Medicine

Diana Eccles

MB ChB, MD, FRCP

Primary position:
Professor of Cancer Genetics
Other positions:
Director of the University of Southampton Clinical Trials Unit

Background

The University of Southampton

Professor Eccles has been Chair of Cancer Genetics since 2004. She graduated from Manchester University on 1983 and has trained in Manchester, Edinburgh and Southampton. After training in general medicine, then specialist training in adult oncology she worked on the molecular genetics of ovarian cancer in the MRC Human Genetics Unit in Edinburgh to gain her MD in 1992. She then moved to Southampton to a research post in Genetic Epidemiology simultaneously training in Clinical Genetics and when appointed to a consultant post in Southampton in 1995 she set up one of the first NHS funded Cancer Genetics Services in the UK within the Wessex Clinical Genetics Service.

Professor Eccles is the Chief Investigator for a large national cohort study (the Prospective study of Outcomes in Sporadic versus Hereditary breast cancer. This study has recruited over 3000 women with breast cancer diagnosed before 41 years of age and provides material for studies investigating the role of inherited genetic mutation in breast cancer risk and prognosis. She is PI for a number of other clinical studies that broadly aim to improve diagnosis or management of genetic predisposition to cancer and incorporates cancer prevention studies.

In addition to research and teaching, Professor Eccles is the Director of the University of Southampton Clinical Trials Unit which is supported by Cancer Research UK and NIHR core grants to design and run large multicenter practice changing clinical trials, particularly studies to improve drug treatments. She continues to work as an NHS consultant in clinical cancer genetics which encompasses diagnosis and management of many different genetic conditions that predispose to tumour development in families.

Qualifications

MB ChB, Medicine and Surgery, Manchester University (1983)
MRCP, Royal College of Physicians Edinburgh (1986)
MD, Molecular Genetics of Ovarian Cancer, Manchester University (1992)

Appointments held

Lecturer in Medical Oncology 1986-1989

Clinical Research Fellow in MRC Human Genetics Unit Edinburgh 1989-1992

Clinical Research Fellow in Cancer Genetics Epidemiology Research Group and Honorary Senior Registrar in Clinical Genetics, Southampton 1992-1994

Consultant in Clinical Genetics (Cancer specialization) and Honorary Senior Lecturer in Cancer Genetics, Southampton 1995-2004

Professor of Cancer Genetics and Honorary Consultant in Clinical Genetics, Southampton 2004-present

