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Steroids not effective for chest infections in adults who don’t have asthma or other chronic lung diseaseLightOral steroids should not be used for treating acute lower respiratory tract infection (or ‘chest infections’) in adults who don’t have asthma or other chronic lung disease, as they do not reduce the duration or severity of symptoms, according to a new study published in the journal JAMA.<p>In the study, carried out by researchers at the Universities of Southampton, Bristol, Nottingham and Oxford, 398 non-asthmatic adults with acute chest infections &minus; but no evidence of pneumonia and not requiring immediate antibiotic treatment &minus; were randomly split into two groups, one receiving 40mg of the oral steroid &lsquo;prednisolone&rsquo; for five days and one receiving a placebo over the same time period.<br /><br />The team found there was no reduction in the duration of cough, the main symptom of chest infections, or the severity of the accompanying symptoms between two and four days after treatment (when symptoms are usually at their most severe) in the prednisolone group compared with the placebo group. The results suggest that steroids are not effective in the treatment of chest infections in non-asthmatic adult patients.<br /><br />Professor Michael Moore, a study co-author from the University of Southampton, said: &ldquo;Oral and inhaled steroids are known to be highly effective in treating acute asthma as well as infective flares of other long-term lung conditions but need to be used carefully because of the risk of unwanted side effects. We chose to test the effect of steroids for chest infections as some of the symptoms of chest infections, such as shortness of breath, wheeze and cough with phlegm, overlap with acute asthma. However, we have conclusively demonstrated they are not effective in this group of patients.&rdquo;<br /><br />Professor Moore said that alternative methods of treating chest infections should be found to reduce the amount of antibiotics being used to combat anti-microbial resistance, which is considered a global health crisis. It does not look as if steroids are the answer, he said.<br /><br />A recent study, led by the University of Southampton, showed that Andrographis Paniculata (A. Paniculata, Chuān Xīn Li&aacute;n), a Chinese herbal medicine, appears beneficial and safe for relieving chest infections symptoms and results in a speedier recovery.<br /><br />The systematic review, published in <em>PLOS ONE</em>, assessed data for 7,175 patients across 33 trials in six countries, which evaluated the effects of relieving chest infection symptoms, particularly cough and sore throat. It showed that A. Paniculata improved severity of cough and sore throat when compared with placebo and had a statistically significant effect in improving overall symptoms when compared to placebo, usual care, and other herbal therapies. Evidence also suggested that A. Paniculata (alone or plus usual care) shortened the duration of cough, sore throat and sick leave/time when compared to usual care.<br /><br />Professor Moore said: &ldquo;It is clear that most of the time antibiotics have very limited impact on the symptoms from chest infections, so the search is on to find alternative approaches to provide symptom relief.&nbsp; Andrographis appears both safe and helpful in this area. More needs to be done to find alternative treatments to antibiotics if we are to get ahead of antibiotic resistance, which is increasing at an alarming rate. Herbal remedies could have a potential role to play.&rdquo;</p> <p>&nbsp;</p>2017/08/22{304D81AC-8AED-4922-97C5-1B1F90387640}Research and Innovation Services/Photos/Web images/New folder/40.jpgStudy published in JAMASteroids not effective for chest infections in adults who don’t have asthma/assets/imported/transforms/site/news-release/PageThumbnail/304D81AC8AED492297C51B1F90387640/40.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/304D81AC8AED492297C51B1F90387640/40.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/304D81AC8AED492297C51B1F90387640/40.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/304D81AC8AED492297C51B1F90387640/40.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/304D81AC8AED492297C51B1F90387640/40.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedNoColour/templatedata/site/staff-profile/data/medicine/mvm198.xmlExperimental drug trial seeks to improve treatment for lymphomaLightPatients with a common type of fast-growing cancer are being given fresh hope in a new clinical trial.<p>Scientists at the University of Southampton are, for the first time, to trial a new experimental drug, in combination with immunochemotherapy, in certain patients with diffuse large B-cell lymphoma (DLBCL).<br /><br />DLBCL is the most common type of fast-growing non-Hodgkin lymphoma. For many people, the standard treatment, called R-CHOP, uses a combination of an immunotherapy called&nbsp;rituximab and four chemotherapy drugs to find and destroy lymphoma cells. But sometimes DLBCL does not go away, or comes back after a period of remission.<br /><br />Researchers at the University of Southampton want to find out whether a new protein inhibitor called acalabrutinib* improves patient response to standard treatments. Acalabrutinib is being developed by Acerta Pharma, a member of the AstraZeneca group.<br /><br />The ACCEPT trial, which has launched at seven centres** across the country and is being funded by Acerta Pharma, will be managed by the Southampton Clinical Trials Unit, and will for the first time combine acalabrutinib with R-CHOP***.<br /><br />The first phase of the trial will help determine a safe and tolerable dose of the drug. Patients will receive multiple low doses of acalabrutinib, while samples of blood and other fluids, collected at various time points, are analysed for information on how the body processes the drug in combination with R-CHOP.&nbsp;&nbsp;<br /><br />The subsequent phase will evaluate whether this treatment combination is effective at treating DLBCL and preventing its return.<br /><br />Researchers on this trial are accepting patients aged 16 years and above, with previously untreated CD20 positive**** diffuse large B-cell lymphoma, requiring a full course of chemotherapy.<br /><br />Dr Andrew Davies, lead researcher on the trial and associate professor and consultant in medical oncology at the University of Southampton, said: &ldquo;For some lymphoma patients standard treatments are not effective, so we urgently need trials like this to help more people survive their disease.<br /><br />&ldquo;Results from previous trials that use acalabrutinib to fight other blood cancers have been very promising. This new and unique drug combination will attack the cancer from two sides. Not only will it mark the cancer cells so the immune system can find them and kill them, but it will also prevent the activity of key proteins that play an important role in the spread and survival of malignant B cells. We believe this new combination will benefit patients in addition to standard treatment.&rdquo;<br /><br />ACCEPT is the first clinical trial to be run as part of the Precision Medicine for Aggressive Lymphoma Consortium (PMAL).***** Gene expression data gathered as part of this trial will be used by PMAL to improve diagnosis and treatment for lymphoma. It will contribute to a sophisticated database which could one day match patients to targeted therapies based on genetic profiling.&nbsp;<br /><br />Professor Peter Johnson, director of the&nbsp;Southampton Cancer Research UK Centre, said: &ldquo;Our research into the molecular changes that make lymphomas grow has given us important new leads on how we might treat them more effectively.&nbsp;<br /><br />&ldquo;This trial is exciting because it uses a new targeted cancer drug to switch off key signals in lymphoma cells, and at the same time we will be able to collect information about whether this is a good approach for more patients in the future.