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The University of Southampton
OLIGOMED - Oligonucleotides for medical applications

ESR Project. 3, CNRS Marseille (FR)

Functional dendrimer nanosystems for oligonucleotides delivery

Host institution
Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Centre National de la Recherche Scientifique (CNRS), Aix-Marseille University, Marseille, France

Supervisor
Dr. Ling Peng

Co-Supervisors
Dr. Carlo Vascotto, University of Udine, Udine, Italy (Academic)
Dr. Shalini Andersson, AstraZeneca, Sweden (Industrial)

 

Project description

The Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), a joint laboratory of Aix-Marseille University and Centre National de la Recherche Scientifique (CNRS) in France is seeking to recruit an Early Stage Research (ESR) Fellow. The successful candidate will be researching key topics in the use of synthetic oligonucleotides (ONs) for medical applications leading to submission of their PhD thesis after 3 years. A successful thesis will receive the PhD degree in Chemistry from Aix-Marseille University.

The aim of this ESR PhD project will be the development and optimization of dendrimer nanovectors for ON delivery. In this project, various amphiphilic dendrimers for ON delivery will be designed and synthesized. These dendrimers will be then studied for their self-assembling and complexing with ONs to form nanosized complexes in the view to protecting ONs from degradation and promoting cellular uptake of ONs. The resulting biological effects of the delivered ONs will be evaluated in vitro using cell-based experiments and in vivo using animal models of cardiovascular diseases, Huntington disease and cancers in collaboration with AstraZenaca (AZ) and Stockholms Laens Landsting (SLL) through secondments in partner organizations.

Host laboratory

Research activities in the group of Dr. Ling PENG in CINaM-CNRS are focused on developing dendrimer nanotechnology-based delivery systems for nucleic acid therapeutics. The laboratory has all the key facilities and expertise in synthesizing, characterizing and evaluating the dendrimer molecules and nanosystems for ON delivery. The host institute has full access to NMR, MS, HPLC, DLS, TEM, cell culture and all the necessary infrastructure and arrangement in place to host the ESR fellow.

Secondments

This project is carried out in strong collaboration with the following groups, and visits to their laboratories is expected during the project. A willingness to travel and spend time abroad is therefore essential:

Required Skills

Enquire

For additional information on this project, please contact Dr. Ling Peng (ling.peng@univ-amu.fr).

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