Director of University of Southampton Clinical Trials Unit December 2009-present

Professor Diana Eccles's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Copson, E., Maishman, T., Gerty, S., Eccles, B., Stanton, L., Cutress, R .I., Altman, D.G., Durcan, L., Simmonds, P., Jones, L., Tapper, W. and Eccles, Diana (2013) Ethnicity and outcome of young breast cancer patients in the United Kingdom: the POSH study. British Journal of Cancer, 1-12. (doi:10.1038/bjc.2013.650).
Eccles, Suzanne A., Aboagye, Eric O., Ali, Simak, Anderson, Annie S., Armes, Jo, Berditchevski, Fedor, Blaydes, Jeremy P., Brennan, Keith, Brown, Nicola J., Bryant, Helen E., Bundred, Nigel J., Burchell, Joy M., Campbell, Anna M., Carroll, Jason S., Clarke, Robert B., Coles, Charlotte E., Cook, Gary J.R., Cox, Angela, Curtin, Nicola J., Dekker, Lodewijk V., dos Santos Silva, Isabel, Duffy, Stephen W., Easton, Douglas F., Eccles, Diana M., Edwards, Dylan R., Edwards, Joanne, Evans, D. Gareth, Fenlon, Deborah F., Flanagan, James M., Foster, Claire, Gallagher, William M., Garcia-Closas, Montserrat, Gee, Julia M.W., Gescher, Andy J., Goh, Vicky, Groves, Ashley M., Harvey, Amanda J., Harvie, Michelle, Hennessy, Bryan T., Hiscox, Stephen, Holen, Ingunn, Howell, Sacha J., Howell, Anthony, Hubbard, Gill, Hulbert-Williams, Nick, Hunter, Myra S., Jasani, Bharat, Jones, Louise J., Key, Timothy J., Kirwan, Cliona C., Kong, Anthony, Kunkler, Ian H., Langdon, Simon P., Leach, Martin O., Mann, David J., Marshall, John F., Martin, Lesley Ann, Martin, Stewart G., Macdougall, Jennifer E., Miles, David W., Miller, William R., Morris, Joanna R., Moss, Sue M., Mullan, Paul, Natrajan, Rachel, O’Connor, James P.B., O’Connor, Rosemary, Palmieri, Carlo, Pharoah, Paul D.P., Rakha, Emad A., Reed, Elizabeth, Robinson, Simon P., Sahai, Erik, Saxton, John M., Schmid, Peter, Smalley, Matthew J., Speirs, Valerie, Stein, Robert, Stingl, John, Streuli, Charles H., Tutt, Andrew N. J., Velikova, Galina, Walker, Rosemary A., Watson, Christine J., Williams, Kaye J., Young, Leonie S. and Thompson, Alastair M. (2013) Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research, 15, (5) (doi:10.1186/bcr3493).
Upstill-Goddard, R., Eccles, Diana, Ennis, Sarah, Rafiq, Sajjad, Tapper, William, Fliege, Jörg and Collins, Andrew (2013) Support vector machine classifier for estrogen receptor positive and negative early-onset breast cancer. PLoS ONE, 8, (7), e68606. (doi:10.1371/journal.pone.0068606).
Copson, Ellen, Eccles, Bryony, Maishman, Tom, Gerty, Sue, Stanton, L., Cutress, Ramsey I., Altman, Douglas G., Durcan, Lorraine, Simmonds, Peter, Lawrence, Gill, Jones, Louise, Bliss, Judith and Eccles, Diana (2013) Prospective Observational Study of Breast Cancer Treatment Outcomes for UK Women Aged 18–40 Years at Diagnosis: The POSH Study. JNCI Journal of the National Cancer Institute, 105, (13), 978-988. (doi:10.1093/jnci/djt134). (PMID:23723422).
Recio, Alejandra, Gerty, Sue, Foster, Claire, Cutress, R.I. and Eccles, Diana (2013) Information required for surgical decision making in young women with breast cancer. European Journal of Surgical Oncology (EJSO), 39, (5), 498. (doi:10.1016/j.ejso.2013.01.168).
Mavaddat, N., Peock, S., Frost, D., Ellis, S., Platte, R., Fineberg, E., Evans, D.G., Izatt, L., Eeles, R.A., Adlard, J., Davidson, R., Eccles, D., Cole, T., Cook, J., Brewer, C., Tischkowitz, M., Douglas, F., Hodgson, S., Walker, L., Porteous, M.E., Morrison, P.J., Side, L.E., Kennedy, M.J., Houghton, C., Donaldson, A., Rogers, M.T., Dorkins, H., Miedzybrodzka, Z., Gregory, H., Eason, J., Barwell, J., McCann, E., Murray, A., Antoniou, A.C. and Easton, D.F. (2013) Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE. JNCI Journal of the National Cancer Institute (doi:10.1093/jnci/djt095).
Garcia-Closas, Montserrat, Couch, Fergus J., Lindstrom, Sara, Michailidou, Kyriaki, Schmidt, Marjanka K., Brook, Mark N., Orr, Nick, Rhie, Suhn Kyong, Riboli, Elio, Feigelson, Heather S., Le Marchand, Loic, Buring, Julie E., Eccles, Diana, Miron, Penelope, Fasching, Peter A., Brauch, Hiltrud, Chang-Claude, Jenny, Carpenter, Jane, Godwin, Andrew K., Nevanlinna, Heli, Giles, Graham G., Cox, Angela, Hopper, John L., Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Dicks, Ed, Howat, Will J., Schoof, Nils, Bojesen, Stig E., Lambrechts, Diether, Broeks, Annegien, Andrulis, Irene L., Guénel, Pascal, Burwinkel, Barbara, Sawyer, Elinor J., Hollestelle, Antoinette, Fletcher, Olivia, Winqvist, Robert, Brenner, Hermann, Mannermaa, Arto, Hamann, Ute, Meindl, Alfons, Lindblom, Annika, Zheng, Wei, Devillee, Peter, Goldberg, Mark S., Lubinski, Jan, Kristensen, Vessela, Swerdlow, Anthony, Anton-Culver, Hoda, Dörk, Thilo, Muir, Kenneth, Matsuo, Keitaro, Wu, Anna H., Radice, Paolo, Teo, Soo Hwang, Shu, Xiao-Ou, Blot, William, Kang, Daehee, Hartman, Mikael, Sangrajrang, Suleeporn, Shen, Chen-Yang, Southey, Melissa C., Park, Daniel J., Hammet, Fleur, Stone, Jennifer, Veer, Laura J. Van't, Rutgers, Emiel J., Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Peto, Julian, Schrauder, Michael G., Ekici, Arif B., Beckmann, Matthias W., dos Santos Silva, Isabel, Johnson, Nichola, Warren, Helen, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Marme, Federick, Schneeweiss, Andreas, Sohn, Christof, Truong, Therese, Laurent-Puig, Pierre, Kerbrat, Pierre, Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Milne, Roger L., Perez, Jose Ignacio Arias, Menéndez, Primitiva, Müller, Heiko, Arndt, Volker, Stegmaier, Christa, Lichtner, Peter, Lochmann, Magdalena, Justenhoven, Christina, Ko, Yon-Dschun, Muranen, Taru A., Aittomäki, Kristiina, Blomqvist, Carl, Greco, Dario, Heikkinen, Tuomas, Ito, Hidemi, Iwata, Hiroji, Yatabe, Yasushi, Antonenkova, Natalia N., Margolin, Sara, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Balleine, Rosemary, Tseng, Chiu-Chen, Berg, David Van Den, Stram, Daniel O., Neven, Patrick, Dieudonné, Anne-Sophie, Leunen, Karin, Rudolph, Anja, Nickels, Stefan, Flesch-Janys, Dieter, Peterlongo, Paolo, Peissel, Bernard, Bernard, Loris, Olson, Janet E., Wang, Xianshu, Stevens, Kristen, Severi, Gianluca, Baglietto, Laura, McLean, Catriona, Coetzee, Gerhard A., Feng, Ye, Henderson, Brian E., Schumacher, Fredrick, Bogdanova, Natalia V., Labrèche, France, Dumont, Martine, Yip, Cheng Har, Taib, Nur Aishah Mohd, Cheng, Ching-Yu, Shrubsole, Martha, Long, Jirong, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Knight, Julia A., Glendon, Gord, Mulligan, Anna Marie, Tollenaar, Robertus A. E. M., Seynaeve, Caroline M., Kriege, Mieke, Hooning, Maartje J., van den Ouweland, Ans M. W., van Deurzen, Carolien H. M., Lu, Wei, Gao, Yu-Tang, Cai, Hui, Balasubramanian, Sabapathy P., Cross, Simon S., Reed, Malcolm W. R., Signorello, Lisa, Cai, Qiuyin, Shah, Mitul, Miao, Hui, Chan, Ching Wan, Chia, Kee Seng, Jakubowska, Anna, Jaworska, Katarzyna, Durda, Katarzyna, Hsiung, Chia-Ni, Wu, Pei-Ei, Yu, Jyh-Cherng, Ashworth, Alan, Jones, Michael, Tessier, Daniel C., González-Neira, Anna, Pita, Guillermo, Alonso, M. Rosario, Vincent, Daniel, Bacot, Francois, Ambrosone, Christine B., Bandera, Elisa V., John, Esther M., Chen, Gary K., Hu, Jennifer J., Rodriguez-Gil, Jorge L., Bernstein, Leslie, Press, Michael F., Ziegler, Regina G., Millikan, Robert M., Deming-Halverson, Sandra L., Nyante, Sarah, Ingles, Sue A., Waisfisz, Quinten, Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel, Bui, Minh, Gibson, Lorna, Müller-Myhsok, Bertram, Schmutzler, Rita K., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Czene, Kamila, Irwanto, Astrid, Liu, Jianjun, Turnbull, Clare, Rahman, Nazneen, Meijers-Heijboer, Hanne, Uitterlinden, Andre G., Rivadeneira, Fernando, Olswold, Curtis, Slager, Susan, Pilarski, Robert, Ademuyiwa, Foluso, Konstantopoulou, Irene, Martin, Nicholas G., Montgomery, Grant W., Slamon, Dennis J., Rauh, Claudia, Lux, Michael P., Jud, Sebastian M., Bruning, Thomas, Weaver, JoEllen, Sharma, Priyanka, Pathak, Harsh, Tapper, Will, Gerty, Sue, Durcan, Lorraine, Trichopoulos, Dimitrios, Tumino, Rosario, Peeters, Petra H., Kaaks, Rudolf, Campa, Daniele, Canzian, Federico, Weiderpass, Elisabete, Johansson, Mattias, Khaw, Kay-Tee, Travis, Ruth, Clavel-Chapelon, Françoise, Kolonel, Laurence N., Chen, Constance, Beck, Andy, Hankinson, Susan E., Berg, Christine D., Hoover, Robert N., Lissowska, Jolanta, Figueroa, Jonine D., Chasman, Daniel I., Gaudet, Mia M., Diver, W. Ryan, Willett, Walter C., Hunter, David J., Simard, Jacques, Benitez, Javier, Dunning, Alison M., Sherman, Mark E., Chenevix-Trench, Georgia, Chanock, Stephen J., Hall, Per, Pharoah, Paul D. P., Vachon, Celine, Easton, Douglas F., Haiman, Christopher A. and Kraft, Peter (2013) Genome-wide association studies identify four ER negative–specific breast cancer risk loci. Nature Genetics, 45, (4), 392-398. (doi:10.1038/ng.2561). (PMID:23535733).
Permuth-Wey, Jennifer, Lawrenson, Kate, Shen, Howard C., Velkova, Aneliya, Tyrer, Jonathan P., Chen, Zhihua, Lin, Hui-Yi, Ann Chen, Y., Tsai, Ya-Yu, Qu, Xiaotao, Ramus, Susan J., Karevan, Rod, Lee, Janet, Lee, Nathan, Larson, Melissa C., Aben, Katja K., Anton-Culver, Hoda, Antonenkova, Natalia, Antoniou, Antonis C., Armasu, Sebastian M., Bacot, François, Baglietto, Laura, Bandera, Elisa V., Barnholtz-Sloan, Jill, Beckmann, Matthias W., Birrer, Michael J., Bloom, Greg, Bogdanova, Natalia, Brinton, Louise A., Brooks-Wilson, Angela, Brown, Robert, Butzow, Ralf, Cai, Qiuyin, Campbell, Ian, Chang-Claude, Jenny, Chanock, Stephen, Chenevix-Trench, Georgia, Cheng, Jin Q., Cicek, Mine S., Coetzee, Gerhard A., Cook, Linda S., Couch, Fergus J., Cramer, Daniel W., Cunningham, Julie M., Dansonka-Mieszkowska, Agnieszka, Despierre, Evelyn, Doherty, Jennifer A., Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Easton, Douglas F., Eccles, Diana, Edwards, Robert, Ekici, Arif B., Fasching, Peter A., Fenstermacher, David A., Flanagan, James M., Garcia-Closas, Montserrat, Gentry-Maharaj, Aleksandra, Giles, Graham G., Glasspool, Rosalind M., Gonzalez-Bosquet, Jesus, Goodman, Marc T., Gore, Martin, Górski, Bohdan, Gronwald, Jacek, Hall, Per, Halle, Mari K., Harter, Philipp, Heitz, Florian, Hillemanns, Peter, Hoatlin, Maureen, Høgdall, Claus K., Høgdall, Estrid, Hosono, Satoyo, Jakubowska, Anna, Jensen, Allan, Jim, Heather, Kalli, Kimberly R., Karlan, Beth Y., Kaye, Stanley B., Kelemen, Linda E., Kiemeney, Lambertus A., Kikkawa, Fumitaka, Konecny, Gottfried E., Krakstad, Camilla, Krüger Kjaer, Susanne, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Lancaster, Johnathan M., Le, Nhu D., Leminen, Arto, Levine, Douglas A., Liang, Dong, Kiong Lim, Boon, Lin, Jie, Lissowska, Jolanta, Lu, Karen H., Lubiński, Jan, Lurie, Galina, Massuger, Leon F.A.G, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R., Menon, Usha, Modugno, Francesmary, Moysich, Kirsten B., Nakanishi, Toru, Narod, Steven A., Nedergaard, Lotte, Ness, Roberta B., Nevanlinna, Heli, Nickels, Stefan, Noushmehr, Houtan, Odunsi, Kunle, Olson, Sara H., Orlow, Irene, Paul, James, Pearce, Celeste L., Pejovic, Tanja, Pelttari, Liisa M., Pike, Malcolm C., Poole, Elizabeth M., Raska, Paola, Renner, Stefan P., Risch, Harvey A., Rodriguez-Rodriguez, Lorna, Anne Rossing, Mary, Rudolph, Anja, Runnebaum, Ingo B., Rzepecka, Iwona K., Salvesen, Helga B., Schwaab, Ira, Severi, Gianluca, Shridhar, Viji, Shu, Xiao-Ou, Shvetsov, Yurii B., Sieh, Weiva, Song, Honglin, Southey, Melissa C., Spiewankiewicz, Beata, Stram, Daniel, Sutphen, Rebecca, Teo, Soo-Hwang, Terry, Kathryn L., Tessier, Daniel C., Thompson, Pamela J., Tworoger, Shelley S., van Altena, Anne M., Vergote, Ignace, Vierkant, Robert A., Vincent, Daniel, Vitonis, Allison F., Wang-Gohrke, Shan, Palmieri Weber, Rachel, Wentzensen, Nicolas, Whittemore, Alice S., Wik, Elisabeth, Wilkens, Lynne R., Winterhoff, Boris, Ling Woo, Yin, Wu, Anna H., Xiang, Yong-Bing, Yang, Hannah P., Zheng, Wei, Ziogas, Argyrios, Zulkifli, Famida, Phelan, Catherine M., Iversen, Edwin, Schildkraut, Joellen M., Berchuck, Andrew, Fridley, Brooke L., Goode, Ellen L., Pharoah, Paul D.P., Monteiro, Alvaro N.A., Sellers, Thomas A. and Gayther, Simon A. (2013) Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nature Communications, 4, 1627. (doi:10.1038/ncomms2613).