&rdquo;</p>2017/08/11{8E2AB04A-7EA1-42B1-B77D-4B7A881971A1}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/lymphoma_cells.jpglymphoma cellsExperimental drug trial seeks to improve treatment for lymphoma/assets/imported/transforms/site/news-release/PageThumbnail/8E2AB04A7EA142B1B77D4B7A881971A1/lymphoma_cells.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8E2AB04A7EA142B1B77D4B7A881971A1/lymphoma_cells.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8E2AB04A7EA142B1B77D4B7A881971A1/lymphoma_cells.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8E2AB04A7EA142B1B77D4B7A881971A1/lymphoma_cells.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8E2AB04A7EA142B1B77D4B7A881971A1/lymphoma_cells.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedctu/ctu_news_feedNoColour/templatedata/site/staff-profile/data/medicine/ad1o07.xml<p>*On 01 August 2017, acalabrutinib was recently given Breakthrough Therapy Designation (BTD) by the US Food and Drug Administration for the treatment of a non-Hodgkin lymphoma called Mantle cell Lymphoma.&nbsp; It works by blocking the action of a B-cell associated protein called Bruton tryrosine kinase (BTK). Clinical studies have shown that inhibiting BTK with a drug called ibrutinib (a currently approved BTK inhibitor) in combination with R-CHOP chemotherapy for previously untreated B-cell non Hodgkin lymphoma is safe. Acalabrutinib is BTK inhibitor in development that has shown increased target selectivity compared to ibrutinib.&nbsp;<br /><br />**The ACCEPT trial will take place at the Universities of Southampton, Plymouth, Oxford, Nottingham, UCL, Leeds Teaching Hospitals NHS Trust - St James's University Hospital and the Manchester Christie Hospital.&nbsp;<br /><br />***R-CHOP is a combination of an immunotherapy called&nbsp;rituximab and four chemotherapy drugs called Cyclophosphamide, doxorubicin, vincristine and prednisolone. <br /><br />****Rituximab targets a protein called CD20 on the surface of lymphoma cells. The antibody sticks to all the CD20 proteins it finds. Then the cells of the immune system pick out the marked cells and kill them.<br /><br />***** <a href=""></a></p>Going below the surfaceLightFor centuries, humans have been drawn to the sea - as a source of food, a means of transportation and an enigma that has captured the imagination. <p>Its allure has driven artists and poets to romanticise about its many mysteries and the waters draw scientists to its shores and depths to go beneath the surface in search of strange new worlds.</p> <p>Many of those modern-day writers and explorers are now based at the University of Southampton which has a global reputation for its study and understanding of Ocean and Earth Science. The University&rsquo;s experts are driven by their fascination for the sea and their shared passion for discovery.&nbsp;</p> <p><a href="">Philip Hoare</a>, Professor of Creative Writing at Southampton, was born and grew up in Southampton where the sea became a part of life from an early age. His books Levithian or, The Whale, The Sea Inside and most recent RISINGTIDEFALLINGSTAR all reveal aspects of his lifelong relationship with the sea and his encounters with his beloved Cetaceans &ndash; whales, dolphins and porpoises.</p> <p><a href="">Rachel Mills </a>is s Professor of Marine Chemistry and Dean of Natural and Environmental Sciences at the University. Unlike Philip, Rachel came to the sea as a scientist and whilst she had visited the coast at times during her formative years, she wasn&rsquo;t fully aware of oceanography until she completed a module on the subject as a Chemistry student at Southampton.</p> <p>Philip and Rachel recently met for the first time at the National Oceanography Centre Southampton to discuss their fascination for the sea and their fears for its future.</p> <p>With thanks to Andrew Sutton for the image of Philip Hoare swimming with sperm whales.</p> <p>&nbsp;</p>2017/08/10{8BDC0F6B-3025-42D1-BB29-BE9554770C4A}Communications & Marketing/Photos/Images for the web/Philip with whales.jpgPhilip Hoare swimming with whalesAuthor and Creative Writing Professor Philip Hoare swims with Sperm Whales. Credit: Andrew Sutton/assets/imported/transforms/site/news-release/PageThumbnail/8BDC0F6B302542D1BB29BE9554770C4A/Philip with whales.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8BDC0F6B302542D1BB29BE9554770C4A/Philip with whales.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8BDC0F6B302542D1BB29BE9554770C4A/Philip with whales.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8BDC0F6B302542D1BB29BE9554770C4A/Philip with whales.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8BDC0F6B302542D1BB29BE9554770C4A/Philip with whales.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedNoColourlargeleftStudy highlights complex causes of Maldives floodingLightThe causes of coastal flooding in the Maldives are more complex than previously thought, according to a new study from the University of Southampton.<p>Authors of the paper, published in the journal <a href="">Natural Hazards</a>, examined wave and sea level data around historic flood events and found that multiple factors contribute to flooding in the Indian Ocean island chain, which has an average land elevation of just one metre.<br /><br />Wave &lsquo;set up&rsquo; &ndash; the raising of water levels at the coast caused by breaking waves &ndash; was found to be the main cause of flooding. This effect was increased by prolonged swell wave conditions, where large, energetic waves are generated by wind storms thousands of miles away in the Southern Ocean. High astronomical tides, caused mainly by the gravitational pull of the Sun and the Moon, were also found to play a part.<br /><br />In addition, sea levels in the region are rising at a rate of about 4mm a year.<br /><br />Lead author Dr Matthew Wadey said: &ldquo;This study gives us a better understanding of flooding in the Maldives. Monitoring waves, sea level and floods is important, but further work is needed to better understand processes that cause flooding in reef environments in the Maldives and other low-lying coasts.&rdquo;<br /><br />At least 30 flood events have been recorded in the Maldives over the last 50 years, including major floods in the capital city, Mal&eacute;.<br /><br />Flood defences, including sea walls and breakwaters, have reduced the flood risk in the islands, but adaptation is essential to all inhabited islands in the country, the authors warn.<br /><br />Ali Shareef, Director of the Climate Change Department at the Maldives&rsquo; Ministry of Environment and Energy, commented: &ldquo;We have experienced some serious flooding in recent times, especially the 2007 event and others more recently. A better understanding of what is happening with the driving factors is critical if we are to address the implications of flooding, especially when they could exacerbate the situation of rising sea levels.&rdquo;<br /><br />The study is part of ongoing research into coastal flooding and climate change adaptation at the University, led by Professor Robert Nicholls and Dr Sally Brown.</p> <p>&nbsp;</p>2017/08/07{DE2A1045-AC23-4FC8-B748-540E7107CB80}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/17_87 sea defences in the Maldives credit University of Southampton.JPGPicture of Maldives sea defencesSea defences in the Maldives. Credit: University of Southampton/assets/imported/transforms/site/news-release/PageThumbnail/DE2A1045AC234FC8B748540E7107CB80/17_87 sea defences in the Maldives credit University of Southampton.JPG_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/DE2A1045AC234FC8B748540E7107CB80/17_87 sea defences in the Maldives credit University of Southampton.JPG_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/DE2A1045AC234FC8B748540E7107CB80/17_87 sea defences in the Maldives credit University of Southampton.JPG_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/DE2A1045AC234FC8B748540E7107CB80/17_87 sea defences in the Maldives credit University of Southampton.JPG_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/DE2A1045AC234FC8B748540E7107CB80/17_87 sea defences in the Maldives credit University of Southampton.JPG_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedhome/news/latest-research-newsChancellor Dame Helen AlexanderLightUniversity of Southampton President and Vice-Chancellor, Professor Sir Christopher Snowden, has paid tribute to Dame Helen Alexander following the announcement of her death. Dame Helen, who was 60, had been Chancellor of the University since 2011.