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PsychologyOur news, events & seminars

Predicting response to CBT for depression in primary care: how close are we to stratified care?  Seminar

15:00 - 16:00
9 May 2016
Building 44 (Shackleton), Room 2103 L/T C

For more information regarding this seminar, please telephone Sue McNally on 02380 595150 or email .

Event details

Stratified medicine aims to improve clinical and cost-effectiveness by identifying moderators of treatment that indicate differential response to treatment, and treating patients accordingly. While the rationale for such an approach is sound, the evidence to support effective stratification for common mental health problems is lacking. I will present data from analyses using data from two large randomised controlled trials of Cognitive Behavioural Therapy (CBT) for depression in primary care. We used linear regression to test for interactions between treatment effect and putative moderator variables using data from the IPCRESS and CoBalT randomised controlled trials. Despite a couple of potential moderators, the findings were largely null. I will discuss the limitations of these findings and our approach more generally, and discuss whether recent developments in analysis from other groups in the field are more promising.

Speaker information

Dr Katherine Button, University of Bath. My research focuses on the cognitive mechanisms that contribute to common mental health disorders such as anxiety and depression, and translating this to improve cognitive-based intervention for patients in primary care. I use experimental techniques from cognitive psychology and neuroscience to explore these mechanisms to inform how they may be modified to reduce anxiety and improve mood. I use epidemiological investigations to understand how dysfunctional cognitions arise. I also work with clinical data from randomised controlled trials to investigate factors associated with response to cognitive behavioural therapy.

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