The University of Southampton
Biological Sciences

Dr Amritpal Mudher BSc, DPhil

Associate Professor in Neurosciences, Principal Investigator (Neurodegenerative diseases), National and International Schools Liaison Officer, Alzheimer Research UK South Coast Network Coordinator

Dr Amritpal Mudher's photo
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Dr Amritpal Mudher is Associate Professor in Neurosciences within the Centre for Biological Sciences at the University of Southampton.

Career history

Associate Professor in Neuroscience. University of Southampton, UK.
Senior Lecturer in Neurosciences. University of Southampton, UK.
Lecturer in Neurosciences. University of Southampton, UK.
Alzheimer Society Research Fellow (Modelling Tauopathies in Drosophila). Institute of Psychiatry, University of London, UK.
Post Doctoral Research Worker (Wnt signalling and Alzheimer's Disease). Institute of Psychiatry, University of London, UK.

Academic qualifications

BSc (Biomedical Sciences). King's College, University of London, UK.
DPhil (Neuroscience). Merton College, University of Oxford, UK.

Research

Publications

Teaching

Contributions

Contact

Research interests

The overarching aim our research is to investigate the mechanisms that underpin tau-mediated dysfunction and degeneration in tauopathies such as Alzheimer’s disease and fronto-temporal dementia (see Mudher et al 2004, Mol Psychiatry, Chee et al 2005 for early investigations). This work led us to identify disease-modifying tau-centred therapeutic targets (See Quriase et al 2013 Mol. Psychiatry). It has also raised interesting questions about the pathological significance of estasblished tau aggregates such as soluble forms of tau, tau oligomers and tau filaments. More recently we are assessing whether tau-mediated axonal degeneration is wallerian in nature.

A related project investigates the cross talk between tau and other disease-associated proteins such as Abeta peptide and alpha-synuclein. Using transgenic models in which tau is co-expressed with these proteins, we investigate the effect of co-expression on established tau phenotypes and then assess the molecular mechanism(s) underpinning this.

Another branch of research focuses on understanding how cellular processes such as TOR signalling, autophagic/proteosomal  clearance, oxidative stress and others change with age. In parallel we seek to investigate how these changes contribute to development of Alzhiemer’s disease by studying their interaction with both tau and amyloid pathologies and phenotypes.

We are also interested in using label-free Raman spectroscopic techniques to identify aggregated tau and amyloid proteins. By generating unique spectral signatures for various disease associated forms of these proteins, we hope to use this technology to probe biological fluids for biomarkers of early disease.

Key current research projects include:

a) Understanding the mechanisms underpinning tau mediated neuronal dysfunction and degeneration in tauopathies such as Alzheimer’s disease (Granular tau oligomer project/Dr.   Catherine Cowan and Wallerian degeneration in tauopathies project/Katy Stubbs in collaboration with Prof. VH Perry).
b) Identifiying disease-modifying tau-centred therapeutic targets (NAP project/Dr. Shmma Quraishe – see Quraishe et al Mol. Psychiatry 2013).
c) Unravelling mechanisms that underpin cross talk between tau and Abeta peptide in Alzheimer’s disease (protein aging project Dr. Louisa Moro in collaboration with Dr. Delphine Boche)
d) Understanding the mechanisms by which aging processes contribute to neurodegenerative diseases like Alzheimer’s disease (Aging project/Megan Sealey in collaboration with Dr. Delphine Boche and Prof. Chris Proud).
e) Using the unique structural attributes of misfolded proteins to develop label-free biomarkers (Spectral signature project/Kelly Howard in collaboration with Dr. Sumeet Mahajan)

Developing novel Drosophila models of asthma to investigate role played by genome wide association loci (pilot project in collaboration with Prof. Donna Davies, Dr. Jane Collins, Dr. Hans M Haitchi and Prof. Thomas Roeder).

Research group(s)

Biomedical Sciences

Affiliate research group(s)

Molecular and Cellular Biosciences, Institute for Life Sciences (IfLS), Southampton Neuroscience Group (SoNG)

Research project(s)

Use of Drosophila Models to Explore the Function of Asthma Susceptibility Genes

Using Drosophila models to replace, augment and inform vertebrate asthma models by allowing first-pass elucidation of key asthma genes, and providing an in vivo model for rapid high through-put drug screening.

An integrated approach to CNS inflammation: cooperation between antibodies and CD8 T cells

Microtubule destabilisation is believed to be a key mechanism by which phosphorylated tau causes dysfunction in tauopathies. In Alzheimer’s disease Abeta peptide toxicity is mediated by phosphorylated tau. This PhD project investigates whether microtubule destabilisation underpins this tau-Abeta interaction.

Unravelling the role of microtubule stabilisation in the pathogenesis of Alzheimer’s disease

Microtubule destabilisation is believed to be a key mechanism by which phosphorylated tau causes dysfunction in tauopathies. In Alzheimer’s disease Abeta peptide toxicity is mediated by phosphorylated tau. This PhD project investigates whether microtubule destabilisation underpins this tau-Abeta interaction.

Label-free spectroscopy for diagnosing and monitoring AD

Spectral signatures for disease-associated protein aggregates.

Protein misfolding and the neuroprotective role of molecular chaperones

Molecular chaperones such as heat shock proteins (HSPs) regulate protein folding, misfolding, protein degradation and signalling pathways involved in neuronal death and survival.

Immunity, neurodegeneration and ageing

Knowing exactly how the nervous system degenerates and becomes more vulnerable with age would further our understanding of how ageing occurs and how to prevent the debilitating neurological effects of ageing.

Does Wlds mediate protection in a Drosophila model of tauopathies?

Can Wlds protect against axonal dysfunction and degeneration in a transgenic model of Alzheimer’s disease?

Article(s)

Book(s)

Book Section(s)

Module coordinator

BIOL1011 Foundations of Physiology I
BIOL1012 Foundations of Physiology I
BIOL3048 Neurodegenerative diseases

 

University of Southampton

National and International Schools Liaison officer
Athena Swan committee panel member
REECH committee panel member

Professional Affiliations

Member of editorial board of Journal of Molecular Neurosciences
Member of editorial board of Acta Neuropathol. Communications

Dr Amritpal Mudher
Centre for Biological Sciences Faculty of Natural & Environmental Sciences Life Sciences Building 85 University of Southampton Highfield Campus Southampton SO17 1BJ

Room Number: 85/3057

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