Rafiq, Sajjad, Tapper, William, Collins, Andrew, Khan, Sofia, Politopoulos, Ionnis, Gerty, Sue, Blomqvist, Carl, Couch, Fergus J., Nevanlinna, Heli, Liu, Jianjun and Eccles, Diana (2013) Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Cancer Research, 73, (6), 1883-1891. (doi:10.1158/0008-5472.CAN-12-3377). (PMID:23319801).
Smith, Miriam J., O'Sullivan, James, Bhaskar, Sanjeev S., Hadfield, Kristen D., Poke, Gemma, Caird, John, Sharif, Saba, Eccles, Diana, Fitzpatrick, David, Rawluk, Daniel, du Plessis, Daniel, Newman, William G. and Evans, D. Gareth (2013) Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas. Nature Genetics, 45, (3), 295-298. (doi:10.1038/ng.2552). (PMID:23377182).
Dent, T., Jbilou, J., Rafi, I., Segnan, N., Törnberg, S., Chowdhury, S., Hall, A., Lyratzopoulos, G., Eeles, R., Eccles, D., Hallowell, N., Pashayan, N., Pharoah, P. and Burton, H. (2013) Stratified cancer screening: the practicalities of implementation. Public Health Genomics (doi:10.1159/000345941). (PMID:23363703).
Ellis, Nathan A., Thompson, Ella R., Rowley, Simone M., Sawyer, Sarah, kConFab, , Eccles, Diana M., Trainer, Alison H., Mitchell, Gillian, James, Paul A. and Campbell, Ian G. (2013) Analysis of RAD51D in ovarian cancer patients and families with a history of ovarian or breast cancer. PLoS ONE, 8, (1), e54772. (doi:10.1371/journal.pone.0054772).
Ruark, Elise, Snape, Katie, Humburg, Peter, Loveday, Chey, Bajrami, Ilirjana, Brough, Rachel, Rodrigues, Daniel Nava, Renwick, Anthony, Seal, Sheila, Ramsay, Emma, Duarte, Silvana Del Vecchio, Rivas, Manuel A., Warren-Perry, Margaret, Zachariou, Anna, Campion-Flora, Adriana, Hanks, Sandra, Murray, Anne, Pour, Naser Ansari, Douglas, Jenny, Gregory, Lorna, Rimmer, Andrew, Walker, Neil M., Yang, Tsun-Po, Adlard, Julian W., Barwell, Julian, Berg, Jonathan, Brady, Angela F., Brewer, Carole, Brice, Glen, Chapman, Cyril, Cook, Jackie, Davidson, Rosemarie, Donaldson, Alan, Douglas, Fiona, Eccles, Diana, Evans, D. Gareth, Greenhalgh, Lynn, Henderson, Alex, Izatt, Louise, Kumar, Ajith, Lalloo, Fiona, Miedzybrodzka, Zosia, Morrison, Patrick J., Paterson, Joan, Porteous, Mary, Rogers, Mark T., Shanley, Susan, Walker, Lisa, Gore, Martin, Houlston, Richard, Brown, Matthew A., Caufield, Mark J., Deloukas, Panagiotis, McCarthy, Mark I., Todd, John A., Turnbull, Clare, Reis-Filho, Jorge S., Ashworth, Alan, Antoniou, Antonis C., Lord, Christopher J., Donnelly, Peter and Rahman, Nazneen The Breast and Ovarian Cancer Susceptibility Collaboration and Wellcome Trust Case Control Consortium (2013) Letter. Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature, 493, (7432), 406-410. (doi:10.1038/nature11725). (PMID:23242139).
Rosenthal, Adam N., Fraser, Lindsay, Manchanda, Ranjit, Badman, Philip, Philpott, Susan, Mozersky, Jessica, Hadwin, Richard, Cafferty, Fay H., Benjamin, Elizabeth, Singh, Naveena, Evans, D. Gareth, Eccles, Diana M., Skates, Steven J., Mackay, James, Menon, Usha and Jacobs, Ian J. (2013) Results of annual screening in phase I of the United Kingdom familial ovarian cancer screening study highlight the need for strict adherence to screening schedule. Journal of Clinical Oncology, 31, (1), 49-57. (doi:10.1200/JCO.2011.39.7638). (PMID:23213100).
Moore, K., Thomas, G., Duffy, S., Warwick, J., Gabe, R., Chou, P., Ellis, I., Green, A., Haider, S., Brouilette, K., Saha, A., Vallath, S., Bowen, R., Chelala, C., Eccles, D., Tapper, W., Thompson, A., Quinlan, P., Jordan, L., Gillett, C., Brentall, A., Violette, S., Weinreb, P., Kendrew, J., Barry , S., Hart, I., Jones, L. and Marshall, J. (2013) Therapeutic targeting of integrin αvβ6 in breast cancer. Journal of the National Cancer Institute (In Press).
Siddiq, A., Couch, F.J., Chen, G.K., Lindstrom, S., Eccles, D., Millikan, R.C., Michailidou, K., Stram, D.O., Beckmann, L., Rhie, S.K., Ambrosone, C.B., Aittomaki, K., Amiano, P., Apicella, C., Baglietto, L., Bandera, E.V., Beckmann, M.W., Berg, C.D., Bernstein, L., Blomqvist, C., Brauch, H., Brinton, L., Bui, Q.M., Buring, J.E., Buys, S.S., Campa, D., Carpenter, J.E., Chasman, D.I., Chang-Claude, J., Chen, C., Clavel-Chapelon, F., Cox, A., Cross, S.S., Czene, K., Deming, S.L., Diasio, R.B., Diver, W.R., Dunning, A.M., Durcan, L., Ekici, A.B., Fasching, P.A., Feigelson, H.S., Fejerman, L., Figueroa, J.D., Fletcher, O., Flesch-Janys, D., Gaudet, M.M., Gerty, S.M., Rodriguez-Gil, J.L., Giles, G.G., van Gils, C.H., Godwin, A.K., Graham, N., Greco, D., Hall, P., Hankinson, S.E., Hartmann, A., Hein, R., Heinz, J., Hoover, R.N., Hopper, J.L., Hu, J.J., Huntsman, S., Ingles, S.A., Irwanto, A., Isaacs, C., Jacobs, K.B., John, E.M., Justenhoven, C., Kaaks, R., Kolonel, L.N., Coetzee, G.A., Lathrop, M., Le Marchand, L., Lee, A.M., Lee, I.-M., Lesnick, T., Lichtner, P., Liu, J., Lund, E., Makalic, E., Martin, N.G., McLean, C.A., Meijers-Heijboer, H., Meindl, A., Miron, P., Monroe, K.R., Montgomery, G.W., Muller-Myhsok, B., Nickels, S., Nyante, S.J., Olswold, C., Overvad, K., Palli, D., Park, D.J., Palmer, J.R., Pathak, H., Peto, J., Pharoah, P., Rahman, N., Rivadeneira, F., Schmidt, D.F., Schmutzler, R.K., Slager, S., Southey, M.C., Stevens, K.N., Sinn, H.-P., Press, M.F., Ross, E., Riboli, E., Ridker, P.M., Schumacher, F.R., Severi, G., dos Santos Silva, I., Stone, J., Sund, M., Tapper, W.J., Thun, M.J., Travis, R.C., Turnbull, C., Uitterlinden, A.G., Waisfisz, Q., Wang, X., Wang, Z., Weaver, J., Schulz-Wendtland, R., Wilkens, L.R., Van Den Berg, D., Zheng, W., Ziegler, R.G., Ziv, E., Nevanlinna, H., Easton, D.F., Hunter, D.J., Henderson, B.E., Chanock, S.J., Garcia-Closas, M., Kraft, P., Haiman, C.A. and Vachon, C.M. (2012) A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Human Molecular Genetics, 21, (24), 5373-5384. (doi:10.1093/hmg/dds381). (PMID:22976474).
Mathers, John C., Movahedi, Mohammad, Macrae, Finlay, Mecklin, Jukka-Pekka, Moeslein, Gabriela, Olschwang, Sylviane, Eccles, Diana, Evans, Gareth, Maher, Eamonn R, Bertario, Lucio, Bisgaard, Marie-Luise, Dunlop, Malcolm, Ho, Judy W.C., Hodgson, Shirley, Lindblom, Annika, Lubinski, Jan, Morrison, Patrick J., Murday, Victoria, Ramesar, Raj, Side, Lucy, Scott, Rodney J., Thomas, Huw J.W., Vasen, Hans, Gerdes, Anne-Marie, Barker, Gail, Crawford, Gillian, Elliott, Faye, Pylvanainen, Kirsi, Wijnen, Juul, Fodde, Riccardo, Lynch, Henry, Bishop, D. Timothy and Burn, John CAPP2 Investigators (2012) Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. The Lancet Oncology, 13, (12), 1242-1249. (doi:10.1016/S1470-2045(12)70475-8). (PMID:23140761).
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Spurdle, A.B., Whiley, P.J., Thompson, B., Feng, B., Healey, S., Brown, M.A., Pettigrew, C., Van Asperen, C.J., Ausems, M.G.E.M., Kattentidt-Mouravieva, A.A., van den Ouweland, A.M.W., Belgium UV Consortium, D., Lindblom, A., Pigg, M.H., Schmutzler, R.K., Engel, C., Meindl, A., Caputo, S., Sinilnikova, O.M., Lidereau, R., Couch, F.J., Guidugli, L., Hansen, T.v.O., Thomassen, M., Eccles, D.M., Tucker, K., Benitez, J., Domchek, S.M., Toland, A.E., Van Rensburg, E.J., Wappenschmidt, B., Borg, A., Vreeswijk, M.P.G. and Goldgar, D.E. (2012) BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk. Journal of Medical Genetics, 49, (8), 525-532. (doi:10.1136/jmedgenet-2012-101037). (PMID:22889855).
Thompson, Ella R., Gorringe, Kylie L., Choong, David Y.H., Eccles, Diana M., Mitchell, Gillian and Campbell, Ian G. (2012) Analysis of KLLN as a high-penetrance breast cancer predisposition gene. Breast Cancer Research and Treatment, 134, (2), 543-547. (doi:10.1007/s10549-012-2088-3).
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Maia, Ana-Teresa, Antoniou, Antonis C, O'Reilly, Martin, Samarajiwa, Shamith, Dunning, Mark, Kartsonaki, Christiana, Chin, Suet-Feung, Curtis, Christina N., McGuffog, Lesley, Domchek, Susan M., Easton, Douglas F., Peock, Susan, Frost, Debra, Evans, D.G., Eeles, Ros, Izatt, Louise, Adlard, Julian, Eccles, Diana, Sinilnikova, Olga M., Mazoyer, Sylvie, Stoppa-Lyonnet, Dominique, Gauthier-Villars, Marion, Faivre, Laurence, Venat-Bouvet, Laurence, Delnatte, Capucine, Nevanlinna, Heli, Couch, Fergus J., Godwin, Andrew K., Caligo, Maria A., Barkardottir, Rosa B., Chen, Xiaoqing, Beesley, Jonathan, Healey, Sue, Caldas, Carlos, Chenevix-Trench, Georgia and Ponder, Bruce A.J. (2012) Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers. Breast Cancer Research, 14, (2), R63. (doi:10.1186/bcr3169). (PMID:22513257).
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Walker, Logan C., Fredericksen, Zachary S., Wang, Xianshu, Tarrell, Robert, Pankratz, Vernon S., Lindor, Noralane M., Beesley, Jonathan, Healey, Sue, Chen, Xiaoqing, Stoppa-Lyonnet, Dominique, Tirapo, Carole, Giraud, Sophie, Mazoyer, Sylvie, Muller, Daniele, Fricker, Jean-Pierre, Delnatte, Capucine, Schmutzler, Rita K., Wappenschmidt, Barbara, Engel, Christoph, Schonbuchner, Ines, Deissler, Helmut, Meindl, Alfons, Hogervorst, Frans B., Verheus, Martijn, Hooning, Maartje J., van den Ouweland, Ans M.W., Nelen, Marcel R., Ausems, Margreet G.E.M., Aalfs, Cora M., van Asperen, Christi J., Devilee, Peter, Gerrits, Monique M., Waisfisz, Quinten, Szabo, Csilla I., Easton, Douglas F., Peock, Susan, Cook, Margaret, Oliver, Clare T., Frost, Debra, Harrington, Patricia, Evans, D. Gareth, Lalloo, Fiona, Eeles, Ros, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Eccles, Diana, Ong, Kai-Ren, Cook, Jackie, Rebbeck, Tim, Nathanson, Katherine L., Domchek, Susan M., Singer, Christian F, Gschwantler-Kaulich, Daphne, Dressler, Anne-Catharina, Pfeiler, Georg, Godwin, Andrew K., Heikkinen, Tuomas, Nevanlinna, Heli, Agnarsson, Bjarni A., Caligo, Maria Adelaide, Olsson, Hakan, Kristoffersson, Ulf, Liljegren, Annelie, Arver, Brita, Karlsson, Per, Melin, Beatrice, Sinilnikova, Olga M., McGuffog, Lesley, Antoniou, Antonis C., Chenevix-Trench, Georgia, Spurdle, Amanda B. and Couch, Fergus J. GEMO Study Collaborators, kConFab, Hebon, ModSQuaD and Embrace (2010) Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Research, 12, (6), R102. (doi:10.1186/bcr2785). (PMID:21114847).
Turnbull, Clare, Hines, Sarah, Renwick, Anthony, Hughes, Deborah, Pernet, David, Elliott, Anna, Seal, Sheila, Warren-Perry, Margaret, Gareth Evans, D., Eccles, Diana, Stratton, Michael R. and Rahman, Nazneen (2010) Mutation and association analysis of GEN1 in breast cancer susceptibility. Breast Cancer Research and Treatment, 124, (1), 283-288. (doi:10.1007/s10549-010-0949-1). (PMID:20512659 ).
