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The University of Southampton

Does an Indian spice hold the key for treating Alzheimer’s disease?

Published: 18 December 2008
Dr Amrit Mudher

Researchers at the University of Southampton are investigating whether an Indian spice could hold the key to treating Alzheimer’s disease.

The study, funded by the Alzheimer’s Society, will investigate whether curcumin, found in the popular Indian spice turmeric, and a number of other drugs, could benefit people with Alzheimer’s.

The researchers will examine whether the drugs could counteract some of the brain changes that are characteristic of the disease. The study is one of eight new Alzheimer’s Society research projects.

Dr Amrit Mudher, lead researcher from the University of Southampton, says: “Dementia is a condition that is drastically underfunded and there are so many avenues of Alzheimer’s research being left unexplored. There is also no commercial gain in exploring existing drugs developed for other conditions, which is why it is so important that Alzheimer’s Society, as a charity, is able to fund this project.

“Indian communities that regularly eat curcumin have a surprisingly low incidence of Alzheimer’s, but we do not know why. Part of our research will investigate how curcumin may help protect the brain and prevent the disease.”

In healthy people, proteins in the brain’s nerve cells help them to communicate with each other. In Alzheimer sufferers these tau proteins become abnormal and disrupt the cells’ ability to communicate with each other and the nerve cells eventually die.

Does an Indian spice hold the key for treating Alzheimer’s disease?
Dr Amrit Mudher
Does an Indian spice hold the key for treating Alzheimer’s disease?
Nerve expressing abnormal tau protein

The Alzheimer’s Society previously funded research using genetically modified fruit flies with nerve cells containing abnormal proteins similar to those found in people with Alzheimer’s. Dr Mudher’s team will now use this model to see whether a number of potential drugs counteract the harmful effects of abnormal tau and warrant further investigation.

Dr Susanne Sorensen, Head of Research at the Alzheimer’s Society, says: “Unless we act now, one million people will develop dementia in the next 10 years. Alzheimer’s is a devastating disease that robs people of their lives. A cheap, accessible and safe treatment could transform the quality of life of thousands of people with the disease. With the right investment, dementia can be defeated.”

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