<p>Sir Christopher Snowden said, &ldquo;It is with deep regret and sadness that I have let members of our University community know that our Chancellor, Dame Helen Alexander, passed away peacefully on Saturday night. She had been battling cancer for some time and succumbed to a final aggressive stage.</p> <p>&ldquo;Dame Helen was very popular across the University, especially at graduations, where her friendly and caring character was most evident,&rdquo; he continued. &ldquo;She was always keen to help the University and its members and would regularly ask me about news of our successes. We will all miss her enthusiasm and personal warmth, and our thoughts are with her family at this very sad time.&rdquo;</p> <p>Dr Gill Rider, Chair of the University of Southampton Council said, "Helen was a wonderful role model to a generation of men and women who followed her career and was always approachable, happily offering her support and mentoring. &nbsp;It&nbsp;was a delight and privilege to know her."&nbsp;</p> <p>As Chancellor of Southampton, Dame Helen played a leading ambassadorial role on behalf of the University, presiding over degree ceremonies at graduation. Her strengths and leadership across a range of business sectors led to her appointment as Chancellor in 2011.</p> <p>Well-known for her leadership and successful career in business, Dame Helen continued to fulfil her role as Chair of UBM plc until her death. She also held a number of non-executive directorships, including Huawei Technologies (UK), Rolls Royce, esure Group Holdings, Incisive Media, Thomson-Reuters, and more recently Bain Capital and UBM.</p> <p>Dame Helen also sat on the board of Said Business School at the University of Oxford, was a Trustee of Sir Tim Berners-Lee's World Wide Web Foundation and formerly served as Chair of the Port of London Authority between 2010 and 2015.</p> <p>Her career began with the publishing company Faber and Faber and she went on to spend 11 years as Chief Executive of the Economist Group until 2008. In 2004, she received a CBE for services to publishing. In 2011 she became the first female President of the Confederation of British Industry (CBI) and was awarded a DBE for services to business the same year.</p> <p>Dame Helen received an MA from Oxford, an MBA from INSEAD and in 2015 was awarded the French Legion d'honneur.</p> <p>Dame Helen&rsquo;s family have expressed their wish for friends and colleagues to donate to the Centre for Cancer Immunology in Dame Helen&rsquo;s memory <a href=" " target="_blank">via JustGiving</a>.</p> <p>&nbsp;</p>2017/08/07{33E5B2B5-2485-441C-A641-4F4B3A01A48F}Communications & Marketing/Photos/Images for the web/Dame Helen Alexander, University of Southampton.jpgDame Helen AlexanderDame Helen Alexander was appointed Chancellor of the University of Southampton in 2011/assets/imported/transforms/site/news-release/PageThumbnail/33E5B2B52485441CA6414F4B3A01A48F/Dame Helen Alexander, University of Southampton.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/33E5B2B52485441CA6414F4B3A01A48F/Dame Helen Alexander, University of Southampton.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/33E5B2B52485441CA6414F4B3A01A48F/Dame Helen Alexander, University of Southampton.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/33E5B2B52485441CA6414F4B3A01A48F/Dame Helen Alexander, University of Southampton.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/33E5B2B52485441CA6414F4B3A01A48F/Dame Helen Alexander, University of Southampton.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feed£2m to help reduce deaths from road accidentsLightThe University of Southampton has been awarded nearly £2m to research and help reduce the high number of fatalities from road traffic accidents in low and middle-income countries (LMICs).<p>The money is part of &pound;120m from the&nbsp;<a title="National Institute for Health Research" href="">National Institute for Health Research</a> (NIHR) given to <a title="33 research units and groups" href="">33 research units and groups</a>, with the aim of improving the health of patients and public.<br /><br />Southampton&rsquo;s money will go to the NIHR Group on <a title="Global Road Safety" href="">Global Road Safety</a>, part of the University&rsquo;s <a title="Transportation Research Group" href="">Transportation Research Group</a>.&nbsp; It will fund work to collect road transport data, develop and simulate solutions to road safety problems, and help shape policies and regulations to reduce accidents in LMICs.<br /><br />Lead researcher Professor Neville Stanton commented: &ldquo;World Health Organisation figures tell us that low and middle-income countries have more than twice as many road traffic fatalities, per head of population, compared to high-income countries. They represent 82 per cent of the global population, but they only have 54 per cent of registered motor vehicles &ndash; demonstrating a disproportionate number of deaths relative to their level of motorisation.<br /><br />&ldquo;We aim to reduce the number and severity of road accidents in LMICs through our underpinning philosophy of &lsquo;local solutions for local problems&rsquo; &ndash; working with partners in four key countries.&nbsp; We don&rsquo;t set out to impose a westernised view of road safety; instead we seek to capture the current challenges and develop and evaluate relevant and realistic solutions.&rdquo;<br /><br />The team will conduct research in four countries, from low-income through to upper middle-income. They will collaborate with universities in Bangladesh (Bangladesh University of Engineering and Technology), Kenya (Strathmore University), Vietnam (National University of Civil Engineering) and China (Tsinghua University).<br /><br />Following the success of the initial national call for projects by the NIHR, a call for a second round of applications has now been launched, funded by &pound;40m from the Department of Health Official Development Assistance (ODA) budget.&nbsp; Health Minister Lord O&rsquo;Shaughnessy said: &ldquo;This funding allows our universities to strengthen their research and expertise as leaders in global health research.&nbsp; The UK will continue to be at the forefront of health knowledge, and it is only right that we support other nations as they improve care for patients and public.&rdquo;</p>2017/08/02{87825B8F-14D5-4584-9CEC-04852D236D73}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/2017 (private)/Busy street in Dhaka Bangladesh_shutterstock.jpgBusy street, Dhaka, BangladeshBusy street in Dhaka, Bangladesh/assets/imported/transforms/site/news-release/PageThumbnail/87825B8F14D545849CEC04852D236D73/Busy street in Dhaka Bangladesh_shutterstock.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/87825B8F14D545849CEC04852D236D73/Busy street in Dhaka Bangladesh_shutterstock.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/87825B8F14D545849CEC04852D236D73/Busy street in Dhaka Bangladesh_shutterstock.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/87825B8F14D545849CEC04852D236D73/Busy street in Dhaka Bangladesh_shutterstock.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/87825B8F14D545849CEC04852D236D73/Busy street in Dhaka Bangladesh_shutterstock.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedhome/news/latest-research-newsNoColour/templatedata/site/staff-profile/data/engineering/ns4c08.xmlClimate change could put rare bat species at greater riskLightAn endangered bat species with a UK population of less than 1,000 could be further threatened by the effects of global warming, according to a new study led by the University of Southampton.