oreffo, R. O. C. (2016).
Human endothelial and foetal femur-derived stem cell co-cultures modulate osteogenesis and angiogenesis.
Stem Cell Research & Therapy,
7(13), 1-16. DOI:
10.1186/s13287-015-0270-3 Xavier, M., Rosendahl, P., Herbig, M., Kräter, M.
, Spencer, D., Bornhäuser, M., ... Otto, O. (2016).
Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry. Integrative Biology,
8, 616-623. DOI:
10.1039/c5ib00304k Scarpa, E., Bailey, J. L., Janeczek, A. A., Stumpf, P. S., Johnston, A. H., Oreffo, R. O. C., ... Newman, T. A. (2016).
Quantification of intracellular payload release from polymersome nanoparticles.
Scientific Reports,
6(29460), 29460. DOI:
10.1038/srep29460,
10.1038/srep29460 Greenhough, J., Papadakis, M., Cutress, R., Townsend, P., Oreffo, R., & Tare, R. (2016).
Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1).
Scientific Reports, 1-39. DOI:
10.1038/srep33504 Jenkins, T.
, Coutts, L. V., D'Angelo, S., Dunlop, D. G., Oreffo, R. O., Cooper, C., ... Chan, K. (2016).
Site dependent reference point microindentation complements clinical measures for improved fracture risk assessment at the human femoral neck.
Journal of Bone and Mineral Research,
31(1), 196-203. DOI:
10.1002/jbmr.2605Moreno-Jiménez, I., Hulsart Billstrom, G., Lanham, S. A., Janeczek, A. A.
, Kontouli, N., Kanczler, J. M., ... Oreffo, R. O. C. (2016).
The chorioallantoic membrane (CAM) assay for the study of human bone regeneration: a refinement animal model for tissue engineering. Scientific Reports,
6(32168), 1-12. DOI:
10.1038/srep32168 Black, C. R. M., Goriainov, V., Gibbs, D., Kanczler, J., Tare, R. S., & Oreffo, R. O. C. (2015).
Bone tissue engineering.
Current molecular biology reports,
1(3), 132-140. DOI:
10.1007/s40610-015-0022-2 Birkin, P. R., Offin, D. G.
, Vian, C. J. B., Howlin, R. P., Dawson, J. L.
, Secker, T. L., ... Leighton, T. G. (2015).
Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream.
Physical Chemistry Chemical Physics,
17(32), 20574-20579. DOI:
10.1039/C5CP02406D Takahashi, A.
, de Andrés, M. C., Hashimoto, K., Itoi, E.
, & Oreffo, R. O. C. (2015).
Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis.
Osteoarthritis and Cartilage,
23(11), 1946-1954. DOI:
10.1016/j.joca.2015.02.168Gothard, D., Smith, E. L.
, Kanczler, J. M., Black, C. R., Wells, J. A., Roberts, C. A.
, ... Oreffo, R. O. C. (2015).
In vivo assessment of bone regeneration in alginate/bone ECM hydrogels with incorporated skeletal stem cells and single growth factors.
PLoS ONE,
10(12), 1-23. DOI:
10.1371/journal.pone.0145080 Gothard, D., Cheung, K., Kanczler, J. M., Wilson, D. I., & Oreffo, R. O. C. (2015).
Regionally-derived cell populations and skeletal stem cells from human foetal femora exhibit specific osteochondral and multi-lineage differentiation capacity in vitro and ex vivo.
Stem Cell Research & Therapy,
6(251), 1-17. DOI:
10.1186/s13287-015-0247-2 Sisti, K. E.
, de Andrés, M. C., Johnston, D., Almeida-Filho, E., Guastaldi, A. C.
, & Oreffo, R. O. C. (2015).
Skeletal stem cell and bone implant interactions are enhanced by LASER titanium modification.
Biochemical and Biophysical Research Communications, 1-7. DOI:
10.1016/j.bbrc.2015.10.013Smus, J. P., Moura, C. C., McMorrow, E.
, Tare, R. S., Oreffo, R. O. C., & Mahajan, S. (2015).
Tracking adipogenic differentiation of skeletal stem cells by label-free chemically selective imaging.
Chemical Science, 1-8. DOI:
10.1039/C5SC02168EJaneczek, A. A.
, Tare, R. S., Scarpa, E., Moreno-Jimenez, I., Rowland, C. A., Jenner, D.
, ... Evans, N. D. (2015).
Transient canonical Wnt stimulation enriches human bone marrow mononuclear cell isolates for osteoprogenitors.
Stem Cells, 1-13. DOI:
10.1002/stem.2241Coutts, L. V., Jenkins, T., Li, T.
, Oreffo, R. O., Dunlop, D. G., Cooper, C., ... the OStEO group (2015).
Variability in reference point microindentation and recommendations for testing cortical bone: location, thickness and orientation heterogeneity.
Journal of the Mechanical Behavior of Biomedical Materials,
46, 292-304. DOI:
10.1016/j.jmbbm.2015.02.004 Jenkins, T.
, Coutts, L. V., Dunlop, D. G., Oreffo, R. O. C., Cooper, C., Harvey, N. C., & Thurner, P. J. (2015).
Variability in reference point microindentation and recommendations for testing cortical bone: Maximum load, sample orientation, mode of use, sample preparation and measurement spacing. Journal of the Mechanical Behavior of Biomedical Materials,
42, 311-324. DOI:
10.1016/j.jmbbm.2014.09.030Tayton, E., Purcell, M.
, Aarvold, A., Smith, J. O., Briscoe, A.
, Kanczler, J. M., ... Oreffo, R. O. C. (2014).
A comparison of polymer and polymer-hydroxyapatite composite tissue engineered scaffolds for use in bone regeneration. An in vitro and in vivo study. Journal of Biomedical Materials Research Part A,
102(8), 2613-2624. DOI:
10.1002/jbm.a.34926Li, S.
, Glynne-Jones, P., Andriotis, O. G., Ching, K. Y., Jonnalagadda, U. S.
, Oreffo, R. O. C., ... Tare, R. S. (2014).
Application of an acoustofluidic perfusion bioreactor for cartilage tissue engineering.
Lab on a Chip,
14(23), 4475-4485. DOI:
10.1039/c4lc00956hImagawa, K., de Andrés, M. C., Hashimoto, K., Itoi, E., Otero, M., Roach, H. I.
, ... Oreffo, R. O. C. (2014).
Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation.
Arthritis & Rheumatology,
66(11), 3040-3051. DOI:
10.1002/art.38774Goriainov, V., Cook, R., Latham, J.
, Dunlop, D., & Oreffo, R. O. C. (2014).
Bone and metal - an orthopaedic perspective on osseointegration of metals.
Acta Biomaterialia, 1-15. DOI:
10.1016/j.actbio.2014.06.004 Oreffo, R. O. C. (2014).
Centre for human development, stem cells & regeneration.
Regenerative Medicine,
9(5), 563-567. DOI:
10.2217/RME.14.48 Dawson, J. I.
, Kanczler, J., Tare, R., Kassem, M.
, & Oreffo, R. O. C. (2014).
Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies - Where are we now? Stem Cells,
32(1), 35-44. DOI:
10.1002/stem.1559Smith, E. L.