Wilson, J.R.F., Bateman, A.C. , Hanson, H., An, Q., Evans , G., Rahman, N., Jones, L.J. and Eccles, D.M. (2010) A novel HER2-positive breast cancer phenotype arising from germline TP53 mutations. Journal of Medical Genetics, 47, (11), 771-774. (doi:10.1136/jmg.2010.078113).
Antoniou, Antonis C., Wang, Xianshu, Fredericksen, Zachary S., McGuffog, Lesley, Tarrell, Robert, Sinilnikova, Olga M., Healey, Sue, Morrison, Jonathan, Kartsonaki, Christiana, Lesnick, Timothy, Ghoussaini, Maya, Barrowdale, Daniel, Peock, Susan, Cook, Margaret, Oliver, Clare, Frost, Debra, Eccles, Diana, Evans, D. Gareth, Eeles, Ros, Izatt, Louise, Chu, Carol, Douglas, Fiona, Paterson, Joan, Stoppa-Lyonnet, Dominique, Houdayer, Claude, Mazoyer, Sylvie, Giraud, Sophie, Lasset, Christine, Remenieras, Audrey, Caron, Olivier, Hardouin, Agnès, Berthet, Pascaline, Hogervorst, Frans B. L., Rookus, Matti A., Jager, Agnes, van den Ouweland, Ans, Hoogerbrugge, Nicoline, van der Luijt, Rob B., Meijers-Heijboer, Hanne, Gómez García, Encarna B., Devilee, Peter, Vreeswijk, Maaike P. G., Lubinski, Jan, Jakubowska, Anna, Gronwald, Jacek, Huzarski, Tomasz, Byrski, Tomasz, Górski, Bohdan, Cybulski, Cezary, Spurdle, Amanda B., Holland, Helene, Goldgar, David E., John, Esther M., Hopper, John L., Southey, Melissa, Buys, Saundra S., Daly, Mary B., Terry, Mary-Beth, Schmutzler, Rita K., Wappenschmidt, Barbara, Engel, Christoph, Meindl, Alfons, Preisler-Adams, Sabine, Arnold, Norbert, Niederacher, Dieter, Sutter, Christian, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy, Blum, Joanne L., Piedmonte, Marion, Rodriguez, Gustavo C., Wakeley, Katie, Boggess, John F., Basil, Jack, Blank, Stephanie V., Friedman, Eitan, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Kirchhoff, Tomas, Vijai, Joseph, Gaudet, Mia M., Altshuler, David, Guiducci, Candace, Loman, Niklas, Harbst, Katja, Rantala, Johanna, Ehrencrona, Hans, Gerdes, Anne-Marie, Thomassen, Mads, Sunde, Lone, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Viel, Alessandra, Radice, Paolo, Caldes, Trinidad, de la Hoya, Miguel, Singer, Christian F, Fink-Retter, Anneliese, Greene, Mark H., Mai, Phuong L., Loud, Jennifer T., Guidugli, Lucia, Lindor, Noralane M., Hansen, Thomas V. O., Nielsen, Finn C., Blanco, Ignacio, Lazaro, Conxi, Garber, Judy, Ramus, Susan J., Gayther, Simon A., Phelan, Catherine, Narod, Stephen, Szabo, Csilla I., Benitez, Javier, Osorio, Ana, Nevanlinna, Heli, Heikkinen, Tuomas, Caligo, Maria A., Beattie, Mary S., Hamann, Ute, Godwin, Andrew K., Montagna, Marco, Casella, Cinzia, Neuhausen, Susan L., Karlan, Beth Y., Tung, Nadine, Toland, Amanda E., Weitzel, Jeffrey, Olopade, Olofunmilayo, Simard, Jacques, Soucy, Penny, Rubinstein, Wendy S., Arason, Adalgeir, Rennert, Gad, Martin, Nicholas G., Montgomery, Grant W., Chang-Claude, Jenny, Flesch-Janys, Dieter, Brauch, Hiltrud, Severi, Gianluca, Baglietto, Laura, Cox, Angela, Cross, Simon S, Miron, Penelope, Gerty, Sue M., Tapper, William, Yannoukakos, Drakoulis, Fountzilas, George, Fasching, Peter A., Beckmann, Matthias W., dos Santos Silva, Isabel, Peto, Julian, Lambrechts, Diether, Paridaens, Robert, Rüdiger, Thomas, Försti, Asta, Winqvist, Robert, Pylkäs, Katri, Diasio, Robert B., Lee, Adam M., Eckel-Passow, Jeanette, Vachon, Celine, Blows, Fiona, Driver, Kristy, Dunning, Alison, Pharoah, Paul P. D., Offit, Kenneth, Pankratz, V Shane, Hakonarson, Hakon, Chenevix-Trench, Georgia, Easton, Douglas F. and Couch, Fergus J. (2010) A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population. Nature Genetics, 42, (10), 885-892. (doi:10.1038/ng.669).
Grindedal, Eli M., Renkonen-Sinisalo, Laura, Vasen, Hans, Evans, Gareth, Sala, Paola, Blanco, Ignacio, Gronwald, Jacek, Apold, Jaran, Eccles, Diana, Sanchez, Ángel Alonso, Sampson, Julian, Jarvinen, Heikki J., Bertario, Lucio, Crawford, Gillan C., Stormorken, Astrid T., Maehle, Lovise and Moller, Pal (2010) Survival in women with MMR mutations and ovarian cancer: a multicentre study in Lynch syndrome kindreds. Journal of Medical Genetics, 47, (2), 99-102. (doi:10.1136/jmg.2009.068130). (PMID:19635727).
Turnbull, Clare, Ahmed, Shahana, Morrison, Jonathan, Pernet, David, Renwick, Anthony, Maranian, Mel, Seal, Sheila, Ghoussaini, Maya, Hines, Sarah, Healey, Catherine S, Hughes, Deborah, Warren-Perry, Margaret, Tapper, William, Eccles, Diana, Evans, D Gareth, Hooning, Maartje, Schutte, Mieke, van den Ouweland, Ans, Houlston, Richard, Ross, Gillian, Langford, Cordelia, Pharoah, Paul D P, Stratton, Michael R, Dunning, Alison M, Rahman, Nazneen and Easton, Douglas F (2010) Genome-wide association study identifies five new breast cancer susceptibility loci. Nature Genetics, 42, (6), 504-507. (doi:10.1038/ng.586). (PMID:20453838).
Walker, Logan C., Whiley, Phillip J., Couch, Fergus J., Farrugia, Daniel J., Healey, Sue, Eccles, Diana, Lin, Feng, Butler, Samantha A., Goff, Sheila A., Thompson, Bryony A., Lakhani, Sunil R., Da Silva, Leonard M., Tavtigian, Sean V., Goldgar, David E., Brown, Melissa A. and Spurdle, Amanda B. (2010) Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity. Human Mutation, 31, (6), E1484-E1505. (doi:10.1002/humu.21267).
Craddock, Nick, Hurles, Matthew E., Cardin, Niall, Pearson, Richard D., Plagnol, Vincent, Robson, Samuel, Vukcevic, Damjan, Barnes, Chris, Conrad, Donald F., Giannoulatou, Eleni, Holmes, Chris, Marchini, Jonathan L., Stirrups, Kathy, Tobin, Martin D., Wain, Louise V., Yau, Chris, Aerts, Jan, Ahmad, Tariq, Daniel Andrews, T., Arbury, Hazel, Attwood, Anthony, Auton, Adam, Ball, Stephen G., Balmforth, Anthony J., Barrett, Jeffrey C., Barroso, Inês, Barton, Anne, Bennett, Amanda J., Bhaskar, Sanjeev, Blaszczyk, Katarzyna, Bowes, John, Brand, Oliver J., Braund, Peter S., Bredin, Francesca, Breen, Gerome, Brown, Morris J., Bruce, Ian N., Bull, Jaswinder, Burren, Oliver S., Burton, John, Byrnes, Jake, Caesar, Sian, Clee, Chris M., Coffey, Alison J., Connell, John M.C., Cooper, Jason D., Dominiczak, Anna F., Downes, Kate, Drummond, Hazel E., Dudakia, Darshna, Dunham, Andrew, Ebbs, Bernadette, Eccles, Diana, Edkins, Sarah, Edwards, Cathryn, Elliot, Anna, Emery, Paul, Evans, David M., Evans, Gareth, Eyre, Steve, Farmer, Anne, Nicol Ferrier, I., Feuk, Lars, Fitzgerald, Tomas, Flynn, Edward, Forbes, Alistair, Forty, Liz, Franklyn, Jayne A., Freathy, Rachel M., Gibbs, Polly, Gilbert, Paul, Gokumen, Omer, Gordon-Smith, Katherine, Gray, Emma, Green, Elaine, Groves, Chris J., Grozeva, Detelina, Gwilliam, Rhian, Hall, Anita, Hammond, Naomi, Hardy, Matt, Harrison, Pile, Hassanali, Neelam, Hebaishi, Husam, Hines, Sarah, Hinks, Anne, Hitman, Graham A., Hocking, Lynne, Howard, Eleanor, Howard, Philip, Howson, Joanna M.M., Hughes, Debbie, Hunt, Sarah, Isaacs, John D., Jain, Mahim, Jewell, Derek P., Johnson, Toby, Jolley, Jennifer D., Jones, Ian R., Jones, Lisa A., Kirov, George, Langford, Cordelia F., Lango-Allen, Hana, Mark Lathrop, G., Lee, James, Lee, Kate L., Lees, Charlie, Lewis, Kevin, Lindgren, Cecilia M., Maisuria-Armer, Meeta, Maller, Julian, Mansfield, John, Martin, Paul, Massey, Dunecan C.O., McArdle, Wendy L., McGuffin, Peter, McLay, Kirsten E., Mentzer, Alex, Mimmack, Michael L., Morgan, Ann E., Morris, Andrew P., Mowat, Craig, Myers, Simon, Newman, William, Nimmo, Elaine R., O’Donovan, Michael C., Onipinla, Abiodun, Onyiah, Ifejinelo, Ovington, Nigel R., Owen, Michael J., Palin, Kimmo, Parnell, Kirstie, Pernet, David, Perry, John R. B., Phillips, Anne, Pinto, Dalila, Prescott, Natalie J., Prokopenko, Inga, Quail, Michael A., Rafelt, Suzanne, Rayner, Nigel W., Redon, Richard, Reid, David M., Renwick, Anthony, Ring, Susan M., Robertson, Neil, Russell, Ellie, St Clair, David, Sambrook, Jennifer G., Sanderson, Jeremy D., Schuilenburg, Helen, Scott, Carol E., Scott, Richard, Seal, Sheila, Shaw-Hawkins, Sue, Shields, Beverley M., Simmonds, Matthew J., Smyth, Debbie J., Somaskantharajah, Elilan, Spanova, Katarina, Steer, Sophia, Stephens, Jonathan, Stevens, Helen E., Stone, Millicent A., Su, Zhan, Symmons, Deborah P.M., Thompson, John R., Thomson, Wendy, Travers, Mary E., Turnbull, Clare, Valsesia, Armand, Walker, Mark, Walker, Neil M., Wallace, Chris, Warren-Perry, Margaret, Watkins, Nicholas A., Webster, John, Weedon, Michael N., Wilson, Anthony G., Woodburn, Matthew, Wordsworth, B. Paul, Young, Allan H., Zeggini, Eleftheria, Carter, Nigel P., Frayling, Timothy M., Lee, Charles, McVean, Gil, Munroe, Patricia B., Palotie, Aarno, Sawcer, Stephen J., Scherer, Stephen W., Strachan, David P., Tyler-Smith, Chris, Brown, Matthew A., Burton, Paul R., Caulfield, Mark J., Compston, Alastair, Farrall, Martin, Gough, Stephen C.L., Hall, Alistair S., Hattersley, Andrew T., Hill, Adrian V.S., Mathew, Christopher G., Pembrey, Marcus, Satsangi, Jack, Stratton, Michael R., Worthington, Jane, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P., McCarthy, Mark I., Ouwehand, Willem H., Parkes, Miles, Rahman, Nazneen, Todd, John A., Samani, Nilesh J. and Donnelly, Peter The Wellcome Trust Case Control Consortium (2010) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature, 464, (7289), 713-720. (doi:10.1038/nature08979).
Mitra, Anita V., Bancroft, Elizabeth K., Barbachano, Yolanda, Page, Elizabeth C., Foster, C.S., Jameson, C., Mitchell, G., Lindeman, G.J., Stapleton, A., Suthers, G., Evans, D.G., Cruger, D., Blanco, I., Mercer, C., Kirk, J., Maehle, L., Hodgson, S., Walker, L., Izatt, L., Douglas, F., Tucker, K., Dorkins, H., Clowes, V., Male, A., Donaldson, A., Brewer, C., Doherty, R., Bulman, B., Osther, P.J., Salinas, M., Eccles, D., Axcrona, K., Jobson, I., Newcombe, B., Cybulski, C., Rubinstein, W.S., Buys, S., Townshend, S., Friedman, E., Domchek, S., Ramon y Cajal, T., Spigelman, A., Teo, S.H., Nicolai, N., Aaronson, N., Ardern-Jones, A., Bangma, C., Dearnaley, D., Eyfjord, J., Falconer, A., Grönberg, H., Hamdy, F., Johannsson, O., Khoo, V., Kote-Jarai, Z., Lilja, H., Lubinski, J., Melia, J., Moynihan, C., Peock, S., Rennert, G., Schröder, F., Sibley, P., Suri, M., Wilson, P., Bignon, Y.J., Strom, S., Tischkowitz, M., Liljegren, A., Ilencikova, D., Abele, A., Kyriacou, K., van Asperen, C., Kiemeney, L., Easton, D.F. and Eeles, Rosalind A. The IMPACT Study Collaborators (2010) Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study. BJU International, 107, (1), 28-39. (doi:10.1111/j.1464-410X.2010.09648.x). (PMID:20840664).
Eccles, Diana and Tapper, William (2010) The influence of common polymorphisms on breast cancer. Cancer Treatment and Research, 155, 15-32. (doi:10.1007/978-1-4419-6033-7_2). (PMID:20517686).
Nolan, L., Eccles, D., Cross, E., Crawford, G., Beck, N., Bateman, A. and Ottensmeier, C. (2009) First case report of Muir-Torre syndrome associated with non-small cell lung cancer. Familial Cancer, 8, (4), 359-362. (doi:10.1007/s10689-009-9247-7).
Edwards, Emma, Yearwood, Catharina, Sillibourne, Julie, Baralle, Diana and Eccles, Diana (2009) Identification of a de novo BRCA1 mutation in a woman with early onset bilateral breast cancer. Familial Cancer, 8, (4), 479-482. (doi:10.1007/s10689-009-9270-8).
