Research project

The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)

Research groups:
Lead researcher:

Dr Yihua Wang
Research funder:

The Academy of Medical Sciences
Status:

Not active

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

Cell Signalling in Disease
Epithelial-Mesenchymal Crosstalk
Pulmonary Fibrosis

Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Integrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activation

Hualong Zhao, Siyuan Wang, Yilu Zhou, Ayse Ertay, Philip Williamson, Robert Ewing, Xinhui Tang, Jialian Wang & Yihua Wang, 2022, Frontiers in Plant Science, 13

DOI: 10.3389/fpls.2022.994036

Type: article

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S.N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie V. Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang & Mark G. Jones, 2022, eLife, 11

DOI: 10.7554/eLife.69348

Type: article

Autophagy in pulmonary fibrosis: friend or foe?

Charlotte Hill & Yihua Wang, 2021, Genes and Diseases, 9(6), 1594-1607

DOI: 10.1016/j.gendis.2021.09.008

Type: review

Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis

Liudi Yao, Yilu Zhou, Juanjuan Li, Leanne Wickens, Franco Conforti, Anna Simron Rattu, Fathima M Ibrahim, Aiman Alzetani, Benjamin Marshall, Sophie Fletcher, David Hancock, Timothy Wallis, Julian Downward, Robert Ewing, Luca Richeldi, Paul Skipp, Donna Davies, Mark Glynne Jones & Yihua Wang, 2021, Journal of Biological Chemistry, 297(3)

DOI: 10.1016/j.jbc.2021.101096

Type: article

Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition

Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark Jones, Donna Davies, Robert Ewing, Paul Skipp & Yihua Wang, 2021, Frontiers in Molecular Biosciences, 8

DOI: 10.3389/fmolb.2021.595712

Type: article