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Research project

NIHR Southampton Biomedical Research Centre 2017-2022

Staff

Lead researcher

Professor Robert Read

Chair of Infectious Diseases
Other researchers

Professor Chris Byrne

Professor of Endocrinol & Met

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology

Research interests

  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone mineral accrual in childhood

Professor Philip Calder

Head of School

Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.

Professor Keith Godfrey

Associate Dean Enterprise

Professor Hasan Arshad

Prof in Allergy & Clinical Immunology

Dr Stephen Wootton PhD FAfN OBE

Associate Professor

Professor Graham Roberts

Prof in Paed. Allergy & Resp. Medicine

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect

Research outputs

The global approach to rehabilitation following an osteoporotic fragility fracture: a review of the rehabilitation working group of the International Osteoporosis Foundation (IOF) committee of scientific advisors
,
,
Daniel Pinto,
M. Alshahrani,
R. Chapurlat,
Thierry Chevalley,
Elaine Dennison,
B.M. Camargos,
A. Papaioannou,
Stuart Silverman,
Jean-Francois Kaux,
N.E. Lane,
J Morales Torres,
J. Paccou,
Rene Rizzoli,
Olivier Bruyere,
& Cyrus Cooper
, 2022 , Osteoporosis International , 33 (3) , 527--540
DOI: 10.1007/s00198-021-06240-7
Type: review
Myo-inositol moderates glucose-induced effects on human placental 13C-arachidonic acid metabolism
Oliver C. Watkins,
Victoria K.B. Cracknell-Hazra,
Reshma Appukuttan Pillai,
Preben Selvam,
Hannah E.J. Yong,
Neha Sharma,
Sathya Narayanan Patmanathan,
Amaury Cazenave-Gassiot,
Anne K. Bendt,
Keith Godfrey,
Rohan Lewis,
Markus R. Wenk,
& Shiao-Yng Chan
, 2022 , Nutrients , 14 (19)
DOI: 10.3390/nu14193988
Type: article
Sex-dependent regulation of placental oleic acid and palmitic acid metabolism by maternal glycemia and associations with birthweight.
Oliver C. Watkins,
Hannah E.J. Young,
Tania Ken Lin Mah,
Victoria Kathryn Bonnell Cracknell,
Reshma Appukuttan Pillai,
Preben Selvam,
Neha Sharma,
Amaury Cazenave-Gassiot,
Anne K. Bendt,
Keith Godfrey,
Rohan Lewis,
Markus R. Wenk,
& Shiao-Yng Chan
, 2022 , International Journal of Molecular Sciences , 23 (15)
DOI: 10.3390/ijms23158685
Type: article
Phase 1/2a Safety and Immunogenicity of an Adenovirus 26 Vector Respiratory Syncytial Virus (RSV) Vaccine Encoding Prefusion F in Adults 18–50 Years and RSV-Seropositive Children 12–24 Months
Arabella S.V. Stuart,
Miia Virta,
Kristi Williams,
Ilkka Seppa,
Robyn Hartvickson,
Melanie Greenland,
Edmund Omoruyi,
Arangassery Rosemary Bastian,
Wouter Haazen,
Nadine Salisch,
Efi Gymnopoulou,
Benoit Callendret,
Saul N Faust,
Matthew D Snape,
& Esther Heijnen
, 2022 , The Journal of Infectious Diseases , 227 (1) , 71--82
DOI: 10.1093/infdis/jiac407
Type: article
Association of differential mast cell activation with granulocytic inflammation in severe asthma
,
Angelica Tiotiu,
Yusef Badi,
Nazanin Zounemat Kermani,
Marek Sanak,
Johan Kolmert,
Craig E. Wheelock,
Philip M. Hansbro,
Sven Erik Dahlén,
Peter J. Sterk,
Ratko Djukanovic,
Yike Guo,
Sharon Mumby,
Ian M. Adcock,
Kian Fan Chung,
Uruj Hoda,
Christos Rossios,
Elisabeth Bel,
Navin Rao,
David Myles,
Chris Compton,
Marleen Van Geest,
Peter Howarth,
Graham Roberts,
Diane Lefaudeux,
Bertrand De Meulder,
Aruna T. Bansal,
Richard Knowles,
Damijn Erzen,
Scott Wagers,
Norbert Krug,
Tim Higenbottam,
John Matthews,
Veit Erpenbeek,
Leon Carayannopoulos,
Amanda Roberts,
David Supple,
Pim deBoer,
Massimo Caruso,
Pascal Chanez,
Ildikó Horváth,
Jacek Musial,
& Thomas Sandström
, 2022 , American Journal of Respiratory and Critical Care Medicine , 205 (4) , 397--411
DOI: 10.1164/rccm.202102-0355OC
Type: article