Filter projects :
- A genome-wide approach to understand domestication
Harnessing genomic technologies to investigate how humans have altered the genomes of wild plants into the crops we see today.
- Activity dependent control of adult neural hippocampal stem cells in 3D cell culture
Neurogenesis in the dentate gyrus is necessary for hippocampal dependent learning and mood control, and there is strong evidence that increased neurogenesis is an important mechanism by which antidepressants elevate mood.
- Adaptive differences in response to flooding in Populus alba and Populus tremula
Utilising Populus to assess the flood tolerance mechanisms in repeated anoxic flooding events.
- An individual-based perspective on macroevolution
How variation among individuals generates variation among species.
- An integrated approach to CNS inflammation: cooperation between antibodies and CD8 T cells
Using novel cell-labelling techniques and functionalised nanoparticles, we track macrophages and T cell recruitment to the brain and assess the role of cell mediated and humoral immunity in the initiation and/or progression of CNS inflammation.
- Anionic lipids in cell signalling: a mechanism for the modulation of ABC multidrug transporters
It is becoming apparent that lipids in biological membrane do more than simply provide a permeability barrier in which the membrane proteins are embedded. Here we investigate their role in binding to and modulating the activity of a model membrane protein.
- Antimicrobial copper: Biocidal efficacy and killing mechanism of copper and copper alloy dry surfaces against bacterial and viral pathogens
Touch surfaces are an important conduit for transmission of bacteria, viruses and fungi, leading to mass outbreaks of disease in the community and healthcare acquired infections by multiple antibiotic resistant microorganisms causing great morbidity and mortality.
- Antimicrobial Tolerance in Bacterial Biofilms: An Inter-Disciplinary Approach
Persisters are dormant bacterial cells capable of surviving antibiotic treatment. Subpopulations of persister cells are present within bacterial biofilm communities. This inter-disciplinary project uses population ecology theory to understand the phenomenon of persister cells in bacterial populations.
- Are GTGs a new class of plant anion channels regulating pH in the endomembrane system?
Given the significant sequence similarity between members of the GTG/GPHR family, we are testing whether the GTG/GPHR family has a conserved physiological function in diverse organisms.
- Bioenergy value chains: Whole systems analysis and optimisation
Bioenergy is a complex and sometimes controversial subject. This project integrates models of different aspects of the UK bioenergy supply chains across multiple scales. The resulting tool will provide guidance to decision makers about the complex social and environmental impacts of differing bioenergy strategies to aid policy development.
- Biofouling control for in-situ lab-on-a-chip environmental sensors
Using microscopy and molecular community analysis techniques, the effects of antifouling methods will be assessed.
- Biofouling control for in-situ lab-on-a-chip environmental sensors
Using microscopy and molecular community analysis techniques, the effects of antifouling methods will be assessed.
- BioliSME II: Demonstration, validation and preliminary promotion of a commercial prototype speedy system for sampling and detecting Listeria monocytogenes
The objective of the work developed by the partner University of Southampton is to firstly optimize the formation of L. monocytogenes biofilms and then conduct experiments to calculate the detachment forces required to remove L. monocytogenes biofilms.
- Calcium ATPases - role in calcium homeostasis and signalling
- Calcium Pump Targeting
We are currently investigating the way in which calcium pumps and their modulators, phospholamban and sarcolipin, are targeted to the relevant organelles in cells.
- Calcium Pumps and Thermogenesis
We are investigating the mechanism by which uncoupling of calcium transport is achieved. In addition, we are examining sarcolipin levels in muscle tissue.
Understanding processes determining soil carbon balances under perennial bioenergy crops.
- Causes and consequences of microglial priming in the ageing brain
This project addresses two different areas of neuroimmunology; neuron-glia communication and communication between the peripheral immune system and the brain, two areas that have been little investigated in the context of ageing.
- Characterisation of cue-dependent behaviour in plant parasitic nematodes: the neurobiology of host plant invasion
The neurobiology of plant parasitic nematodes.
