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Dr Tristan Clark BM, MRCP, DTM&H, MD

Associate Professor and Honorary Consultant in Infectious Diseases

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Dr Tristan Clark is an Associate Professor and Honorary Consultant in Infectious Diseases at the University of Southampton and University Hospitals Southampton NHS trust. His research is focussed on clinical trials of vaccines, antivirals and rapid diagnostic tests for respiratory viruses and other infections. He has published articles in the New England Journal of Medicine and Lancet series journals. He currently holds an NIHR post-doctoral fellowship to evaluate the clinical impact and cost effectiveness of molecular point-of-care tests for influenza and other respiratory viruses. 

My research aims to improve the speed, accuracy and impact of diagnostic testing for infections.


Appointments held

Research interests

Point-of-care tests, impact assessment, diagnostic accuracy, vaccines, antivirals, influenza, Covid-19

Pandemic Influenza vaccines

Dr Clark was part of a team that evaluated the safety and immunogenicity of pandemic influenza vaccines against swine origin H1N1, the results of which have been published in high impact international journals. He has also evaluated a prime-boost vaccination strategy against avian H5 influenza. Potential ongoing projects include vaccine evaluation against the newly emerging H7N9 influenza virus in China, which has pandemic potential.

Respiratory viruses in hospitalised adults

Dr Clark is currently running clinical trials at UHS examining the use of point-of-care diagnostics for respiratory virus infection in hospitalised adults.
Dr Clark has examined the role of respiratory viruses in adults hospitalised with acute respiratory illness and found a high burden of viruses, particularly Human Rhinovirus. Potential ongoing projects include prospective studies in hospitalised adults using universal screening.

Rapid diagnostic tests and biomarkers

Dr Clark has explored the role of biomarkers such as CRP and Procalcitonin and rapid diagnostic tests for influenza and pneumococcus in improving the clinical management of hospitalised adults with acute respiratory disease. Potential ongoing projects include evaluating the use of novel rapid molecular diagnostic tests for influenza.

Other research projects
  • COV-19POC Trial
  • SARIPOC Trial
  • FLUPOC Trial
  • RESPOC Trial
  • NORCAP Trial

Research group

Clinical and Experimental Sciences

Research project(s)

CERAbTc-19 (Clinical Evaluation of Rapid Antibody Test for Covid-19)

  • Regional Speciality Advisor, Royal College of Physicians
  • Deputy Training Programme Director and Speciality Training
  • Committee member for Infectious Disease Training, Wessex
  • Scientific Affairs Committee member, British Infectious Association
  • NIHR Clinical Research Network Speciality lead for Infection, Wessex
  • Associate Editor, Journal of Infection
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  • Batchelor of medicine BM5, theme lead for infection and microbiology
  • Module lead for BM5 Year 3 ICE
  • Module lead for BM5 Year 3 Student Selected Unit (Masterclasses in Infectious Diseases)
Dr Tristan Clark
Faculty of Medicine, Room AB215, Mailpoint 801, South Academic Block, University Hospital Southampton, Tremona Road, Southampton, SO16 6YD

Room Number : SGH/LF101

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