The Upper Gastrointestinal (UGI) multidisciplinary team (MDT) makes critical treatment decisions in every oesophageal cancer patient’s journey (e.g., neoadjuvant therapies, expedited surgery or palliation). This has a profound impact on survival and quality of life. Recent studies have highlighted that rising caseloads and time pressures can lead to inconsistent and suboptimal decisions. Machine learning (ML) offers the potential to standardise and deliver data-driven decisions. We will mirror the decision-making process by incorporating human-selected critical variables and work with practitioners to assess regulatory and practical challenges (as human-AI partnerships) to ensure that the solution is trustworthy for routine clinical use.