- Characterisation of glycosyltransferases functioning during the synthesis of the secondary cell wall hemicellulose glucuronoxylan
The IRX10, IRX10-Like, IRX14 and IRX14-Like glycosyltransferases are required for GX backbone synthesis
- Circadian Developmental Requirements
This project uses the fruit fly Drosophila melanogaster to investigate the developmental role of the conserved circadian clock component CLOCK/CYCLE.
- CleanWeb - the Web as an enabler of environmental sustainability
This research is exploring the potential for internet technologies & data to help tackle major environmental challenges such as climate change.
- Cold Atmospheric Plasma (CAP) for the decontamination of reusable surgical instruments
To evaluate the potential of Cold Atmospheric Plasma as a tool for the decontamination of reusable surgical instruments and endoscopes, thus significantly reducing the risk of iatrogenic infections with prions and potentially other resilient agents.
- Consequences of early embryo environment
Maternal nutrient restriction exclusive to the preimplantation period has a pronounced influence on fetal and postnatal growth and organ development, as well as postnatal physiology.
- Control of adult neurogenesis during chronic neurodegeneration
Neurogenesis is increased during acute and chronic neurodegeneration, with the potential to replace damaged neurons at the sites of neuronal loss.
- Control of Drosophila circadian behaviour by the RHO1-signalling pathway
This project studies how regulation of cell structure affects daily timekeeping in animals.
- Control of fruitflies in Malaysian fruit crops
Sulaiman Zulkifly (sponsored by MARDI), is looking at the formulation of naturally occurring entomopathogenic fungi that have the potential to infect and kill fruitfly pests, as an alternative control strategy.
- Development of anti-fouling strategies for long-term deployed in situ sensors in marine environments
Analysis of biofilms in the marine environment and of the effectiveness of antifouling strategies
- Development of endoscope decontamination procedures
This project will assess the cleanliness of existing endoscopes and the efficacy of current decontamination procedures, using a new highly sensitive microscopy imaging method to identify and quantify residual contamination from a range of flexible endoscopes, and new cell assays to assess potential prion infectivity.
- Development of improved perennial non-food biomass and bioproduct crops for water-stressed environments (WATBIO)
Working on three novel non-food crops for bioenergy applications, we are using the latest RNA-Seq and Genome Wide Association Studies to identify genes linked to traits for improved water use efficiency.
- Development of novel methods to assess the viability and infectivity of pathogens in biofilms found in drinking water supply systems.
Using novel methods, the infectivity of sub-lethally stressed bacterial pathogens such as those in drinking water biofilms is being assessed and monitored.
- Developmental function of the RGII component of pectin in plants
We are using a transactivation based approach to alter the adundance of key sugars required for RGII synthesis in different tissues of Arabidopsis.
- Diet and immune responses in Drosophila melanogaster
Investigating the effect of nutrition on immunity, using Drosophila melanogaster, its parasites and its pathogens as a model system.
- Differentiation therapy and cancer
Many childhood cancers are caused by a failure to differentiate for instance neuroblastoma a childhood cancer of sympathetic nervous system arises when neural crest cells fail to differentiate.
- Digital life
Computational methods can shed light on evolutionary processes in a way which is not feasible using actual living organsisms.
- Dispersal of Biofilm in Cystic Fibrosis using Low Dose Nitric Oxide
Using low dose nitric oxide to disperse bacterial biofilms in cystic fibrosis and improve antibiotic efficacy.
- Dissecting pathways involved in Manganese homeostasis and stress in higher plant cells
This project is focussed on the role of transporters in the acquisition, distribution and homeostasis of Mn, and aspects of their regulation.
- DNA quadruplexes and their interaction with ligands
We are studying the structure of DNA quadruplexes in linear and supercoiled DNA and are examining their effects on gene expression when they are located in promoters.
