Risk of Aneurysm Rupture (ROAR-DNA)

The aim of this study is to identify rare and common genetic variants:

• associated with intracranial aneurysm (IA) development – to select for IA screening
• associated with IA rupture – to select for IA treatment
• that identify molecular pathways – to target therapeutically

ROAR-DNA will obtain DNA from patients in the ROAR study and perform whole genome sequencing (WGS) and customised array genotyping. WGS will be used in a subset of patients to identify rare variants of interest, which will then be included on the customised array used to type the remaining participants.

For more information visit: https://roarstudy.co.uk/