The University of Southampton
Courses

BIOL6039 Cellular and Molecular Pathology

Module Overview

The module will cover recent advances in selected areas of molecular cell biology explaining key aspects of cell and molecular biology required to understand these studies. The relevance of these studies to advancement of medical science will also be explored.

Aims and Objectives

Module Aims

• To study recent advances in selected areas of biomedical science. • To gain insight into the use of basic science in understanding the cell and molecular biology of specific disease processes. • To be competent to evaluate the scientific literature relevant to the module content using a critical approach

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • Regulation of epithelial cell-cell adhesion by tumour suppressors and protooncogenes. Dysregulation of this process in invasion and metastasis of cancer cells;
  • Basic outline of control of the cell cycle and alterations in cell cycle checkpoints in cancer cells. Relationship of Warburg effect to misregulation of these processes;
  • Key aspects of apoptosis and its misregulation in cancers;
  • Key aspects of the molecular basis of ageing;
  • Understand the mechanisms of tumour cell motility, and how cancers spread;
  • Define the processes that occur during acute brain injury, and the pathogenesis of acute neurodegeneration;
  • The role of stem cells in normal physiology, and their potential for therapy. The potential of IVF and preimplantation genetic diagnosis.

Syllabus

To define recent advances in selected areas of molecular cell biology. To learn aspects of basic cell and molecular biology required to understand these studies To demonstrate how these advances are expanding our knowledge of medical science

Special Features

At the end of selected lecture sets (x2 in total), students will be given a specific paper to read that covers an additional aspect of the lecture topic that will not be specifically examined in the written 2 hour exam paper. Students will be required to study the paper in detail and independently write a review (~1500 words) to be submitted via Turnitin.

Learning and Teaching

Teaching and learning methods

Lectures, research paper reviews and independent study.

TypeHours
Independent Study126
Lecture20
Tutorial4
Total study time150

Assessment

Summative

MethodPercentage contribution
Literature review with presentation  (1500 words) 30%
Written exam  (2 hours) 70%

Referral

MethodPercentage contribution
Literature review with presentation 30%
Written exam  (2 hours) 70%

Linked modules

Prerequisites: BIOL2002 or BIOL2003 or BIOL2014 or MEDI2013. Resources: Organisational, lecture and background materials will be provided through the course pages on Blackboard.

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