<p>Scientists warn that, while conditions in the UK could actually become more favourable for the grey long-eared bat (<em>Plecotus austriacus</em>), populations in southern Europe that hold the key for the survival of the species as a whole could be devastated.<br /><br />Working with its partners, the University has developed a new framework to identify wildlife populations threatened by climate change.<br /><br />The study outlining the framework, published in the journal <a href=""><em>Molecular Ecology Resources</em></a>, focuses on the grey long-eared bat and shows that its populations in Spain and Portugal are particularly at risk as conditions there become too harsh.<br /><br />This is of great concern to ecologists because the populations in these areas include pockets with the highest levels of genetic diversity, thanks to their ancestors having survived major climate change events such as ice ages. This makes them better suited to the hotter, drier conditions associated with climate change.<br /><br />However, other populations in the region that lack such genetic diversity and are unable to adapt to the harsher conditions could become isolated if they cannot fly to more climatically suitable areas because the landscape in between is unsuitable.<br /><br />This could also stop the bats from better-adapted populations &ndash; whose genes could help the threatened bat populations survive &ndash; from reaching them.<br /><br />Lead author Dr Orly Razgour, of the University of Southampton, explained: &ldquo;Long-lived, slow-reproducing species with smaller population sizes are not likely to be able to adapt to future climate change fast enough through the spread of new mutations arising in the population.<br /><br />&ldquo;Instead they will depend on the spread of adaptive genetic variation between populations through the movement of individuals.<br /><br />&ldquo;As climate change progresses and the environment becomes less suitable for the bats, they will not only struggle to survive where they are currently found but they will also find it more difficult to shift their range to climatically suitable areas.<br /><br />&ldquo;This reduced connectivity between populations will in turn affect the ability to adapt to changing climatic conditions because of reduced movement of individuals that are better adapted to warmer and drier conditions into the population.&rdquo;<br /><br />The framework developed by Dr Razgour and her colleagues at partner institutions uses three measures to identify wildlife populations at risk from climate change.<br /><br />It uses ecological modelling and climate data to looking at where climate change is likely to be most extreme; gathers genomic data to assess which species are likely to be most sensitive to the effects of future climate change (in the case of the bats, wing biopsy samples were collected from eight populations in the Iberian Peninsula and two populations in England); and considers range shift potential &ndash; i.e. the ability of a species to move from an unsuitable to a suitable area.<br /><br />Using these three measures, levels of risk are generated for each population &ndash; low risk, medium, medium-high and high risk.<br /><br />Dr Razgour said: &ldquo;The framework we have developed can be used to identify the wildlife populations that are most under threat, and therefore help decide how to focus conservation efforts to help the species survive under future climate&nbsp;change.<br /><br />&ldquo;In the case of the bats, this may require people moving them to a more climatically suitable area.<br /><br />&ldquo;Alternatively, we can focus our conservation efforts on medium-high risk populations, where we can encourage&nbsp;the bats to move to more suitable areas through increasing connectivity with other&nbsp;populations and to areas where climatic conditions will remain more suitable.&rdquo;<br /><br />Dr Razgour was funded to conduct the study as part of a Natural Environment Research Council (NERC) Independent Research Fellowship.</p> <p>&nbsp;</p>2017/08/02{5F058E18-86D6-46BB-9F26-5730DBAB7B8F}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/17_84 grey long eared bat Credit Antton Alberdi.jpgPicture of grey long-eared batGrey long-eared bats could be hard hit by climate change. Credit: Antton Alberdi/assets/imported/transforms/site/news-release/PageThumbnail/5F058E1886D646BB9F265730DBAB7B8F/17_84 grey long eared bat Credit Antton Alberdi.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/5F058E1886D646BB9F265730DBAB7B8F/17_84 grey long eared bat Credit Antton Alberdi.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/5F058E1886D646BB9F265730DBAB7B8F/17_84 grey long eared bat Credit Antton Alberdi.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/5F058E1886D646BB9F265730DBAB7B8F/17_84 grey long eared bat Credit Antton Alberdi.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/5F058E1886D646BB9F265730DBAB7B8F/17_84 grey long eared bat Credit Antton Alberdi.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedhome/news/latest-research-newsNoColour/templatedata/site/staff-profile/data/biosci/onr1f15.xmlSea ice decline could weaken ocean currents of the North AtlanticLightArctic ice loss could lead to harsher winters and stormier weather in Europe because of its impact on Atlantic ocean currents, warn the authors of a new study led by the University of Southampton.<p>The research, published in Nature Climate Change and conducted in partnership with Yale University, found that a decline in sea ice cover caused by global warming could weaken the Atlantic Meridional Overturning Circulation (AMOC) &ndash; a large-scale ocean circulation system that affects climate.<br /><br />AMOC is responsible for transporting heat from low to high latitudes. It has a lower limb of dense, cold water that flows south from the North Atlantic, and an upper limb of warm, salty water that flows north from the South Atlantic as part of the Gulf Stream.<br /><br />The authors found that the system &ndash; which plays a major role in the climate of Atlantic rim countries, particularly those in Europe &ndash; could lose up to 50 per cent of its strength, leading to a cooling of the ocean surface in parts of the North Atlantic.<br /><br />Lead author Dr Florian S&eacute;vellec, of the University of Southampton, said: &ldquo;We suggest that Arctic ocean changes on a multi-decadal time scale, such as the decline in sea ice cover that we are currently experiencing, can efficiently weaken the large-scale ocean circulation of the North Atlantic, which is responsible for the oceanic transport of heat from the Equator to high latitudes.<br /><br />&ldquo;This in turn would have significant impacts on our daily weather, since the slow-down of this circulation, and its induced ocean surface cooling, has been shown in other studies to lead to an increase in storminess, to harsher winters, and to drier summers in Europe, for instance.&rdquo;<br /><br />Co-author Professor Alexey Fedorov, of Yale University, added: &ldquo;Our study establishes a new mechanism that links the loss of sea ice and the AMOC. Potentially, this mechanism could lead to a reduction of between 30 and 50 per cent of the AMOC&rsquo;s strength.&rdquo;<br /><br />In the short term, changes in the subpolar North Atlantic have the greatest impact on AMOC, the researchers found. But over the course of a few decades, it was changes in the Arctic that became most important to AMOC.<br /><br />The researchers based their findings on a combination of comprehensive climate change model simulations and novel computations of the sensitivity of ocean circulation to fluctuations in temperature and salinity at the ocean&rsquo;s surface over time.<br /><br />The research was supported by grants from the Natural and Environmental Research Council UK, the US Department of Energy Office of Science, and the National Oceanic and Atmospheric Administration.</p> <p>&nbsp;</p>2017/08/01{3265C510-DAF7-49F5-80A0-88807BD28FE8}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/17_83.Arctic sea ice 3.jpgPicture of arctic sea ice/assets/imported/transforms/site/news-release/PageThumbnail/3265C510DAF749F580A088807BD28FE8/17_83.Arctic sea ice 3.