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Professor David Baldwin MB BS DM FRCPsych

Professor of Psychiatry, Academic Lead for General Adult Psychiatry for Clinical Academic Training at University of Southampton

Professor David Baldwin is Professor of Psychiatry within Medicine at the University of Southampton.

Professor Baldwin became Head of the Mental Health Group in 2008 and was awarded a Personal Chair in 2010. He trained in medicine at Charing Cross Hospital Medical School, London and then in psychiatry at St Mary's Hospital Medical School and the Maudsley Hospital, London.

Professor Baldwin leads a group that aims to improve clinical outcomes in patients with mood and anxiety disorders. This involves investigating the role of neurobiological and psychological factors in causing and maintaining illness; through improving trial design when evaluating efficacy and tolerability of treatment interventions; by assessing the effectiveness and acceptability of treatment interventions in wider clinical practice; through identifying more accurately those patient groups at particular risk of poor outcomes; and by offering a specialist clinical service to patients with chronic and treatment-resistant conditions.

He leads the Anxiety Disorders Research Network, an international multi-centre independent collaborative cross-disciplinary research grouping, with support from the European College of Neuropsychopharmacology (ECNP).

He is an Honorary Consultant Psychiatrist in Southern Health NHS Foundation Trust, where he leads the tertiary referral specialist service for patients with mood and anxiety disorders.

Qualifications

MB BS Medicine and Surgery, University of London 1984
DM University of Southampton 2004
MRCPsych 1988 and FRCPsych 2002

Appointments held

Lecturer in Psychiatry 1987-1988, St Mary’s Hospital Medical School

Clinical Research Fellow 1988-1990, St Mary’s Hospital Medical School

Honorary Senior Lecturer in Psychiatry, 1992-1994 Imperial College London

Senior Lecturer in Psychiatry 1994-2006, Southampton

Reader in Psychiatry 2006-2010, Southampton

Professor of Psychiatry 2010 onwards, Southampton

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Investigating the role of neurobiological and psychological factors in causing and maintaining illness

This includes investigations of attentional and interpretative biases in patients with anxiety disorders, before and after pharmacological treatment, and by conducting similar studies in first-degree relatives and healthy controls, designed to reveal endophenotypes for anxiety disorders. A similar approach is used to explore neuropsychological factors in causing and maintaining sleep disorders.

Improving trial design when evaluating efficacy and tolerability of treatment interventions

I work in partnership with pharmaceutical and biotechnology companies, through the University Research and Enterprise service, to refine the design of randomised controlled trials and facilitate development of improved psychotropic drugs. This has led to better understanding of the relative efficacy and safety of antidepressant and anxiolytic drugs, and of the mechanisms underlying antidepressant-associated sexual dysfunction, and then relationship between an early onset of clinical effect and the likelihood of responding to pharmacological treatment.

Assessing the effectiveness and acceptability of treatment interventions in wider clinical practice

Current collaborative studies include an evaluation of clinical and cost-effectiveness of antidepressant drugs in the treatment of negative symptoms of schizophrenia, and an investigation of the effects of mindfulness-based cognitive therapy in patients with highly recurrent unipolar depressive disorder and persistent mild depressive symptoms.

Identifying more accurately those patient groups at particular risk of poor outcomes

This includes identification of demographic and clinical factors associated with completed suicide after discharge from psychiatric inpatient care. Current research into attempted and completed suicide includes an investigation of suicides on the island of Jersey between 2000 and 2009.

Leading the Anxiety Disorders Research Network

This is an international multi-centre independent collaborative cross-disciplinary research grouping, with support from the ECNP. It currently includes 22 research groups in 16 centres across 10 countries, and aims to address currently unmet needs in anxiety and related disorders. This is achieved by harmonising research and clinical databases and refining research methodologies; by evaluating innovative interventions, particularly in previously neglected patient groups; and by building a platform for pragmatic randomised controlled effectiveness trials. 10 of the ADRN centres are involved in the European and South African Research Network in Anxiety Disorders (EUSARNAD) programme which I coordinate. The EUSARNAD is supported by the Marie Curie Actions (People) International Research Staff Exchange Scheme (PIRES-GA2010-269213).

Offering a specialist clinical research-lead service to patients with chronic and treatment-resistant conditions

Patients with mood and anxiety disorders are referred by secondary care services, across the south of England. Approximately 50% have recurrent unipolar depressive disorder, 25% bipolar disorder, and 25% an anxiety disorder, as the primary diagnosis. Around 50 patients are seen as new referrals each year.

