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Staff

Lead researcher

Professor Jacek Brodzki

Head of School

Research interests

  • Topological data analysis
  • Applications of topology to medicine, biology, chemistry, physics, computer science
  • Noncommutative Geometry
Other researchers

Professor Jeremy Frey

Professor of Physical Chemistry

Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.

Professor Mahesan Niranjan

ISIS Chair

Professor Peter Smith BSc, PhD, MA, FRSB

Professor of Life Sciences

Collaborating research institutes, centres and groups

Centre for Geometry, Topology, and Applications

The Centre fosters cutting-edge collaborative research in geometry, topology, homotopy theory, noncommutative geometry and group theory and provides a focal point for interdisciplinary applications in modern data science.

Computational Systems Chemistry

Our research covers a broad range of domains from nanoscale materials properties, atmospheric chemistry, through to biological systems.

Pure Mathematics

Collaborating around the world to contribute to research in algebra, analysis, geometry and topology.

Vision, Learning and Control

Our work covers a range of technological areas from control, to machine learning and computer vision.

Research outputs

The geometry of synchronization problems and learning group actions
Tingran Gao,
Jacek Brodzki,
& Sayan Mukherjee
, 2019 , Discrete and Computational Geometry , 1--62
DOI: 10.1007/s00454-019-00100-2
Type: article
A new topological descriptor for water network structure
Lee Steinberg,
Jeremy G. Frey,
& John Russo
, 2019 , Journal of Cheminformatics , 11 (48) , 1--11
DOI: 10.1186/s13321-019-0369-0
Type: article
Symmetric cohomology of groups
Mariam Pirashvili
, 2018 , Journal of Algebra , 509 , 397--418
DOI: 10.1016/j.jalgebra.2018.05.020
Type: article
Large-scale label-free quantitative mapping of the sputum proteome
James Schofield,
Dominic Burg,
Joost Brandsma,
Doroteya kancheva K Staykova,
Aruna Bansal,
B.L. Nicholas,
Caterina Folisi,
Aruna Bansal,
Ben Nicholas,
Yang Xian,
Anthony Rowe,
Julie Corfield,
Susan Wilson,
Jonathan Ward,
Rene Lutter,
Louise Fleming,
Dominick E. Shaw,
Per S. Bakke,
Massimo Caruso,
Sven-Erik Dahlén,
Stephen J. Fowler,
Simone Hashimoto,
Ildiko Horvath,
Peter Howarth,
Norbert Krug,
Paolo Montuschi,
Marek Sanak,
Thomas Sandstrom,
Florian Singer,
Charles Auffray,
Kai Sun,
Ioannis Pandis,
Ana R. Sousa,
Ian M. Adcock,
Kian Fan Chung,
Peter J. Sterk,
Ratko Djukanovic,
& Paul Skipp
, 2018 , Journal of Proteome Research , 17 (6) , 1997--2248
DOI: 10.1021/acs.jproteome.8b00018
Type: article
Improved understanding of aqueous solubility modeling through topological data analysis
Mariam Pirashvili,
Jacek Brodzki,
Francisco Belchi guillamon,
Mahesan Niranjan,
Jeremy G. Frey,
& Lee Steinberg
, 2018 , Journal of Cheminformatics , 10
DOI: 10.1186/s13321-018-0308-5
Type: article