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/3265C510DAF749F580A088807BD28FE8/17_83.Arctic sea ice 3.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/3265C510DAF749F580A088807BD28FE8/17_83.Arctic sea ice 3.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/3265C510DAF749F580A088807BD28FE8/17_83.Arctic sea ice 3.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/3265C510DAF749F580A088807BD28FE8/17_83.Arctic sea ice 3.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedhome/news/latest-research-newsNoColour/templatedata/site/staff-profile/data/oes/fs1m10.xmlDoctors develop pioneering nose drop to help fight meningitisLightDoctors in Southampton have pioneered the development of a nose drop containing a type of ‘friendly’ bacteria that could help prevent meningitis and other infections.<p>Professor Robert Read, director of the NIHR Southampton Biomedical Research Centre, and his team have inserted a gene into a harmless bacterium that will be able to live inside the nose.<br /><br />It is hoped that the modified bacteria will protect against the bacterial species responsible for causing a severe type of meningitis.<br /><br />Around 10 per cent&nbsp;of adults carry Neisseria meningitidis &ndash; the cause of meningococcal meningitis &ndash; in the back of their nose and throat with no signs or symptoms.<br /><br />However, in some people, this bacterium can invade the bloodstream and cause life-threatening infections including meningitis and blood poisoning, which is known as septicaemia.<br /><br />Meningitis occurs in people of all age groups but infants, young children and the elderly are more predisposed. Meningococcal meningitis, which is a bacterial form of the disease and is responsible for 1,500 cases a year in the UK, can cause death in as little as four hours from the onset of symptoms.<br /><br />In a previous study, the research team found inoculating adults with a &lsquo;friendly&rsquo; bacterial strain, known as Neisseria lactamica (Nlac), which is a close cousin of N. meningitidis, resulted in Nlac settling harmlessly in the nose for months and prevented them carrying N. meningitidis at the same time.<br /><br />They now hope genetically enhancing the bacteria with a &lsquo;sticky&rsquo; surface protein from N.meningitidis will increase the ability of Nlac to reside in the nose and generate a strong immune response that protects against the meningitis-causing bacteria.<br /><br />If successful, this would offer the potential to prevent the spread of infection or the ability to rapidly control an outbreak as meningococcal meningitis cannot develop in the absence of N. meningitides.<br /><br />The concept of using friendly bacteria to tackle infections, known as &lsquo;bacteriotherapy&rsquo;, is already used to treat inflammatory bowel disease and Clostridium difficile infections.<br /><br />When clinical trials of the nose drop begin at the NIHR Southampton Clinical Research Facility, it will be the first time a genetically modified bacteria has been used in this way to try to prevent infections that develop in the nose and throat.<br /><br />&ldquo;We have already shown that placing Nlac in the nose of healthy adults caused no harm to the volunteers, the bacteria settled and it caused an immune response which we believe could prevent the acquisition of harmful bacteria,&rdquo; said Professor Read, who is a professor of infectious diseases at the University of Southampton.<br /><br />&ldquo;Now, following extensive work in the laboratory, we have developed a nose drop which includes Nlac that has been enhanced with a gene to help broaden its effect to, we hope, exclude N. meningitidis.&rdquo;<br /><br />Professor Read, who is also an honorary consultant at University Hospital Southampton NHS Foundation Trust, added: &ldquo;The next stage of this process is to test the drops on healthy volunteers in a clinical trial to ensure the strain of bacteria we have created is going to stay and grow in the nose.<br /><br />&ldquo;If successful then we will have a future therapy that we can adapt to combat other diseases caused by bacteria that breed in the nasal pathway such as pneumonia and ear disease.&rdquo;<br /><br />As a first step in the process, Professor Read and his research team have applied to the Department for Environment, Food and Rural Affairs (DEFRA) for permission to use the genetically-modified drop in volunteers.<br /><br />It is hoped the study, being run in collaboration with Public Health England and funded by the Medical Research Council, will be underway by the end of the year. For more information, visit <a href=""></a>.</p>2017/08/01{B86D4FF2-1240-44BB-B77A-3C4CBC52CFFC}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/2017 (private)/professor rob read LANDSCAPE LAB.jpgProf Rob ReadProfessor Rob Read/assets/imported/transforms/site/news-release/PageThumbnail/B86D4FF2124044BBB77A3C4CBC52CFFC/professor rob read LANDSCAPE LAB.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/B86D4FF2124044BBB77A3C4CBC52CFFC/professor rob read LANDSCAPE LAB.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/B86D4FF2124044BBB77A3C4CBC52CFFC/professor rob read LANDSCAPE LAB.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/B86D4FF2124044BBB77A3C4CBC52CFFC/professor rob read LANDSCAPE LAB.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/B86D4FF2124044BBB77A3C4CBC52CFFC/professor rob read LANDSCAPE LAB.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedNoColour/templatedata/site/staff-profile/data/medicine/rcr1d11.xmlUniversity of Southampton part of new £100 million Rosalind Franklin InstituteLightLeading Life Sciences researchers from the University of Southampton will play a major role in a new national institute that aims to create a UK centre of excellence in technology development and innovation.<p>The Rosalind Franklin Institute (RFI), which is being funded by a &pound;100 million investment from the government, will bring together the UK&rsquo;s strengths in life sciences, physical sciences and engineering. Theme areas are proposed to develop disruptive technologies in multilevel and correlative imaging, drug development and delivery, as well as spectroscopy and data integration. By working with clinicians and biomedical investigators the outputs will benefit people across the globe.<br /><br />It is named after the pioneering British scientist whose research using X-rays to study biological structures played a crucial role in the discovery of DNA&rsquo;s &lsquo;double helix&rsquo; structure. She was born on the 25 July 1920.<br /><br />Alongside the University of Southampton, other academic partners include Imperial College London and the universities of Birmingham, Cambridge, Edinburgh, King&rsquo;s College London, Leeds, Oxford, Manchester, and University College London. It will be managed by the Engineering and Physical Sciences Research Council. The Institute will be based at Harwell.<br /><br />Professor Peter Smith, Director of the Institute of Life Sciences at the University, said: &ldquo;The University of Southampton has a distinguished track record in nurturing interdisciplinary approaches to scientific challenges and developing them into meaningful solutions that change the world and improve people&rsquo;s lives. We are very proud to be a partner in this new initiative that looks set to push the boundaries of scientific discoveries even further.</p>2017/07/25{E4DFE79D-A27D-4694-BEB1-8594D080106D}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/2017 (private)/Rosalind_Franklin(2).jpgRosalind FranklinRosalind Franklin. Image by Jewish Chronicle Archive/Heritage-Images/assets/imported/transforms/site/news-release/PageThumbnail/E4DFE79DA27D4694BEB18594D080106D/Rosalind_Franklin(2).jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/E4DFE79DA27D4694BEB18594D080106D/Rosalind_Franklin(2).jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/E4DFE79DA27D4694BEB18594D080106D/Rosalind_Franklin(2).jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/E4DFE79DA27D4694BEB18594D080106D/Rosalind_Franklin(2).jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/E4DFE79DA27D4694BEB18594D080106D/Rosalind_Franklin(2).jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedifls/ifls_newsNew qualification to encourage school pupils to live a healthier and more active life LightThe University of Southampton has teamed up with Southampton City Council, Public Health School Nursing and the charity No Limits to deliver a qualification that encourages young people to get involved in health issues in their communities.