Anyone interested in graduate studentships or post-doctoral positions (clinical) within the Mental Health Group are encouraged to contact Professor Baldwin directly.

Research group

Clinical and Experimental Sciences

Affiliate research group

Clinical Neuroscience Research group

Postgraduate student supervision

2013 Ben Ainsworth PhD
2012 David Bartram PhD
2007 Pippa Biswas DM
2006 Andrew Mayers PhD

Current

Faculty of Medicine

Head of Mental Health Group
Deputy Director of Clinical Neuroscience and Psychiatry Academic Sub-Unit

National and international responsibilities

Editor of Human Psychopharmacology
Responsible for liaison between the ECNP and European Medicines Agency
Medical Patron of the Anxiety UK
Past President of Depression Alliance
Vice Chair of the MOD Research Ethics Committee

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Articles

Book

Montgomery, S. A., & Baldwin, D. S. (2006). Clinicians manual on generalized anxiety disorder. London, UK: Current Medicine Group.

Book Chapters

Conferences

Bernard, R., Sabariego, C., Baldwin, D. S., Abou-Zahra, S., & Cieza, A. (2015). BETTER-project: web accessibility for persons with mental disorders. In M. Kurosu (Ed.), Human-Computer Interaction: Users and Contexts (pp. 25-34). (Lecture Notes in Computer Science; Vol. 9171). Springer International Publishing. DOI: 10.1007/978-3-319-21006-3_3
Hou, R. H., Garner, M. J., Teeling, J. L., Culliford, D., & Baldwin, D. S. (2014). A preliminary investigation of associations between attentional control and neuroinflammation. British Association for Psychopharmacology Summer Meeting, United Kingdom.
Hou, R. H., Garner, M. J., Teeling, J., Culliford, D., & Baldwin, D. S. (2014). The role of neuroimmune modulation in cognitive processing. Poster session presented at 27th European College of Neuropsychopharmacology Congress, Germany.

Letters/Editorials

Baldwin, D., Jauhar, S., Hayes, J., Goodwin, G., & Nutt, D. J. (2019). Antidepressants, withdrawal, and addiction; where are we now? Journal of Psychopharmacology, 33(6), 655-659. [JOP-2019-3777]. DOI: 10.1177/0269881119845799
Selvaraj, S., Jauhar, S., Baldwin, D., Cowen, P. J., Goodwin, G., Hayes, J., ... Young, A. H. (2019). Tapering of SSRI treatment to mitigate withdrawal symptoms. Lancet Psychiatry, 6(7), 560-561. DOI: 10.1016/S2215-0366(19)30183-X
Sinclair, J. M. A., Chambers, S. E., & Baldwin, D. S. (2016). Authors’ Reply to Alain Braillon’s Comment on “Safety and Tolerability of Pharmacological Treatment of Alcohol Dependence: Comprehensive Review of Evidence”. Drug Safety, 39(11), 1153-1154. DOI: 10.1007/s40264-016-0448-3

Reports

Aitchison, K. J., Baldwin, D. S., Barnes, T., Hall, J., Howes, O., McAllister-Williams, R. H., ... Young, A. (2017). Use of licensed medicines for unlicensed applications in Psychiatric practice: Psychopharmacology Committee. (2nd Edition ed.) (College Reports; No. CR210). London: Royal College of Psychiatrists.
Peveler, R., Kendrick, A., Buxton, M., Longworth, L., Baldwin, D., Moore, M., ... NCCHTA (2005). A randomised controlled trial to compare the cost-effectiveness of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine. (Health Technology Assessment; No. Vol 9: number 16). Southampton, UK: National Coordinating Centre for Health Technology Assessments. DOI: 10.3310/hta9160

Reviews

BM5. Delivers lectures in Year 2 and seminars in Year 3.

BMedSci. Offers up to 4 project placements (joint supervision) in area of mood and anxiety disorders.

BSc Biomedical Science. ‘Masterclass’ on affective disorders.

Personal tutor for students throughout BM4, BM5 and BM6 curricula.

Professor David Baldwin
University Department of Psychiatry Academic Centre, College Keep 4-12 Terminus Terrace Southampton SO14 3DT Phone: +44 (0) 23 8071 8520 Fax: +44 (0) 23 8071 8532 Email: dsb1@soton.ac.uk

Room Number: 123 Coll. Keep/22

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