Enhancing ASO action and mRNA regulation in cardiometabolic disease |
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Pharmacy Degree
Lille University, France 2013-2019
Master's Degree
Medicinal Chemistry, Lille University France 2016 & 2019
Host institution | AstraZeneca AB, Discovery Sciences, Gothenburg, Sweden |
Supervisor | Dr. Shalini Andersson |
Co-Supervisors | Prof. Roger Strömberg, Karolinska Institutet (Academic) |
Dr. Anders Dahlèn, AstraZeneca (Industrial) | |
Prof. Edvard Smith, SLL (Clinician) |
Project description
The aim of this ESR PhD project is the evaluation of different alternatives for enhancement of mRNA transcription:
During secondments in partner organizations the students will extend his/her knowledge on the effect of ONs derivatization and modification on RNA transcription or translation.
Secondments
This project is carried out in strong collaboration with the following groups:
Host laboratory
We have state-of-the-art purpose-built laboratories with facilities to develop small molecules and nucleotide therapeutics by means of molecular and chemical biology approaches. This includes a wide range of facilities from target identification, compound design and selection; compound synthesis, purification and analysis; compound library generation; high-throughput assays for identifying active compounds; cell and animal model-based preclinical studies; bioinformatics and biomarker discovery; drug delivery as well as clinical trials of drug compounds ( small molecules and oligonucleotides). Expertise in commercialisation (invention-to-market process) and IP protection.