<p>The Youth Health Champions programme, administered by the Royal Society of Public Health, empowers young people aged 14 to 18 years old, in a variety of settings to have a positive influence on their own health and the health of those around them.<br /><br />It teaches young people the skills to understand the benefits of a healthy lifestyle and to make healthier choices; it develops skills for the workplace, increases their knowledge of risks of unhealthy behaviours and helps pupils to develop their CV by providing an additional qualification.<br /><br />The University of Southampton will run the course with support from Public Health School Nursing and No Limits from September. The first part will be delivered through the LifeLab scheme, which gives school pupils opportunities to learn first-hand the science behind the health messages with a view to helping them make better choices about their diet and exercise.<br /><br />The second part will be available to selected pupils who will complete three modules of work and plan a public health campaign for their school.<br /><br />To celebrate the collaboration, the pupils from St George&rsquo;s Catholic College, Redbridge Community School and Cantell School, who have completed the course this year, which was delivered by Solent NHST Trust, were presented with their certificates at LifeLab annual showcase event.<br /><br />Kath Woods-Townsend, LifeLab Manager, said: &ldquo;We are very pleased to be delivering this new qualification and hope many pupils attending LifeLab will complete the course. Helping young people understand the reasons behind the advice is so important to encourage a change in behaviour. Ensuring young people lead a healthier and active lifestyle will protect their own health and also encourages them to think about the health traits they will pass on to their future children.&rdquo;<br /><br />LifeLab, based at University Hospital Southampton, is a state-of-the-art teaching laboratory which gives 11-16 year olds the chance to spend the day as a 'real' scientist, engaging in interactive activities, such as using ultrasound to look at their arteries, measuring body composition, training in CPR and extracting their own DNA to discover how their diets and lifestyles lay the foundations for a healthier life.<br /><br />Cllr Dave Shields, Cabinet Member for Health at Southampton City Council, said: &ldquo;I want to extend my congratulations to all the pupils that have become Youth Health Champions this year. This is an innovative way to teach young people about the links between lifestyle and health whilst giving them the opportunity to earn a qualification from a prestigious national body. Shifting the focus of health education for young people from being just about treatment to prevention is important to protecting the health of future generations.&rdquo;</p>2017/07/21{59989FFA-E819-4162-A8BE-4B7BB8680F57}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/2017 (private)/Youth Health Champions.jpgYouth Health Champions2017 Youth Health Champions/assets/imported/transforms/site/news-release/PageThumbnail/59989FFAE8194162A8BE4B7BB8680F57/Youth Health Champions.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/59989FFAE8194162A8BE4B7BB8680F57/Youth Health Champions.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/59989FFAE8194162A8BE4B7BB8680F57/Youth Health Champions.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/59989FFAE8194162A8BE4B7BB8680F57/Youth Health Champions.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/59989FFAE8194162A8BE4B7BB8680F57/Youth Health Champions.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedSouthampton researchers awarded millions to tackle food and water securityLightA project led by the University of Southampton has secured £5m over four years to help improve food and water security for people in sub-Saharan Africa. The money, from Research Councils UK (RCUK), is part of wider funding from one of the most ambitious international research programmes ever created.<p>Leading experts from the UK, and in developing countries across the world, are joining forces to tackle some of the most serious global challenges.&nbsp; &pound;225m has been invested across 37 interdisciplinary projects to address challenges in fields such as; health, humanitarian crises, conflict, the environment, the economy, domestic violence, society, and technology.&nbsp; The&nbsp;<a title="Global Challenges Research Fund" href="">Global Challenges Research Fund</a> (GCRF) Research Councils UK Collective Fund is supporting these latest projects with awards of between &pound;2m to &pound;8m.<br /><br />The Southampton project, &lsquo;Building research capacity for sustainable water and food security in drylands of sub-Saharan Africa&rsquo; is led by&nbsp;<a title="Professor Justin Sheffield" href="">Professor Justin Sheffield</a> of <a title="Geography and Environment" href="">Geography and Environment</a>.&nbsp; It will connect scientists from Kenya, Ghana and Malawi with each other and UK researchers, to help set in motion water and food research projects aimed at benefitting the region.<br /><br />Professor Sheffield said:&nbsp; &ldquo;Subsistence farmers across Africa rely on rainwater for their crops, so it is vital not only for drinking and food production, but also as a crucial part of the economy.&nbsp; As a fragile and precious resource, we want to collaborate with institutes in the region to help ensure its future supply.&rdquo;<br /><br />Commenting on the funding award, Vice President (Research and Enterprise) at the University of Southampton, Professor Mark Spearing, said: &ldquo;This project is exemplary in bringing very high quality research to bear on a problem of global importance, with a strong group of international partners.&nbsp; I wish the team every success in delivering it and achieving its goals.&rdquo;<br /><br />Dean of Social, Human and Mathematical Sciences at Southampton, Professor Jane Falkingham, added: &ldquo;Today, over 600 million lack access to safe water; almost half of people drinking water from unprotected sources live in sub-Saharan Africa. This project has the potential to make a real difference to the lives of some of the poorest people on our planet, directly contributing to the University&rsquo;s mission of changing the world for the better.&rdquo;<br /><br />Southampton project partner Dr Jean-Marie Kileshye Onema, of WaterNet/SADC, said: &ldquo;As the Southern African Development Community (SADC) institution for capacity-building in water resources management, WaterNet is thrilled to be part of this GCRF collaborative research project, as this will further contribute toward improved people&rsquo;s livelihood through enhanced food and water security in our dry land regions.&rdquo;<br /><br />The Global Challenges Research Fund aims to build upon research knowledge in the UK, and strengthen capacity overseas, to help address challenges, informed by expressed need in developing countries.<br /><br />Jo Johnson, Minister for Universities and Science, said: &ldquo;From healthcare to green energy, the successful projects receiving funding today highlight the strength of the UK&rsquo;s research base and our leadership in helping developing countries tackle some of the greatest global issues of our time.<br /><br />&ldquo;At a time when the pace of scientific discovery and innovation is quickening, we are placing science and research at the heart of our Industrial Strategy to build on our strengths and maintain our status as science powerhouse.