Professor Mark Cragg from the Centre for Cancer Immunology is part of a review of recent discoveries on how antibodies work in our bodies.
In particular, the paper published in Nature Immunology, discusses how antibodies change in our bodies during aging, pregnancy and different diseases, including cancer, in regards to how long they stay in the blood, which other molecules in the immune system they interact with and how well they destroy pathogens”
The authors, which include Professors Falk Nimmerjahn and Gestur Vidarsson who are based in Germany and Amsterdam respectively, discuss how these changes affect the antibody function.
They go on to discuss how we can learn from these findings, provided by Nature to improve our design of therapeutic antibodies for various clinical indications.