Chemistry

Malcolm H Levitt

Primary position:
Professor of Physical Chemistry
Other positions:
Head of Magnetic Resonance

Background

The University of Southampton

Malcolm Levitt's Publications and Citation Metrics

Malcolm Levitt was an undergraduate in Chemistry at Keble College, Oxford, and obtained his PhD from Oxford University in 1981, under the supervision of Professor Ray Freeman. He did postdoctoral research with Shimon Vega in Israel and Richard Ernst at the ETH in Zürich (who received the Nobel Prize in Chemistry in 1991). He was then on the research staff at the Francis Bitter Magnet Laboratory at MIT, Boston, USA, for 4 years. He moved back to England as a Royal Society Research Fellow at the Centre for Superconductivity in Cambridge, before becoming a lecturer at the University of Stockholm, Sweden, where he was made a full professor in 1997. He moved back to England to take up a Professorship in Physical Chemistry at Southampton in April 2001. He is currently Head of Magnetic Resonance at the School of Chemistry, University of Southampton.

Malcolm was elected Fellow of the Royal Society in 2007. He won the LATSIS research prize of the ETH-Zürich in 1985, the Göran Gustafsson prize in Chemistry in 1996, the Ampère prize from the International Society of Magnetic Resonance in 2005, and the Laukien prize in Nuclear Magnetic Resonance Spectroscopy in 2008. He is on the editorial boards of several journals, including the Journal of Magnetic Resonance and the Journal of Chemical Physics. He published Spin Dynamics, a textbook on Nuclear Magnetic Resonance, in 2001. The second Edition was published in 2008.

Apart from science, he composes music, plays jazz, paints and sketches, and is interested in art, languages and politics.

Professor Malcolm H Levitt's photo

Publications

The University of Southampton's electronic library (e-prints)

Key Publications

Beduz, Carlo, Carravetta, Marina, Chen, Judy Y.- C., Concistre, Maria, Denning, Mark, Frunzi, Michael, Horsewill, Anthony J., Johannessen, Ole G., Lawler, Ronald, Lei, Xuegong, Levitt, Malcolm H., Li, Yongjun, Mamone, Salvatore, Murata, Yasujiro, Nagel, Urmas, Nishida, Tomoko, Ollivier, Jacques, Rols, Stephane, Room, Toomas, Sarkar, Riddhiman, Turro, Nicholas J. and Yang, Yifeng (2012) Quantum rotation of ortho and para-water encapsulated in a fullerene cage. Proceedings of the National Academy of Sciences, 109, (32), 12894-12898. (doi:10.1073/pnas.1210790109).
Concistre, Maria, Gansmuller, Axel, McLean, Neville, Johannessen, Ole G., Montesinos, Ildefonso Marin, Bovee-Geurts, Petra H.M., Verdegem, Peter, Lugtenburg, Johan, Brown, Richard C. D., DeGrip, Willem J. and Levitt, Malcolm H. (2008) Double-quantum 13C nuclear magnetic resonance of bathorhodopsin, the first photointermediate in mammalian vision. Journal of the American Chemical Society, 130, (32), 10490-10491. (doi:10.1021/ja803801u).
Tayler, Michael C.D. and Levitt, Malcolm H. (2011) Singlet nuclear magnetic resonance of nearly-equivalent spins. Physical Chemistry Chemical Physics, 13, (13), 5556-5560. (doi:10.1039/C0CP02293D).
Pileio, Giuseppe, Carravetta, Marina and Levitt, Malcolm H. (2010) Storage of nuclear magnetization as long-lived singlet order in low magnetic field. Proceedings of the National Academy of Sciences, 107, (40), 17135-17139. (doi:10.1073/pnas.1010570107).
Pileio, Giuseppe, Carravetta, Marina, Hughes, Eric and Levitt, Malcolm H. (2008) The long-lived nuclear singlet state of 15N-nitrous oxide in solution. Journal of the American Chemical Society, 130, (38), 12582-12583. (doi:10.1021/ja803601d).
Carravetta, M., Johannessen, O.G. and Levitt, M.H. (2004) Beyond the T-1 limit: Singlet nuclear spin states in low magnetic fields. Physical Review Letters, 92, (15), 153003-[4pp]. (doi:10.1103/PhysRevLett.92.153003).
Mamone, Salvatore, Chen, Judy Y.-C., Bhattacharyya, Rangeet, Levitt, Malcolm H., Lawler, Ronald G., Horsewill, Anthony J., Rõõm, Toomas, Bačić, Zlatko and Turro, Nicholas J. (2011) Theory and spectroscopy of an incarcerated quantum rotor: the infrared spectroscopy, inelastic neutron scattering and nuclear magnetic resonance of H2@C60 at cryogenic temperature. [in special issue: A Celebration of Harry B. Gray's Birthday] Coordination Chemistry Reviews, 255, (7-8), 938-948. (doi:10.1016/j.ccr.2010.12.029).
Concistrè, Maria, Johannessen, Ole G., McLean, Neville, Bovee-Geurts, Petra H. M., Brown, Richard C. D., DeGrip, Willem J. and Levitt, Malcolm H. (2012) A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR. Journal of Biomolecular NMR, 53, (3), 247-256. (doi:10.1007/s10858-012-9635-4). (PMID:22639195).
Tayler, Michael C.D., Marco-Rius, Irene, Kettunen, Mikko I., Brindle, Kevin M., Levitt, Malcolm H. and Pileio, Giuseppe (2012) Direct enhancement of nuclear singlet order by dynamic nuclear polarization. Journal of the American Chemical Society, 134, (18), 7668-7671. (doi:10.1021/ja302814e).
Pileio, Giuseppe, Hill-Cousins, Joseph T. , Mitchell, Sam, Kuprov, Ilya, Brown, Lynda J., Brown, Richard C. D. and Levitt, Malcolm H. (2012) Long-lived nuclear singlet order in near-equivalent13C spin pairs. Journal of the American Chemical Society, 134, (42), 17494-17497. (doi:10.1021/ja3089873).