Antoniou, A.C., Sinilnikova, O.M., McGuffog, L., Healey, S., Nevanlinna, H., Heikkinen, T., Simard, J., Spurdle, A.B., Beesley, J., Chen, X., Neuhausen, S.L., Ding, Y.C., Couch, F.J., Wang, X., Fredericksen, Z., Peterlongo, P., Peissel, B., Bonanni, B., Viel, A., Bernard, L., Radice, P., Szabo, C.I., Foretova, L., Zikan, M., Claes, K., Greene, M.H., Mai, P.L., Rennert, G., Lejbkowicz, F., Andrulis, I.L., Ozcelik, H., Glendon, G., Gerdes, A.M., Thomassen, M., Sunde, L., Caligo, M.A., Laitman, Y., Kontorovich, T., Cohen, S., Kaufman, B., Dagan, E., Baruch, R.G., Friedman, E., Harbst, K., Barbany-Bustinza, G., Rantala, J., Ehrencrona, H., Karlsson, P., Domchek, S.M., Nathanson, K.L., Osorio, A., Blanco, I., Lasa, A., Benitez, J., Hammann, U., Hogervorst, F.B., Rookus, M.A., Collee, J.M., Devilee, P., Ligtenberg, M.J., van der Luijt, R.B., Aalfs, C.M., Waisfisz, Q., Wijnen, J., van Roozendaal, C.E., Peock, S., Cook, M., Frost, D., Oliver, C., Platte, R., Evans, D.G., Lalloo, F., Eeles, R., Izatt, L., Davidson, R., Chu, C., Eccles, D., Cole, T., Hodgson, S., Godwin, A.K., Stoppa-Lyonnet, D., Buecher, B., Leone, M., Bressac-de Paillerets, B., Remenieras, A., Caron, O., Lenoir, G.M., Sevenet, N., Longy, M., Ferrer, S.F., Prieur, F., Goldgar, D., Miron, A., John, E.M., Buys, S.S., Daly, M.B., Hopper, J.L., Terry, M.B., Yassin, Y., Singer, C., Gschwantler-Kaulich, D., Staudigl, C., Hansen, T.O., Barkardottir, R.B., Kirchhoff, T., Pal, P., Kosarin, K., Offit, K., Piedmonte, M., Rodriguez, G.C., Wakeley, K., Boggess, J.F., Basil, J., Schwartz, P.E., Blank, S.V., Toland, A.E., Montagna, M., Casella, C., Imyanitov, E.N., Allavena, A., Schmutzler, R.K., Versmold, B., Engel, C., Meindl, A., Ditsch, N., Arnold, N., Niederacher, D., Deissler, H., Fiebig, B., Suttner, C., Schonbuchner, I., Gadzicki, D., Caldes, T., de la Hoya, M., Pooley, J.A., Easton, D.F. and Chenevix-Trench, G. Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer, OCGN, HEBON, EMBRACE, GEMO, Breast Cancer Family Registry and CIMBA (2009) Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics, 18, (22), 4442-4456. (doi:10.1093/hmg/ddp372).
Johnatty, Sharon E., Couch, Fergus J., Fredericksen, Zachary, Tarrell, Robert, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Gschwantler-Kaulich, Daphne, Singer, Christian F., Fuerhauser, Christine, Fink-Retter, Anneliese, Domchek, Susan M., Nathanson, Katherine L., Pankratz, Vernon S., Lindor, Noralane M., Godwin, Andrew K., Caligo, Maria A., Hopper, John, Southey, Melissa C., Giles, Graham G., Justenhoven, Christina, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, Heikkinen, Tuomas, Aaltonen, Kirsimari, Aittomaki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Hall, Per, Czene, Kamila, Liu, Jianjun, Peock, Susan, Cook, Margaret, Platte, Radka, Evans, D. Gareth, Lalloo, Fiona, Eeles, Rosalind, Pichert, Gabriella, Eccles, Diana, Davidson, Rosemarie, Cole, Trevor, Cook, Jackie, Douglas, Fiona, Chu, Carol, Hodgson, Shirley, Paterson, Joan, Hogervorst, Frans B. L, Rookus, Matti A., Seynaeve, Caroline, Wijnen, Juul, Vreeswijk, Maaike, Ligtenberg, Marjolijn, van der Luijt, Rob B., van Os, Theo A. M, Gille, Hans J. P, Blok, Marinus J., Issacs, Claudine, Humphreys, Manjeet K., McGuffog, Lesley, Healey, Sue, Sinilnikova, Olga, Antoniou, Antonis C., Easton, Douglas F. and Chenevix-Trench, Georgia kConFab Investigators, AOCS Group, Swedish BRCA1 and BRCA2 Study Collaborators, HEBON and Breast Cancer Association Consortium and Consortium of Investigators of Modifiers of BRCA1/2 (2009) No evidence that GATA3 rs570613 SNP modifies breast cancer risk. Breast Cancer Research and Treatment, 117, (2), 371-379. (doi:10.1007/s10549-008-0257-1). (Submitted).
Ahmed, S., Ghoussaini, M., Healey, C.S., Humphreys, M.K., Platte, R., Morrison, J., Maranian, M., Pooley, K.A., Luben, R., Eccles, D., Evans, D.G., Fletcher, O., Johnson, N., dos Santos Silva, I., Peto, J., Stratton, M.R., Rahman, N., Jacobs, K., Prentice, R., Anderson, G.L., Rajkovic, A., Curb, J.D., Ziegler, R.G., Berg, C.D., Buys, S.S., McCarthy, C.A., Feigelson, H.S., Calle, E.E., Thun, M.J., Diver, W.R., Bojesen, S., Nordestgaard, B.G., Flyger, H., Dork, T., Schurmann, P., Hillemanns, P., Karstens, J.H., Bogdanova, N.V., Antonenkova, N.N., Zalutsky, I.V., Bermisheva, M., Fedorova, S., Khusnutdinova, E., Kang, D., Yoo, K.Y., Noh, D.Y., Ahn, S.H., Devilee, P., van Asperen, C.J., Tollenaar, R.S., Seynaeve, C., Garcia-Closas, M., Lissowska, J., Brinton, L., Peplonska, B., Nevanlinna, H., Heikkinen, T., Aittomaki, K., Blomqvist, C., Hopper, J.L., Southey, M.C., Smith, L., Spurdle, A.B., Schmidt, M.K., Broeks, A., van Hien, R.R., Cornelissen, S., Milne, R.L., Ribas, G., Gonzalez-Neira, A., Benitez, J., Schmutzler, R.K., Burwinkel, B., Bartram, C.R., Meindl, A., Brauch, H., Justenhoven, C., Hammann, U., Chang-Claude, J., Hein, R., Wang-Gohrke, S., Lindblom, A., Margolin, S., Mannermaa, A., Kosma, V.M., Kataja, V., Olson, J.E., Wang, X., Fredericksen, Z., Giles, G.G., Severi, G., Baglietto, L., English, D.R., Hankinson, S.E., Cox, D.G., Kraft, P., Vatten, L.J., Hveem, K., Kumle, M., Sigurdson, A., Doody, M., Bhatti, P., Alexander, B.H., Hooning, N.J., van den Ouweland, A.M., Oldenburg, R.A., Schutte, M., Hall, P., Czene, K., Liu, J., Li, Y., Cox, A., Elliott, G., Brock, I., Reed, M.W., Shen, C.Y., Yu, J.C., Hsu, G.C., Chen, S.T., Anton-Culver, H., Ziogas, A., Andrulis, I.L., Knight, J.A., Beesley, J., Goode, E.L., Couch, F., Chenevix-Trench, G., Hoover, R.N., Ponder, B.A., Hunter, D.J., Pharaoah, P.D., Dunning, A.M., Chanock, S.J. and Easton, D.F. SEARCH, GENICA Consortium and kConFab; Australian Ovarian Cancer Study Group (2009) Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2. Nature Genetics, 41, (5), 585-590. (doi:10.1038/ng.354). (PMID:19330027).
Evans, D.G.R., Baildam, A.D., Anderson, E., Brain, A., Shenton, A., Vasen, H.F.A., Eccles, D., Lucassen, A., Pichert, G., Hamed, H., Moller, P., Maehle, L., Morrison, P.J., Stoppart-Lyonnet, D., Gregory, H., Smyth, E., Niederacher, D., Nestle-Krämling, C., Campbell, J., Hopwood, P., Lalloo, F. and Howell, A. (2009) Risk reducing mastectomy: outcomes in 10 European centres. Journal of Medical Genetics, 46, (4), 254-258. (doi:10.1136/jmg.2008.062232).
Tapper, William, Hammond, Victoria, Gerty, Sue, Ennis, Sarah, Simmonds, Peter, Collins, Andrew and Eccles, Diana Posh Steering Group (2008) The influence of genetic variation in thirty selected genes on the clinical characteristics of early onset breast cancer. Breast Cancer Research, 10, (6), R108. (doi:10.1186/bcr2213). (PMID:19094228).
Burn, John, Bishop, D.Timothy, Mecklin, Jukka-Pekka, Macrae, Finlay, Möslein, Gabriela, Olschwang, Sylviane, Bisgaard, Marie-Luise, Ramesar, Raj, Eccles, Diana, Maher, Eamonn, Bertario, Lucio, Jarvinen, Heikki J., Lindblom, Annika, Evans, D.Gareth, Lubinski, Jan, Morrison, Patrick J., Ho, Judy W.C., Vasen, Hans F.A., Side, Lucy, Thomas, Huw J.W., Scott, Rodney J., Dunlop, Malcolm, Barker, Gail, Elliott, Faye, Jass, Jeremy R., Fodde, Ricardo, Lynch, Henry T. and Mathers, John C. CAPP2 Investigators (2008) Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch Syndrome. New England Journal of Medicine, 359, (24), 2567-2578. (doi:10.1056/NEJMoa0801297). (PMID:19073976).
Hofstra, Robert M.W., Spurdle, Amanda B., Eccles, Diana M., Foulkes, William D., de Wind, Niels, Hoogerbrugge, Nicoline and Hogervorst, Frans B.L. (2008) Tumor characteristics as an analytic tool for classifying genetic variants of uncertain clinical significance. Human Mutation, 29, (11), 1292-1303. (doi:10.1002/humu.20894). (PMID:1895144).
Plon, S.E., Eccles, D.M., Easton, D., Foulkes, W.D., Genuardi, M., Greenblatt, M.S., Hogervorst, F.B., Hoogerbrugge, N., Spurdle, A.B. and Tavtigian, S.V. IARC Unclassified Genetic Variants Working Group (2008) Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results. Human Mutation, 29, (11), 1282-1291. (doi:10.1002/humu.20880).
Liljegren, A., Barker, G., Elliott, F., Bertario, L., Bisgaard, M.L., Eccles, D., Evans, G., Macrae, F., Maher, E., Lindblom, A., Rotstein, S., Nilsson, B., Mecklin, J.P., Moslein, G., Jass, J., Fodde, R., Mathers, J., Burn, J. and Bishop, D.T. (2008) Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. Journal of Clinical Oncology, 26, (20), 3434-3439. (doi:10.1200/JCO.2007.13.2795).
Antoniou, A.C., Hardy, R., Walker, L., Evans, D.G., Shenton, A., Eeles, R., Shanley, S., Pichert, G., Izatt, L., Rose, S., Douglas, F., Eccles, D., Morrison, P.J., Scott, J., Zimmern, R.L., Easton, D.F. and Pharoah, P.D.P. (2008) Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics. Journal of Medical Genetics, 45, (7), 425-431. (doi:10.1136/jmg.2007.056556).
Gerty, S.M., Simmonds, P.D., Durcan, L. and Eccles, D.M. (2008) Prospective study of outcome in sporadic versus hereditary breast cancer: pros and cons of running a cohort study. Breast Cancer Research, 10, (Suppl 2), S36-S37. (doi:10.1186/bcr1955).
Eccles, Diana M. (2008) Identification of personal risk of breast cancer: genetics. Breast Cancer Research, 10, (Suppl 4), p.S12. (doi:10.1186/bcr2172).
Antoniou, A.C., Spurdle, A.B., Sinilnikova, O.M., Healey, S., Pooley, K.A., Schmutzler, R.K., Versmold, B., Engel, C., Meindl, A., Arnold, N., Hofmann, W., Sutter, C., Niederacher, D., Deissler, H., Caldes, T., Kampjarvi, K., Nevanlinna, H., Simard, J., Beesley, J., Chen, X.Q., Neuhausen, S.L., Rebbeck, T.R., Wagner, T., Lynch, H.T., Isaacs, C., Weitzel, J., Ganz, P.A., Daly, M.B., Tomlinson, G., Olopade, O.I., Bium, J.L., Couch, F. J., Peterlongo, P., Manoukian, S., Barile, M., Radice, P., Szabo, C.I., Pereira, L.H.M., Greene, M.H., Rennert, G., Leibkowicz, F., Barnett-Griness, O., Andrulis, I.L., Ozcelik, H., Gerdes, A.M., Caligo, M.A., Laitman, Y., Kaufman, B., Milgrom, R., Friedman, E., Domchek, S.M., Nathanson, K.L., Osorio, A., Llort, G., Milne, R.L., Benitez, J., Hamann, U., Hogervorst, F.B.L., Manders, P., Ligtenberg, M.J.L., Van den, A.M.W., Peock, S., Cook, M., Platte, R., Evans, D.G., Eeles, R., Pichert, G., Chu, C., Eccles, D., Davidson, R., Douglas, F., Godwin, A.K., Barjhoux, L., Mazoyer, S., Sobol, H., Bourdon, V., Eisinger, F., Chompret, A., Capoulade, C., Paillerets, B.B.D., Lenoir, G.M., Gauthier-Villars, M., Houdayer, C., Stoppa-Lyonnet, D. and Easton, D.F. (2008) Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. American Journal of Human Genetics, 82, (4), 937-948. (doi:10.1016/j.ajhg.2008.02.008).
Antoniou, A.C., Cunningham, A.P., Peto, J., Evans, D.G., Lalloo, F., Narod, S.A., Risch, H.A., Eyfjord, J.E., Hopper, J.L., Southey, M.C., Olsson, H., Johannsson, O., Borg, A., Pasini, B., Radice, P., Manoukian, S., Eccles, D.M., Tang, N., Olah, E., Anton-Culver, H., Warner, E., Lubinski, J., Gronwald, J., Gorski, B., Tryggvadottir, L., Syrjakoski, K., Kallioniemi, O.P., Eerola, H., Nevanlinna, H., Pharoah, P.D. and Easton, D.F. (2008) The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions. British Journal of Cancer, 98, (8), 1457-1466. (doi:10.1038/sj.bjc.6604305).
Dallosso, A.R., Dolwani, S., Jones, N., Jones, S., Colley, J., Maynard, J., Idziaszczyk, S., Humphreys, V., Arnold, J., Donaldson, A., Eccles, D., Ellis, A., Evans, D.G., Frayling, I.M., Hes, F.J., Houlston, R.S., Meyer, E.R., Nielsen, M., Parry, S., Tyler, E., Moskvina, V., Cheadle, J.P. and Sampson, J.R. (2008) Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. Gut: an International Journal of Gastroenterology and Hepatology, 57, (9), 1252-1255. (doi:10.1136/gut.2007.145748).
Foster, C., Watson, M., Eeles, R., Eccles, D., Ashley, S., Davidson, R., Mackay, J., Morrison, P.J., Hopwood, P. and Evans, D.G.R. (2007) Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three year follow up. Psycho-Oncology, 16, (S2), S20-S20. (doi:10.1002/pon.1266).