&rdquo;</p>2017/07/21{4C7795BD-24A0-496B-8198-DF75F06559AF}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/2017 (private)/Water_Africa_cropped_Shutterstock.jpgWater image/assets/imported/transforms/site/news-release/PageThumbnail/4C7795BD24A0496B8198DF75F06559AF/Water_Africa_cropped_Shutterstock.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/4C7795BD24A0496B8198DF75F06559AF/Water_Africa_cropped_Shutterstock.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/4C7795BD24A0496B8198DF75F06559AF/Water_Africa_cropped_Shutterstock.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/4C7795BD24A0496B8198DF75F06559AF/Water_Africa_cropped_Shutterstock.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/4C7795BD24A0496B8198DF75F06559AF/Water_Africa_cropped_Shutterstock.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedhome/news/latest-research-newsgeography/news_feedNoColour/templatedata/site/staff-profile/data/geography/js1c15.xml<p>Partners on the University of Southampton led project are:<br /><br />University of Malawi<br />University of Nairobi<br /> University of Ghana<br /> Kenyatta University, Kenya<br />Technical University of Kenya<br />Masinde Muliro University of Science and Technology, Kenya<br />UNESCO International Hydrology Programme<br />International Institute for Environment and Development<br /> AGRHYMET Regional Center, West-Africa<br /> WaterNet/SADC&nbsp;</p>University to open Public Lecture Series by focusing on sustainable citiesLightThe University of Southampton will open its Public Lecture Series for 2017 on Wednesday, 19 July, with a session titled Sustainable Cities: challenges, trade-offs and innovative approaches.<p>The world&rsquo;s population has tripled in the last 70 years. Most of the global population and capital goods are now concentrated in urban areas. Cities have become central to social development and economic prosperity. Globalisation, urbanisation and climate change are interacting in a way that is unprecedented, placing conflicting pressures on our natural environment and our urban service delivery systems. This presents an urgent challenge to politicians, planners, architects, scientists and engineers alike &ndash; how do we create resilient, sustainable cities?<br /><br />In this session, our experts will explore and discuss the challenges, trade-offs and innovative approaches we are using to make urban systems more environmentally sustainable. We will discuss how we can create an enduring way of life across the four domains of ecology, economics, politics and culture. We will discuss how cities may develop to allow people to feed and accommodate themselves, power themselves with renewable sources of energy, and provide efficient, mass transit systems. We will discuss how we may protect such cities against sea level rise, flooding, natural and man-made disasters, heatwaves and the spread of disease. And we will discuss how we can ensure that these gains are socially inclusive, resilient, and that they are achieved in an environmentally sustainable manner.<br /><br /><strong>Keynote speakers</strong><br /><br /><strong>Professor William Powrie</strong><br />William Powrie is Professor of Geotechnical Engineering and Dean of the Faculty of Engineering and the Environment at the University of Southampton. &nbsp;His main technical areas of expertise are in geotechnical aspects of transport infrastructure, and sustainable waste and resource management. He was elected Fellow of the Royal Academy of Engineering (2009) in recognition of his work in these areas.<br /><br /><strong>Jane Wernick CBE</strong><br /> Jane Wernick CBE FREng Hon FRIBA FIStructE FICE is a University of Southampton alumna and director of engineersHRW, incorporating Jane Wernick Associates.&nbsp; With Arup from 1973-1998, she started and ran their Los Angeles office from 1986-88.&nbsp; Her most notable Arup project was the Millennium Wheel.<br /><br />In 1998 she founded Jane Wernick Associates.&nbsp; Projects include the Young Vic Theatre; the treetop walkway at the Royal Botanic Gardens, Kew; the Living Architecture Houses; and many institutional, cultural and public realm projects. In 2015 Jane stepped back from running the business to concentrate on engineering and broader industry issues.&nbsp; Her practice was incorporated into engineersHRW, a firm with a similar ethos.<br /><br /><strong>Richard Bonner</strong><br /> Richard is the UK Cities Director for Arcadis, focussing on the issues that cities face in addressing their challenges with sustainable urban development.&nbsp; Areas of market focus include housing, mobility, city resiliency and asset productivity working with public and private sector clients and those in regulated industries, working with our global network of City Executives.&nbsp; Richard has worked in the natural and built asset sector since graduating as a Civil Engineer, and has held a number of senior leadership positions with Arcadis in the UK.<br /><br /><strong>Joining our Keynote Speakers for a Panel Discussion will be:<br /></strong><br /><strong>Professor Stephen Holgate</strong>, Medical Research Council Clinical Professor of Immunopharmacology and Honorary Consultant Physician within Medicine at the University of Southampton.<br /><br /><strong>Adam Read</strong>, Resource Efficiency and Waste Management Practice Director at Ricardo.<br /><br />The event runs from 4.30pm at the Institution of Engineering and Technology, Savoy Place, London WC2R OBL. If you are interested in attending, please email with your name and area of interest.</p> <p>The event will also be live-streamed from 5.15pm on our <a href="">website</a>. Register for a reminder <a href="">here</a>.</p> <p>&nbsp;</p> <p>&nbsp;</p> <p>&nbsp;</p> <p>&nbsp;</p>2017/07/11{11ACDE19-EB79-4AD8-8EF4-6510DDA65CE3}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/4030-Brain-on-background.jpgPublic events logoThe new Public Lecture Series begins on July 19./assets/imported/transforms/site/news-release/PageThumbnail/11ACDE19EB794AD88EF46510DDA65CE3/4030-Brain-on-background.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/11ACDE19EB794AD88EF46510DDA65CE3/4030-Brain-on-background.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/11ACDE19EB794AD88EF46510DDA65CE3/4030-Brain-on-background.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/11ACDE19EB794AD88EF46510DDA65CE3/4030-Brain-on-background.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/11ACDE19EB794AD88EF46510DDA65CE3/4030-Brain-on-background.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedExpert calls for global effort to combat threat of rising sea levelsLightA University of Southampton academic has called for a concerted global effort to combat the threat posed by sea level changes, ahead of a major international conference next week. <p>Robert Nicholls, Professor of Coastal Engineering, is an organiser and co-chair of the&nbsp;<a href="">Regional Sea Level Changes and Coastal Impacts</a> conference, taking place at Columbia University, New York, from July 10-14.</p> <p>The event will bring together more than 300 scientists, city planners, coastal zone developers and other stakeholders from 37 countries to discuss the consequences of climate change on sea level rise, which presents a major threat to coastal communities worldwide.<br /><br />The President of the United Nations General Assembly, Peter Thomson, and HRH Prince Albert II of Monaco will address the opening ceremony of the conference, which will see delegates brainstorm ways to strengthen climate change adaptation and disaster resilience.<br /><br />Speaking ahead of the conference, Professor Nicholls said: &ldquo;The very real risks posed to coastal communities by sea level rise are a global problem, and therefore require a global solution. Sea levels have been rising since the mid-20th century, and current projections suggest they could rise by a metre or more in the 21st century if greenhouse gas emissions continue unabated.<br /><br />&ldquo;With substantial and sustained reductions in greenhouse gas emissions these rises can be greatly reduced, but not entirely stopped &ndash; therefore it&rsquo;s essential that we consider the potential impact of sea level rise, and how our coastal communities can adapt to future conditions. If we fail to adapt to sea-level rise, the impacts are likely to be severe.