Article

Mamone, Salvatore, Concistrè, Maria, Heinmaa, Ivo, Carravetta, Marina, Kuprov, Ilya, Wall, Gary, Denning, Mark, Lei, Xuegong, Chen, Judy Y.-C., Li, Yongjun, Murata, Yasujiro, Turro , Nicholas J. and Levitt, Malcolm H. (2013) Nuclear magnetic resonance of hydrogen molecules trapped inside C70 fullerene cages. [in special issue: Containing a special section on NMR Spectroscopy] ChemPhysChem, 14, (13), 3121-3130. (doi:10.1002/cphc.201300269).
Levitt, Malcolm H. (2013) Spectroscopy of light-molecule endofullerenes. Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences, 371, (1998), 1-29. (doi:10.1098/rsta.2012.0429).
Filidou, V., Mamone, S., Simmons, S., Karlen, S.D., Anderson, H.L., Kay, C.W.M., Bagno, A., Rastrelli, F., Murata, Y., Komatsu, K., Lei, X., Li, Y., Turro, N.J., Levitt, M.H. and Morton, J.J.L. (2013) Probing the C60 triplet state coupling to nuclear spins inside and out. Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences, 371, (1998), 1-18. (doi:10.1098/rsta.2012.0475).
Room, T., Peedu, L., Ge, M., Huvonen, D., Nagel, U., Ye, S., Xu, M., Bacic, Z., Mamone, S., Levitt, M.H., Carravetta, M., Chen, J.Y.- C., Lei, X., Turro, N.J., Murata, Y. and Komatsu, K. (2013) Infrared spectroscopy of small-molecule endofullerenes. Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences, 371, 20110631. (doi:10.1098/rsta.2011.0631).
Horsewill, A.J., Goh, K., Rols, S., Ollivier, J., Johnson, M.R., Levitt, M.H., Carravetta, M., Mamone, S., Murata, Y., Chen, J.Y.- C., Johnson, J.A., Lei, X. and Turro, N.J. (2013) Quantum rotation and translation of hydrogen molecules encapsulated inside C60: temperature dependence of inelastic neutron scattering spectra. Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences, 371, (1998), 20110627. (doi:10.1098/rsta.2011.0627).
Pileio, Giuseppe, Bowen, Sean, Laustsen, Christoffer, Tayler, Michael C.D., Hill-Cousins, Joseph T., Brown, Lynda J., Brown, Richard C.D., Ardenkjaer-Larsen, Jan H. and Levitt, Malcolm H. (2013) Recycling and imaging of nuclear singlet hyperpolarization. Journal of the American Chemical Society, 135, (13), 5084-5088. (doi:10.1021/ja312333v).
Concistrè, Maria, Johannessen, Ole G., Carignani, Elisa, Geppi, Marco and Levitt, Malcolm H. (2013) Magic-angle spinning NMR of cold samples. Accounts of Chemical Research (doi:10.1021/ar300323c).
Tayler, Michael C. D. and Levitt, Malcolm H. (2013) Accessing long-lived nuclear spin order by isotope-induced symmetry breaking. Journal of the American Chemical Society, 135, (6), 2120-2123. (doi:10.1021/ja312227h).
Kuzma, N.N., Håkansson, P., Pourfathi, M., Ghosh, R.K., Kara, H., Kadlecek, S.J., Pileio, G., Levitt, M.H. and Rizi, R.R. (2013) Lineshape-based polarimetry of dynamically-polarized in solid-state mixtures. Journal of Magnetic Resonance, 234, 90-94. (doi:10.1016/j.jmr.2013.06.008).
Concistre, M., Mamone, S., Denning, M., Pileio, G., Lei, X., Li, Y., Carravetta, M., Turro, N.J. and Levitt, M.H. (2013) Anisotropic nuclear spin interactions in H2O@C60 determined by solid-state NMR. Philosophical Transactions of The Royal Society A: Mathematical Physical and Engineering Sciences, 371, (1998), 20120102. (doi:10.1098/rsta.2012.0102).
Bocan, Jiri, Pileio, Giuseppe and Levitt, Malcolm H. (2012) Sensitivity enhancement and low-field spin relaxation in singlet NMR. Physical Chemistry Chemical Physics, 14, (46), 16032. (doi:10.1039/c2cp42553j). (PMID:23099351).
Pileio, Giuseppe, Hill-Cousins, Joseph T., Mitchell, Sam, Kuprov, Ilya, Brown, Lynda J., Brown, Richard C.D. and Levitt, Malcolm H. (2012) Long-lived nuclear singlet order in near-equivalent13C spin pairs. Journal of the American Chemical Society, 134, (42), 17494-17497. (doi:10.1021/ja3089873).
Laustsen, Christoffer, Pileio, Giuseppe, Tayler, Michael C.D., Brown, Lynda J., Brown, Richard C.D., Levitt, Malcolm H. and Ardenkjaer-Larsen, Jan H. (2012) Hyperpolarized singlet NMR on a small animal imaging system. Magnetic Resonance in Medicine, 68, (4), 1262-1265. (doi:10.1002/mrm.24430). (PMID:22851334).
