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Research project

Dr Vince O'Connor MRC TSE Highlight

Staff

Lead researcher

Professor Vincent O'connor

Professor of Neurochemistry

Research interests

  • Molecular mechanism of synaptic function and dysfunction
  • Synaptic degeneration
  • Genetic models of synaptic and neuronal dysfunction

Research outputs

Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration
Ayodeji A Asuni,
Bryony Gray,
Joanne Bailey,
Paul Skipp,
V Hugh Perry,
& Vincent O'Connor
, 2014 , The Journal of Biological Chemistry , 289 (7) , 4532--4545
DOI: 10.1074/jbc.M113.502690
Type: article
Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease
Zuzana Šišková,
Richard A. Reynolds,
Vincent O'Connor,
& V. Hugh Perry
, 2013 , PLoS ONE , 8 (1)
DOI: 10.1371/journal.pone.0055004
Type: article
The role of activity in synaptic degeneration in a protein misfolding disease, prion disease
Matteo Caleo,
Laura Restani,
Eleonora Vannini,
Zuzana Siskova,
Hussain Al-Malki,
Ruth Morgan,
Vincent O'Connor,
& V Hugh Perry
, 2012 , PLoS ONE , 7 (7) , e41182
DOI: 10.1371/journal.pone.0041182
Type: article
Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease
Zuzana Sisková,
Don Joseph Mahad,
Carianne Pudney,
Graham Campbell,
Mark Cadogan,
Ayodeji Asuni,
Vincent O'Connor,
Victor Hugh Perry,
&
, 2010 , The American Journal of Pathology , 177 (3) , 1411--1421
DOI: 10.2353/ajpath.2010.091037
Type: article
Synaptopathy: dysfunction of synaptic function?
Nils Brose,
Vincent O'Connor,
& Paul Skehel
, 2010 , Biochemical Society Transactions , 38 (2) , 443--444
DOI: 10.1042/BST0380443
Type: article