- DNA sequence recognition by small molecules
We are using the footprinting technique with natural and synthetic DNA substrates to study the sequence selectivity of novel DNA binding small molecules.
- DNA sequence recognition by triple helix formation
One means of achieving precise DNA sequence recognition over several base pairs involves the formation of intermolecular DNA triple helices.
- Does Wlds mediate protection in a Drosophila model of tauopathies?
Can Wlds protect against axonal dysfunction and degeneration in a transgenic model of Alzheimer’s disease?
- Ecosystem Canaries: biodiversity measures as early warning signals
- Effect of folic acid supplementation during the life course on cancer susceptibility
- Effect of mouse maternal high fat diet during preimplantation and later stages of pregnancy on offspring development and health
An analysis of effects of maternal high fat diet on embryo developmental potential.
- Effects of electric fields on animal behaviour
Animals show species-specific behavioural responses to electrical fields that are dependent upon the type of electric field and species involved
- ENERGYPOPLAR: Understanding traits for bioenergy in poplar
Traits for poplar for bioenergy applications
- Environmental Healthcare Unit Consultancy
Our Consultancy Service has dealt with a wide range of projects in collaboration with both small and large multinational companies.We offer a range of testing services using up-to-date microbiological methods and the latest techniques in specialised microscopy.
- Environmental impact of transgenic (GM) plants
This is a very exciting area of research which is of great scientific and political importance. It illustrates how adopting both proximate and adaptive approaches to science provides dividends.
- Epigenetic mechanisms and the developmental origins of health and disease
Epidemiological studies show that a poor intra-uterine environment induced by restricted maternal diet, placental insufficiency or endocrine factors induces a phenotype in the offspring which in humans is associated with increased risk of developing chronic non-communicable diseases.
- Epigenetic mechanisms in metabolic bone disease: from pathology to biomarker
- EpiHealthNet: Environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing
Effects of assisted conception treatments on embryo development and health into adulthood.
- Establishing the developmental function of the pectic component rhamnogalacturonan II (RGII)
Identifying the functions of rhamnogalacturonan II during root development using an inducible RNAi-based gene knockdown approach in Arabidopsis thaliana.
- EuroChar: Development of technologies for long-term carbon sequestration
Investigating Biochar application as a potential solution to climate change - quantifying the carbon sequester capacity and its effect on plant yield. It has been suggested that biochar could offset up to 12 % of GHG emissions, thus reducing global climate change, but there is limited evidence base on which to make generalisation and EUROCHAR addresses these gaps.
- Evaluation of the role of bacterial biofilms in the pathophysiology of chronic rhinosinusitis
To identify species-specific bacterial biofilms on the mucosa of patients suffering with chronic rhinosinusitis and to evaluate the role of nitric oxide as a novel adjunctive therapy to antibiotics aimed at their eradication.
The Evolution of Trees as drivers of terrestrial biodiversity
- Evolution of cooperation in microbial biofilms
Bacteria often occur in structured communities in nature, called biofilms, in which they form microcolonies.
- Evolutionary aspects of ant-fungus interactions in leaf-cutting ants
There have been a number of researchers looking at Leaf-cutting ants. Projects have ranged from studying the ecological and evolutionary role of the symbiotic fungus in manipulating ant foraging behaviour to the potential of using entomopathogenic fungi for controlling this pest.
- Exploiting C. elegans to provide insight into neural substrates of human alcohol dependence
Changes in the pattern of behavior with increasing alcohol intake in humans reflect its complex effects on the brain.
- Exploring the influence of the plant lateral root gravitropic set point angle on architecture in soils using X-Ray Computed Tomography
- Extending the boundaries of nucleic acid chemistry
We are part of this BBSRC-funded sLoLa project, led by Prof Tom Brown (Chemistry), and are using click-chemistry to generate unusual DNA structures and examine their biological properties.
- Genetic diversification in a multi-species bacterial biofilm community
Using a multispecies biofilm model to understand how interactions between bacteria during biofilm development can influence bacterial diversification.
