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The University of Southampton
Micro and Nano Therapies

Bone Infections

Our inter-disciplinary research in ultrasound mediated therapies for the treatment of biofilms in chronic wounds, seeks to optimise the use of bioactive adjuvants with targeted delivery. Our work to date has successfully demonstrated that micro-scale ultrasound responsive agents, increase the efficacy of ordinarily sub-inhibitory concentrations of antibiotic in the treatment of Pseudomonas aeruginosa biofilms. Our ongoing research in this area explores the use of ultrasound responsive microbubbles and nanodroplets; for the dispersal of biofilms with bioactive conjugates. Moreover, we are exploring the use of surface charge as a means of enhancing interaction between the ultrasound responsive agents and bioiflms. One of the most important aspects of this work is achieving a viable clinical translation; by bringing together biomedical engineers, medical microbiologists and clinicians, we aim to significantly improve treatment outcomes, for patients afflicted with chronic wounds such as diabetic foot ulcers.

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