Skip to main navigationSkip to main content
The University of Southampton
We're launching a new website soon and would love your feedback. See the new design

Research project: ANTidepressants to prevent reLapse in dEpRession (ANTLER)

Currently Active: 

UK surveys have shown that between 5% and 8% of the general public are taking antidepressants, and up to half of these have been taking them long-term. There is little evidence for the effectiveness of long term maintenance treatment in preventing relapse for depression in primary care.  ANTLER is a randomised trial designed to estimate the clinical effectiveness of patients continuing long term maintenance antidepressants.

ANTLER is an individually randomised double blind placebo controlled trial that will recruit patients who have taken antidepressants for at least 9 months but are now well enough to consider stopping the treatment.

Eligible participants will be taking either citalopram 20mg, sertraline 100mg, fluoxetine 20mg or mirtazapine 30mg per day. In the Trial, Patients will either continue to use the active drugs for 12 months or be allocated to placebo group, where the antidepressant medication will be tapered over 2 months to reduce withdrawal effects.

The results will provide clearer, evidence based guidance as to the effectiveness of long term maintenance antidepressant treatment, allowing doctors to give better advice to people who have taken antidepressants for some time.

The research is being organised by University College London in collaboration with the University of Bristol, Southampton and the Hull York Medical School. It is funded by The NHS National Institute for Health Research (NIHR) HTA. The study is also supported by the NIHR Clinical Research Networks.


Duration: Start date November 2017   End date 31 November 2020

Funder: National Institute for Health Research (NIHR) HTA

Contact:  Tel: 023 8059 1863

Website: ANTLER


Related research groups

Primary Care, Population Sciences and Medical Education

Key Publications

Share this research project Share this on Facebook Share this on Twitter Share this on Weibo
Privacy Settings