, Kanczler, J. M., Gothard, D., Roberts, C. A.
, Wells, J. A., White, L. J.
, ... Oreffo, R. O. C. (2014).
Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model.
Acta Biomaterialia,
10(10), 4186-4196. DOI:
10.1016/j.actbio.2014.06.011Smith, E. L.
, Kanczler, J. M., Gothard, D., Roberts, C. A.
, Wells, J. A., White, L. J.
, ... Oreffo, R. O. C. (2014).
Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model.
Acta Biomaterialia,
10(10), 4197-4205. DOI:
10.1016/j.actbio.2014.05.025Cheung, K. S. C.
, Sposito, N., Stumpf, P. S., Wilson, D. I., Sanchez-Elsner, T., & Oreffo, R. O. C. (2014).
MicroRNA-146a regulates human foetal femur derived skeletal stem cell differentiation by down-regulating SMAD2 and SMAD3.
PLoS ONE,
9(6), e98063. DOI:
10.1371/journal.pone.0098063Tsimbouri, P., Gadegaard, N., Burgess, K., White, K., Reynolds, P., Herzyk, P., ... Dalby, M. J. (2014).
Nanotopographical effects on mesenchymal stem cell morphology and phenotype.
Journal of Cellular Biochemistry,
115(2), 380-390. DOI:
10.1002/jcb.24673Cassidy, J. W., Roberts, J. N., Smith, C-A., Robertson, M., White, K., Biggs, M. J., ... Dalby, M. J. (2014).
Osteogenic lineage restriction by osteoprogenitors cultured on nanometric grooved surfaces: the role of focal adhesion maturation. Acta Biomaterialia,
10(2), 651-660. DOI:
10.1016/j.actbio.2013.11.008Gothard, D., Greenhough, J., Ralph, E.
, & Oreffo, R. (2014).
Prospective isolation of human bone marrow stromal cell subsets: a comparative study between Stro-1-, CD146- and CD105-enriched populations.
Journal of Tissue Engineering,
5, 1-17. DOI:
10.1177/2041731414551763 Tayton, E. R., Purcell, M., Smith, J. O.
, Lanham, S., Howdle, S. M., Shakesheff, K. M.
, ... Oreffo, R. O. C. (2014).
The scale-up of a tissue engineered porous hydroxyapatite polymer composite scaffold for use in bone repair: an ovine femoral condyle defect study.
Journal of Biomedical Materials Research Part A,
103(4), 1346-1356. DOI:
10.1002/jbm.a.35279Gothard, D., Smith, E. L.
, Kanczler, J. M., Rashidi, H., Qutachi, O., Henstock, J.
, ... Oreffo, R. O. C. (2014).
Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man.
European Cells & Materials,
28, 166-208.
Tsimbouri, P. M., Murawski, K., Hamilton, G., Herzyk, P.
, Oreffo, R. O. C., Gadegaard, N., & Dalby, M. J. (2013).
A genomics approach in determining nanotopographical effects on MSC phenotype.
Biomaterials,
34(9), 2177-2184. DOI:
10.1016/j.biomaterials.2012.12.019Aarvold, A., Smith, J., Tayton, E. R., Jones, A. M. H.
, Dawson, J. I., Lanham, S. A., ... Oreffo, R. O. C. (2013).
A tissue engineering strategy for the treatment of avascular necrosis of the femoral head.
The Surgeon,
11(6), 319-325. DOI:
10.1016/j.surge.2013.02.008Khan, F., Smith, J. O.
, Kanczler, J. M., Tare, R. S., & Oreffo, R. O. C. (2013).
Discovery and evaluation of a functional ternary polymer blend for bone repair: translation from a microarry to a clinical model.
Advanced Functional Materials, 1-13. DOI:
10.1002/adfm.201202710Lanham, S. A., Roberts, C., Habgood, A. K., Alexander, S., Burne, T. H. J., Eyles, D. W.
, ... Oreffo, R. O. C. (2013).
Effect of Vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life.
Journal of Developmental Origins of Health and Disease,
4(1), 49-55. DOI:
10.1017/S2040174412000542 Tayton, E. R., Smith, J. O., Evans, N. R.
, Dickinson, A., Aarvold, A., Kalra, S.
, ... Oreffo, R. O. C. (2013).
Effects of setting bone cement on tissue-engineered bone graft: a potential barrier to clinical translation? The Journal of Bone and Joint Surgery,
95(8), 192-197. DOI:
10.2106/JBJS.L.00164Nadeem, D., Sjostrom, T., Wilkinson, A., Smith, C-A.
, Oreffo, R. O. C., Dalby, M. J., & Su, B. (2013).
Embossing of micropatterned ceramics and their cellular response.
Journal of Biomedical Materials Research Part A,
101(11), 3247-3255. DOI:
10.1002/jbm.a.34622Dawson, J. I., Smith, J. O.
, Aarvold, A., Ridgway, J. N., Curran, S. J.
, Dunlop, D. G., & Oreffo, R. O. C. (2013).
Enhancing the osteogenic efficacy of human bone marrow aspirate: concentrating osteoprogenitors using wave-assisted filtration.
Cytotherapy,
15(2), 242-252. DOI:
10.1016/j.jcyt.2012.09.004 Neves, N. M., de Andrés, M. C., Kingham, E., Imagawa, K., Gonzalez, A., Roach, H. I.
, ... Oreffo, R. O. C. (2013).
Epigenetic regulation during fetal femur development: DNA methylation matters.
PLoS ONE,
8(1), e54957. DOI:
10.1371/journal.pone.0054957Evans, N. D., Oreffo, R. O. C., Healy, E., Thurner, P. J., & Man, Y. H. (2013).
Epithelial mechanobiology, skin wound healing, and the stem cell niche.
Journal of the Mechanical Behavior of Biomedical Materials,
28, 397-409. DOI:
10.1016/j.jmbbm.2013.04.023 de Andrés, M. C., Imagawa, K., Hashimoto, K., Gonzalez, A., Roach, H. I., Goldring, M. B.
, & Oreffo, R. O. C. (2013).
Loss of methylation in CpG sites in the NF-?B enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes.
Arthritis and Rheumatism,
65(3), 732-742. DOI:
10.1002/art.37806Kingham, E. J., White, K., Gadegaard, N., Dalby, M. J.
, & Oreffo, R. O. C. (2013).
Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells.
Small,
9(12), 2140-2151. DOI:
10.1002/smll.201202340 Rizzoli, R., Reginster, J-Y., Arnal, J-F., Bautmans, I., Beaudart, C., Bischoff-Ferrari, H., ... Bruyère, O. (2013).
Quality of life in sarcopenia and frailty.
Calcified Tissue International,
93(2). DOI:
10.1007/s00223-013-9758-yHashimoto, K., Otero, M., Imagawa, K., de Andres, M. C., Coico, J. M., Roach, H. I., ... Goldring, M. B. (2013).
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin -1B (IL 1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.
The Journal of Biological Chemistry,
288(14), 10061-10072. DOI:
10.1074/jbc.M112.421156Aarvold, A., Smith, J. O., Tayton, E. R.