Eccles, Diana, Gerty, Sue, Simmonds, Peter, Hammond, Victoria, Ennis, Sarah and Altman, Douglas G. (2007) Prospective study of outcomes in Sporadic versus hereditary breast cancer (POSH): study protocol. BMC Cancer, 7, [6pp]. (doi:10.1186/1471-2407-7-160).
Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D.P., Thompson, Deborah, Ballinger, Dennis G., Struewing, Jeffery P., Morrison, Jonathan, Field, Helen, Luben, Robert, Wareham, Nicholas, Ahmed, Shahana, Healey, Catherine S., Bowman, Richard, Meyer, Kerstin B., Haiman, Christopher A., Kolonel, Laurence K., Henderson, Brian E., Le Marchand, Loic, Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Odefrey, Fabrice, Shen, Chen-Yang, Wu, Pei-Ei, Wang, Hui-Chun, Eccles, Diana, Evans, D. Gareth, Peto, Julian, Fletcher, Olivia, Johnson, Nichola, Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Chenevix-Trench, Georgia, Bojesen, Stig E., Nordestgaard, Børge G., Axelsson, Christen K., Garcia-Closas, Montserrat, Brinton, Louise, Chanock, Stephen, Lissowska, Jolanta, Peplonska, Beata, Nevanlinna, Heli, Fagerholm, Rainer, Eerola, Hannaleena, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Hunter, David J., Hankinson, Susan E., Cox, David G., Hal, Per, Wedren, Sara, Liu, Jianjun, Low, Yen-Ling, Bogdanova, Natalia, Schürmann, Peter, Dörk, Thilo, Tollenaar, Rob A.E.M., Jacobi, Catharina E., Devilee, Peter, Klijn, Jan G.M., Sigurdson, Alice J., Doody, Michele M., Alexander, Bruce H., Zhang, Jinghui, Cox, Angela, Brock, Ian W., MacPherson, Gordon, Reed, Malcolm W. R., Couch, Fergus J., Goode, Ellen L., Olson, Janet E., Meijers-Heijboer, Hanne, van den Ouweland, Ans, Uitterlinden, André, Rivadeneira, Fernando, Milne, Roger L., Ribas, Gloria, Gonzalez-Neira, Anna, Benitez, Javier, Hopper, John L., McCredie, Margaret, Southey, Melissa, Giles, Graham G., Schroen, Chris, Justenhoven, Christina, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Hartikainen, Jaana, Day, Nicholas E., Cox, David R. and Ponder, Bruce A. J. the SEARCH collaborators, kConFab and AOCS Management Group (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447, (7148), 1087-1093. (doi:10.1038/nature05887).
Foster, C., Watson, M., Eeles, R., Eccles, D., Ashley, S., Davidson, R., Mackay, J., Morrison, P.J., Hopwood, P. and Evans, D.G.R. Psychosocial Study Collaborators (2007) Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up. British Journal of Cancer, 96, (5), 718-724. (doi:10.1038/sj.bjc.6603610).
Rahman, Nazneen, Seal, Sheila, Thompson, Deborah, Kelly, Patrick, Renwick, Anthony, Elliott, Anna, Reid, Sarah, Spanova, Katarina, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, McGuffog, Lesley, Hanks, Sandra, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F. and Stratton, Michael R. (2007) PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nature Genetics, 39, (2), 165-167. (doi:10.1038/ng1959).
Hammond, V.N., Gerty, S.M., Sillibourne, J., Ward, D., Mattocks, C., Simmonds, P., Graham, N., Armstrong, M. and Eccles, D.M. (2007) Inherited mutations in BRCA1 are much more frequent than in BRCA2 amongst young breast cancer cases. Journal of Medical Genetics, 44, pp.S132.
Rahman, Nazneen, Seal, Sheila, Thompson, Deborah, Kelly, Patrick, Renwick, Anthony, Elliott, Anna, Reid, Sarah, Spanova, Katarina, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, McGuffog, Lesley, Hanks, Sandra, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F. and Stratton, Michael R. The Breast Cancer Susceptibility Collaboration (UK) (2007) PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nature Genetics, 39, (2), 165-167. (doi:10.1038/ng1959).
Shanley, Susan, McReynolds, Kate, Rdern-Jones, Audrey, Ahern, Roger, Fernando, Indrajit, Yarnold, John, Evans, Gareth, Eccles, Diana, Hodgson, Shirley, Ashley, Sue, Ashcroft, Linda, Tutt, Andrew, Bancroft, Elizabeth, Short, Susan, Smith, Ian, Gui, Gerald, Barr, Lester, Baildam, Andrew, Howell, Anthony, Royle, Gavin, Pierce, Lori, Easton, Douglas and Eeles, Rosalind The Breast Unit of the Royal Marsden NHS Foundation Trust (2006) Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom. Clinical Cancer Research, 12, (23), 7033-7038.
Shanley, Susan, McReynolds, Kate, Rdern-Jones, Audrey, Ahern, Roger, Fernando, Indrajit, Yarnold, John, Evans, Gareth, Eccles, Diana, Hodgson, Shirley, Ashley, Sue, Ashcroft, Linda, Tutt, Andrew, Bancroft, Elizabeth, Short, Susan, Gui, Gerald, Barr, Lester, Baildam, Andrew, Howell, Anthony, Royle, Gavin, Pierce, Lori, Easton, Douglas and Eeles, Rosalind The Breast Unit of the Royal Marsden NHS Foundation Trust (2006) Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom. Clinical Cancer Research, 12, (23), 7025-7032.
Seal, Sheila, Thompson, Deborah, Renwick, Anthony, Elliott, Anna, Kelly, Patrick, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, Ahmed, Munaza, Spanova, Katarina, North, Bernard, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R. and Rahman, Nazneen (2006) Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nature Genetics, 38, (11), 1239-1241. (doi:10.1038/ng1902).
Renwick, Anthony, Thompson, Deborah, Seal, Sheila, Kelly, Patrick, Chagtai, Tasnim, Ahmed, Munaza, North, Bernard, Jayatilake, Hiran, Barfoot, Rita, Spanova, Katarina, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R. and Rahman, Nazneen Breast Cancer Susceptibility Collaboration (UK) (2006) ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nature Genetics, 38, (8), 873-875. (doi:10.1038/ng1837).
Gareth, D., Evans, R., Lalloo, F. and Eccles, D. (2006) Optimal selection of individuals for BRCA mutation testing. Journal of Clinical Oncology, 24, (20), 3311. (doi:10.1200/JCO.2006.06.6134).
Kote-Jarai, Zsofia, Matthews, Lucy, Osorio, Ana, Shanley, Susan, Giddings, Ian, Moreews, Francois, Locke, Imogen, Evans, D. Gareth, Eccles, Diana, Williams, Richard D., Girolami, Mark, Campbell, Colin and Eeles, Ros The Carrier Clinic Collaborators (2006) Accurate prediction of BRCA1 and BRCA2 heterozygous genotype using expression profiling after induced DNA damage. Clinical Cancer Research, 12, (13), 3896-3901.
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth, Chenevix-Trench, Georgia, Szabo, Csilla, Southey, Melissa, Renard, Hélène, Odefrey, Fabrice, Lynch, Henry, Stoppa-Lyonnet, Dominique, Couch, Fergus, Hopper, John L., Giles, Graham G., McCredie, Margaret R.E., Buys, Saundra, Andrulis, Irene, Senie, Ruby, Goldgar, David E., Oldenburg, Rogier, Kroeze-Jansema, Karin, Kraan, Jaennelle, Meijers-Heijboer, Hanne, Klijn, Jan G.M., van Asperen, Christi, van Leeuwen, Inge, Vasen, Hans F.A., Cornelisse, Cees J., Devilee, Peter, Baskcomb, Linda, Seal, Sheila, Barfoot, Rita, Mangion, Jon, Hall, Anita, Edkins, Sarah, Rapley, Elizabeth, Wooster, Richard, Chang-Claude, Jenny, Eccles, Diana, Evans, D. Gareth, Futreal, P. Andrew, Nathanson, Katherine L., Weber, Barbara L., Rahman, Nazneen and Stratton, Michael R. (2006) A genome wide linkage search for breast cancer susceptibility genes. Genes, Chromosomes and Cancer, 45, (7), 646-655. (doi:10.1002/gcc.20330).
Copson, Ellen R., White, Helen E., Blaydes, Jeremy P., Robinson, David O., Johnson, Peter W. and Eccles, Diana M. (2006) Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers. BMC Cancer, 6, (80) (doi:10.1186/1471-2407-6-80).
Mitchell, Gillian, Antoniou, Antonis C., Warren, Ruth, Peock, Susan, Brown, Judith, Davies, Russell, Mattison, Jenny, Cook, Margaret, Warsi, Iqbal, Evans, D. Gareth, Eccles, Diana, Douglas, Fiona, Paterson, Joan, Hodgson, Shirley, Izatt, Louise, Cole, Trevor, Burgess, Lucy, Eeles, Ros and Easton, Douglas F. (2006) Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Research, 66, (3), 1866-1872.
Simmonds, P.D., Eccles, D.M. and Gerty, S. (2005) Clinicopathological characteristics of young onset breast cancer: initial results from a prospective cohort study. Breast Cancer Research and Treatment, 94, (Supplement 1), p.S22. (doi:10.1007/s10549-005-1234-6).
Eccles, D.M. and Pichert, G. (2005) Familial non-BRCA1/BRCA2-associated breast cancer. The lancet oncology, 6, (9), 705-711. (doi:10.1016/S1470-2045(05)70318-1).
Thompson, Ella, Dragovic, Rebecca L., Stephenson, Sally-Anne, Eccles, Diana M., Campbell, Ian G. and Dobrovic, Alexander (2005) A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer. BMC Cancer, 5, (1) (doi:10.1186/1471-2407-5-43).
Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, Rassoulian, Hamid, Smith, Matt J., Sillibourne, Julie, Ball, Nicola J., Graham, Nikki J., Briggs, Patricia J., Simpson, Iain A., Phillips, David I.W., Lawlor, Deborah A., Ye, Shu, Humphries, Stephen E., Cooper, Cyrus, Smith, George Davey, Ebrahim, Shah, Eccles, Diana M. and Day, Ian N.M. (2005) Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population. Genome Research, 15, (7), 967-977. (doi:10.1101/gr.3313405).
Tommiska, J., Seal, S., Renwick, A., Barfoot, R., Baskcomb, L., Jayatilake, H., Bartkova, J., Tallila, J., Kaare, M., Tamminen, A., Heikkila, P., Evans, D.G., Eccles, D., Aittomaki, K., Blomqvist, C., Bartek, J., Stratton, M.R., Nevanlinna, H. and Rahman, N. (2005) Evaluation of RAD50 in familial breast cancer predisposition. International Journal of Cancer, 118, (11), 2911-2916. (doi:10.1002/ijc.21738).
Antoniou, A.C., Pharoah, P.D., Narod, S., Risch, H.A., Eyfjord, J.E., Hopper, J.L., Olsson, H., Johannsson, O., Borg, A., Pasini, B., Radice, P., Manoukian, S., Eccles, D.M., Tang, N., Olah, E., Nton-Culver, H., Warner, E., Lubinski, J., Gronwald, J., Gorski, B., Tulinius, H., Thorlacius, S., Eerola, H., Nevanlinna, H., Syrjakoski, K., Kallioniemi, O.P., Thompson, D., Evans, C., Peto, J., Lalloo, F., Evans, D.G. and Easton, D.F. (2005) Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies. Journal of Medical Genetics, 42, (7), 602-603. (doi:10.1136/jmg.2004.024133).
Stirling, Diane, Evans, D. Gareth, Pichert, Gabriella, Shenton, Andrew, Kirk, Elaine N., Rimmer, Sylvia, Steel, C. Michael, Lawson, Sheila, Busby-Earle, R. M. Camille, Walker, Jane, Lalloo, Fiona I., Eccles, Diana M., Lucassen, Anneke M. and Porteous, Mary E. (2005) Screening for familial ovarian cancer: failure of current protocols to detect ovarian cancer at an early stage according to The International Federation of Gynecology and Obstetrics System. Journal of Clinical Oncology, 23, (24), 5588-5596. (doi:10.1200/JCO.2005.05.097).
Eccles, D., Bunyan, D., Barker, S. and Castle, B. (2005) BRCA1 mutation and neuronal migration defect: Implications for chemoprevention. Journal of Medical Genetics, 42, (e24) (doi:10.1136/jmg.2004.028084).
Campbell, I.G., Eccles, D.M. and Choong, D.Y. (2005) No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer. Cancer Letters, 17
Leach, M.O., Boggis, C.R., Dixon, A.K., Easton, D.F., Eeles, R.A., Evans, D.G., Gilbert, F.J., Griebsch, I., Hoff, R.J., Kessar, P., Lakhani, S.R., Moss, S.M., Nerurkar, A., Padhani, A.R., Pointon, L.J., Thompson, D., Warren, R.M. and MARIBS, study group (2005) Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: A prospective multicentre cohort study (MARIBS). Lancet, 365, (9473), 1769-1778. (doi:10.1016/S0140-6736(05)66481-1).
Sharp, Andrew, Pichert, Gabriella, Lucassen, Anneke and Eccles, Diana (2004) RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1. Human Mutation, 24, (3), 272-272. (doi:10.1002/humu.9267).
