Research project

Dr Tilman Sanchez-Elsner: MicroRNAs and their epigenetic regulation as key factors in airway macrophage dysfunction in asthma

Lead researcher:

Professor Tilman Sanchez-Elsner
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researcher

Professor Tilman Sanchez-Elsner

Professor of Molecular Medicine

Connect with Tilman

Email: T.Sanchez-Elsner@soton.ac.uk

Research outputs

Small RNA species and microRNA profiles are altered in severe asthma nanovesicles from broncho alveolar lavage and associate with impaired lung function and inflammation

Ana Soraia Francisco Garcia, Eva Garrido Martin, Hitasha Rupani, Laurie Lau, Rocio T Martinez-nunez, Peter Howarth & Tilman Sanchez-Elsner, 2019, Noncoding RNA, 54(1)

DOI: 10.3390/ncrna5040051

Type: article

Genome-wide posttranscriptional dysregulation by microRNAs in human asthma as revealed by Frac-seq.

Rocio, Teresa Martinez-Nunez, Hitasha Rupani, Manuela Platé, Mahesan Niranjan, Rachel C. Chambers, Peter H. Howarth & Tilman Sanchez-Elsner, 2018, The Journal of Immunology, 201(1), 251-263

DOI: 10.4049/jimmunol.1701798

Type: article

MicroRNA-31 and MicroRNA-155 are overexpressed in ulcerative colitis and regulate IL-13 signaling by targeting interleukin 13 receptor -1

Markus Gwiggner, Rocio T. Martinez-Nunez, Simon R. Whiteoak, Victor P. Bondanese, Andrew Claridge, Jane E. Collins, J.R. Fraser Cummings & Tilman Sanchez-Elsner, 2018, Genes, 9(2)

DOI: 10.3390/genes9020085

Type: article

Modulation of nonsense mediated decay by rapamycin

Rocio Martinez-Nunez, Andrew Wallace, Doyle Coyne, Linnea Jansson, Miles Rush, Hanane Ennajdaoui, Sol Katzman, Joanne Louise Bailey, Katrin Deinhardt, Tilman Sanchez-Elsner & Jeremy R. Sanford, 2016, Nucleic Acids Research, 45(6), 3448-3459

DOI: 10.1093/nar/gkw1109

Type: article

Toll-like receptor 7 is reduced in severe asthma and linked to altered microRNA profile

Hitasha Rupani, Rocio Teresa Martinez-Nunez, Patrick Dennison, Laurie Lau, Nivenka Jayasekera, Tom Havelock, Ana Francisco-Garcia, Chris Grainge, Peter Howarth & Tilman Sanchez-Elsner, 2016, American Journal of Respiratory and Critical Care Medicine, 194(1), 26-37

DOI: 10.1164/rccm.201502-0280OC

Type: article