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The University of Southampton
Psychology

Research project: Comparative Efficacy and Tolerability of ADHD Medications

Currently Active: 
Yes

The project aims to answer clinically relevant questions. Under the lead of Professor Cortese, the EAGG has been successful in compiling the most comprehensive database of RCTs of ADHD medications across the lifespan, including published and unpublished data. Based on this dataset, a network meta-analysis on the efficacy and tolerability of ADHD medications was published in 2018 (Cortese at al., Lancet Psychiatry, 2018). The dataset will be periodically updated and analysed with the most advanced approaches of evidence synthesis. An ongoing project focuses on a network meta-analysis aimed at comparing ADHD drugs in terms of individual side effects.  

The project aims to compare ADHD medications in terms of efficacy and tolerability via advanced meta-analytic approaches. The first study of the project has been published (https://pubmed.ncbi.nlm.nih.gov/30097390/). Ongoing projects include: assessment of placebo effect, assessment of individual adverse events, and collection of individual patient data.

Related research groups

Centre for Innovation in Mental Health (CiMH)

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