Genetics in drug discovery and development Seminar
- Date:
- 25 October 2012
- Venue:
- Building 54 Room 10037
For more information regarding this seminar, please email Mrs Jane Revell at j.revell@southampton.ac.uk .
Event details
Statistics research seminar
Abstract
There are a number of possible uses of genetics to support drug discovery and development. Most obviously, we discuss pharmacogenetics, that is the investigation of genetic variants that contribute to variation in the risk of drug related adverse events or the efficacy of medicines, using examples from recent GSK oncology projects. In addition, genetics may provide information to support intervention on particular targets, and hence increase the reason to believe that certain medicines might be effective against particular indications, or suggest new indications for existing medicines. This is essentially a form of causal inference, and we discuss this briefly before describing a number of applications, including a recent GSK project based on second generation sequencing of 202 genes encoding GSK drug targets in 15000 individuals across a number of diseases. A brief introduction to genetics will be included for those not familiar with the area, and technical details, both genetic and statistical, will be avoided wherever possible throughout.
Speaker information
Professor John Whittaker , London School of Hygiene and Tropical Medicine. Professor of Genetic Epidemiology and Statistics