, Lanham, S. A., Chaudhuri, J. B., Turner, I. G.
, & Oreffo, R. O. C. (2013).
The effect of porosity of a biphasic ceramic scaffold on human skeletal stem cell growth and differentiation in vivo. Journal of Biomedical Materials Research Part A,
101(12), 3431-3437. DOI:
10.1002/jbm.a.34646 Tayton, E., Fahmy, S., Purcell, M.
, Aarvold, A., Smith, J. O., Kalra, S.
, ... Oreffo, R. O. C. (2012).
An analysis of polymer type and chain length for use as a biological composite graft extender in impaction bone grafting: a mechanical and biocompatibility study.
Journal of Biomedical Materials Research Part A,
100(12), 3211-3219. DOI:
10.1002/jbm.a.34264Aarvold, A., Smith, J. O., Tayton, E. R., Jones, A. M. H., Dawson, J. I., Lanham, S.
, ... Oreffo, R. O. C. (2012).
From bench to clinic and back: skeletal stem cells and impaction bone grafting for regeneration of bone defects. Journal of Tissue Engineering and Regenerative Medicine. DOI:
10.1002/term.1577Tare, R. S., Mitchell, P. D.
, Kanczler, J., & Oreffo, R. O. C. (2012).
Isolation, differentiation, and characterisation of skeletal stem cells from human bone marrow in vitro and in vivo.
Methods in Molecular Biology,
816, 83-99.
McNamara, L. E., Sjöström, T., Meek, R. M. D.
, Oreffo, R. O. C., Su, B., Dalby, M. J., & Burgess, K. E. V. (2012).
Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine.
Journal of the Royal Society Interface,
9(73), 1713-1724. DOI:
10.1098/rsif.2012.0169Dawson, J. I., Kingham, E., Evans, N. R., Tayton, E.
, & Oreffo, R. O. C. (2012).
Skeletal Regeneration: application of nanotopography and biomaterials for skeletal stem cell based bone repair.
Inflammation and Regeneration,
32(3), 72-89. DOI:
10.2492/inflammregen.32.072 Tayton, E., Purcell, M., Aarvold, A., Smith, J. O., Kalra, S., Briscoe, A.
, ... Oreffo, R. O. C. (2012).
Supercritical CO2 fluid-foaming of polymers to increase porosity: a method to improve the mechanical and biocompatibility characteristics for use as a potential alternative to allografts in impaction bone grafting? Acta Biomaterialia,
8(5), 1918-1927. DOI:
10.1016/j.actbio.2012.01.024González-García, C., Moratal, D.
, Oreffo, R. O. C., Dalby, M. J., & Salmerón-Sánchez, M. (2012).
Surface mobility regulates skeletal stem cell differentiation.
Integrative Biology,
4(5), 531-539. DOI:
10.1039/C2IB00139JSmith, J. O.
, Sengers, B. G., Aarvold, A., Tayton, E. R.
, Dunlop, D. G., Oreffo, R. O. C., & sm, N. (2012).
Tantalum trabecular metal - addition of human skeletal cells to enhance bone implant interface strength and clinical application.
Journal of Tissue Engineering and Regenerative Medicine. DOI:
10.1002/term.1525Aarvold, A., Smith, J. O., Tayton, E. R., Edwards, C. J., Fowler, D. J., Gent, E. D.
, & Oreffo, R. O. C. (2012).
The role of osteoblast cells in the pathogenesis of unicameral bone cysts.
Journal of Children's Orthopaedics,
6(4), 339-346. DOI:
10.1007/s11832-012-0419-x Tayton, E. R., Smith, J. O., Aarvold, A., Kalra, S.
, Dunlop, D. G., & Oreffo, R. O. C. (2012).
Translational hurdles for tissue engineering: an in vitro analysis of commonly used local anaesthetics on skeletal stem cell survival.
The Journal of Bone and Joint Surgery,
94(6), 848-855. DOI:
10.1302/0301-620X.94B6.28479Tsimbouri, P. M., McMurray, R. J., Burgess, K. V., Alakpa, E. V., Reynolds, P. M., Murawski, K., ... Dalby, M. J. (2012).
Using nanotopography and metabolomics to identify biochemical effectors of multipotency.
ACS Nano,
6(11), 10239-10249. DOI:
10.1021/nn304046mMotterlini, N.
, Dimitrov, B. D., Bradley, M., Bennett, K., & Fahey, T. (2012).
Variations in General Practitioners' prescribing patterns in Ireland: preliminary results.
Irish Journal of Medical Science,
181(4), 119-119. DOI:
10.1007/s11845-012-0838-1Gennero, I., Laurencin-Dalicieux, S., Conte-Auriol, F., Briand-Mésange, F., Laurencin, D., Rue, J., ... Salles, J. P. (2011).
Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.
Bone,
49(3), 395-403. DOI:
10.1016/j.bone.2011.04.018Dawson, J. I., Kanczler, J. M., Yang, X. B.
, Attard, G. S., & Oreffo, R. O. C. (2011).
Clay gels for the delivery of regenerative microenvironments.
Advanced Materials,
23(29), 3304-3308. DOI:
10.1002/adma.201100968 Lanham, S., Fowden, A. L., Roberts, C.
, Cooper, C., Oreffo, R. O. C., & Forhead, A. J. (2011).
Effects of hypothyroidism on the structure and mechanical properties of bone in the ovine fetus.
Journal of Endocrinology. DOI:
10.1530/JOE-11-0138 Gothard, D.
, Tare, R. S., Mitchell, P. D.
, Dawson, J. I., & Oreffo, R. O. C. (2011).
In search of the skeletal stem cell: isolation and separation strategies at the macro/micro scale for skeletal regeneration.
Lab on a Chip,
11(7), 1206-1220. DOI:
10.1039/C0LC00575DMcMurray, R. J., Gadegaard, N., Tsimbouri, P. M., Burgess, K. V., McNamara, L. E.
, Tare, R., ... Dalby, M. J. (2011).
Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency.
Nature Materials,
10(8), 637-644. DOI:
10.1038/nmat3058Kantawong, F., Robertson, M. E., Gadegaard, N.
, Oreffo, R. O. C., Burchmore, R. J., & Dalby, M. J. (2011).
Protein expression of STRO-1 cells in response to different topographic features.
Journal of Tissue Engineering,
2(1), 534603. DOI:
10.4061/2011/534603McNamara, L. E., Sjöström, T., Burgess, K. E. V., Kim, J. J. W., Liu, E., Gordonov, S., ... Dalby, M. J. (2011).
Skeletal stem cell physiology on functionally distinct titania nanotopographies.
Biomaterials,
32(30), 7403-7410. DOI:
10.1016/j.biomaterials.2011.06.063Smith, J. O.
, Aarvold, A., Tayton, E. R.
, Dunlop, D. G., & Oreffo, R. O. C. (2011).
Skeletal tissue regeneration: current approaches, challenges, and novel reconstructive strategies for an aging population.
Tissue Engineering Part B Reviews,
17(5), 307-320. DOI:
10.1089/ten.teb.2011.0143de Andres, M. C., Imagawa, K., Hashimoto, K., Gonzalez, A., Goldring, M. B., Roach, H. I.