Horsewill, A., Panesar, K., Rols, S., Ollivier, J., Johnson, M., Carravetta, M., Mamone, S., Levitt, M., Murata, Y., Komatsu, K., Chen, J., Johnson, J., Lei, X. and Turro, N. (2012) Inelastic neutron scattering investigations of the quantum molecular dynamics of a H2 molecule entrapped inside a fullerene cage. Physical Review B, 85, (20), 1-12. (doi:10.1103/PhysRevB.85.205440).
Levitt, Malcolm H. (2012) Singlet nuclear magnetic resonance. Annual Review of Physical Chemistry, 63, (1), 89-105. (doi:10.1146/annurev-physchem-032511-143724).
McLean, Neville J., Gansmuller, Axel, Concistre, Maria, Brown, Lynda J., Levitt, Malcom H. and Brown, Richard C.D. (2011) Syntheses of 13C2-labelled 11Z-retinals. Tetrahedron, 67, (43), 8404-8410. (doi:10.1016/j.tet.2011.07.092).
Sarkar, Riddhiman, Concistre, Maria, Johannessen, Ole G., Beckett, Peter, Denning, Mark, Carravetta, Marina, al-Mosawi, Maitham, Beduz, Carlo, Yang, Yifeng and Levitt, Malcolm H. (2011) An NMR thermometer for cryogenic magic-angle spinning NMR: the spin-lattice relaxation of 127I in cesium iodide. Journal of Magnetic Resonance, 212, (2), 460-463. (doi:10.1016/j.jmr.2011.08.021).
Ghosh, R.K., Kadlecek, S.J., Ardenkjaer-Larsen, J.H., Pullinger, B.M., Pileio, G., Levitt, M.H., Kuzma, N.N. and Rizi, R.R. (2011) Measurements of the persistent singlet state of N2O in blood and other solvents - potential as a magnetic tracer. Magnetic Resonance in Medicine, 66, (4), 1177-1180. (doi:10.1002/mrm.23119).
Ge, Min, Nagel, U., Hüvonen, D., Rõõm, T., Mamone, S., Levitt, M. H., Carravetta, M., Murata, Y., Komatsu, K., Lei, Xuegong and Turro, N. J. (2011) Infrared spectroscopy of endohedral HD and D2 in C60. Journal of Chemical Physics, 135, (11), 114511-114521. (doi:10.1063/1.3637948). (PMID:21950875).
Salager, Elodie, Dumez, Jean-Nicolas, Emsley, Lyndon and Levitt, Malcolm H. (2011) A scaling factor theorem for homonuclear dipolar decoupling in solid-state NMR spectroscopy. Journal of Magnetic Resonance, 212, (1), 11-16. (doi:10.1016/j.jmr.2011.05.017).
Tayler, Michael C.D. and Levitt, Malcolm H. (2011) Paramagnetic relaxation of nuclear singlet states. Physical Chemistry Chemical Physics, 13, (20), 9128. (doi:10.1039/c1cp20471h).
Ge, Min, Nagel, U., Hüvonen, D., Rõõm, T., Mamone, S., Levitt, M.H., Carravetta, M., Murata, Y., Komatsu, K., Chen, J.Y.-C. and Turro, N.J. (2011) Interaction potential and infrared absorption of endohedral H2 in C60. Journal of Chemical Physics, 134, (5), 054507.
Thureau, Pierre, Sauerwein, Andrea C., Concistrè, Maria and Levitt, Malcolm H. (2011) Selective internuclear coupling estimation in the solid-state NMR of multiple-spin systems. Physical Chemistry Chemical Physics, 13, (1), 93-96. (doi:10.1039/C0CP01262A). (PMID:20967326).
Paul, Subhradip, Thakur, Rajendra Singh, Levitt, M.H. and Madhu, P.K. (2010) 1H homonuclear dipolar decoupling using rotor-synchronised pulse sequences: Towards pure absorption phase spectra. Journal of Magnetic Resonance, 205, (2), 269-275. (doi:10.1016/j.jmr.2010.05.009). (PMID:20570540).
Mamone, Salvatore, Pileio, Giuseppe and Levitt, Malcolm H. (2010) Orientational sampling schemes based on four dimensional polytopes. Symmetry, 2, (3), 1423-1449. (doi:10.3390/sym2031423).
Tayler, Michael C.D., Marie, Sabrina, Ganesan, A. and Levitt, Malcolm H. (2010) Determination of molecular torsion angles using nuclear singlet relaxation. Journal of the American Chemical Society, 132, (24), 8225-8227. (doi:10.1021/ja1012917).
Horsewill, A.J., Rols, S., Johnson, M.R., Murata, Y., Murata, M., Komatsu, K., Carravetta, M., Mamone, S., Levitt, M.H., Chen, J.Y-C., Johnson, J.A., Lei, X. and Turro, N.J. (2010) Inelastic neutron scattering of a quantum translator-rotator encapsulated in a closed fullerene cage: Isotope effects and translation-rotation coupling in H_{2}@C_{60} and HD@C_{60}. Physical Review B, 82, (8), 081410. (doi:10.1103/PhysRevB.82.081410).
