The University of Southampton
Medicine

Research project: BARACK-D Benefits of aldosterone receptor antagonism in chronic kidney disease

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Chronic kidney disease (CKD) affects around 10% of the UK population. It is linked with increasing age and is more common in people with other illnesses such as hypertension, diabetes mellitus, obesity and primary renal disorders.

Project Overview

Chronic kidney disease (CKD) affects around 10% of the UK population. It is linked with increasing age and is more common in people with other illnesses such as hypertension, diabetes mellitus, obesity and primary renal disorders. Of interest to this study, CKD is a major contributor to cardiovascular disease, with CKD patients showing a greater incidence of heart failure and sudden cardiac death. Conventional treatments for cardiovascular disease have been disappointing in CKD patients. There are also limited treatment options to prevent further decline in kidney function.

Established drugs called aldosterone receptor antagonists reduce deaths in patients with heart disease. There is also evidence that these drugs may reduce kidney damage attributed to circulating aldosterone. In order to answer the research question, we will conduct a prospective randomised open blinded endpoint (PROBE) trial using a low dose of the aldosterone receptor antagonist, spironolactone.

Patients with more advanced (stage 3B) CKD will be randomised into two groups. One group will be given current standard care. The other group will receive this same care along with a low dose of spironolactone. Patients will be followed up for 156 weeks and again at 5 years.

We aim to establish whether the group receiving spironolactone need less frequent hospital admissions for cardiovascular disease and experience fewer deaths, and whether there are other beneficial cardiovascular and kidney function blood tests taken. An important aspect of these tests will include the safety of spironolactone.

Local Investigator: Prof Paul Little

Duration: 2013-2017

Funder: NIHR Health Technology Assessment

Contact for the study: barackd@soton.ac.uk

Related research groups

Primary Care & Population Sciences Academic Units

Staff

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