, & Oreffo, R. O. C. (2011).
Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis.
Biochemical and Biophysical Research Communications,
1(407), 54-59.
Aarvold, A., Smith, J. O., Tayton, E. R., Tilley, S.
, Dawson, J. I., Lanham, S. A., ... Oreffo, R. O. C. (2011).
Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case.
Regenerative Medicine,
6(4), 461-467. DOI:
10.2217/rme.11.33 Kanczler, J. M., Sura, H. S., Magnay, J., Green, D.
, Oreffo, R. O. C., Dobson, J. P., & El Haj, A. J. (2010).
Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology.
Tissue Engineering Part A,
16(10), 3241-3250. DOI:
10.1089/ten.tea.2009.0638 Kantawong, F., Burgess, K. E. V., Jayawardena, K., Hart, A., Riehle, M. O.
, Oreffo, R. O., ... Burchmore, R. (2010).
Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells.
Acta Biomaterialia,
6(9), 3694-3703. DOI:
10.1016/j.actbio.2010.02.038Forristal, C. E., Wright, K. L., Hanley, N. A.
, Oreffo, R. O. C., & Houghton, F. D. (2010).
Hypoxia inducible factors regulate pluripotency and proliferation in human proliferation in human embryonic stem cells cultured at reduced oxygen tensions.
Reproduction,
139(1), 85-97. DOI:
10.1530/REP-09-0300 Hails, L. A., Babister, J. C.
, Inglis, S., Davis, S. A.
, Oreffo, R. O., & Mann, S. (2010).
Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins.
Small,
6(18), 1986-1991. DOI:
10.1002/smll.201000939Lanham, S. A., Roberts, C., Hollingsworth, T., Sreekumar, R., Elahi, M.
, Cagampang, F. R., ... Oreffo, R. O. C. (2010).
Maternal high-fat diet: effects on offspring bone structure.
Osteoporosis International,
21(10), 1703-1714. DOI:
10.1007/s00198-009-1118-4 McNamara, L. E., McMurray, R. J., Biggs, M. J., Kantawong, F.
, Oreffo, R. O., & Dalby, M. J. (2010).
Nanotopographical control of stem cell differentiation.
Journal of Tissue Engineering,
2010(120623), 120623-[13pp]. DOI:
10.4061/2010/120623Tare, R. S., Kanczler, J., Aarvold, A., Jones, A. M. H.
, Dunlop, D. G., & Oreffo, R. O. C. (2010).
Skeletal stem cells and bone regeneration: translational strategies from bench to clinic.
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine,
224(12), 1455-1470. DOI:
10.1243/09544119JEIM750 Kanczler, J., Ginty, P., White, L.
, Clarke, N., Howdle, S., Shakesheff, K.
, & Oreffo, R. (2010).
The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation.
Biomaterials,
31(6), 1241-1250. DOI:
10.1016/j.biomaterials.2009.10.059 Andres de, M. C., Imagawa, K., Hashimoto, K., gonzalez, A.
, Oreffo, R. O. C., & Roach, H. I. (2010).
The role of epigenetics in iNos induction in osteoarthritic chondrocytes.
Osteoarthritis and Cartilage,
18, S167.
Tare, R. S., Khan, F., Tourniaire, G., Morgan, S. M., Bradley, M.
, & Oreffo, R. O. C. (2009).
A microarray approach to the identification of polyurethanes for the isolation of human skeletal progenitor cells and augmentation of skeletal cell growth.
Biomaterials,
30(6), 1045-1055. DOI:
10.1016/j.biomaterials.2008.10.038 Green, D. W., Bolland, B. J. R.
, Kanczler, J. M., Lanham, S. A., Walsh, D., Mann, S.
, & Oreffo, R. O. C. (2009).
Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites.
Biomaterials,
30(10), 1918-1927. DOI:
10.1016/j.biomaterials.2008.12.052Kanczler, J. M., Mirmalek-Sani, S-H., Hanley, N. A., Ivanov, A. L., Barry, J. J. A., Upton, C.
, ... Oreffo, R. O. C. (2009).
Biocompatibility and osteogenic potential of human fetal femur-derived cells on surface selective laser sintered scaffolds.
Acta Biomaterialia,
5(6), 2063-2071. DOI:
10.1016/j.actbio.2009.03.010 Collins, A. M., Skaer, N. J. V., Gheysens, T., Knight, D., Bertram, C., Roach, H. I., ... Mann, S. (2009).
Bone like resorbable silk based scaffolds for load bearing osteoregenerative applications.
Advanced Materials,
20(1), 75-78. DOI:
10.1002/adma.200802239Mirmalek-Sani, S. H., Stokes, P. J.
, Tare, R. S., Ralph, E. J.
, Inglis, S., Hanley, N. A.
, ... Oreffo, R. O. (2009).
Derivation of a novel undifferentiated human fetal phenotype in serum-free cultures with BMP-2.
Journal of Cellular and Molecular Medicine,
13(9B), 3541-3555. DOI:
10.1111/j.1582-4934.2009.00742.xHashimoto, K.
, Oreffo, R. O. C., Gibson, M. B., Goldring, M. B., & Roach, H. I. (2009).
DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes.
Arthritis and Rheumatism,
60(11), 3303-3313. DOI:
10.1002/art.24882Berry, C. C., Harianawalw, H., Loebus, J.
, Oreffo, R. O. C., & de la Fuente, J. (2009).
Enhancement of human bone marrow cell uptake of quantum dots using tat peptide.
Current Nanoscience,
5(4), 390-395. DOI:
10.2174/157341309789378122Sjostrom, T., Dalby, M. J., Hart, A.
, Tare, R. S., Oreffo, R. O. C., & Su, B. (2009).
Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells.
Acta Biomaterialia,
5(5), 1433-1441. DOI:
10.1016/j.actbio.2009.01.007Morgan, S. M., Ainsworth, B. J.
, Kanczler, J. M., Babister, J. C., Chaudhuri, J. B.
, & Oreffo, R. O. C. (2009).
Formation of a human-derived fat tissue layer in P(DL)LGA hollow fibre scaffolds for adipocyte tissue engineering.
Biomaterials,
30(10), 1910-1917. DOI:
10.1016/j.biomaterials.2008.12.033Babister, J. C., Hails, L. A.
, Oreffo, R. O. C., Davis, S., & Mann, S. (2009).
The effect of pre-coating human bone marrow stromal cells with hydroxyapatite/amino acid nanoconjugates on osteogenesis.
Biomaterials,
30(18), 3174-3182. DOI:
10.1016/j.biomaterials.2009.02.024Williams, E. L., Roach, H. I.
, Cooper, C., Oreffo, R. O. C., & Edwards, C. J. (2009).
The effects of inflammatory cytokines from arthritic synovium on skeletal stem cell function – implications for reparative strategies.
Rheumatology,
48, i40-i41. DOI:
10.1093/rheumatology/kep718Biggs, M. J., Richards, R. G., Gadegaard, N., Wilkinson, C. D. W.
, Oreffo, R. O., & Dalby, M. J. (2009).
The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+enriched skeletal stem cells.