Pileio, Giuseppe, Carravetta, Marina and Levitt, Malcolm H. (2009) Extremely low-frequency spectroscopy in low-field nuclear magnetic resonance. Physical Review Letters, 103, (8), 083002-[4pp]. (doi:10.1103/PhysRevLett.103.083002).
Pileio, Giuseppe and Levitt, Malcolm H. (2009) Theory of long-lived nuclear spin states in solution nuclear magnetic resonance. II. Singlet spin locking. Journal of Chemical Physics, 130, (21), p.214501. (doi:10.1063/1.3139064 ).
Concistre, Maria, Gansmuller, Axel, McLean, Neville, Johannessen, Ole G., Marin Montesinos, Ildefonso, Bovee-Geurts, Petra H.M., Brown, Richard C.D., DeGrip, Willem J. and Levitt, Malcolm H. (2009) Light penetration and photoisomerization in rhodopsin studied by numerical simulations and double-quantum solid-state NMR spectroscopy. Journal of the American Chemical Society, 131, (17), 6133-6140. (doi:10.1021/ja809878c).
Subhradip, Paul, Thakur, Rajendra Singh, Goswami, Mithun, Sauerwein, Andrea C., Mamone, Salvatore, Concistre, Maria, Foerster, Hans, Levitt, Malcolm H. and Madhu, P. K. (2009) Supercycled homonuclear dipolar decoupling sequences in solid-state NMR. Journal of Magnetic Resonance, 197, (1), 14-19. (doi:10.1016/j.jmr.2008.11.011).
Mamone, S., Ge, Min, Hüvonen, D., Nagel, U., Danquigny, A., Cuda, F., Grossel, M.C., Murata, Y., Komatsu, K., Levitt, M.H., Rõõm, T. and Carravetta, M. (2009) Rotor in a cage: infrared spectroscopy of an endohedral hydrogen-fullerene complex. Journal of Chemical Physics, 130, (8), 081103-[4pp]. (doi:10.1063/1.3080163). (PMID:19256588).
Horsewill, A.J., Panesar, K.S., Rols, S., Johnson, M.R., Murata, Y., Komatsu, K., Mamone, S., Danquigny, A., Cuda, F., Maltsev, S., Grossel, M.C., Carravetta, M. and Levitt, M.H. (2009) Quantum translator-rotator: Inelastic neutron scattering of dihydrogen molecules trapped inside anisotropic fullerene cages. Physical Review Letters, 102, (1), 013001. (doi:10.1103/PhysRevLett.102.013001).
Pileio, Giuseppe, Mamone, Salvatore, Mollica, Giulia, Montesinos, Ildefonso Marin, Gansmüller, Axel, Carravetta, Marina, Brown, Steven P. and Levitt, Malcolm H. (2008) Estimation of internuclear couplings in the solid-state NMR of multiple-spin systems: selective spin echoes and off-magic-angle sample spinning. Chemical Physics Letters, 456, (1-3), 116-121. (doi:10.1016/j.cplett.2008.03.021).
Panesar, K.S., Horsewill, A.J., Cuda, F., Carravetta, M., Mamone, S., Danquigny, A., Grossel, M.C. and Levitt, M.H. (2008) Thermal history effects and methyl tunneling dynamics in a supramolecular complex of calixarene and para-xylene. Journal of Chemical Physics, 128, (14), 144512-[8pp]. (doi:10.1063/1.2889003).
Pileio, Giuseppe and Levitt, Malcolm H. (2008) Isotropic filtering using polyhedral phase cycles: application to singlet state NMR. Journal of Magnetic Resonance, 191, (1), 148-155. (doi:10.1016/j.jmr.2007.11.021).
Mamone, Salvatore, Dorsch, André, Johannessen, Ole G., Naik, Manoj V., Madhu, P.K. and Levitt, Malcolm H. (2008) A Hall effect angle detector for solid-state NMR. Journal of Magnetic Resonance, 190, (1), 135-141. (doi:10.1016/j.jmr.2007.07.012).
Levitt, M.H. (2008) Symmetry in the design of NMR multiple-pulse sequences. Journal of Chemical Physics, 128, (5) (doi:10.1063/1.2831927).
Carravetta, M., Danquigny, A., Mamone, S., Cuda, F., Johannessen, O.G., Heinmaa, I., Panesar, K., Stern, R., Grossel, M.C., Horsewill, A.J., Samoson, A., Murata, M., Murata, Y., Komatsu, K. and Levitt, M.H. (2007) Solid-state NMR of endohedral hydrogen-fullerene complexes. Physical Chemistry Chemical Physics, 9, (35), 4879-4894. (doi:10.1039/b707075f).
Pileio, Giuseppe, Guo, Ying, Pham, Tran N., Griffin, John M., Levitt, Malcolm H. and Brown, Steven P. (2007) Residual dipolar couplings by off-magic-angle spinning in solid-state nuclear magnetic resonance spectroscopy. Journal of the American Chemical Society, 129, (36), 10972-10973. (doi:10.1021/ja0721115).
Pileio, G. and Levitt, M.H. (2007) J-Stabilization of singlet states in the solution NMR of multiple-spin systems. Journal of Magnetic Resonance, 187, (1), 141-145. (doi:10.1016/j.jmr.2007.03.019).