&rdquo;<br /><br />Many of the world&rsquo;s biggest cities and economic hubs lie along coastlines and so are exposed to coastal flooding, storm surge and high tides, as are entire small island developing states.<br /><br />Causes of sea level change include thermal expansion of warming ocean water and the melting of glaciers and ice sheets, as well as geological factors.<br /><br />The aims of the conference are to: identify the key factors contributing to past, present and future regional sea level rise and its variability; reduce the uncertainty of these factors; and identify stakeholder needs for sea-level information for coastal planning and management purposes.</p> <p>&nbsp;</p>2017/07/07{8B2653DE-5BAC-4FEC-9A0F-90F662696B1D}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/2017 (private)/Ocean waves shutterstock_110095448.jpgPicture of stormy sea/assets/imported/transforms/site/news-release/PageThumbnail/8B2653DE5BAC4FEC9A0F90F662696B1D/Ocean waves shutterstock_110095448.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8B2653DE5BAC4FEC9A0F90F662696B1D/Ocean waves shutterstock_110095448.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8B2653DE5BAC4FEC9A0F90F662696B1D/Ocean waves shutterstock_110095448.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8B2653DE5BAC4FEC9A0F90F662696B1D/Ocean waves shutterstock_110095448.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/8B2653DE5BAC4FEC9A0F90F662696B1D/Ocean waves shutterstock_110095448.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedNoColour/templatedata/site/staff-profile/data/engineering/rjn.xmlNurse-led intervention helps carers’ manage medication and cancer painLightA study led by the University of Southampton shows the potential benefits of a new nurse-led intervention in supporting carers to manage pain medication in people with terminal cancer.<p>Researchers from the University of Southampton, Cardiff University and University of Leeds have developed a nurse-led intervention to help carers with medication management, and evaluated its use in routine practice.&nbsp;<br /><br />The Cancer Carers&rsquo; Medicines Management (CCMM) intervention addresses carers&rsquo; beliefs, knowledge and skills and promotes self-evaluation of competence. It centres on a structured conversational process between a nurse and carer.<br /><br />It is the first time that a study has attempted to integrate an intervention developed using input from carers and nurses into routine palliative care.<br /><br />The research, which was funded by Marie Curie and Dimbleby Cancer Care, showed that the CCMM intervention compared favourably with current practice as it offered a more systematic and comprehensive approach to supporting carer management of pain medicines.&nbsp;<br /><br />Researchers noted that nurses particularly valued the toolkit resource &ndash; which included information about opioids and simple charts for documenting pain and medication, because they were of immediate practical value to carers.<br /><br />The findings also identified some positive changes in medicines management, such as increased acceptance of the need for opiates, and behavioural changes, responding more readily to patients&rsquo; request for pain relief and improved systems in place for giving and recording medicines.<br /><br />Many people with advanced cancer experience persistent pain and are typically prescribed analgesics, including opioids. Carers often help patients to manage pain medicines, especially near the end of life, but often do not receive the support they need.</p>2017/07/07{2D4DC7D6-C0E5-4EAC-B62F-46C14841672B}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/2017 (private)/Nurse-led-intervention.jpgnurse-led careNurse-led intervention helps carers’ manage medication and cancer pain/assets/imported/transforms/site/news-release/PageThumbnail/2D4DC7D6C0E54EACB62F46C14841672B/Nurse-led-intervention.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/2D4DC7D6C0E54EACB62F46C14841672B/Nurse-led-intervention.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/site/news-release/PageThumbnail/2D4DC7D6C0E54EACB62F46C14841672B/Nurse-led-intervention.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/site/news-release/PageThumbnail/2D4DC7D6C0E54EACB62F46C14841672B/Nurse-led-intervention.jpg_SIA_JPG_fit_to_width_XL.jpg/assets/imported/transforms/site/news-release/PageThumbnail/2D4DC7D6C0E54EACB62F46C14841672B/Nurse-led-intervention.jpg_SIA_JPG_fit_to_width_INLINE.jpghome/news/home-news-feedNoColour{22BC110E-B9FC-415A-9BEE-8FBFAD2272D4}Communications & Marketing/Photos/COMMUNICATIONS & MARKETING PRIVATE/Mediacentre/2017 (private)/Sue-Latter-nurse-led-intervention.jpgrightProfessor Sue LatterProfessor Sue Latter/assets/imported/transforms/content-block/CB_RImg/22BC110EB9FC415A9BEE8FBFAD2272D4/Sue-Latter-nurse-led-intervention.jpg_SIA_JPG_fit_to_width_SMALL.jpg/assets/imported/transforms/content-block/CB_RImg/22BC110EB9FC415A9BEE8FBFAD2272D4/Sue-Latter-nurse-led-intervention.jpg_SIA_JPG_fit_to_width_MEDIUM.jpg/assets/imported/transforms/content-block/CB_RImg/22BC110EB9FC415A9BEE8FBFAD2272D4/Sue-Latter-nurse-led-intervention.jpg_SIA_JPG_fit_to_width_LARGE.jpg/assets/imported/transforms/content-block/CB_RImg/22BC110EB9FC415A9BEE8FBFAD2272D4/Sue-Latter-nurse-led-intervention.jpg_SIA_JPG_background_image.jpg/assets/imported/transforms/content-block/CB_RImg/22BC110EB9FC415A9BEE8FBFAD2272D4/Sue-Latter-nurse-led-intervention.jpg_SIA_JPG_fit_to_width_INLINE.jpg<p>Professor Sue Latter, the lead researcher from the University of Southampton, said:&nbsp; &ldquo;Despite the heavy burden placed on carers to help manage pain medication at home, there is a real lack of reliable research on effective methods of supporting carers with medicines management.&nbsp;<br /><br />&ldquo;Medication management requires knowledge and practical skill, and involves carers in monitoring and interpreting symptoms, as well as selecting, administering and evaluating the effectiveness of medicines.&nbsp; Often, carers will not have&nbsp;training for their role and will have preconceived views about pain and analgesics, particularly opioids.&rdquo;<br /><br />Professor Jane Hopkinson from Cardiff University, and co-author, said: &ldquo;Cancer Carers&rsquo; Medicines Management made clinical sense to nurses, who recognised the challenges faced by carers managing analgesics at the end of life and saw potential benefits in improving education and support.&rdquo;<br /><br />Most studies conclude that healthcare professionals need to provide carers with more information, training and continuing support.<br /><br />Dee Sissons, Director of Nursing at Marie Curie, said:&nbsp; &ldquo;The responsibility of taking on a caring role for someone who is terminally ill can be immensely rewarding, but also daunting.&nbsp; Family carers play a critical role in supporting people with a terminal illness so they can be cared for and die at home when this is their wish.&nbsp;<br /><br />This new study shows that nurses and carers can work together to better manage pain medication at home and enable carers to respond more readily to their loved ones request for pain relief with greater confidence.&rdquo;<br /><br />The nurses who participated in the study also provided feedback on how to use the intervention more widely in palliative care nursing practice.&nbsp; Their suggestions included: involving patients with other terminal illnesses, including other &lsquo;end of life care&rsquo; medication and introducing it earlier in the course of a patient&rsquo;s illness, which could increase benefits to carers.<br /><br />The study results have informed further NIHR funded research on nurses supporting self-management of medicines at the end of life.<br /><br />The research published in <em>Palliative Medicine</em> was funded by the Dimbleby Marie Curie Research Fund.</p> <p>&nbsp;</p>/templatedata/site/staff-profile/data/healthsciences/sml.xml
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