Hopwood, P., Wonderling, D., Watson, M., Cull, A., Douglas, F., Cole, T., Eccles, D., Gray, J., Murday, V., Steel, M., Burn, J. and McPherson, K. (2004) A randomised comparison of UK genetic risk counselling services for familial cancer: psychosocial outcomes. British Journal of Cancer, 91, (5), 884-892. (doi:10.1038/sj.bjc.6602081).
Foster, C., Evans, D. G., Eeles, R., Eccles, D., Ashley, S., Brooks, L., Cole, T., Cook, J., Davidson, R., Gregory, H., Mackay, J., Morrison, P. J. and Watson, M. (2004) Non-uptake of predictive genetic testing for BRCA1/2 among relatives of known carriers: attributes, cancer worry, and barriers to testing in a multicenter clinical cohort. Genetic Testing, 8, (1), 23-29. (doi:10.1089/109065704323016003).
Evans, D. G. R., Eccles, D. M., Rahman, N., Young, K., Bulman, M., Amir, E., Shenton, A., Howell, A. and Lalloo, F. (2004) A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO. Journal of Medical Genetics, 41, (6), 474-480.
Montgomery, Karen G., Liu, Mira C.P., Eccles, Diana M. and Campbell, Ian G. (2004) The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case-control study. Breast Cancer Research, 6, (4), R390-R394. (doi:10.1186/bcr807).
Shorrocks, Julie, Tobi, Simon E., Latham, Harry, Peacock, John H., Eeles, Ros, Eccles, Diana and McMillan, Trevor J. (2004) Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment. International Journal of Radiation Oncology, Biology, Physics, 58, (2), 470-478. (doi:10.1016/j.ijrobp.2003.09.042).
Bunyan, D.J., Eccles, D.M., Sillibourne, J., Wilkins, E., Thomas, N. Simon, Shea-Simonds, J., Duncan, P.J., Curtis, C.E., Robinson, D.O., Harvey, J.F. and Cross, N.C.P. (2004) Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification. British Journal of Cancer, 91, (6), 1155-1159. (doi:10.1038/sj.bjc.6602121).
Copson, E., White, H.E., Cross, N.C.P., Eccles, D. and Robinson, D.O. (2004) Use of Pyrosequencing technology to quantitate allele expression in patients with BRCA1 mutations. Journal of Medical Genetics, 41, pp.S72.
Veugelers, Mark, Wilkes, David, Burton, Kimberly, McDermott, Deborah A., Song, Yan, Goldstein, Marsha M., La Perle, Krista, Vaughan, Carl. J., O'Hagan, Art, Bennett, Kenneth R., Meyer, Beat J., Legius, Eric, Karttunen, Mervi, Norio, Reijo, Kaariainen, Helena, Lavyne, Michael, Neau, Jean-Philippe, Richter, Gert, Kirali, Kaan, Farnsworth, Alan, Stapleton, Karen, Morelli, Peter, Takanashi, Yoshinori, Bamforth, John-Steven, Eitelberger, Franz, Noszian, Irene, Manfroi, Waldimiro, Powers, James, Mochizuki, Yoshihiko, Imai, Tsuneo, Ko, Gary T. C., Driscoll, Deborah A., Goldmuntz, Elizabeth, Edelberg, Jay M., Collins, Amanda, Eccles, Diana, Irvine, Alan D., McKnight, G. Stanley and Basson, Craig T. (2004) Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. Proceedings of the National Academy of Sciences of the United States of America, 101, (39), 14222-14227. (doi:10.1073/pnas.0405535101).
Sampson, Julian R., Dolwani, Sunil, Jones, Sian, Eccles, Diana, Ellis, Anthony, Evans, D. Gareth, Frayling, Ian, Jordan, Sheila, Maher, Eamonn R., Mak, Tony, Maynard, Julie, Pigatto, Francesco, Shaw, Joan and Cheadle, Jeremy P. (2003) Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. The Lancet, 362, (9377), 39-41. (doi:10.1016/S0140-6736(03)13805-6).
Seal, Sheila, Barfoot, Rita, Jayatilake, Hiran, Smith, Paula, Renwick, Anthony, Bascombe, Linda, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R. and Rahman, Nazneen (2003) Evaluation of Fanconi Anemia genes in familial breast cancer predisposition. Cancer Research, 63, (24), 8596-8599.
Lim, W., Hearle, N., Shah, B., Murday, V., Hodgson, S.V., Lucassen, A., Eccles, D., Talbot, I., Neale, K., Lim, A.G., O'Donohue, J., Donaldson, A., Macdonald, R.C., Young, I.D., Robinson, M.H., Lee, P.W., Stoodley, B.J., Tomlinson, I., Alderson, D., Holbrook, A.G., Vyas, S., Swarbrick, E.T., Lewis, A.A., Phillips, R.K. and Houlston, R.S. (2003) Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. British Journal of Cancer, 89, (2), 308-313. (doi:10.1038/sj.bjc.6601030).
Schutte, Mieke, Seal, Sheila, Barfoot, Rita, Meijers-Heijboer, Hanne, Wasielewski, Marijke, Evans, D. Gareth, Eccles, Diana, Meijers, Carel, Lohman, Frans, Klijn, Jan, van den Ouweland, Ans, Futreal, P. Andrew, Nathanson, Katherine L., Weber, Barbara L., Easton, Douglas F., Stratton, Michael R. and Rahman, Nazneen (2003) Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility. American Journal of Human Genetics, 72, (4), 1023-1028.
Antoniou, A., Pharoah, P.D.P., Narod, S., Risch, H.A., Eyfjord, J.E., Hopper, J.L., Loman, N., Olsson, H., Johannsson, O., Borg, A., Pasini, B., Radice, P., Manoukian, S., Eccles, D.M., Tang, N., Olah, E., Anton-Culver, H., Warner, E., Lubinski, J., Gronwald, J., Gorski, B., Tulinius, H., Thorlacius, S., Eerola, H., Nevanlinna, H., Syrjäkoski, K., Kallioniemi, O.-P., Thompson, D., Evans, C., Peto, J., Lalloo, F., Evans, D.G. and Easton, D.F. (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. American Journal of Human Genetics, 72, (5), 1117-1130.
Campbell, Ian G., Allen, James and Eccles, Diana M. (2003) Prohibitin 3' untranslated region polymorphism and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention, 12, 1273-1274.
Eccles, Diana M. (2003) Genetic testing for BRCA1 mutation in the UK. The Lancet, 361, (9352), 178-179. (doi:10.1016/S0140-6736(03)12213-1).
Camplejohn, R.S., Gilchrist, R., Easton, D., McKenzie-Edwards, E., Barnes, D.M., Eccles, D.M., Ardern-Jones, A., Hodgson, S.V., Duddy, P.M. and Eeles, R.A. (2003) Apoptosis, ageing and cancer susceptibility. British Journal of Cancer, 88, (4), 487-490. (doi:10.1038/sj.bjc.6600767).
Eccles, D. M., Barker, S., Pilz, D. T. and Kennedy, C. (2003) Neuronal migration defect in a BRCA1 gene carrier: possible focal nullisomy? Journal of Medical Genetics, 40, (e24)
Jones, Natalie, Vogt, Stefanie, Nielsen, Maartje, Christian, Daria, Wark, Petra A., Eccles, Diana, Edwards, Emma, Evans, D. Gareth, Maher, Eamonn R., Vasen, Hans F., Hes, Frederik J., Aretz, Stefan and Sampson, Julian R. (2002) Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH. Gastroenterology, 137, (2), 489-494. (doi:10.1053/j.gastro.2009.04.047).
Campbell, Ian G., Baxter, Simon W., Eccles, Diana M. and Choong, David Y. H. (2002) Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer. Breast Cancer Research, 4, (6) (doi:10.1186/bcr457).
Thompson, Deborah, Szabo, Csilla I., Mangion, Jon, Oldenburg, Rogier A., Odefrey, Fabrice, Seal, Sheila, Barfoot, Rita, Kroeze-Jansema, Karin, Teare, Dawn, Rahman, Nazneen, Renard, Hélène, Mann, Graham, Hopper, John L., Buys, Saundra S., Andrulis, Irene L., Senie, Ruby, Daly, Mary B., West, Dee, Ostrander, Elaine, Offit, Ken, Peretz, Tamar, Osorio, Ana, Benitez, J., Nathanson, Katherine L., Sinilnikova, Olga M., Olàh, Edith, Bignon, Yves-Jean, Ruiz, Pablo, Badzioch, Michael D., Vasen, Hans F.A., Futreal, Andrew P., Phelan, Catherine M., Narod, Steven A., Lynch, Henry T., Ponder, Bruce A.J., Eeles, Ros A., Meijers-Heijboer, Hanne, Stoppa-Lyonnet, Dominique, Couch, Fergus J., Eccles, Diana M., Evans, D. Gareth, Chang-Claude, Jenny, Lenoir, Gilbert, Weber, Barbara L., Devilee, Peter, Easton, Douglas F., Goldgar, David E. and Stratton, Michael R. (2002) Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium. Proceedings of the National Academy of Sciences of the United States of America, 99, (2), 827-831. (doi:10.1073/pnas.012584499).
Leach, M.O., Eeles, R.A., Turnbull, L.W., Dixon, A.K., Brown, J., Hoff, R.J., Coulthard, A., Dixon, J.M., Easton, D.F., Evans, D.G., Gilbert, F.J., Hawnaur, J., Hayes, C., Kessar, P., Lakhani, S., Liney, G., Moss, S.M., Padhani, A.P., Pointon, L.J., Sydenham, M., Walker, L.G., Warren, R.M., Haites, N.E., Morrison, P., Cole, T., Rayter, Z., Donaldson, A., Shere, M., Rankin, J., Goudie, D., Steel, C.M., Davidson, R., Chu, C., Ellis, I., Mackay, J., Hodgson, S.V., Homfray, T., Douglas, F., Quarrell, O.W., Eccles, D. M., Gilbert, F.G., Crothers, G., Walker, C.P., Jones, A., Slack, N., Britton, P., Sheppard, D.G., Walsh, J., Whitehouse, G., Teh, W., Rankin, S., Boggis, C., Potterton, J., McLean, L., Gordon, P.A. and Rubin, C. (2002) The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS). Journal of Experimental and Clinical Cancer Research, 21, (3 Suppl), 107-114.
Baxter, Simon W., Choong, David Y.H., Eccles, Diana M. and Campbell, Ian G. (2002) Transforming growth factor β receptor 1 polyalanine polymorphism and exon 5 mutation analysis in breast and ovarian cancer. Cancer Epidemiology, Biomarkers & Prevention, 11, (2), 211-214.
Cuzick, J., Forbes, J., Edwards, R., Baum, M., Cawthorn, S., Coates, A., Hamed, A., Howell, A., Powles, T. and Eccles, D. M. (2002) First results from the International Breast Cancer Intervention Study (IBIS-I): a randomised prevention trial. The Lancet, 360, (9336), 817-824. (doi:10.1016/S0140-6736(02)09962-2).
Meijers-Heijboer, Hanne, Van den, Ans, Klijn, Jan, Wasielewski, Marijke, De Snoo, Anja, Oldenburg, Rogier, Hollestelle, Antoinette, Houben, Mark, Crepin, Ellen, Van Veghel-Plandsoen, Monique, Elstrodt, Fons, Van Duijn, Cornelia, Bartels, Carina, Meijers, Carel, Schutte, Mieke, McGuffog, Lesley, Thompson, Deborah, Easton, Douglas F., Sodha, Nayanta, Seal, Sheila, Barfoot, Rita, Mangion, Jon, Chang-Claude, Jenny, Eccles, Diana, Eeles, Rosalind, Evans, D. Gareth, Houlston, Richard, Murday, Victoria, Narod, Steven, Peretz, Tamara, Peto, Julian, Phelan, Catherine, Zhang, Hong Xiang, Szabo, Csilla, Devilee, Peter, Goldgar, David, Futreal, P. Andrew, Nathanson, Katherine L., Weber, Barbara L., Rahman, Nazneen and Stratton, Michael R. (2002) Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nature Genetics, 31, (1), 55-59. (doi:10.1038/ng879).
Eccles, Diana, Simmonds, Peter, Goddard, Jonathan, Coultas, Marie, Hodgson, Shirley, Lalloo, Fiona, Evans, Gareth and Haites, Neva (2001) Familial breast cancer: an investigation into the outcome of treatment for early stage disease. Familial Cancer, 1, (2), 65-72. (doi:10.1023/A:1013867917101).
Lucassen, Anneke, Watson, Elia and Eccles, Diana (2001) Evidence based case report. Advice about mammography for a young woman with a family history of breast cancer. British Medical Journal, 322, (7293), 1040-1042.
Aldahmesh, M., Spanakis, E., Day, I.N.M. and Eccles, D.M. (2001) The application of microplate array diagonal gel electrophoresis (melt-MADGE) to high throughput inexpensive BRCA1 mutation analysis. Journal of Medical Genetics, 38, pp.S58.
Reddy, T. Damodar, Eccles, Diana M., Theaker, Jeffrey, Keeton, Barry R. and Temple, Karen (2001) Skin spots and heart tumors. Journal of Pediatrics, 139, (6), 901-902. (doi:10.1067/mpd.2001.119595).
Parham, D.M. and Eccles, D.M. (2001) Fibroadenoma with atypical giant cells occurring in Li Fraumeni Syndrome. The Breast, 10, (4), 330-332. (doi:10.1054/brst.2000.0250).
Eccles, Diana, Harvey, John, Bateman, Adrian and Ross, Fiona (2001) A novel 3' mutation in the APC gene in a family presenting with a desmoid tumour. Journal of Medical Genetics, 38, (12), 861-863.
Baxter, S.W., Choong, D.Y.H., Eccles, D.M. and Campbell, I.G. (2001) Polymorphic variation in CYP19 and the risk of breast cancer. Carcinogenesis, 22, (2), 347-349.
Gough, A.C., Coleman, M.G., Bunyan, D.J., Braham, D., Eccles, D.M. and Primrose, J.N. (2001) Minisatellite instability is found in colorectal tumours with mismatch repair deficiency. British Journal of Cancer, 85, (10), 1486-1491. (doi:10.1054/bjoc.2001.2058).

