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Research project

OPTIMISE - Optimising Treatment for Mild Systolic hypertension in the Elderly

  • Research groups:
  • Lead researcher:
    Dr Mark Lown
  • Other researchers:
    Professor Paul Little
  • Research funder:
    National Institute of Health and Care Research
  • Status:
    Not active

Project overview

This study is now complete, please see associated publications. This is a Primary Care based, open label, randomised controlled trial with embedded qualitative components and the aims are: To safely reduce the amount of blood pressure medication taken by older people using self-monitoring of blood pressure. To see if reducing the amount of medication taken by older people results in fewer falls or other harmful events and side-effects. To see if reducing the number of blood pressure lowering medications can improve the quality of life of individuals entering older age.

Staff

Lead researcher

Dr Mark Lown

Clinical Lecturer
Other researchers

Professor Paul Little

Professor in Primary Care Research

Collaborating research institutes, centres and groups

Primary Care Research Centre

We increase understanding of the psychosocial effects of cancer on daily life to improve health outcomes and help people live well.

Research outputs

Effect of antihypertensive medication reduction vs usual care on short-term blood pressure control in patients with hypertension aged 80 years and older: The OPTIMISE randomized clinical trial
James P. Sheppard,
Jenni Burt,
Mark Lown,
Eleanor Temple,
Rebecca Lowe,
Rosalyn Fraser,
Julie Allen,
Gary A. Ford,
Carl Heneghan,
F. D.Richard Hobbs,
Sue Jowett,
Shahela Kodabuckus,
Paul Little,
Jonathan Mant,
Jill Mollison,
Rupert A. Payne,
Marney Williams,
Ly Mee Yu,
& Richard J. McManus
, 2020 , JAMA , 323 (20) , 2039--2051
DOI: 10.1001/jama.2020.4871
Type: article
OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial
Paul Little,
james p sheppard,
Jenni Burt,
Mark Lown,
Eleanor Temple,
john benson,
Gary A Ford,
Carl Heneghan,
FD Richard Hobbs,
Sue Jowett,
Jonathan Mant,
Jill Mollison,
Alecia Nickless,
Emma Ogburn,
Rupert Payne,
Marney Williams,
Ly-Mee Yu,
& Richard J. McManus
, 2018 , BMJ Open
DOI: 10.1136/bmjopen-2018-022930
Type: article
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