Welcome to John Langley's Group Webpage
We are an analytical chemistry group within the School of Chemistry
at the University
Our work is focused on the fundamentals and
application of mass spectrometry (MS) and separation science (GC-MS,
LC-MS and SFC-MS). Current research projects are focused on
high throughput methodologies, including
Ion Chemistry of Pharmaceutically Interesting Small Molecules
using MS/MS and Molecular Modelling (AZ), Hybridisation-Ligation
Mass Tagged Bioanalysis of DNA/RNA (BBSRC/Pfizer) and the
Application of Hyphenated Approaches to the Analysis of
Petrochemicals and Biofuels (EPSRC/BP).
Other research interests revolve
around MS of oligonucleotides and continued development of a web-based open access mass spectrometry interface (with SpectralWorks).
Previous projects have involved,
novel low mass MALDI approaches, metabolite identification using MSn
techniques (BBSRC/Pfizer), application of SFC in relation to the
high throughput analysis of pharmaceutical compounds (CCE
consortium), factors that influence the accuracy and precision of
accurate mass measurement (LGC), direct and indirect MS approaches to DNA/PNA analysis, use of the improved high throughput use of the ChemiLuminescent Nitrogen Detector and the use of an Artificial Intelligence software package to automatically interpret MS/MS spectra of non-peptidic systems produced by combichem methods. Improved MS/MS data interpretation projects are still ongoing.