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Research project

HEIF 2017/18 Coldwell

Status:
Not active

Project overview

Development of a high throughput bioluminescent assay for real time monitoring of the directional transmission and early stages of misfolded Tau propagation in neurons
Coldwell Deinhardt West
HEIF 2017/18
Award £11488
Output tbc

Staff

Other researchers

Doctor Katrin Deinhardt

Associate Professor

Research interests

  • Our research is focused on cellular and molecular neurobiology. Fascinated by the beautiful but complicated shape of individual neurons, we study the complex intracellular logistics required to form, maintain and remodel these cells throughout life.Neurons extend processes that cover vast territories, which allow them to directly connect with cells distant from the soma. Our research interest is to understand how neurons integrate the different extracellular cues that they receive at distinct parts of the cell in time and space to maintain and adapt their structure and connectivity. To this end, we investigate the interplay of short- and long-range trafficking and signalling, and how these events ultimately converge to initiate changes in neuronal morphology and physiology in health and neurodegeneration.

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Doctor Jonathan West

Lecturer in Biomedical Microfluidics

Research interests

  • Platelet Diversity The lab has a keen interest in understanding the nature and consequences of platelet functional diversity. Using a droplet microfluidics strategy we can measure intrinsic platelet behaviour. Broad-continuum sensitivity was identified, with hypersensitive platelets able to drive heterotypic system polarisation. Current research aims at characterising platelet dynamics and transcriptome remodelling in response to stimulation to pin-point sub-populations governing thrombosis.

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