Book Section

Day, Ian N.M., Aldahmesh, Mohammed A., Haddad, Lema, Alharbi, Khalid K., Chen, Xiao-he, Rassoulian, Hamid, Humphries, Steve E., Spanakis, Emmanuel and Eccles, Diana, Human Genome Organization (HUGO) (2005) MeltMADGE: economical very high-throughput mutation scanning using thermal ramp electrophoresis in conjunction with MADGE (microplate array) gels. In, Taylor, Graham R. and Day, Ian N. (eds.) Guide to Mutation Detection. Hoboken, USA, Wiley, 85-99.
Smith, Matthew J., Alharbi, Khalid K., Aldahmesh, Mohammed A., Pante-de-Sousa, Gabriella, Hou, Guangwei, Chen, Xiao-he, Gaunt, Tom R., Eccles, Diana M., Fox, Keith R. and Day, Ian N.M. (2004) MADGE-based technologies for identification of unknown mutations at the population level: MeltMADGE and EndoVII-MADGE. In, Hecker, Karl H. (ed.) Genetic Variance Detection: Technologies for Pharmacogenomics. Glendale, US, DNA Press, 145-152. (The Nuts & Bolts Series).
 

Research

Research Interests

Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (acronym POSH). This National Cancer Research Network Portfolio study has recruited over 3000 women diagnosed with breast cancer at very young ages (before 41 years. Breast cancer diagnosed at these young ages comprises less than 10% of all breast cancers. Young age at diagnosis is associated with a lower chance of survival and this group is also enriched patients who carry genetic factors that predispose to breast cancer. Comprehensive clinical data and DNA samples for most recruits are available. Flagging in the national Medical Research Information Service database means that the patients taking part in the study can be tracked for twenty years following diagnosis. Mean and median follow up of the cohort is approaching 5 years and a variety of early outcome studies are now being completed including

The effect of high risk genes on survival: this project is exploring whether breast cancer caused by the high risk predisposition genes BRCA1 and BRCA2 respond differently to conventional treatments.

The effect of common genetic variants on breast cancer diagnosis and survival is being explored in a series of international collaborative experiments linking in closely with the bioinformatics research group.

Exploring the validity of available prognostic predictors in younger women with breast cancer as a project within the MSc Clinical Trials and Statistics course in Southampton.

In addition, linking in with researchers in qualitative medicine in the Faculty of Health Sciences, a Research for Patient Benefit project (funded by the NIHR) will use the POSH patient cohort and experience of the diagnosis and treatment of breast cancer in this age group to explore and improve approaches to information giving at diagnosis. A Decision Aid aimed specifically at younger women will be developed and piloted in preparation for a future randomised trial of its use.

Tumour tissue is being collected for all the cases and in collaboration QMUL tissue micro arrays (TMAs) are being assembled. Pathology and breast cancer radiological images are being captured and reported electronically using software developed in house by the database and IT support group.

One of the most potent cancer predisposition syndromes known is the Li Fraumeni syndrome. This is caused by an inherited mutation in the very important gene TP53. An inherited fault in this gene greatly increases the risk of cancers but particularly early onset breast cancer. A new study (COPE) is aiming to determine the type and timing of the key molecular events in breast cancers arising in patients with a germline TP53 mutation.

Academic unit:  Cancer Sciences

Responsibilities

Postgraduate student supervision

Completed

1995-1998 Wendy Sotheran MD
2000-2004 Mohammed Al-Dahmesh PhD
2004-2008 Ellen Copson PhD
2006-2010 Victoria Hammond PhD
2008-2013 Ioannis Politopoulos PhD

Current

2011-present Rosanna Upstill-Goddard
2012-present Kate Packwood 

University of Southampton

Director of University of Southampton Clinical Trials Unit (UoSCTU)

Chair Athena Swan self assessment team for the Faculty of Medicine

National and International responsibilities

Chair of the UK Cancer Genetics Group 2002-2005
General Secretary of the British Society of Human Genetics (Elected 2006-2009)
Panel member of the National Cancer Research Institute Breast Cancer Studies Group 2002-2008. Reselected 2010-2014
Scientific Advisory Board for the Breast Cancer Campaign (2002-2006)
Scientific Advisory Board for GenOMEL (Genetics of Melanoma Network of Excellence) 2006-2011
Italian Integrated Oncology Research Programme Advisory Board member 2008-2011
HEFCE (Higher Education Funding Council for England) Clinical Senior Lectureship Awards selection panel member from 2008-2010
Human Fertilisation and Embryology Authority (HFEA), PGD peer reviewer from November 2009 - present
Health Technology Assessment (HTA) Diagnostic Technologies and Screening Panel 2010 - 2011
Medical Research Council Board - Clinical and Training Career Development Panel, from January 2011 - 2015
Member of the international steering committee Breast Cancer Information Core (http://research.nhgri.nih.gov/bic/) from April 2011
Norwegian Research Council programme grant review boards (Chaired the last panel - Biobanking)

Teaching Responsibilities

Professor Eccles delivers the Cancer Genetics lecture in Semester 4 for the BM5 students and acts as personal tutor to undergraduate medical students as they progress through the course.

Professor Eccles’ main teaching commitment is to training at specialist and F2 level in Clinical Genetics, she is the Wessex Regional Specialist Advisor for Genetics Foundation year 2 lead tutor for Clinical Genetics. Nationally she is the Academic Vice President of the Clinical Genetics Society and a member of the RCP Specialist Advisory Committee for Clinical Genetics. She also advises on genetic education in the Oncology trainees curriculum and is involved in training for oncology registrars in the Wessex Region.

As an expert in Cancer genetics, Professor Eccles is a regular faculty member at a variety of national and international educational fora including the European Society for Medical Oncology conference, European School of Oncology, the European School of Human Genetics and the Anglo-Indian Genetics Collaboration.

Contact

Professor Diana Eccles
Phone: (023) 8120 8537
Fax: (023) 8120 4346
Email: d.m.eccles@soton.ac.uk

Room Number: PAH/G/MP105