The University of Southampton
Medicine

Research project: The Hampshire Acute Kidney Injury Study

Currently Active: 
Yes

Acute kidney injury (AKI, a sudden reduction in kidney function) is a common, often unrecognised and potentially preventable cause of poor clinical outcomes, particularly in people admitted to hospital. This project is about identifying who is at risk of developing AKI and evaluating the effects of AKI electronic alerts sent to clinicians and an AKI clinician education programme.

Project Overview

Related research groups

Primary Care & Population Sciences Academic Units

Acute kidney injury (AKI, a rapid reduction in kidney function) is common and under-recognised in the NHS and associated with poor clinical outcomes and high healthcare costs. A significant proportion of AKI is potentially preventable and two thirds of AKI seen in hospital is estimated to have arisen in the community. This study aims to use data in the Hampshire Health Record (HHR, an anonymized shared clinical database) to identify the incident rate, risk factors and outcomes of AKI, to develop and validate a predictive score for community-acquired AKI and to evaluate the effect of the introduction of hospital and primary care AKI e-alerts. It will also evaluate the effectiveness of an AKI-education intervention for hospital clinicians and GPs, and estimate the costs of AKI in Wessex and the cost-effectiveness of the education interventions. To achieve these aims, it will use a cohort design incorporating all people in HHR GP practices (estimated about 600,000 people with complete data) followed for up to five years and assess those admitted to hospital and those not admitted for AKI using a standardized national algorithm based on changes in serum creatinine values. It will link with the Wessex Cardiovascular Disease Network’s AKI initiative in order to inform and evaluate the education interventions. Outcomes from the study will be disseminated locally and nationally and influence clinical practice in Wessex to improve the prevention, identification and management of AKI.

Lead Investigator: Dr Simon Fraser

Duration: 2015-2018

Funder: NIHR CLAHRC Wessex

Contact: s.fraser@soton.ac.uk

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