- Global transcriptomic responses to parasitism
Comparison of genome-wide gene expression of parasitised and unparasitised larvae focuses on genes which play a role in the actual immune response.
- Grant - Charting Intercellular Space
The principal aim of this project is to demonstrate sensing in the extracellular/intercellular space using functionalized quantum dots. Spatial and temporal information on intercellular concentrations will allow us to study how analyte concentrations in the EICS are linked to physiological status.
- Harnessing the Genetic Diversity of Watercress (Rorippa nasturtium-aquaticum) for Improved Morphology and Anti-cancer Benefits: Underpinning Data for Molecular Breeding.
Establish a collection of watercress sourced from around the world and breed watercress that not only has a reduced stem length but is also nutritionally beneficial therefore breed an ‘ideal' watercress cultivar.
- How do preimplantation embryos sense and respond to maternal nutrition affecting fetal development and adult health
Mechanisms by which maternal diet affects embryo development and health into adulthood.
- How does natural and anthropogenic disturbance change human population growth?
Understanding momentum as a driver of 21st century population health.
- Identification of novel crustacean pathogen receptor proteins
Combining bioinformatics and molecular biology to identify novel pathogen receptor proteins in marine crustaceans.
- Identification of perinatal epigenetic markers of later phenotype
- Identifying the regulating factors of biodiversity in deep time
Identifying and investigating the underlying mechanisms that drive changes in biodiversity.
- Immune-to-brain communication in immune-mediated lung inflammation; studies of neuronal mechanisms and the impact of immunomodulators
Using immunocytochemistry, molecular biology and formal behavioural testing techniques we investigate the biological nature of immune-to-brain communication elicited by immune-mediated lung disease.
- Immunity, neurodegeneration and ageing
Knowing exactly how the nervous system degenerates and becomes more vulnerable with age would further our understanding of how ageing occurs and how to prevent the debilitating neurological effects of ageing.
L-arginine is a pre-cursor for nitric oxide (NO), which is known to play a key role in insect immunity. Part of our research project is aimed at the temporal and spatial dynamics of the nitric oxide synthase (NOS) gene.
- Implications of drought conditions for microbial soil ecology: a metagenomic approach
Using NGS technology and bioinformatics techniques to better understand the implications of drought for soil microbe communities.
- Improving immunotherapy for Alzheimer’s diseases by modulating FcR interaction: an antibody engineering approach.
This MRC funded CASE studenship aims to understanding the role of FcγR in immunotherapy for neurodegenerative diseases. This work is done in collaboration with Lundbeck.
- Improving solar conversion efficiency in marine microalgae
Solar energy conversion efficiency during photosynthesis has been identified as a critical factor in determining productivity in mass algal cultures. This project aims to improve this efficiency by manipulation of light-harvesting antenna size using a range of molecular genetic approaches applied to marine algae.
- Improving the sustainability of water use in baby leaf salad crops
Using quantitative genetics and infra-red imaging to improve the sustainability of water use in baby leaf salad agriculture.
- Inflammation in chronic neurodegeneration and the contribution of systemic inflammation
We are investigating the microglia activation in a model of prion disease, mouse scrapie.
- Integrated in silico prediction of protein-protein interaction motifs
Integrating leading computational techniques to predict novel protiein-protein interaction moitfs.
- Interactome-wide prediction of short linear protein interaction motifs in humans
Large-scale prediction of functionally important protein-protein interaction motifs.
- Investigating Novel Genes in Poplar for Improved Cell Wall Disassembly
Improving the properties of Poplar as a raw material for bioethanol production.
- Investigating the interface between metabolism and neurodegeneration
This project seeks to combine electrophysiological and oxygen flux detection techniques to examine alterations in metabolism and synaptic functioning in health and disease.
- Investigating the role of membranes on protein aggregation and neurotoxicity of the huntingtin protein.