Pileio, G., Concistre, M., McLean, N., Gansmulller, A., Brown, R.C.D. and Levitt, M.H. (2007) Analytical theory of gamma-encoded double-quantum recoupling sequences in solid-state nuclear magnetic resonance. Journal of Magnetic Resonance, 186, (1), 65-74. (doi:10.1016/j.jmr.2007.01.009).
Pileio, Giuseppe, Guo, Ying, Pham, Tran N., Griffin, John M., Levitt, Malcolm H. and Brown, Steven P. (2007) Residual dipolar couplings by off-magic-angle spinning in solid-state nuclear magnetic resonance Spectroscopy. Journal of the American Chemical Society, 129, (36), 10972-10973. (doi:10.1021/ja0721115).
Marin-Montesinos, Ildefonso, Mollica, Giulia, Carravetta, Marina, Gansmuller, Axel, Pileio, Giuseppe, Bechmann, Matthias, Sebald, Angelika and Levitt, Malcolm H. (2006) Truncated dipolar recoupling in solid-state nuclear magnetic resonance. Chemical Physics Letters, 432, (4-6), 572-578. (doi:10.1016/j.cplett.2006.10.101).
Pileio, Giuseppe, Concistrè, Maria, Carravetta, Marina and Levitt, Malcolm H. (2006) Long-lived nuclear spin states in the solution NMR of four-spin systems. Journal of Magnetic Resonance, 182, (2), 353-357. (doi:10.1016/j.jmr.2006.06.034).
Kristiansen, Per Eugen, Carravetta, Marina, van Beek, Jacco D., Lai, Wai Cheu and Levitt, Malcolm H. (2006) Theory and applications of supercycled symmetry-based recoupling sequences in solid-state NMR. Journal of Chemical Physics, 124, (234510), 1-19. (doi:10.1063/1.2205857).
Lai, Wai Cheu, McLean, Neville, Gansmüller, Axel, Verhoeven, Michiel A., Antonioli, Gian Carlo, Carravetta, Marina, Duma, Luminita, Bovee-Geurts, Petra H.M., Johannessen, Ole G., de Groot, Hub J.M., Lugtenburg, Johan, Emsley, Lyndon, Brown, Steven P., Brown, Richard C.D., DeGrip, Willem J. and Levitt, Malcolm H. (2006) Accurate measurements of 13C-13C J-couplings in the rhodopsin chromophore by double-quantum solid-state NMR spectroscopy. Journal of American Chemical Society, 128, (2), 3878-3879. (doi:10.1021/ja0581604).
Carravetta, Marina, Johannessen, Ole G., Levitt, Malcolm H., Heinmaa, Ivo, Stern, Raivo, Samoson, Ago, Horsewill, Anthony, Murata, Y. and Komatsu, Koichi (2006) Cryogenic NMR spectroscopy of endohedral hydrogen-fullerene complexes. Journal of Chemical Physics, 124, (10), 104507-104520. (doi:10.1063/1.2174012).
van Beek, Jaco D., Dupree, Ray and Levitt, Malcolm H. (2006) Symmetry-based recoupling of (17)O-(1)H spin pairs in magic-angle spinning NMR. Journal of Magnetic Resonance, 179, (1), 38-48. (doi:10.1016/j.jmr.2005.11.003).
Marin-Montesinos, Ildefonso, Brouwer, Darren H., Antonioli, Giancarlo, Lai, Wai Cheu, Brinkmann, Andreas and Levitt, Malcolm H. (2005) Heteronuclear decoupling interference during symmetry-based homonuclear recoupling in solid-state NMR. Journal of Magnetic Resonance, 177, (2), 307-317. (doi:10.1016/j.jmr.2005.07.020).
Brouwer, Darren H., Darton, Richard J., Morris, Russell E. and Levitt, Malcolm H. (2005) A solid-state NMR method for solution of zeolite crystal structures. Journal of the American Chemical Society, 127, (29), 10365-10370. (doi:10.1021/ja052306h).
Carravetta, Marina and Levitt, Malcolm H. (2005) Theory of long-lived nuclear spin states in solution nuclear magnetic resonance. I. Singlet states in low magnetic field. The Journal of Chemical Physics, 122, (21) (doi:10.1063/1.1893983).
Fayon, Franck, Massiot, Dominique, Levitt, Malcolm H., Titman, Jeremy J., Gregory, Duncan H., Duma, Luminita, Emsley, Lyndon and Brown, Steven P. (2005) Through-space contributions to two-dimensional double-quantum J correlation NMR spectra of magic-angle-spinning solids. Journal of Chemical Physics, 122, (19)
Brouwer, Darren H., Kristiansen, Per Eugen, Fyfe, Colin A. and Levitt, Malcolm H. (2005) Symmetry-based 29Si dipolar recoupling magic angle spinning NMR spectroscopy: a new method for investigating three-dimensional structures of zeolite frameworks. Journal of the American Chemical Society, 127, (2), 542-543. (doi: 10.1021/ja043228l).