Biomaterials,
30(28), 5094-5103. DOI:
10.1016/j.biomaterials.2009.05.049Kantawong, F., Burgess, K. E. V., Jayawardena, K., Hart, A., Burchmore, R. J., Gadegaard, N., ... Dalby, M. J. (2009).
Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling.
Biomaterials,
30(27), 4723-4732. DOI:
10.1016/j.biomaterials.2009.05.040Biggs, M. J. P., Richards, R. G., McFarlane, S., Wilkinson, C. D. W.
, Oreffo, R. O. C., & Dalby, M. J. (2008).
Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330nm deep microgrooves.
Journal of the Royal Society Interface,
5(27), 1231-1242. DOI:
10.1098/rsif.2008.0035Tare, R. S., Townsend, P. A.
, Packham, G., Inglis, S., & Oreffo, R. O. C. (2008).
BCL-2 associated athanogene-1 (BAG-1): A transcriptional regulator mediating chondrocyte survival and differentiation during endochondral ossification.
Bone,
42(1), 113-128. DOI:
10.1016/j.bone.2007.08.032 Dawson, J. I., Wahl, D. A.
, Lanham, S. A., Kanczler, J. M., Czernuszka, J. T.
, & Oreffo, R. O. C. (2008).
Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells.
Biomaterials,
29(21), 3105-3116. DOI:
10.1016/j.biomaterials.2008.03.040 Kantawong, F., Burchmore, R., Wilkinson, C. D. W.
, Oreffo, R. O. C., & Dalby, M. J. (2008).
Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance.
Acta Biomaterialia,
5(4), 1137-1146. DOI:
10.1016/j.actbio.2008.11.001Pollintine, P., Barrett, G. W., Millais, I. E.
, Green, L. R., Cooper, C., Lanham, S. A., ... Dolan, P. (2008).
Early nutritional compromise affects the mechanical properties of sheep spines.
Journal of Bone and Joint Surgery,
90B(Supplement 2), 373-374.
Babister, J. C.
, Tare, R. S., Green, D. W.
, Inglis, S., Mann, S.
, & Oreffo, R. R. O. C. (2008).
Genetic manipulation of human mesenchymal progenitors to promote chondrogenesis using “bead-in-bead” polysaccharide capsules.
Biomaterials,
29(1), 58-65. DOI:
10.1016/j.biomaterials.2007.09.006Dalby, M. J., Andar, A., Nag, A., Affrossman, S.
, Tare, R., McFarlane, S.
, & Oreffo, R. O. C. (2008).
Genomic expression of mesenchymal stem cells to altered nanoscale topographies.
Journal of the Royal Society Interface,
5(26), 1055-1065. DOI:
10.1098/rsif.2008.0016Biggs, M. J., Richards, R. G., Gadegaard, N., McMurray, R. J., Affrossman, S., Wilkinson, C. D. W., ... Dalby, M. J. (2008).
Interaction with nanoscale topography: Adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage.
Journal of Biomedical Materials Research Part A,
91A(1), 195-208. DOI:
10.1002/jbm.a.32196Lanham, S. A., Roberts, C., Perry, M. J.
, Cooper, C., & Oreffo, R. O. (2008).
Intrauterine programming of bone. Part 2: alteration of skeletal structure.
Osteoporosis International,
19(2), 157-167. DOI:
10.1007/s00198-007-0448-3 Gribbon, C., Channon, K. J.
, Zhang, W., Banwell, E. F., Bromley, E. H. C., Chaudhuri, J. B., ... Woolfson, D. N. (2008).
Magic-wand: a single, designed peptide that assembles to stable, ordered helical fibres.
Biochemistry,
47(39), 10365-10371. DOI:
10.1021/bi801072sKantawong, F., Burchmore, R., Gadegaard, N.
, Oreffo, R. O. C., & Dalby, M. J. (2008).
Proteomic analysis of human osteoprogenitor response to disordered nanotopography.
Journal of the Royal Society Interface,
6(40), 1075-1086. DOI:
10.1098/?rsif.2008.0447Tare, R. S., Babister, J. C.
, Kanczler, J., & Oreffo, R. O. C. (2008).
Skeletal stem cells: phenotype, biology and environmental niches informing tissue regeneration.
Molecular and Cellular Endocrinology,
288(1-2), 11-21. DOI:
10.1016/j.mce.2008.02.017 Bolland, B. J.
, Kanczler, J. M., Ginty, P. J., Howdle, S. M., Shakesheff, K. M.
, Dunlop, D. G., & Oreffo, R. O. (2008).
The application of human bone marrow stromal cells and poly(dl-lactic acid) as a biological bone graft extender in impaction bone grafting.
Biomaterials,
29(22), 3221-3227. DOI:
10.1016/j.biomaterials.2008.04.017Kanczler, J. M., Ginty, P. J., Barry, J. J.
, Clarke, N. M., Howdle, S. M., Shakesheff, K. M.
, & Oreffo, R. O. (2008).
The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation.
Biomaterials,
29(12), 1892-1900. DOI:
10.1016/j.biomaterials.2007.12.031 Pollintine, P., Cooper, I., Anderson, H. L.
, Green, L. R., Cooper, C., Lanham, S. A., ... Dolan, P. (2008).
The influence of early nutritional compromise on bone structure and strength.
Journal of Bone and Joint Surgery,
90-B(Supp II), p.392.
Bolland, B. J. R. F., New, A. M. R., Madabhushi, G.
, Oreffo, R. O. C., & Dunlop, D. G. (2008).
The role of vibration and drainage in femoral impaction bone grafting.
Journal of Arthroplasty,
23(8), 1-8. DOI:
10.1016/j.arth.2007.10.011Xu, Y., Mirmalek-Sani, S-H., Lin, F., Zhang, J.
, & Oreffo, R. O. C. (2007).
Adipocyte differentiation induced using nonspecific siRNA controls in cultured human mesenchymal stem cells.
RNA,
13(8), 1179-1183. DOI:
10.1261/rna.527207Bolland, B. J. R. F., Tilley, S.
, New, A. M. R., Dunlop, D. G., & Oreffo, R. O. C. (2007).
Adult mesenchymal stem cells and impaction grafting – a new clinical paradigm shift.
Expert Review of Medical Devices,
4(3), 393-404. DOI:
10.1586/17434440.4.3.393Bolland, B. J., Tilley, S., New, A. M.
, Dunlop, D. G., & Oreffo, R. O. (2007).
Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift.
Expert Review of Medical Devices,
4(3), 393-404.
Pound, J. C., Green, D. W., Roach, H. I., Mann, S.
, & Oreffo, R. O. C. (2007).
An ex vivo model for chondrogenesis and osteogenesis.
Biomaterials,
28(18), 2839-2849. DOI:
10.1016/j.biomaterials.2007.02.029Tare, R. S., Townsend, P. A.
, Packham, G. K., Inglis, S., & Oreffo, R. O. C. (2007).
BCL-2-associated athanogene-1: A transcriptional regulator mediating chondrocyte survival and differentiation during endochondral ossification.
Journal of Bone and Mineral Research,
22(7), p.1129.
Gonzalez-McQuire, R., Green, D. W., Partridge, K. A.