- In-Vivo Imaging of Soil, Roots and Root Hairs for Improved Understanding of Phosphate Uptake by Plants
Improving understanding of the uptake of phosphate by plants from soils by imaging root systems using X-Ray Computed Tomography.
- Label-free spectroscopy for diagnosing and monitoring AD
Spectral signatures for disease-associated protein aggregates.
- Light regulation of amino acid uptake in marine cyanobacteria
- Light regulation of chloroplast development and tetrapyrrole synthesis
This projects aims to understand the signalling pathways regulating chloroplast development with a focus on the synthesis of the tetrapyrrole, chlorophyll. Current work is examining phytochrome and gibberellin signalling in the model plant Arabidopsis and wheat, a major crop plant.
- Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing
Mechanisms by which assisted conception treatments may affect embryo development and health into adulthood.
- Linking the immune system to the central nervous system: a role for antibodies and Fcγ receptors in neuronal damage.
Using immunocytochemistry, molecular biology and formal behavioural testing techniques we investigate antibody-mediated neuronal damage in lupus.
- Mammalian Neurodegeneration
- Manganese homeostasis in higher plants
Investigating membrane proteins of Arabidopsis involved in alleviating manganese toxicity and deficiency across the plant.
- Mapping the supply and demand of bioenergy in Great Britain to 2050
This project explores the potential use of bioenergy crops across GB, looking at feasibility, sustainability implications, and constraints on production opportunities, in relation to current and future demand for energy.
- Maternal mechanisms induced by diet regulating embryo developmental plasticity affecting life-long health
Discovering the maternal mechanisms induced by diet which act through embryo developmental plasticity to alter later health.
- ME7 Synaptopathy model: a protein aggregation disease to model Alzheimer’s disease and other chronic neurodegeneration
We are using a mouse model of prion disease which like Alzheimer’s is associated with the extracellular deposition of misfolded protein and an accompanying loss of synapses.
- Mechanism for delayed senescence in Populus in a high CO2 world
- Mechanisms of DNA damage and repair in mature oocytes
Understanding how mammalian oocytes sense and repair damage to their DNA
- Metabotropic Glutamate receptors (mGluRs) models to investigate synaptic organization
Metabotropic glutamate receptors (mGlurs) are important determinants of glutamatergic transmission.
- mGluRs model for genes to behaviour
These receptors are evolutionary conserved and we have been able to investigate how these molecules control simple behaviours in the 302 neuronal cell (aprox 6000 synapse) simple nervous system of C.elegans.
- Microbial interactions in multi-species drinking water biofilm community
Using the model organism Pseudomonas aeruginosa to investigate mechanisms by which drinking water biofilms harbour important pathogenic microorganism and how these interactions within multi-species biofilms can enhance genetic adaptation and evolution of microbial pathogens.
- Modelling neural responses
Insects are able to produce precise movements of their limbs even though the numbers of neurones present are many orders of magnitude less than in mammals.
- Modifying nucleic acid nanostructures by triplex formation
We are exploiting the formation of DNA triplexes as a means for generating new DNA nanostructures.
- Modifying Uracil DNA Glycosylase
We are generating mutants of this DNA repair enzyme, which have altered recognition properties, and are using these as tools in biotechnological applications.
- Molecular breeding for quality and health benefits in lettuce
Developing nutritionally enhanced lettuce with improved disease prevention potential.
- Molecular mechanisms controlling heart cells proteins synthesis and cardiac hypertrophy
Cardiac hypertrophy involves growth of the cells of the heart muscle and entails increased rates of protein synthesis. We are studying the signalling processes involved in this. We are also studying the mechanisms involved in the control of heart protein synthesis in response to hormones and stresses such as hypoxia.
- Molecular mechanisms underlying the communication between the peripheral immune system and the brain
We are exploring if and how the brain adapts to chronic, repeated inflammatory challenges, and found that while the peripheral immune system becomes tolerant to repeated immune challenges, the brain continues to respond.
