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The University of Southampton
Southampton Chemistry Analytical Solutions

High Resolution MAS NMR Spectroscopy

In solid-phase organic synthesis compounds are immobilised on resin supports and as a consequence constraints are placed on the analytical techniques that are available. The HR-MAS NMR probe allows 1H and 13C NMR spectroscopy to be used to follow reactions without removing the substrate from the support.

While the majority of NMR experiments undertaken on the HR-MAS probe are acquired from poly(styrene) resin supported samples, lately spectra have also been acquired on solid biological samples.

Example spectra:

On resin reaction monitoring

Attenuation of broadest signals from the PS resin backbone (CPMG pulse sequence)

Technical information: 

Gel-phase resin spectra are acquired using a high-resolution magic angle spinning probe (4 mm) that allows 1D and 2D 1H NMR, 13C NMR with 1H decoupling and 2D experiments such as HMQC and HMBC.

In addition, the probe includes a 2H lock channel and variable temperature capability.

Contact us

Email: scas@soton.ac.uk
Tel: +44(0)23 8059 8028
Office hours: Monday - Friday 0900-1700

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