Zhao, Xin, Hoffbauer, Wilfried, auf der Gunne, Jörn Schmedt and Levitt, Malcolm H. (2004) Heteronuclear polarization transfer by symmetry-based recoupling sequences in solid-state NMR. Solid State Nuclear Magnetic Resonance, 26, (2), 57-64. (doi: 10.1016/j.ssnmr.2003.11.001).
Kristiansen, Peter Eugen, Carravetta, Marina, Lai, Wai Cheu and Levitt, Malcolm H. (2004) A robust pulse sequence for the determination of small homonuclear dipolar couplings in magic-angle spinning NMR. Chemical Physics Letters, 390, (1-3), 1-7. (doi:10.1016/j.cplett.2004.03.075).
Kristiansen, PE, Carravetta, M, Lai, Wai Chi and Levitt, Malcolm H. (2004) A robust pulse sequence for the determination of small homonuclear dipolar couplings in magic-angle spinning NMR. Chemical Physics Letters, 390, (1-3), 1-7.
Carravetta, M., Murata, Y., Murata, M., Heinmaa, I., Stern, R., Tontcheva, A., Samoson, A., Rubin, Y., Komatsu, K. and Levitt, M. H. (2004) Solid-state NMR spectroscopy of molecular hydrogen trapped inside an open-cage fullerene. Journal of the American Chemical Society, 126, (13), 4092-4093. (doi:10.1021/ja031536y).
Hughes, Colan E., Carravetta, Marina and Levitt, Malcolm H. (2004) Some conjectures for cogwheel phase cycling. Journal of Magnetic Resonance, 167, (2), 259-265. (doi:10.1016/j.jmr.2004.01.001).
Hughes, Colan E., Carravetta, Marina and Levitt, Malcolm H. (2004) Some conjectures on cogwheel phase cycling. Journal of Magnetic Resonance, 167, (2), 259-265. (doi:10.1016/j.jmr.2004.01.001).
Carravetta, Marina, Zhao, Xin, Johannessen, Ole G., Lai, Wai C., Verhoeven, Michiel A., Bovee-Geurts, Petra H.M., Verdegem, Peter J.E., Kiihne, Suzanne, Luthman, Henrik, de Groot, Huub J.M., deGrip, William J., Lugtenburg, Johan and Levitt, Malcolm H. (2004) Protein-induced bonding perturbation of the rhodopsin chromophore detected by double-quantum solid-state NMR. Journal of the American Chemical Society, 126, (12), 3948-3953. (doi: 10.1021/ja039390q).
Duma, Luminita, Lai, Wai Cheu, Carravetta, Marina, Emsley, Lyndon, Brown, Steven P. and Levitt, Malcolm H. (2004) Principles of spin-echo modulation by J-couplings in magic-angle spinning solid state NMR. ChemPhysChem, 5, (6), 815-833. (doi:10.1002/cphc.200301213).
Carravetta, Marina and Levitt, Malcolm H. (2004) Long lived nuclear spin states in high-field solution NMR. Journal of the American Chemical Society, 126, (20), 6228-6229. (doi:10.1021/ja0490931).
Mahesh, T.S., Sinha, Neeraj, Ghosh, Arindam, Das, Ranabir, Suryaprakash, N., Levitt, Malcolm H., Ramanathan, K.V. and Kumar, Anil (2003) Quantum information processing by NMR using strongly coupled spins. Current Science, 85, (7), 932-944.
Ivchenko, Natala, Hughes, Colan E. and Levitt, Malcolm H. (2003) Application of cogwheel phase cycling to sideband manipulation experiments in solid-state NMR. Journal of Magnetic Resonance, 164, (2), 286-293. (doi:10.1016/S1090-7807(03)00206-4).
Madhu, P.K., Johannessen, Ole G., Pike, Kevin J., Dupree, Ray, Smith, Mark E. and Levitt, Malcolm H. (2003) Application of amplitude-modulated radiofrequency fields to the magic-angle spinning NMR of spin-7/2 nuclei. Journal of Magnetic Resonance, 163, (2), 310-317. (doi:10.1016/S1090-7807(03)00159-9).
Carravetta, Marina, Zhao, Xin, Bockmann, Anja and Levitt, Malcolm H. (2003) Coherence transfer selectivity in two-dimensional solid-state NMR. Chemical Physics Letters, 376, (3-4), 515-523. (doi:10.1016/S0009-2614(03)00944-8).
Hughes, Colan E., Schmedt auf der Günne, Jörn and Levitt, Malcolm H. (2003) A test for the number of coupled spins I = 1/2 in magic-angle-spinning solids: zero-quantum recoupling of multiple-quantum coherences. ChemPhysChem, 4, (5), 457-465. (doi: 10.1002/cphc.200200470).
Madhu, P.K., Pike, K.J., Dupree, R., Levitt, M.H. and Smith, M.E. (2003) Modulation-aided signal enhancement in the magic angle spinning NMR of spin-5/2 nuclei. Chemical Physics Letters, 367, (1-2), 150-156. (doi: 10.1016/S0009-2614(02)01691-3).