- Multitrophic interactions - inducted plant resistance and plant S.O.S. signalling
The importance of considering interactions from a multitrophic perspective has become increasingly realised in the last decade. The majority of research in this area has been focussed on crop plants, insect pest herbivores and predators/parasitoids.
- Neuronal information processing and network modelling
- Nuclear phosphoinositides and their role in the regulation of myogenic differentiation
Nuclear PI5P regulates the basal transcription complex by interacting with the PHD finger of TAF3. Deregulation of TAF3 by PI5P interaction impacts on muscle cell differentiation.
- Nutrient stress in plants in relation to biofortification and phytoremediation
Dr Lorraine Williams (Southampton) has collaborated with a team of European labs exploring the mechanisms regulating absorption, distribution and storage of both micronutrients (essential elements) and non-essential potentially toxic metals in plants (Arabidopsis, barley, wheat and tobacco). This research has important implications for agriculture, human nutrition and health as plants are the basis of all foodstuffs we ingest. The goal of biofortification is to develop plants that have an increased content of bioavailable nutrients in their edible parts
- Origin and evolution of chess-like board games
This project employs phylogenetic techniques to investigate the origin and subsequent evolution of chess and chess-like board games.
- OtoAcoustic Biometrics
- Parallel domestication as a model to understand the repeatability of phenotypic evolution
Are the same genes involved when evolutionary processes occur more than once?
- Physiological function of the GTG/GPHRs, a highly conserved family of eukaryotic membrane proteins
Is there a conserved function for the GTG/GPHR family of membrane proteins?
- Physiological role of sucrose and amino acid permeases in higher plants
- Physiology, genetics and evolution of predictive adaptive responses in Drosophila
Predictive adaptive responses (PARs) are long-term phenotypic plastic responses, made during development in anticipation of the future adult environment.
- Physiology, genetics and genomics of drought adaptation in Populus
Using physiology and genetics to investigate adaptation to drought in two populations of Populus.
- Plasticity of behaviour for good and bad
We have established facets of worm behaviour that can be readily measured in response to food withdrawal, a mimic of a starvation response.
- Plasticity through scaffolding molecules
The classic model used to study long-term changes is long-term potentiation (LTP), in the hippocampus. It is thought that the molecular changes that occur to bring about LTP are important for learning and memory.
- Plastid-to-nucleus signalling in plants
Plastid-to-nucleus (retrograde) signalling provides critical information to the nucleus on the developmental state of the chloroplast (plastid) during chloroplast biogenesis. We are trying to uncover the nature of these signals and determine the role of tetrapyrroles in this signalling pathway.
- Predictive Adaptive Responses in Drosophila
We study Predictive Adaptive Responses (PARs), using Drosophila melanogaster as a model system, and focusing on diet composition.
- Prevention and minimisation of biofilms on urinary catheters and equipment
Biofilm development on urinary catheters is a major healthcare issue, leading to infection and blockage. Here we are using advanced microscopy and viability techniques to improve our understanding of biofilm development and persistence on urinary catheters.
- Protein misfolding and the neuroprotective role of molecular chaperones
Molecular chaperones such as heat shock proteins (HSPs) regulate protein folding, misfolding, protein degradation and signalling pathways involved in neuronal death and survival.
- Rapid assessment of surface contamination and decontamination efficacy
Development of rapid, sensitive, advanced EDIC/EF light microscopy based protocols to assess the efficacy of current bio-decontamination systems.
- Reducing the Burden of intravenous drug/nutrition delivery system infections using novel anti-biofilm strategies.
- Regulation of microglial proliferation during chronic neurodegeneration
An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's and prion disease, is the generation of an innate inflammatory response within the central nervous system (CNS).
- Regulation of ribosome biogenesis
Ribosome production is essential for cell growth and proliferation, and is activated in cancer cells. This is a complex and expensive process for the cell, and must be tightly regulated. We are studying the control mechanisms involved in regulating thr production of ribosomal RNA and proteins.
