The University of Southampton
Medicine

Research project: ATTOM Access to Transplantation and Transplant Outcome Measures

Currently Active: 
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The team in Southampton led by Professor P Roderick and Dr Gerry Leydon, in collaboration with Dr Rommel Ravanan from Southmead Hospital, Bristol will lead on research on access to the kidney transplant waiting-list. This will include qualitative research with patients and staff, a national survey of renal units, a delphi consensus study and a quantitative analysis of patient and unit level factors associated with listing.

Project Overview

 

Transplantation has the potential to extend and improve the quality of life for patients with endstage kidney failure. There is variability in access to transplantation between UK kidney units,, due to factors that are poorly understood. Given the shortage of available organs it is essential that patient selection for transplantation and the national organ allocation policies are fair, based on best clinical evidence and designed to take account of a range of equity, quality of Life [QoL] and utility factors.

 

This ATTOM study is an NIHR funded Programme grant which aims to understand the reasons behind inter-centre variability as well as develop tools to maximise transplant outcomes in the UK. To achieve this we will collect detailed information starting dialysis, receiving a transplant and a similar number of matched patients active on the transplant list, from all units in the UK over a one year period. Information on QoL will be obtained by administering questionnaires to the patients. Dedicated, specialist renal research nurses in each unit will collect the required information by reading case notes, talking to the doctors & nurses in each unit and patients directly. Only anonymised data will be analysed and reported, therefore there is no potential for breach of patient confidentiality. Patients will be followed for 3 years after recruitment.

 

The collected data will help us understand which patient factors influence whether patients are put on the waiting list and which patients gain most from transplantation. Parallel assessments of how units perform will help inform why some centres do better. Correlation with quality of life data and cost effectiveness will allow us to develop alternative organ allocation schemes. The findings will benefit patients with kidney failure by providing them with individualised predictions on likely outcomes, to allow informed decision making, along with uniformly applicable and evidence-based assessment criteria for entry onto transplant waiting lists. The development of new organ allocation schemes will explore the possibility of maximising clinical outcomes as well as quality of life after transplantation whilst ensuring best use of all available organs.

 

Local Investigator: Professor Paul Roderick

Duration: 2011-2016

Funder: Cambridge University Hospitals Trust

CONTACT for the study: m.calestani@soton.ac.uk

 

Related research groups

Primary Care & Population Sciences Academic Units

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