Ivchenko, Natala, Hughes, Colan E. and Levitt, Malcolm H. (2003) Multiplex phase cycling. Journal of Magnetic Resonance, 160, (1), 52-58. (doi:10.1016/S1090-7807(02)00108-8).
Zhao, Xin, Carravetta, Marina, Madhu, P.K. and Levitt, Malcolm H. (2003) Symmetry-based pulse sequences in solid-state NMR and applications to biological systems. Recent Research Developments in Biophysics, 2, 121-146.
Carravetta, Marina, Schmedt auf der Günne, Jörn and Levitt, Malcolm H. (2003) Enhanced triple-quantum excitation in 13C magic-angle spinning NMR. Journal of Magnetic Resonance, 162, (2), 443-453. (doi:10.1016/S1090-7807(03)00059-4).
Hughes, C.E., Pratima, R., Karlsson, T. and Levitt, M.H. (2002) Double-quantum solid-state NMR of 13C spin pairs coupled to 14N. Journal of Magnetic Resonance, 159, (1), 25-35. (doi:10.1016/S1090-7807(02)00118-0).
van Dam, Lorens, Ouwerkerk, Niels, Brinkmann, Andreas, Raap, Jan and Levitt, Malcolm H. (2002) Solid-state NMR determination of sugar ring pucker in 13C-labeled 2'-deoxynucleosides. Biophysical Journal, 83, (5), 2835-2844.
Brinkmann, Andreas, Schmedt auf der Günne, Jörn and Levitt, Malcolm H. (2002) Homonuclear zero-quantum recoupling in fast magic-angle spinning nuclear magnetic resonance. Journal of Magnetic Resonance, 156, (1), 79-96. (doi:10.1006/jmre.2002.2525).
Murali, K.V.R.M., Sinha, Neeraj, Mahesh, T.S., Levitt, Malcolm H., Ramanathan, K.V. and Kumar, Anil (2002) Quantum-information processing by nuclear magnetic resonance: experimental implementation of half-adder and subtractor operations using an oriented spin-7/2 system. Physical Review A, 66, (2), 022313-[5pp]. (doi:10.1103/PhysRevA.66.022313).
Levitt, Malcolm H., Madhu, P.K. and Hughes, Colan E. (2002) Cogwheel phase cycling. Journal of Magnetic Resonance, 155, (2), 300-306. (doi:10.1006/jmre.2002.2520).
Zhao, Xin, Sudmeier, James L., Bachovchin, William W. and Levitt, Malcolm H. (2001) Measurement of NH bond lengths by fast magic-angle spinning solid-state NMR spectroscopy: a new method for the quantification of hydrogen bonds. Journal of the American Chemical Society, 123, (44), 11097-11098. (doi:10.1021/ja016328p).
Madhu, P.K., Zhao, X. and Levitt, M.H. (2001) High-resolution 1H NMR in the solid state using symmetry-based pulse sequences. Chemical Physics Letters, 346, (1-2), 142-148. (doi:10.1016/S0009-2614(01)00876-4).
Zhao, Xin, Eden, Mattias and Levitt, Malcolm H. (2001) Recoupling of heteronuclear dipolar interactions in solid-state NMR using symmetry-based pulse sequences. Chemical Physics Letters, 342, (3-4), 353-361. (doi:10.1016/S0009-2614(01)00593-0).
Carravetta, Marina, Schmedt auf der Gunne, Jörn and Levitt, Malcolm H. (2001) Enhanced triple-quantum excitation in solid-state MAS NMR. Journal of Magnetic Resonance, 162, (2), 443-453. (doi:10.1016/S1090-7807(03)00059-4).
Karlsson, T., Hughes, C.E., Schmedt auf der Günne, J. and Levitt, M.H. (2001) Double-quantum excitation in the NMR of spinning solids by pulse-assisted rotational resonance. Journal of Magnetic Resonance, 148, (2), 238-247. (doi:10.1006/jmre.2000.2243).
Carravetta, Marina, Edén, Mattias, Johannessen, Ole G., Luthman, Henrik, Verdegem, Peter J.E., Lugtenburg, Johan, Sebald, Angelika and Levitt, Malcolm H. (2001) Estimation of carbon-carbon bond lengths and medium-range internuclear distances by solid-state nuclear magnetic resonance. Journal of the American Chemical Society, 123, (43), 10628-10638. (doi:10.1021/ja016027f).
Ravindranathan, S., Karlsson, T., Lycknert, K., Widmalm, G. and Levitt, M.H. (2001) Conformation of the glycosidic linkage in a disaccharide investigated by double-quantum solid-state NMR. Journal of Magnetic Resonance, 151, (1), 136-141. (doi:10.1006/jmre.2001.2357).
Carravetta, Marina, Edén, Mattias, Johannessen, Ole G., Luthman, Henrik, Verdegem, Peter J.E., Lugtenburg, Johan, Sebald, Angelika and Levitt, Malcolm H. (2001) Estimation of carbon-carbon bond lengths and medium-range internuclear distances by solid-state nuclear magnetic resonance. Journal of the American Chemical Society, 123, (43), 10628-10638. (doi: 10.1021/ja016027f).