- Role of antibody-mediated immune responses in the CNS
We have made exciting and interesting observations on antibody mediated responses in the CNS which are particularly relevant for novel immunotherapeutic strategies to treat neurodegenerative diseases (Alzheimer’s disease) or autoimmune diseases (lupus and MS).
- Role of autophagy during polyglutamine aggregation
In collaboration with A.M. Tolkovsky (Dept of Biochemistry, University of Cambridge, UK) we are studying how autophagy regulates the degradation of proteins that are prone to aggregation.
- Role of electrostatics in entomology
we have established that insects walking on dielectric surfaces accumulate electrostatic charges and have developed a model to explain the relationship between insect movement and charge accumulation for a variety of surfaces.
- Role of hypoxia and DNA mismatch repair in tumorigenesis
Using a multicellular tumour spheroid model to investigate the role of hypoxia and DNA mismatch repair on the fundamental processes of importance in tumour development
- Role of maternal diet on regulation of embryonic neural stem cells
Effect of mouse maternal diet on development and characteristics of neural stem cells.
- Role of membrane transporters in light-regulated seedling development
- Role of Pax-3 in sensory neurogenesis
Pax-3 is a member of a family of evolutionary conserved transcription factors which contain a conserved DNA binding domain of 128 aa, known as the paired domain.
- Roles of the Mnks (MAP kinase-activated protein kinases) in cell physiology
The Mnks link MAP kinase signalling to the control of protein synthesis and other key cellular processes. We are investigating how they regulate cell function, especially in relation to cancer, in collaboration with the pharmaceutical industry.
- SecurEau – Security and decontamination of drinking water distribution systems following a deliberate contamination event.
This work aims to design novel methodologies for the detection of low levels of contaminants, model the distribution of contaminants throughout a network and identify the point of origin, develop the use of sensors for surveillance and provide decontamination protocols for polluted networks and installations, including the neutralisation of contaminated water and residues.
- Structural basis of the elongation factor 2 kinase (EF2K) activation by Calcium/Calmodulin
Eukaryotic elongation factor 2 kinase (eEF2K) is a calcium/calmodulin (Ca2+/CaM)-dependent protein kinase, which phosphorylates and inactivates the translation elongation factor eEF2, thereby slowing down the rate of translation elongation.
- Structure and Function of Membrane Proteins
Although significant advances have been made in obtaining crystal structures of membrane proteins, very few membrane proteins have been crystallised. Certain parts of the structure still remain elusive.
- Structure, function and regulation of eukaryotic elongation factor 2 kinase (eEF2K)
eEF2 kinase controls the rate of translation elongation. eEF2K is tightly regulated by many pathways; we are exploring its role oin normal physiology, e.g., in learning and memory and in the cardiovascular system, and in diseases such as cancers, where it helps protect cells against lack of nutrients.
- Structure, function and regulation of eukaryotic initiation factor eIF2B
eIF2B plays a key role in regulating protein synthesis. We are studying its structure and regulation, and why defects in this protein lead to the neurological disease vanishing white matter.
- Sustainable urban planning decision support for urban planning BRIDGE
Modeling the green spaces in two European cities to determine how vegetation can be managed for optium polution mitigation.
- Systemic inflammation in progressive MS
In this project we are investigating whether systemic infections can contribute to driving the progression of the progressive phase of multiple sclerosis.
- Taste coding and modulation in the locust
Understanding how tastes are encoded by networks of neurones in insects not only provides us with a greater understanding of sensory processing and integration in the central nervous system, but also an understanding of how pest species select food and avoid noxious chemicals.
- Temperature entrainment of the molecular circadian clock circuits in Drosophila
This project studies how temperature affects daily timekeeping in animals.
- The impact of systemic bacterial and viral infections on innate immune responses in the brain
Using immunocytochemistry, cell biology, imaging and formal behavioural testing techniques we investigate how systemic infections impact on the brain.