, Oreffo, R. O. C., Mann, S., & Davis, S. A. (2007).
Coating of human mesenchymal cells in 3D culture with bioinorganic nanoparticles promotes osteoblastic differentiation and gene transfection.
Advanced Materials,
19(17), 2236-2240. DOI:
10.1002/adma.200602770Heyde, M., Partridge, K. A., Howdle, S. M.
, Oreffo, R. O. C., Garnett, M. C., & Shakesheff, K. M. (2007).
Development of a slow non-viral DNA release system from PDLLA scaffolds fabricated using a supercritical CO2 technique.
Biotechnology and Bioengineering,
98(3), 679-693. DOI:
10.1002/bit.21446Hollingworth, T.
, Lanham, S. A., Roberts, C.
, Hanson, M., Elahi, M.
, Cagampang, F., ... Oreffo, R. O. C. (2007).
Effects of maternal-dietary cholesterol on offspring bone development.
Early Human Development,
83(Supplement 1), S155-S156. DOI:
10.1016/S0378-3782(07)70428-0Morgan, S. M., Tilley, S., Perera, S., Ellis, M. J.
, Kanczler, J., Chaudhuri, J. B.
, & Oreffo, R. O. (2007).
Expansion of human bone marrow stromal cells on poly-(DL-lactide-co-glycolide) (PDL LGA) hollow fibres designed for use in skeletal tissue engineering.
Biomaterials,
28(35), 5332-5343. DOI:
10.1016/j.biomaterials.2007.08.029Heyde, M., Partridge, K. A.
, Oreffo, R. O. C., Howdle, S. M., Shakesheff, K. M., & Garnett, M. C. (2007).
Gene therapy used for tissue engineering applications.
Journal of Pharmacy and Pharmacology,
59(3), 329-350.
Berry, C. C., Curtis, A. S. G.
, Oreffo, R. O. C., Agheli, H. D. S., & Sutherland, D. S. (2007).
Human fibroblast and human bone marrow cell response to lithographically nanopatterned adhesive domains on protein rejecting substrates.
IEEE Transactions on Nanobioscience,
6(3), 201-209. DOI:
10.1109/TNB.2007.903457Lanham, S. A., Roberts, C., Perry, M. J.
, Oreffo, R. O. C., & Cooper, C. (2007).
Intrauterine programming of bone-deleterious effects of a low protein diet in late adulthood on the osteogenic environment.
Journal of Bone and Mineral Research,
22(7).
Hart, A., Gadegaard, N., Wilkinson, C. D.
, Oreffo, R. O., & Dalby, M. J. (2007).
Osteoprogenitor response to low-adhesion nanotopographies originally fabricated by electron beam lithography.
Journal of Materials Science: Materials in Medicine,
18(6), 1211-1218. DOI:
10.1007/s10856-007-0157-7Bolland, B. J.
, Kanczler, J., Ginty, P., Shakesheff, K. M.
, Dunlop, D. G., & Oreffo, R. O. C. (2007).
Poly lactic acid scaffold augmented with human bone marrow stromal cells as a bone graft extender in impaction brone grafting.
Tissue Engineering,
13(7), p.1742.
Tare, R., Khan, F., Tourniaire, G., Morgan, S. M., Bradley, M.
, & Oreffo, R. O. C. (2007).
Selection of human mesenchymal osteoprogenitors from bone marrow stromal cell populations using polymer microarrays.
Tissue Engineering,
13(7), p.1754.
Kanczler, J. M., Barry, J., Ginty, P., Howdle, S. M., Shakesheff, K. M.
, & Oreffo, R. O. (2007).
Supercritical carbon dioxide generated vascular endothelial growth factor encapsulated poly(DL-lactic acid) scaffolds induce angiogenesis in vitro.
Biochemical and Biophysical Research Communications,
352(1), 135-141.
Dalby, M. J., Gadegaard, N.
, Tare, R., Andar, A., Riehle, M. O., Herzyk, P.
, ... Oreffo, R. O. C. (2007).
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder.
Nature Materials,
6, 7pp. DOI:
10.1038/nmat2013Bolland, B. J. R. F.
, New, A. M. R., Madabhushi, S. P. G.
, Oreffo, R. O. C., & Dunlop, D. G. (2007).
Vibration-assisted bone-graft compaction in impaction bone grafting of the femur.
Journal of Bone and Joint Surgery,
89-B(5), 686-692. DOI:
10.1302/0301-620X.89B5.18695MacArthur, B. D., Tare, R. S., Please, C. P., Prescott, P., & Oreffo, R. C. (2006).
A non-invasive method for in situ quantification of subpopulation behaviour in mixed cell culture.
Journal of the Royal Society Interface,
3(6), 63-69. DOI:
10.1098/rsif.2005.0080 Bolland, B. J. R. F., Partridge, K.
, Tilley, S., New, A. M. R.
, Dunlop, D. G., & Oreffo, R. O. C. (2006).
Biological and mechanical enhancement of impacted allograft seeded with human bone marrow stromal cells: potential clinical role in impaction bone grafting.
Regenerative Medicine,
1(4), 457-467. DOI:
10.2217/17460751.1.4.457Roach, H. I.
, Inglis, S., Partridge, K.
, Oreffo, R., & Clarke, N. M. P. (2006).
Can epigenetic changes in DNA metylations explain the altered gene expression in osteoarthritis? Journal of Bone and Joint Surgery,
88-B(Supplement III), 385-386.
Partridge, K., Heyde, M., Garnett, M., Howdle, S. M., Shakesheff, K.
, & Oreffo, R. (2006).
Cloning and expression of human BMP-2 potential for use in skeletal tissue engineering.
Journal of Bone and Mineral Research,
21(7).
Yamada, N., Cheung, K. S. C., Tilley, S.
, Clarke, N. M. P., Oreffo, R. O. C., Kokobun, S., ... Roach, H. I. (2006).
Does epigenetics play a role in the pathology of osteoarthritis? Journal of Bone and Joint Surgery,
88-B(Supplement III), p.403.
Yang, X. B., Webb, D., Blaker, J., Boccaccini, A. R., Maquet, V.
, Cooper, C., & Oreffo, R. O. C. (2006).
Evaluation of human bone marrow stromal cell growth on biodegradable polymer/Bioglass composites.
Biochemical and Biophysical Research Communications,
342(4), 1098-1107. DOI:
10.1016/j.bbrc.2006.02.021Ginty, P. J., Howard, D., Rose, F. R. A. J., Whitaker, M. J., Barry, J. J. A., Tighe, P., ... Shakesheff, K. M. (2006).
Mammalian cell survival and processing in supercritical CO2.
Proceedings of the National Academy of Sciences of the United States of America,
103(19), 7426-7431. DOI:
10.1073/pnas.0508895103Kanczler, J., Barry, J., Ginty, P., Sebald, W., Howdle, S., Shakesheff, K.
, & Oreffo, R. O. (2006).
New scaffolds for skeletal regeneration stimulating angiogenesis and osteogenesis.
Journal of Bone and Mineral Research,
21(7), p.1153.
Dalby, M. J., McCloy, D., Robertson, M., Agheli, H. D., Affrossman, S.
, & Oreffo, R. O. (2006).