Book

Levitt, Malcolm H. (2001) Spin dynamics: basics of nuclear magnetic resonance, Chichester, UK, Wiley, 710pp.

Book Section

Levitt, Malcolm H. (2002) Seven-fold dynamical symmetry in solid-state nuclear magnetic resonance. In, Hargittai, I. and Laurent, T.C. (eds.) Symmetry 2000. London, UK, Portland Press.
Levitt, Malcolm H. (2002) Symmetry-based pulse sequences in magic-angle spinning solid-state NMR. In, Grant, David M. and Harris, Robin K. (eds.) Encyclopedia of Nuclear Magnetic Resonance. Volume 9, Advances in NMR. Chichester, UK, Wiley, 165-196.
Glaubitz, Clemens, Carravetta, Marina, Edén, Mattias and Levitt, Malcolm H. (2001) Towards dipolar recoupling in macroscopically ordered samples of membrane proteins rotating at the magic angle. In, Kiihne, S.R. and de Groot, H.J.M. (eds.) Perspectives on Solid State NMR in Biology. Dordrecht, The Netherlands, Kluwer Academic, 71-83. (Focus on Structural Biology, 1).
Brinkmann, Andreas, Carravetta, Marina, Zhao, Xin, Edén, Mattias, Schmedt auf der Günne, Jörn and Levitt, Malcolm H. (2001) Using symmetry to design pulse sequences in solid-state NMR. In, Kiihne, S.R. and de Groot, H.J.M. (eds.) Perspectives on Solid State NMR in Biology. Dordrecht, The Netherlands, Kluwer Academic, 3-14. (Focus on Structural Biology, 1).
 

Research

Research Interests

Our group develops new experimental techniques in nuclear magnetic resonance (NMR) spectroscopy, and applies those techniques to systems of interest in biology and materials science. For example, we have developed new NMR techniques for determining the atomic-scale structure in non-crystalline solids, and have applied those methods to the membrane protein rhodopsin and to the class of inorganic network solids called zeolites. We are currently working on extending solid-state NMR to the study of samples at very low temperatures, which will allow us to achieve higher signal strength and allow the study of cryogenic physical phenomena such as quantum rotation by NMR. We have also demonstrated the existence of nuclear spin states with unusually long lifetimes in room-temperature liquids, and are currently exploring the possibilities of exploiting such long-lived nuclear spin states for NMR imaging.

Research keywords

Nuclear magnetic resonance. Pulse sequences. Structural biology. Membrane proteins. Spin dynamics. Nuclear singlet states. Endohedral fullerenes. Rhodopsin.

Research funding

2012-2013 "Fast Sample Shuttle Probe for Nuclear Magnetic Resonance", Royal Society, £72k

2012-2016 "Hyperpolarized Singlet NMR", ERC Advanced Grant, £2.4M

2012-2014 "Laboratory for Enhanced Magnetic Resonance Imaging", Royal Society, £393k

2011-2014 "Hyperpolarized Nuclear Singlet States", EPSRC, £1.4M (with Prof R. Brown, University of Southampton)

2011-2017 "A UK Magnetic Resonance Basic Technology Centre for Doctoral Training", £3.96M (with Universities of Warwick, St Andrews, Dundee, Nottingham and Aberdeen)

2011-2014 "Magnetic Resonance of Dihydrogen Endofullerenes", EPSRC, £606k (with Prof. A. J. Horsewill, University of Nottingham)

2009-2013 "Singlet nuclear magnetic resonance: from theory to practice", Leverhulme Trust, £249k

2007-2009 "Long-lived spin states in nuclear magnetic resonance", EPSRC, £348k.

2007-2010 "Multiple-spin recoupling in nuclear magnetic resonance", EPSRC, £450k.

2005-2009 "Cryogenic magic-angle-spinning NMR", Basic Technology Program, RCUK, £2.81M. Collaborative grant with Prof. P. J. F. Henderson, Department of Biochemistry, University of Leeds; Dr. A. Horsewill, School of Physics and Astronomy, University of Nottingham; Dr. M. Grossel, School of Chemistry, University of Southampton; Prof. Y. Yang, School of Engineering, University of Southampton; Dr. J. Werner, School of Biological Sciences, University of Southampton.

2005-2008 "Multiple-quantum 17O NMR in solids", Royal Society, £15.5k. Collaborative grant with Dr. P. K. Madhu, Tata Institute for Fundamental Research, Mumbai, India.

 

Primary research group:  Magnetic Resonance

Research projects

Levitt: Cryogenic Nuclear Magnetic Resonance

Levitt: Molecular Structure Determination by Solid-State NMR

Levitt: Solid-State NMR of Rhodopsin

Levitt: Long-lived Nuclear Singlet States

Contact

Professor Malcolm H Levitt
Chemistry
University of Southampton
Highfield
Southampton
SO17 1BJ

Room Number: 27/2026

Telephone: (023) 8059 6753
Facsimile: (023) 8059 3781
Email: mhl@soton.ac.uk