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The University of Southampton
SAFA study

Welcome to the Spironolactone for Adult Female Acne (SAFA) Research study 

The SAFA study is looking at the effectiveness of spironolactone for acne or spots by comparing two treatment groups: either spironolactone or placebo (dummy pill).

SAFA during Covid-19

We are currently working on reopening our study hospitals for recruitment in a phased manner. If the study hospital closest to you is not listed as ‘open for recruitment’ yet, please email safa@soton.ac.uk and we will contact you as soon as we know when the study will reopen at your local study hospital. 

For women who would like to join the study, please keep looking at the social media updates on Twitter (@SafaAcne) and Instagram (safaclinicaltrial) where we will update you as things progress. 

The Covid-19 pandemic is a significant cause for concern but we would like to reassure you that continuing to take the medication in the SAFA trial is very safe, whether placebo or spironolactone. The study medication will not result in any additional side effects or problems.

What is SAFA?

What is SAFA?

Find out more about the SAFA study and why we are doing it

180 women recruited

The Spironolactone for Adult Female Acne (SAFA) Research Study

The SAFA study is looking at the effectiveness of spironolactone for acne or spots by comparing two treatment groups: either spironolactone or placebo (dummy pill).

Spironolactone is currently used to treat high blood pressure, but it may also be effective as an acne treatment.

What's this acne study all about?

This research study will include 434 adult women (aged 18 years or over). It is being run in six dermatology centres across the UK (Birmingham, Bristol, Epsom, Harrogate, Poole and Portsmouth).

We currently recruiting participants - find out whether you're eligible to take part.

What this study involves

If you are eligible to take part and you decide to join the study, you'll attend 3 visits (when you start the study, at 6 weeks and 12 weeks) and take either spironolactone or a dummy pill for 24 weeks (6 months). Your first visit when you start the study will take place at the clinic in person. The visits at 6 weeks and 12 weeks can take place as virtual clinics.

You will stop taking the study tablets at 24 weeks and we will ask you to complete a questionnaire about how satisfied your were with the treatment and to asses if there was any improvement in your spots/acne. We will send you a final follow-up questionnaire 6 months or sooner after you stopped taking the study tablets. You may continue to use creams, gels or lotions for acne while in the study.

As a thank you for your participation, we will give you a £20 shopping voucher at your first clinic visit and a £10 shopping voucher at 6 weeks and 12 weeks.

SAFA study timeline

Get in touch

If you are eligible and whish to take part in this research acne study, please contact your nearest study centre to book your first clinic visit.

Find out more about spironolactone for acne and the SAFA study. 

Our study sites and collaborators

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Study Sites
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Sponsor, Funder and Study Coordinating Centre
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Collaborators
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