Osteoprogenitor response to semi-ordered and random nanotopographies.
Biomaterials,
27(15), 2980-2987. DOI:
10.1016/j.biomaterials.2006.01.010Pound, J. C.
, Green, D. W., Chaudhuri, J. B., Mann, S., Roach, H. I.
, & Oreffo, R. O. C. (2006).
Strategies to promote chondrogenesis and osteogenesis from human bone marrow cells and articular chondrocytes encapsulated in polysaccharide templates.
Tissue Engineering,
12(10), 2789-2799. DOI:
10.1089/ten.2006.12.2789Tilley, S., Bolland, B. J. R. F., Partridge, K.
, New, A. M. R., Latham, J. M.
, Dunlop, D. G., & Oreffo, R. O. C. (2006).
Taking tissue engineering principles into theatre: augmentation of impacted allograft with human bone marrow stromal cells.
Regenerative Medicine,
1(5), 685-692. DOI:
10.2217/17460751.1.5.685 Tilley, S., Bolland, B. J. R. F., Partridge, K., New, A. M. R., Latham, J. M.
, & Dunlop, D. G. (2006).
Taking tissue-engineering principles into theater: augmentation of impacted allograft with human bone marrow stromal cells.
Regenerative Medicine,
1(5), 685-692. DOI:
10.2217/17460751.1.5.685 Yang, X. B.
, Green, D. W., Roach, H. I., Anderson, H. C., Howdle, S. M., Shakesheff, K. M.
, & Oreffo, R. O. C. (2006).
The effect of an admix of bone morphogenetic proteins on human osteoprogenitor activity in vitro and in vivo.
Tissue Engineering,
12(4), 1002-1003. DOI:
10.1089/ten.2006.12.983Silva, M. M., Cyster, L. A., Barry, J. J., Yang, X. B.
, Oreffo, R. O., Grant, D. M., ... Rose, F. R. (2006).
The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds.
Biomaterials,
27(35), 5909-5917. DOI:
10.1016/j.biomaterials.2006.08.010Berry, C. C., Dalby, M. J.
, Oreffo, R. O., McCloy, D., & Affrosman, S. (2006).
The interaction of human bone marrow cells with nanotopographical features in three dimensional constructs.
Journal of Biomedical Materials Research Part A,
79(2), 431-439.
Xu, Y., Mirmalek-Sani, S-H., Yang, X., Zhang, J.
, & Oreffo, R. O. C. (2006).
The use of small interfering RNAs to inhibit adipocyte differentiation in human preadipocytes and fetal-femur-derived mesenchymal cells.
Experimental Cell Research,
312(10), 1856-1864. DOI:
10.1016/j.yexcr.2006.02.016Roach, H. I., Yamada, N., Cheung, K. S. C.
, Tilley, S., Clarke, N. M. P., Oreffo, R. O. C., ... Bronner, F. (2005).
Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions.
Arthritis and Rheumatism,
52(10), 3110-3124. DOI:
10.1002/art.21300Green, D. W., Leveque, I., Walsh, D., Howard, D., Yang, X., Partridge, K.
, ... Oreffo, R. O. C. (2005).
Biomineralized polysaccharide capsules for encapsulation, organization, and delivery of human cell types and growth factors.
Advanced Functional Materials,
15(6), 917-923. DOI:
10.1002/adfm.200400322Mirmalek-Sani, S-H.
, Tare, R. S., Morgan, S. M., Roach, H. I.
, Wilson, D. I., Hanley, N. A.
, & Oreffo, R. O. C. (2005).
Characterization and multipotentiality of human fetal femur-derived cells: implications for skeletal tissue regeneration.
Stem Cells,
24(4), 1042-1053. DOI:
10.1634/stemcells.2005-0368Mirmalek-Sani, S. H., Roach, H. I., Hanley, N. A.
, Wilson, D. I., & Oreffo, R. O. C. (2005).
Characterization and plasticity of human fetal-derived cartilage cells: implications for skeletal tissue regeneration.
International Journal of Experimental Pathology,
86(3), A18-A19. DOI:
10.1111/j.0959-9673.2005.00426.xGonzalez-McQuire, R., Green, D., Walsh, D., Hall, S., Chane-Ching, J-Y.
, Oreffo, R. O. C., & Mann, S. (2005).
Fabrication of hydroxyapatite sponges by dextran sulphate/amino acid templating.
Biomaterials,
26(33), 6652-6656. DOI:
10.1016/j.biomaterials.2005.04.037Oreffo, R. O. C., Cooper, C., Mason, C., & Clements, M. (2005).
Mesenchymal stem cells: lineage, plasticity and skeletal therapeutic potential.
Stem Cell Reviews and Reports,
1(2), 169-178. DOI:
10.1385/SCR:1:2:169 Dalby, M. J., McCloy, D., Robertson, M., Wilkinson, C. D. W.
, & Oreffo, R. O. C. (2005).
Osteoprogenitor response to defined topographies with nanoscale depths.
Biomaterials,
27(8), 1306-1315. DOI:
10.1016/j.biomaterials.2005.08.028Tare, R. S., Howard, D., Pound, J. C., Roach, H. I.
, & Oreffo, R. O. C. (2005).
Tissue engineering strategies for cartilage generation - micromass and three dimensional cultures using human chondrocytes and a continuous cell line.
Biochemical and Biophysical Research Communications,
333(2), 609-621. DOI:
10.1016/j.bbrc.2005.05.117 Yang, X. B., Whitaker, M. J., Sebald, W.
, Clarke, N., Howdle, S. M., Shakesheff, K. M.
, & Oreffo, R. O. C. (2004).
Human osteoprogenitor bone formation using encapsulated bone morphogenetic protein 2 in porous polymer scaffolds.
Tissue Engineering,
10(7), 1037-1045. DOI:
10.1089/ten.2004.10.1037Green, D., Walsh, D., Yang, X. B., Mann, S.
, & Oreffo, R. O. C. (2004).
Stimulation of human bone marrow stromal cells using growth factor encapsulated calcium carbonate porous microspheres.
Journal of Materials Chemistry,
14(14), 2206-2212. DOI:
10.1039/b400486hHall, S. R., Walsh, D., Green, D.
, Oreffo, R. O. C., & Mann, S. (2003).
A novel route to highly porous bioactive silica gels.
Journal of Materials Chemistry,
13(2), 186-190. DOI:
10.1039/b209300fYang, X.
, Tare, R. S., Partridge, K. A., Roach, H.
, Clarke, N. M. P., Howdle, S. M.
, ... Oreffo, R. O. C. (2003).
Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering.
Journal of Bone and Mineral Research,
18(1), 47-57. DOI:
10.1359/jbmr.2003.18.1.47Oreffo, R. O. C., Lashbrooke, B., Roach, H. I.
, Clarke, N. M., & Cooper, C. (2003).
Maternal protein deficiency affects mesenchymal stem cell activity in the developing offspring.
Bone,
33(1), 100-107. DOI:
10.1016/S8756-3282(03)00166-2 Green, D. W., Howard, D., Yang, X., Kelly, M.
, & Oreffo, R. O. C. (2003).
