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The University of Southampton
µ-VIS: Multidisciplinary, Multiscale, Microtomographic Volume Imaging

µ-VIS X-ray Imaging Centre

Short clips and photorealistic 3D rendering movies

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Scatter-free X-ray tomography: introducing CLARITy

CLARITy imaging mode is a single slice -based scatter-free imaging modality that allows stunning image sharpness and contrast of dense specimens

Scanner: custom 450 kVp/225 kVp Hutch; Imaging mode: CLARITy (450kV source + CLDA detector); Sample: additive manufactured curved stainless steal pipe with flanges; Specimen size: 50 mm diametre

Real-time X-Ray videography of a working clock

Sample: wall clock; Sample size: 270 mm (diameter); Scanner: custom 450 kVp/225 kVp hutch; Imaging mode: Flat panel & 225 kV source; Sample owner: μ-VIS

Dissolution behaviour of a 3D printed dosage form captured with time-resolved CT imaging

Time-resolved volume rendering of a 3D printed showing the volumetric changes of a printed dosage form during consequent exposure in media that simulated exposure to gastrointestinal environment.

Scanner used: Modified 225 kVp Nikon/Xtek HMX

From Gioumouxouzis, C. I., Katsamenis, O. L., Bouropoulos, N., & Fatouros, D. G. (2017). 3D printed oral solid dosage forms containing hydrochlorothiazide for controlled drug delivery. Journal of Drug Delivery Science and Technology, 40, 164-171

Cavitation damage on metallic impellor blades

Volume rendering showing cavitation damage on metallic impellor blades

Sample diameter: ~300 mm; Scanner: custom 450 kVp/225 kVp hutch; Imaging mode: CLARITy (scatter-free imaging); Sample owner: Dr Nicola Symonds (nC2 -

Mouse embryo at 16 days post fertilisation

µCT imaging, segmentation and reconstruction of a mouse embryo at 16 days post fertilisation.

Scanner: Nikon Med-X prototype; Data processing by David Chatelet, Biomedical Imaging Unit, University of Southampton.

Inspection of a marine engine injector

Sample: Marine engine injector; Sample size: diameter: 20 mm; length 130 mm; Scanner: custom 450 kVp/225 kVp hutch; Sample owner: Dr. Nicola Symonds, nC 2 | Read more about this study here

Multiple areas of active fibrosis identified by µCT

Sample: human lung biopsy; Sample size: ~ 10 x 10 x 5 mm (length); Scanner: custom 450 kVp/225 kVp hutch; Sample owner: Dr Mark Jones | Read more about this project here

The Weymouth Bay Pliosaur

Sample: fossilised bone; Sample size: 2.4m (length); Scanner: custom 450 kVp/225 kVp hutch; Sample owner: Dorset County Museum | Read more on BBC and Dorset County Museum websites

Treble recorder made by Peter Bressan

Sample: Bressan Alto Recorder; Sample diameter: length: 400 mm;  diameter: 20 mm; Sample composition: wood; Scanner: Custom 225 kVp; Nikon/Metris HMX ST; Sample owner: Andrew Lamb (Oxford university Bate Collection) | Read more about this project here

Synchrotron Radiation µ-CT imaging of the planktonic foraminifera Orbulina universa

Sample: planktonic foraminifera (Orbulina universa); Sample diameter: 500 μm; Sample composition: CaCO 3 ; Facility: TOMCAT beamline at the SLS at the Paul Scherrer Institute; Sample owner: Dr Thomas H. G. Ezard (University of Southampton)

High resolution X-Ray CT imagining of a "Culicoides sonorensis" (a.k.a. biting midge)

Sample: Culicoides sonorensis; Staining: Phosphotungstic acid (PTA); Sample size: aprox.[1.0 x 1.0 x 0.5] mm; Scanner: ZEISS Xradia 510 Versa 3D X-ray microscope; Sample owner: Dr Pippa Hawes / Dr. Anthony Wilson (The Pirbright Institute; )

Stereoscopic rendering of a Bumblebee

Sample: Bumblebee; Resolution: 11.8 μm; Sample size: aprox. 20mm (length); Staining: Non stained; Scanner: Custom 225 kVp Nikon/Metris HMX ST; Sample owner: Dr. Richard P. Boardman (μ-VIS)

X-CT of a railway ballast for particle analysis

Sample: Railway ballast (core); Voxel size: ~ 300 μm; Sample size: aprox. 300 mm (length) x 400 mm (diameter); Scanner: Custom 450/225 kVp Hutch; Sample owner: Dr. Sharif Ahmed

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