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Dr Simon Crabb BSc, MBBS, MRCP, PhD

Associate Professor in Medical Oncology

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Dr Simon Crabb is an Associate Professor in Medical Oncology within Medicine at the University of Southampton and the Associate Clinical Director of the Southampton Clinical Trials Unit.

Dr Crabb graduated in medicine from St George’s Hospital Medical School, London in 1996. He joined the University of Southampton in 2002 as a Cancer Research UK Clinical Research Fellow and was awarded his PhD in 2006 for work involving novel histone deacetylase inhibitors. Following a Clinical Research Fellowship at the BC Cancer Agency in Vancouver, he returned to the Cancer Sciences Unit in Southampton where he now works as an Associate Professor and Honorary Consultant in Medical Oncology. 
Dr Crabb’s research interests are in the development of novel therapeutic strategies for bladder cancer and prostate cancer, epigenetic therapeutic agents and mechanisms of systemic cancer treatment resistance. He is an active clinical and translational researcher who leads and collaborates on a number of early phase clinical trials for genitourinary cancers.


BSc, Biochemistry, University of London, 1993

MBBS, Medicine, University of London, 1996

MRCP, Royal College of Physicians, 2000

PhD, University of Southampton, 2006

Appointments held

Associate Professor in Medical Oncology, University of Southampton Faculty of Medicine

Honorary Consultant in Medical Oncology, University Hospital Southampton NHS Foundation Trust

Research interests

Dr Crabb's research interests are focused on the development of new therapeutic options for genitourinary cancers, early phase clinical trials, epigenetic therapeutic agents and mechanisms of systemic treatment resistance. Some of the current clinical trials in this program include the following:

  • Chief Investigator of the SPIRE trial, which is testing the use of the DNA methyltransferase inhibitor guadecitabine in combination with cisplatin based chemotherapy for bladder cancer 
  • Chief Investigator of the ProCAID trial testing the addition of the AKT inhibitor AZD5363 to chemotherapy in prostate cancer 
  • UK Lead Investigator of the BL-13 trial testing immunotherapy following chemo-radiotherapy for bladder cancer 
  • Chief Investigator for the MANCAN2 trial testing cognitive behavioural therapy for men with hot flushes and night sweats due to prostate cancer hormonal therapy 
  • Co-Chief Investigator for the GUSTO trial testing biomarker selection for neoadjuvant chemotherapy and immunotherapy for bladder cancer 
  • Lead for the rucaparib arm of the ATLANTIS trial testing biomarker selection for the use of PARP inhibition for advanced urothelial cancer 


Cancer Sciences

Affiliate Department(s)

Cancer Sciences Research group

  • Southampton Clinical Trials Unit, Associate Clinical Director from 2018
  • Southampton Experimental Cancer Medicine Centre, Deputy Director
  • Southampton Phase I Cancer Trials Clinic, lead from 2016
  • NCRI Bladder and Renal Group, member 2012 to 2018, and from 2019
  • NCRI Prostate Group, member 2012 to 2018, and form 2019
  • Advanced Bladder Cancer Subgroup of the NCRI Bladder Cancer Clinical Studies Group, member from 2010, Chair from 2014 to 2018
  • Bladder Cancer Genomics England Clinical Interpretation Partnership for the 100,000 Genomes Project, Chair
  • Cancer Sub-Specialty Lead, Urology Clinical Research, Wessex NIHR Clinical Research Network, from 2015
  • Cancer Research UK Experimental Medicine Expert Review Panel, member from 2015   

Prior roles  

  • British Association for Cancer Research Executive Committee, member 2012 to 2015 
  • ECMC Combination Alliance Extended Joint Steering Committee, member from 2015 to 2019
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Book Chapter




BM5 and BM4. Provides clinical teaching to all years, based at Southampton General Hospital

Dr Simon Crabb
Somers Cancer Research Building Southampton General Hospital
Mailpoint 824 Tremona Road Southampton SO16 6YD

Room Number: SGH/CSB/MP824

Telephone:(023) 8120 3483
Facsimile:(023) 8120 5152

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