Natural marine sponge fiber skeleton: a biomimetic scaffold for human osteoprogenitor cell attachment, growth, and differentiation.
Tissue Engineering,
9(6), 1159-1166.
Yang, X. B., Green, D. W., Roach, H. I.
, Clarke, N. M. P., Anderson, H. C., Howdle, S. M.
, ... Oreffo, R. O. C. (2003).
Novel osteoinductive biomimetic scaffolds stimulate human osteoprogenitor activity: implications for skeletal repair.
Connective Tissue Research,
44(Supplement 1), 312-317. DOI:
10.1080/713713599Salem, A. K., Rose, F. R. A. J.
, Oreffo, R. O. C., Yang, X. B., Davies, M. C., Mitchell, J. R., ... Shakesheff, K. M. (2003).
Porous polymer and cell composites that self-assemble in situ.
Advanced Materials,
15(3), 210-213. DOI:
10.1002/adma.200390047Roach, H. I., Mehta, G.
, Oreffo, R. O. C., Clarke, N. M. P., & Cooper, C. (2003).
Temporal analysis of rat growth plates: cessation of growth with age despite presence of a physis.
Journal of Histochemistry and Cytochemistry,
51(3), 373-383.
Partridge, K., Yang, X.
, Clarke, N. M. P., Okubo, Y., Bessho, K., Sebald, W.
, ... Oreffo, R. O. C. (2002).
Adenoviral BMP-2 gene transfer in mesenchymal stem cells: in vitro and in vivo bone formation on biodegradable polymer scaffolds.
Biochemical and Biophysical Research Communications,
292(1), 144-152. DOI:
10.1006/bbrc.2002.6623Tare, R. S., Oreffo, R. O. C., Sato, K., Rauvala, H.
, Clarke, N. M. P., & Roach, H. I. (2002).
Effects of targeted overexpression of pleiotrophin on postnatal bone development.
Biochemical and Biophysical Research Communications,
298(3), 324-332. DOI:
10.1016/S0006-291X(02)02456-7 Howard, D., Partridge, K., Yang, X.
, Clarke, N. M. P., Okubo, Y., Bessho, K.
, ... Oreffo, R. O. C. (2002).
Immunoselection and adenoviral genetic modulation of human osteoprogenitors: in vivo bone formation on PLA scaffold.
Biochemical and Biophysical Research Communications,
299(2), 208-215. DOI:
10.1016/S0006-291X(02)02561-5Mehta, G., Roach, H. I., Langley-Evans, S., Taylor, P.
, Reading, I., Oreffo, R. O. C., ... Cooper, C. (2002).
Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats.
Calcified Tissue International,
71(6), 493-498. DOI:
10.1007/s00223-001-2104-9Yang, X. B., Roach, H. I.
, Clarke, N. M. P., Howdle, S. M., Quirk, R., Shakesheff, K. M.
, & Oreffo, R. O. C. (2001).
Human osteoprogenitor growth and differentiation on synthetic biodegradable structures after surface modification.
Bone,
29(6), 523-531. DOI:
10.1016/S8756-3282(01)00617-2Oreffo, R. O., Romberg, S., Virdi, A. S., Joyner, C. J., Berven, S., & Triffitt, J. T. (1999).
Effects of interferon alpha on human osteoprogenitor cell growth and differentiation in vitro.
Journal of Cellular Biochemistry,
74(3), 372-385. DOI:
10.1002/(SICI)1097-4644(19990901)74:3<372::AID-JCB6>3.0.CO;2-H Oreffo, R. O., Kusec, V., Virdi, A. S., Flanagan, A. M., Grano, M., Zambonin-Zallone, A., & Triffitt, J. T. (1999).
Expression of estrogen receptor-alpha in cells of the osteoclastic lineage.
Histochemistry and Cell Biology,
111(2), 125-133. DOI:
10.1007/s004180050342 Zambonin, G., Grano, M., Greco, G.
, Oreffo, R. O. C., & Triffitt, J. T. (1999).
Hydroxyapatite coated with insulin-like growth factor-1 (IGF-1) stimulates human osteoblast activity in vitro.
Acta Orthopaedica Scandinavica,
70(2), 217-220.
Virdi, A. S., Shore, E. M.
, Oreffo, R. O., Li, M., Connor, J. M., Smith, R., ... Triffitt, J. T. (1999).
Phenotypic and molecular heterogeneity in fibrodysplasia ossificans progressiva. Calcified Tissue International,
65(3), 250-255.
Bonewald, L. F.
, Oreffo, R. O., Lee, C. H., Park-Snyder, S., Twardzik, D., & Mundy, G. R. (1997).
Effects of retinol on activation of latent transforming growth factor-? by isolated osteoclasts.
Endocrinology,
138(2), 657-666.
Oreffo, R. O., Marshall, G. J., Kirchen, M., Garcia, C., Gallwitz, W. E., Chavez, J., ... Bonewald, L. F. (1993).
Characterization of a cell line derived from a human giant cell tumor that stimulates osteoclastic bone resorption.
Clinical Orthopaedics and Related Research,
296, 229-241.
Mundy, G. R., Roodman, G. D., Bonewald, L. F.
, Oreffo, R. O., & Boyce, B. F. (1991).
Assays for bone resorption and bone formation.
Methods in Enzymology,
198, 502-510. DOI:
10.1016/0076-6879(91)98049-CBonewald, L. F., Wakefield, L.
, Oreffo, R. O., Escobedo, A., Twardzik, D. R., & Mundy, G. R. (1991).
Latent forms of transforming growth factor-? (TGF?) derived from bone cultures: identification of a naturally occurring 100-kDa complex with similarity to recombinant latent TGF? Molecular endocrinology,
5(6), 741-751.
Oreffo, R. O., Bonewald, L., Kukita, A., Garrett, I. R., Seyedin, S. M., Rosen, D., & Mundy, G. R. (1990).
Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-? on isolated osteoclasts.
Endocrinology,
126(6), 3069-3075.
Garrett, I. R., Boyce, B. F.
, Oreffo, R. O., Bonewald, L., Poser, J., & Mundy, G. R. (1990).
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.
Journal of Clinical Investigation,
85(3), 632-639. DOI:
10.1172/JCI114485Oreffo, R. O., Teti, A., Triffitt, J. T., Francis, M. J., Carano, A., & Zallone, A. Z. (1988).
Effect of vitamin A on bone resorption: evidence for direct stimulation of isolated chicken osteoclasts by retinol and retinoic acid.
Journal of Bone and Mineral Research,
3(2), 203-210. DOI:
10.1002/jbmr.5650030213 Teti, A.
, Oreffo, R. O., zambonin-Zallone, A., Triffitt, J. T., & Francis, M. J. (1986).
Acid phosphatase activity is stimulated in isolated osteoclasts by vitamin A.
Bollettino della Società Italiana di Biologia Sperimentale,
62(10), 1311-1314.
Teti, A.
, Oreffo, R. O., Zambonin Zallone, A., Triffitt, J. T., & Francis, M. J. (1986).
The effect of retinol on osteoclasts is mediated by a specific cytosolic binding protein.
Bollettino della Società Italiana di Biologia Sperimentale,
62(10), 1315-1319.
