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The University of Southampton

Research project: REFRAMED

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"REFRAMED" is the study acronym for REFRActory depression - Mechanisms and Efficacy of Radically Open Dialectical Behaviour Therapy. REFRAMED is a multi-site randomised controlled trial funded by NIHR-EME, and aims to investigate RO-DBT for people with long-term and chronic depression.  For more information about RO-DBT research studies, click here. For information about RO-DBT treatment, click here.

Standard Dialectical Behaviour Therapy (DBT) has proved to be effective in treating borderline PD. Radically Open DBT (RO-DBT), a new treatment approach with strong roots in standard DBT has demonstrated promise for patients with difficult-to-treat depression and related overcontrolled disorders. In this study, we shall test RO-DBT for treatment of TRD and refractory depression. The aim of the study is to compare RO-DBT to Treatment as Usual (or standard clinical care).

This is a multi-site randomised controlled trial funded by the Efficacy and Mechanisms Evaluations programme of the Medical Research council. The University of Southampton acts as the research sponsor for this project, while the therapy will take place at the Dorset HealthCare University NHS Foundation Trust, the Southern Health NHS Foundation Trust, and the Betsi Cadwaladr University Health Board.

You can find more information about the study and the inclusion and exclusion criteria here:


Related research groups

Emotion and Personality Bio-behavioural Laboratory
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