- The regulation of epigenetic signalling by nuclear phosphoinositides
Epigenetic signalling and nuclear phosphoinositides.
- The regulatory mechanisms controlling zinc content in wheat
Developing an increased understanding of the regulatory mechanisms controlling zinc content in wheat may allow the formulation of targeted breeding programmes and biofortification strategies to enhance the zinc content of this staple cereal.
- The role of IgG Fc receptors in the pathogenesis of age related macular degeneration and its implications for therapeutic intervention.
Using novel models for AMD, we will investigate the functional role of antibodies in disease onset and progression.
- The role of nitric oxide in the control of biofilm and zoonotic pathogen colonisation of the salad phylloplane
Investigating the use of the signalling molecule nitric oxide for microbial control at the phylloplane
- Transcriptome-wide prediction of eukaryotic translation initiation
Combining bioinformatics searches with experimental data to broaden our knowledge of eukaryotic translation initiation.
- Tsetse fly control
Tsetse fly are responsible for transmitting a variety of Trypanosoma protozoal parasites that cause sickness in humans and cattle.
- Understanding oligodendrocyte progenitor dynamics and myelin loss in Alzheimer’s Disease
Oligodendrocyte progenitor cells (OPCs) may be altered in Alzheimer’s disease.
- Understanding the role of lipid-protein interactions in the intracellular localisation of proteins and its role in muscular dystrophy.
Using a range of biophysical techniques we are investigating how the lipid composition of the intracellular compartments affects protein structure and the role this may play of intracellular localisation.
- Understanding the role of serum amyloid-P component in the stabilization of amyloid deposits
Using a combination of liquid and solid-state NMR spectroscopy we aim to understand how serum amyloid-P component recognises amyloid fibrils and the role this plays in their stabilization.
- Use of Drosophila Models to Explore the Function of Asthma Susceptibility Genes
Using Drosophila models to replace, augment and inform vertebrate asthma models by allowing first-pass elucidation of key asthma genes, and providing an in vivo model for rapid high through-put drug screening.
- Using Next Generation Sequencing to understand acclimation and adaption of Plantago lanceolata to a changing environment
Using NGS to investigate novel acclimations and adaptions to elevated atmosphere CO2 in Plantago lanceolata to help explain what the future environment holds for plants.
- Using transcriptomics to understand adaptation and speciation in an island radiation
This studentship will use a homoploid hybrid Argyranthemum species from the Canary Islands as an exemplary scenario with which to investigate the genomics of adaptation, reproductive isolation and hybrid speciation.
- Vitacress Research Unit: Improving the quality and healthy-giving benefits of baby salad leaves
Includes identification of the genetic basis of shelf life and understanding the role of cell wall loosening and cell biophysical characteristics in determining shelf life.
- Wildlife corridors for large mammals in Belize
Creation of a natural corridor for wildlife to connect the two largest areas of protected rainforest in Belize.
- WISER: Which Ecosystem Service Models best capture the needs of the rural poor?
- A global framework for quantifying the ecosystem service impacts of oil and biofuel production - Dormant
The main objective of this 2 year project is to develop a way of comparing the impact on ecosystem services of two very different sources of transport fuel - biofuels and petroleum.
- An ecosystem service approach to quantifying the role of freshwater biodiversity in supporting food security - Dormant
Quantifying linkages between livelihoods, freshwater biodiversity, and drivers of food security and other ecosystem services.
- Climate-proof habitat refugia - Dormant
- Conservation and adaptation in the landscape: A review of landscape scale approaches in Britain - Dormant
This project created a (spatial) database of all ‘landscape-scale' conservation projects in Britain, and then used existing dataset to evaluate the extent to which these meet their biodiversity objectives.
- Safe operating spaces for regional rural development: a new conceptual tool for evaluating complex socio-ecological system dynamics - Dormant