Below are the Southampton Clinical and Experimental Neurology Team's research studies related to brain haemorrhage.
Haptoglobin as a treatment after subarachnoid haemorrhage
Haptoglobin is a natural protein which binds haemoglobin and can protect the brain from haemoglobin toxicity.
Funded by the Engineering and Physical Sciences Research Council.
Genome-wide association study (GWAS) of outcome after subarachnoid haemorrhage
Studying the genetic determinants of clinical outcome after subarachnoid haemorrhage in order to identify novel therapeutic targets and improve current prognostic algorithms. This is an international study of the HATCH consortium, led from the University of Southampton.
Funded by the University of Southampton.
Haemoglobin scavenging kinetics in the brain after subarachnoid haemorrhage
Haemoglobin is neurotoxic once outside red blood cells. Treatments to improve haemoglobin clearance from the brain after haemorrhage may be possible. We are studying the kinetics of haemoglobin clearance to define the limits of the therapeutic window.
Funded by the Medical Research Council.
Sulphoradex After Subarachnoid haemorrhage (SAS) study
A randomized controlled study of a stable formulation of sulforaphane after subarachnoid haemorrhage (see protocol here). Sulforaphane improves the brain’s ability to deal with toxic extracellular haemoglobin.
Funded by Evgen.
Haptoglobin genotype and long-term clinical outcome after aneurysmal subarachnoid haemorrhage
Haptoglobin exists in two forms which might differ in how this protein affects clinical outcome after subarachnoid haemorrhage. With over 1000 participants, this is the largest single study examining this issue.
Funded by the Medical Research Council.
Haptoglobin genotype and outcome after intracerebral haemorrhage
Haptoglobin exists in two forms which might differ in how this protein affects clinical outcome after intracerebral haemorrhage.
Funded by the Medical Research Council.
SubArachnoid Haemorrhage Outcome Tool (SAHOT)
Developing a clinical outcome tool specific for subarachnoid haemorrhage.
Funded by the University of Southampton and National Institute for Health Research.
Hearing loss and cognitive outcomes after subarachnoid haemorrhage
We have discovered that hearing loss affects a significant proportion of survivors after subarachnoid haemorrhage, and is characterized as a central auditory processing disorder. We have worked out the underlying mechanism of development of this hearing loss, and are currently investigating its relationship with cognitive outcomes in a UK Biobank study.
Funded by the University of Southampton.
A neuropathological study of the haemoglobin scavenging system after subarachnoid haemorrhage
To understand how haemoglobin is cleared from the brain, using post-mortem specimens from people after subarachnoid haemorrhage and control individuals.
Funded by the University of Southampton.
Haptoglobin after subarachnoid haemorrhage: an individual patient level data analysis
Haptoglobin exists in two forms which might differ in how this protein affects clinical outcome after subarachnoid haemorrhage. This is an international collaboration to enable re-analysis of small published and unpublished studies.
Funded by the University of Southampton.
Haptoglobin genotype and outcome after sepsis
Haptoglobin exists in two forms which might differ in how this protein affects clinical outcome after sepsis.
Funded by the University of Southampton.